{"title":"iMuscle","description":"\u003cp\u003eiMuscle is one of the third-party brands sold through Muscle Market alongside our own Free Muscle range. This collection lists every iMuscle product we currently stock. It is the widest SARM selection of any single brand on the site: seven single-compound capsule listings with a stated strength per capsule, plus five multi-compound packs. Every pack in our data contains 60 capsules. Each compound also has its own collection page where iMuscle can be compared with the other brands we hold.\u003c\/p\u003e\n\n\u003ch2\u003eWhat is in the iMuscle range\u003c\/h2\u003e\n\u003cp\u003eSingle-compound listings, all 60 capsules, with the strength per capsule recorded in our product data:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eYK-11\u003c\/strong\u003e, 10 mg: \u003ca href=\"\/products\/imuscle-yk-11-60-10mg\"\u003eiMuscle YK-11\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/yk-11\"\u003eYK-11\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRAD-140 (Testolone)\u003c\/strong\u003e, 10 mg: \u003ca href=\"\/products\/imuscle-testolon-rad-140-60-10mg\"\u003eiMuscle Testolone RAD-140\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/rad-140\"\u003eRAD-140\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSR-9009 (Stenabolic)\u003c\/strong\u003e, 10 mg: \u003ca href=\"\/products\/imuscle-stenabolic-sr-9009-60-10mg\"\u003eiMuscle Stenabolic SR-9009\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/sr9009\"\u003eSR9009\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eS-23\u003c\/strong\u003e, 15 mg: \u003ca href=\"\/products\/imuscle-s-23-60-15mg\"\u003eiMuscle S-23\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/s-23\"\u003eS-23\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOstarine (MK-2866)\u003c\/strong\u003e, 15 mg: \u003ca href=\"\/products\/imuscle-ostarine-k2866-60-15mg\"\u003eiMuscle Ostarine MK-2866\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/ostarine\"\u003eOstarine\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLGD-4033 (Ligandrol)\u003c\/strong\u003e, 8 mg: \u003ca href=\"\/products\/imuscle-ligandrol-lgd4033-60-8mg\"\u003eiMuscle Ligandrol LGD-4033\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMK-677 (Ibutamoren)\u003c\/strong\u003e, 10 mg: \u003ca href=\"\/products\/imuscle-ibutamoren-mk-677-60-10mg\"\u003eiMuscle Ibutamoren MK-677\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/mk-677\"\u003eMK-677\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMulti-compound packs, each 60 capsules. These are listed as the manufacturer supplies them; the combination is a product fact, not a suggestion of any protocol:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/products\/imuscle-testolon-yk11-ibutamoren\"\u003eTestolone, YK-11 and Ibutamoren\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/imuscle-ostarine-andarine-cardarine\"\u003eOstarine, Andarine and Cardarine\u003c\/a\u003e (see also \u003ca href=\"\/collections\/andarine\"\u003eAndarine\u003c\/a\u003e and \u003ca href=\"\/collections\/cardarine\"\u003eCardarine\u003c\/a\u003e)\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/products\/imuscle-ligandrol-testolon-yk-11\"\u003eLigandrol, Testolone and YK-11\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/products\/imuscle-ligandrol-ibutamoren-ostarine\"\u003eLigandrol, Ibutamoren and Ostarine\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/products\/imuscle-cardarine-testolon-rad140\"\u003eCardarine and Testolone RAD-140\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAll combination packs across brands are grouped under \u003ca href=\"\/collections\/market-bundles\"\u003eBundles and Stacks\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow to compare listings\u003c\/h3\u003e\n\u003cp\u003eFor a single-compound pack, multiply the stated strength by 60 to get the total milligrams, then work out the cost per milligram and set it against the same compound from another brand. The \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram article\u003c\/a\u003e shows the method. Multi-compound packs cannot be compared this way unless the per-compound content is stated on the listing.\u003c\/p\u003e\n\n\u003ch2\u003eBatch testing and certificates of analysis\u003c\/h2\u003e\n\u003cp\u003eiMuscle is a third-party manufacturer, so its batches are not covered by the Janoshik Analytical programme that tests every Free Muscle batch. For iMuscle products, a certificate of analysis is shown only where the manufacturer supplies one for the specific batch we hold; where none is available, the listing does not claim one. A usable certificate names the batch, confirms the identity of the compound and states the measured purity. A generic PDF without a batch number is not a batch certificate. See our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e for what is provided per brand.\u003c\/p\u003e\n\n\u003ch2\u003eLegal status in the UK\u003c\/h2\u003e\n\u003cp\u003eNone of these compounds is a licensed medicine. None has been assessed by the MHRA, and none is an authorised food supplement. They are supplied to adults aged 18 or over for laboratory research only and are not for human consumption. SARMs (YK-11, RAD-140, S-23, Ostarine, LGD-4033, Andarine), the growth hormone secretagogue MK-677 and the metabolic modulators SR-9009 and Cardarine are all prohibited in sport under the World Anti-Doping Agency list. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e covers the class in more depth.\u003c\/p\u003e\n\n\u003ch2\u003eDelivery and returns\u003c\/h2\u003e\n\u003cp\u003eEvery order ships with free tracked UK delivery in plain packaging. Orders placed before 2pm Monday to Friday are processed the same working day. EU delivery takes 3 to 7 working days. Unopened items can be returned within 30 days. Full details are on our \u003ca href=\"\/pages\/shipping\"\u003eshipping page\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee page\u003c\/a\u003e. Customers must be 18 or over.\u003c\/p\u003e\n\n\u003ch2\u003eRelated reading\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/sarms-explained-how-selective-androgen-receptor-modulators-work-1135-86\"\u003eSARMs explained: how selective androgen receptor modulators work\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/why-post-cycle-therapy-pct-matters\"\u003eWhy post-cycle therapy (PCT) matters\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eHow to read a certificate of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003eCompound pages: \u003ca href=\"\/collections\/rad-140\"\u003eRAD-140\u003c\/a\u003e, \u003ca href=\"\/collections\/ostarine\"\u003eOstarine\u003c\/a\u003e, \u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033\u003c\/a\u003e, \u003ca href=\"\/collections\/mk-677\"\u003eMK-677\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cem\u003eAll products in this collection are sold for laboratory research use only. They have not been evaluated by the MHRA, EMA or FDA, are not medicines or food supplements, and are not for human consumption. Buyers must be 18 or over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"imuscle-andarine-s4-60-15mg","title":"iMuscle Andarine S-4 — 60 caps, 15mg","description":"\u003cp\u003eiMuscle Andarine S-4 is supplied as 60 capsules stated at 15 mg each, for a total of 900 mg of andarine per pack. Andarine (S-4) is an early non-steroidal selective androgen receptor modulator whose published evidence comes from animal studies. The product is manufactured by iMuscle and stocked by Free Muscle for laboratory research by adults, with free tracked UK delivery.\u003c\/p\u003e\u003ch2\u003eAbout Andarine (S-4)\u003c\/h2\u003e\u003cp\u003eAndarine, usually written S-4 or S4 and coded GTx-007 during development, is one of the earliest non-steroidal selective androgen receptor modulators. It came from the aryl-propionamide series developed at the University of Tennessee and GTx Inc. in the early 2000s. Like testosterone, it binds and activates the androgen receptor. The series aimed at action on muscle and bone with less effect on other androgen-sensitive tissue; for andarine, that aim was tested only in animals.\u003c\/p\u003e\u003cp\u003eThe published data for S-4 are preclinical. In a 2007 study of 120 female rats, ovariectomised to model accelerated bone loss and treated for 120 days, S-4 maintained whole-body and trabecular bone mineral density and cortical bone content, increased the strength of the femur on mechanical testing and reduced body fat (Kearbey et al., 2007). No controlled human trial of andarine has been published, and the development programme was discontinued. In informal reports the most frequently described effect is a yellow tint to vision and slower adaptation to darkness, attributed in those accounts to the molecule binding in the retina; that finding has not been characterised in a clinical study.\u003c\/p\u003e\u003cp\u003eAndarine has never been approved as a medicine and is named under section S1.2 of the WADA Prohibited List. The animal findings summarised here are not claims about this product.\u003c\/p\u003e\u003ch3\u003eChemical identity\u003c\/h3\u003e\u003cp\u003eThese PubChem identifiers define the substance a certificate for this pack should report. The (2S) marks the molecule's single stereocentre.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystematic name\u003c\/strong\u003e: (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number\u003c\/strong\u003e: 401900-40-1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula and molecular weight\u003c\/strong\u003e: C19H18F3N3O6, 441.4 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInChIKey\u003c\/strong\u003e: YVXVTLGIDOACBJ-SFHVURJKSA-N\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID\u003c\/strong\u003e: 9824562\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eCompound: Andarine (S-4)\u003c\/li\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStated strength: 15 mg per capsule (manufacturer's label claim)\u003c\/li\u003e\n\u003cli\u003eStated total per pack: 900 mg\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eThe strength is the manufacturer's label claim; only a batch certificate confirms it. To compare brands of Andarine, use total milligrams per pack, as explained in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eAndarine in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eBehind searches such as \"andarine UK\", \"S4 SARM UK\" and \"S4 SARM for sale\" sit two questions: can andarine lawfully be bought here, and what makes a listing checkable rather than something taken on trust.\u003c\/p\u003e\u003ch3\u003eThe legal position\u003c\/h3\u003e\u003cp\u003eAndarine is not a licensed medicine in the UK: it has no MHRA marketing authorisation, is not an authorised food supplement, and cannot lawfully be sold for human consumption. Nor is it a controlled drug under the Misuse of Drugs Act 1971. Free Muscle supplies it to adults aged 18 or over for laboratory research only. It is prohibited at all times under section S1 (anabolic agents) of the WADA Prohibited List. Buyers are responsible for the rules that apply to them, including any anti-doping code and, for orders sent to the EU, their own country's import rules. Background on the class is in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eWhat a checkable listing shows, and how this one measures up\u003c\/h3\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCheck\u003c\/th\u003e\n\u003cth\u003eThis listing\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStrength, count and pack total that agree\u003c\/td\u003e\n\u003ctd\u003e15 mg per capsule, 60 capsules, 900 mg per pack\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eManufacturer and seller identified\u003c\/td\u003e\n\u003ctd\u003eMade by iMuscle; sold and dispatched by FreeMuscle LTD, a UK company in Scunthorpe\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCertificate tied to a lot number\u003c\/td\u003e\n\u003ctd\u003eThe manufacturer's COA, where iMuscle supplies one for the batch held (see the certificate section)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTerms of sale\u003c\/td\u003e\n\u003ctd\u003eLaboratory research only, adults aged 18 or over, no instructions for use, no before-and-after images or claims about results\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDelivery\u003c\/td\u003e\n\u003ctd\u003eFree tracked UK delivery in plain packaging; same-working-day processing for orders before 2pm Monday to Friday; EU delivery in 3-7 working days\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReturns\u003c\/td\u003e\n\u003ctd\u003eUnopened items within 30 days; see \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eA listing without an amount per capsule fails the first check: it can be neither priced per milligram nor compared with an assay.\u003c\/p\u003e\u003cp\u003eThis matters for andarine in particular. In 2009 anti-doping researchers at the German Sport University Cologne found andarine in oily liquids sold online as green tea extract and face moisturiser, and described the case as the first proof that SARMs were being sold and misused without any clinical approval (Thevis et al., 2009). Only analysis revealed what those bottles held; reviews and Reddit threads about \"S4\" record experiences, not contents. More checks are in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eThree formats are sold under the andarine name: capsules, liquids and loose powder. Chemically they are identical; they differ in where the quantity per unit gets fixed and in how anyone can verify it. We know of no published comparison of andarine formats.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCapsules (this product).\u003c\/strong\u003e Powder is blended and filled into shells at manufacture, so the 15 mg per capsule is set before the pot is sealed and a certificate can measure it directly. The limit is uniformity: an assay of pooled capsules reports their average, and variation between capsules shows only if units are tested one by one.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiquids.\u003c\/strong\u003e Labelled by concentration, so any portion is only as accurate as the volume measured. Solvent evaporating from a bottle opened repeatedly concentrates what remains, and a dissolved compound can come out of solution in the cold, so a certificate describes the liquid only as it was when sampled.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLoose powder.\u003c\/strong\u003e Sold by weight, which places accuracy entirely on the balance and handling of the laboratory using it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInjection.\u003c\/strong\u003e Sometimes asked about by analogy with peptides. Andarine is a small synthetic molecule, not a peptide, so the objection raised against swallowed peptides, breakdown by digestive enzymes, does not apply in the same way (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e). No published human study has given andarine by injection or any other route.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eOn stability, dry powder sealed in a capsule is kept away from the solvents and water in which chemical breakdown usually proceeds fastest. That is a general principle, not a measured result: we know of no published shelf-life data for andarine in any format.\u003c\/p\u003e\u003ch2\u003eAndarine compared with ostarine\u003c\/h2\u003e\u003cp\u003e\"Andarine vs ostarine\" is the comparison searched most often for this compound, and the two are close relatives: aryl-propionamide SARMs from the same GTx programme, built on the same (2S)-2-hydroxy-2-methylpropanamide backbone with a trifluoromethyl group on the anilide ring. They differ in two substituents, and in how far each went in development.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFeature\u003c\/th\u003e\n\u003cth\u003eAndarine (this product)\u003c\/th\u003e\n\u003cth\u003eOstarine\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eS-4, S4, GTx-007\u003c\/td\u003e\n\u003ctd\u003eMK-2866, enobosarm, GTx-024\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGroup on the anilide ring\u003c\/td\u003e\n\u003ctd\u003eNitro\u003c\/td\u003e\n\u003ctd\u003eCyano\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGroup on the phenoxy ring\u003c\/td\u003e\n\u003ctd\u003eAcetamido\u003c\/td\u003e\n\u003ctd\u003eCyano\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula, molecular weight, CAS\u003c\/td\u003e\n\u003ctd\u003eC19H18F3N3O6, 441.4, 401900-40-1\u003c\/td\u003e\n\u003ctd\u003eC19H14F3N3O3, 389.3, 841205-47-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublished evidence\u003c\/td\u003e\n\u003ctd\u003eRat studies only\u003c\/td\u003e\n\u003ctd\u003ePhase 2 trials in older adults and in people with cancer; phase 3 trials in cancer-related muscle wasting\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAdverse findings in people\u003c\/td\u003e\n\u003ctd\u003eNone from controlled studies; visual changes in informal reports\u003c\/td\u003e\n\u003ctd\u003eAdverse events recorded in monitored trials; named in published reports of liver injury outside them\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLicensed as a medicine\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS1.2, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eS1.2, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThe real difference is depth of evidence. Ostarine's trials enrolled people under medical supervision and published what they measured, adverse events included; that record and its limits are set out in \u003ca href=\"\/blogs\/news\/ostarine-mk-2866-research-guide\"\u003eOstarine (MK-2866): the most-studied SARM, what trials found\u003c\/a\u003e. Andarine has no equivalent, so claims that it is \"stronger\" or \"milder\" than ostarine in people rest on anecdote. Milligrams do not translate either: andarine is the heavier molecule, so equal figures on two labels are not equal amounts of substance, and no study establishes any equivalence between them.\u003c\/p\u003e\u003cp\u003eIn law and in sport there is no difference, and both are sold here for laboratory research only. Ostarine brands, including \u003ca href=\"\/products\/imuscle-ostarine-k2866-60-15mg\"\u003eiMuscle Ostarine\u003c\/a\u003e, are compared in the \u003ca href=\"\/collections\/ostarine\"\u003eOstarine (MK-2866) collection\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand, so any certificate of analysis (COA) for this pack is the manufacturer's, not ours. Where iMuscle supplies a COA for the batch we hold, we show it; where none exists for the batch in stock, we say so rather than show a generic document. Free Muscle-brand compounds are assayed batch by batch at Janoshik Analytical; that programme does not cover iMuscle. A real andarine batch certificate should answer each point below.\u003c\/p\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhich compound.\u003c\/strong\u003e Andarine, S-4 or GTx-007, ideally with CAS 401900-40-1. A document headed only \"SARM\" says nothing about this pot.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity, and by what method.\u003c\/strong\u003e HPLC matches the sample's retention time to a reference standard; LC-MS adds a molecular mass that should fit C19H18F3N3O6 (441.4 g\/mol). The 2009 Cologne analysis confirmed identity against reference material by both liquid chromatography and high-resolution mass spectrometry (Thevis et al., 2009).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Usually an HPLC area percentage: the share of detected material that is andarine. It is the line that would expose a by-product like the one in that 2009 sample, left by poor purification at roughly a tenth of the andarine present. It says nothing about milligrams per capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The assayed milligrams in a capsule, the figure that tests the 15 mg claim. If it is missing, so is any check on the 900 mg total.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStereochemistry.\u003c\/strong\u003e Andarine is the (2S) form. Its (2R) mirror image has the same formula and mass and is not separated by standard HPLC; only a chiral method tells them apart. A certificate silent on this has not tested for it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLot number, test date and laboratory.\u003c\/strong\u003e The lot on the report has to be the lot on your pot; the test date tells you how old the result is; and the issuing laboratory, if named, can be asked whether the report is genuine.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003eAny blank line means the matching label figure is still unverified; \u003ca href=\"\/pages\/contact\"\u003econtact us\u003c\/a\u003e and we will tell you what documentation exists for the stock we hold. See also \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eAndarine is named in section S1.2 (other anabolic agents) of the WADA Prohibited List and is banned in and out of competition; WADA has prohibited SARMs as a class since 2008 (Thevis et al., 2010). Anti-doping rules apply strict liability: an athlete is responsible for any prohibited substance in their sample, whatever its source, a mislabelled product included.\u003c\/p\u003e\u003cp\u003eTesting does not depend on finding the unchanged molecule. The same Cologne group then characterised andarine's urinary metabolites by liquid chromatography with high-resolution mass spectrometry and confirmed targets for routine doping control: glucuronic acid conjugates of andarine and of its hydroxylated or deacetylated products, a hydrolysis product formed when one of its two aromatic rings is removed, and sulfate conjugates of the hydroxylated and deacetylated metabolites (Thevis et al., 2010).\u003c\/p\u003e\u003cp\u003eWhat the published record does not give is a detection window. We know of no verified study reporting how long andarine or its metabolites remain detectable, so for this product the accurate statement is: detectable, window not established. The absence of a figure is not evidence of a short window. Anyone subject to anti-doping rules should treat any contact with andarine as a risk of an adverse analytical finding.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eWe know of no published stability study of andarine capsules, so the expiry or best-before date printed by iMuscle is the working limit, and a certificate describes the batch as it was on its test date, not as it is now.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eContainer.\u003c\/strong\u003e Leave the capsules in the pot they came in and close it after every opening. Separated from that pot and its lot number, capsules can no longer be matched to a certificate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConditions.\u003c\/strong\u003e A cool, dry cupboard away from direct light and from radiators, ovens and sunny windowsills. Steam from bathrooms and kitchens softens capsule shells and makes powder clump.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecords.\u003c\/strong\u003e Write the opening date next to the lot number. Any portion taken for analysis needs its own label giving compound, lot and date.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChanges in appearance.\u003c\/strong\u003e Capsules that have discoloured, softened or stuck together are no longer the material a certificate describes; set them aside and \u003ca href=\"\/pages\/contact\"\u003econtact us\u003c\/a\u003e with the lot number.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHandling and disposal.\u003c\/strong\u003e Wear gloves for opened capsules or powder, work away from food and drink, keep the pot out of reach of children and pets, and dispose of unwanted material as chemical waste under local rules, never in household bins or drains.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: selective androgen receptor modulator; a non-steroidal ligand of the androgen receptor, pursued in the hope of anabolic action in muscle and bone with less action on the prostate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAndrogen receptor\u003c\/strong\u003e: the protein inside cells that testosterone and dihydrotestosterone activate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAryl-propionamide\u003c\/strong\u003e: the chemical family of andarine, ostarine and S-23, in which a propanamide chain links two substituted benzene rings.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePreclinical\u003c\/strong\u003e: research in cells or animals, before or instead of trials in people.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOvariectomised rat\u003c\/strong\u003e: a female rat with the ovaries removed, a standard model of bone loss after oestrogen deficiency.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBone mineral density\u003c\/strong\u003e: mineral content of bone per unit of area or volume, measured in the 2007 study by dual-energy X-ray absorptiometry.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnantiomers\u003c\/strong\u003e: two mirror-image forms of a molecule with a stereocentre, such as (2S)- and (2R)-andarine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC\u003c\/strong\u003e: high-performance liquid chromatography, which separates a sample's components for identification and measurement against a standard.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLC-MS\u003c\/strong\u003e: liquid chromatography coupled to mass spectrometry, adding each component's mass for a stronger identity check.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolite\u003c\/strong\u003e: a breakdown or conversion product formed in the body; some persist longer than the parent molecule, which is why testers look for them.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucuronide\u003c\/strong\u003e: a metabolite formed when the body attaches glucuronic acid to a molecule, easing its excretion in urine.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/andarine\"\u003eAll brands of Andarine (S-4)\u003c\/a\u003e, compared on strength, pack size and batch testing\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e stocked at Free Muscle\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/ostarine\"\u003eOstarine (MK-2866)\u003c\/a\u003e, \u003ca href=\"\/collections\/s-23\"\u003eS-23\u003c\/a\u003e and \u003ca href=\"\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It is not a medicine, has not been evaluated by the MHRA, EMA or FDA, and is not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eKearbey JD, et al. Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res. 2007;24(2):328-35. PMID: 17063395.\u003c\/li\u003e\n\u003cli\u003eThevis M, et al. Detection of the arylpropionamide-derived selective androgen receptor modulator (SARM) S-4 (Andarine) in a black-market product. Drug Test Anal. 2009;1(8):387-92. PMID: 20355219.\u003c\/li\u003e\n\u003cli\u003eThevis M, et al. Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator andarine (S-4) for routine doping control purposes. Rapid Commun Mass Spectrom. 2010;24(15):2245-54. PMID: 20623476.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468978893026,"sku":null,"price":39.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/ANDARINES4_720x_7a53b342-6ae9-441a-853c-b0481db9dbc3.jpg?v=1789931395"},{"product_id":"imuscle-cardarine-gw501516-60-10mg","title":"iMuscle Cardarine GW-501516 — 60 caps, 10mg","description":"\u003cp\u003e\u003cstrong\u003eiMuscle Cardarine GW-501516, 60 caps, 10mg\u003c\/strong\u003e is an iMuscle listing of Cardarine, labelled at 10 mg per capsule, 60 capsules per pack, 600 mg in total. It is supplied through the Muscle Market range for laboratory research only, is not for human consumption, and is sold to adults aged 18 and over. Below: what the published research reports, including why development was abandoned, the UK legal position, and how batch certificates are handled for iMuscle products.\u003c\/p\u003e\n\u003ch2\u003eAbout Cardarine\u003c\/h2\u003e\n\u003cp\u003eGW-501516 is the development code; Cardarine, GW501516, GW1516 and endurobol are the other names under which the same molecule is sold. Pharmacologically it is a synthetic PPAR-delta agonist. PPAR-delta is a nuclear receptor, and in skeletal muscle it controls genes that govern how fatty acids are oxidised for energy. GlaxoSmithKline and Ligand took the compound forward as a possible treatment for lipid disorders. Sellers often place it next to SARMs, but it never touches the androgen receptor, and despite occasional searches for \"cardarine peptide\" it is a small molecule of about 454 g\/mol rather than an amino acid chain.\u003c\/p\u003e\n\u003ch3\u003eWhat the published research reports\u003c\/h3\u003e\n\u003cp\u003eIn a 2008 study in mice, GW-501516 combined with treadmill training increased oxidative muscle fibres and running endurance more than training alone, and the authors described PPAR-delta and AMPK agonists as exercise mimetics; in the same paper it was AICAR, a different compound, that raised endurance in untrained mice (Narkar et al., 2008). A GlaxoSmithKline trial published in 2012, in 268 people with low HDL cholesterol, reported that over twelve weeks HDL rose while LDL cholesterol and triglycerides fell from baseline; the trial was short and not designed to assess long-term safety (Olson et al., 2012). Anti-doping researchers later summarised the clinical programme as having reached phase II trials in dyslipidaemia and metabolic syndrome (Thevis et al., 2010).\u003c\/p\u003e\n\u003cp\u003eDevelopment was abandoned in 2007 after two-year carcinogenicity studies in rats and mice found tumours in multiple organs. Those toxicology results were presented at a conference and are not indexed on PubMed, so they are not cited here, but they are the most important fact about this compound. No later human trial has been completed and Cardarine has never been approved as a medicine anywhere. Nothing above is a claim about this product.\u003c\/p\u003e\n\u003ch3\u003eChemical identity\u003c\/h3\u003e\n\u003cp\u003eThese PubChem identifiers describe the molecule a batch certificate for this pack should name.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystematic name\u003c\/strong\u003e: 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number\u003c\/strong\u003e: 317318-70-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula and molecular weight\u003c\/strong\u003e: C21H18F3NO3S2, 453.5 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInChIKey\u003c\/strong\u003e: YDBLKRPLXZNVNB-UHFFFAOYSA-N\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID\u003c\/strong\u003e: 9803963\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eManufacturer: iMuscle\u003c\/li\u003e\n\u003cli\u003eCompound: Cardarine (GW-501516)\u003c\/li\u003e\n\u003cli\u003eForm: Capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStrength: 10 mg per capsule, as stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eTotal in pack: 600 mg (10 mg x 60 capsules)\u003c\/li\u003e\n\u003cli\u003eBatch certificate of analysis: shown where iMuscle supplies one for the batch we hold\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption, adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe 10 mg figure is iMuscle's label claim. Only an assay of the batch confirms it. To compare this pack with other Cardarine listings, work from the total milligrams per pack and the cost per milligram, as set out in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e, and then check what certificate each seller holds.\u003c\/p\u003e\n\u003ch2\u003eCardarine in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eSearches such as \"cardarine UK\", \"cardarine UK legal\", \"cardarine UK buy\" and \"cardarine for sale\" come down to two questions: may Cardarine be bought here at all, and how can a buyer tell a listing that can be checked from one that asks to be trusted.\u003c\/p\u003e\n\u003ch3\u003eThe legal position\u003c\/h3\u003e\n\u003cp\u003eCardarine is not a licensed medicine in the UK, has not been assessed by the MHRA, and is not an authorised food supplement, so it cannot lawfully be sold for people to swallow. It is not a controlled drug under the Misuse of Drugs Act 1971. Free Muscle sells it to adults aged 18 and over for laboratory research only, and gives no instructions for use. GW-501516 is named on the WADA Prohibited List under section S4 (hormone and metabolic modulators) as a PPAR-delta agonist and is prohibited at all times in sport. WADA issued a specific warning about it in 2013. Buyers are responsible for the rules that apply to them, including import rules for EU orders. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eresearch guide\u003c\/a\u003e covers the wider legal picture for compounds sold alongside SARMs.\u003c\/p\u003e\n\u003ch3\u003eWhat a checkable UK listing shows\u003c\/h3\u003e\n\u003cp\u003eMany sites file Cardarine under SARMs, but the category label proves nothing. What counts is a short list of verifiable facts, set against this listing below.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eWhat to look for\u003c\/th\u003e\n\u003cth\u003eThis listing\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eA stated strength, a unit count and a pack total that agree\u003c\/td\u003e\n\u003ctd\u003e10 mg per capsule, 60 capsules, 600 mg per pack\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eA named manufacturer and a named seller\u003c\/td\u003e\n\u003ctd\u003eMade by iMuscle; sold by FreeMuscle LTD, a UK company based in Scunthorpe\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eA certificate tied to the batch number on the pot\u003c\/td\u003e\n\u003ctd\u003eThe manufacturer's certificate, where iMuscle supplies one for the batch we hold\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResearch-only terms with no usage directions\u003c\/td\u003e\n\u003ctd\u003eResearch use only, 18+, no amounts, schedules or result claims\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTracked delivery and discreet packaging\u003c\/td\u003e\n\u003ctd\u003eFree tracked UK delivery in plain packaging; orders placed before 2pm Monday to Friday processed the same working day; EU delivery in 3-7 working days\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eA returns policy\u003c\/td\u003e\n\u003ctd\u003e30-day returns on unopened items, see \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eA listing that promises results, quotes user reviews as evidence or shows before-and-after pictures is advertising a use, which a research supplier cannot lawfully do. The fuller supplier checklist is in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eCardarine appears in three physical forms: filled capsules like this pack, liquids sold by concentration, and loose powder sold by weight. The molecule is the same; what differs is where the quantity per unit is fixed and how easily it can be verified. No published study compares these formats for GW-501516.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCapsules.\u003c\/strong\u003e The 10 mg per capsule is fixed when powder is blended and filled at manufacture, so an assay can measure it directly and the figure cannot drift once the pot is sealed. The weak point is uniformity between individual capsules, which a pooled assay averages out.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiquids.\u003c\/strong\u003e Accuracy depends on the concentration being correct and on how precisely a volume is measured. Carrier solvents can evaporate from a bottle that is opened repeatedly, raising the concentration of what is left, and cold storage can cause the compound to crystallise out.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePowder.\u003c\/strong\u003e Accuracy rests entirely on the balance and technique of the laboratory weighing it.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBecause Cardarine is a small molecule and not a peptide, the argument that digestive enzymes break down peptides taken by mouth does not apply to it in the same way (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e). On stability, a dry powder sealed in a capsule is kept away from water and solvents, where chemical breakdown generally proceeds fastest, but we know of no published shelf-life study for any Cardarine format.\u003c\/p\u003e\n\u003ch2\u003eCardarine compared with SR9009\u003c\/h2\u003e\n\u003cp\u003e\"Stenabolic vs cardarine\" is the comparison searched most often for this compound, largely because both are sold under metabolic or endurance headings. Pharmacologically they have little in common beyond being synthetic ligands of nuclear receptors.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFeature\u003c\/th\u003e\n\u003cth\u003eCardarine (this product)\u003c\/th\u003e\n\u003cth\u003eSR9009 (stenabolic)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eTarget\u003c\/td\u003e\n\u003ctd\u003ePPAR-delta, a fatty acid sensing receptor\u003c\/td\u003e\n\u003ctd\u003eREV-ERB alpha and beta, repressors in the body clock machinery\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOrigin\u003c\/td\u003e\n\u003ctd\u003eGlaxoSmithKline and Ligand, lipid disorders programme\u003c\/td\u003e\n\u003ctd\u003eAcademic laboratory at the Scripps Research Institute\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and CAS\u003c\/td\u003e\n\u003ctd\u003eC21H18F3NO3S2, 317318-70-0\u003c\/td\u003e\n\u003ctd\u003eC20H24ClN3O4S, 1379686-30-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman data\u003c\/td\u003e\n\u003ctd\u003eShort phase II lipid trials\u003c\/td\u003e\n\u003ctd\u003eNo published human trial\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eKey limiting finding\u003c\/td\u003e\n\u003ctd\u003eTumours in two-year rodent studies; development stopped in 2007\u003c\/td\u003e\n\u003ctd\u003eEvidence confined to cells and animals\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLicensed as a medicine\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS4, metabolic modulator, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eS4, metabolic modulator, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eSR9009 was first described in 2012, when a Scripps group reported that synthetic REV-ERB agonists altered circadian behaviour and the daily pattern of clock and metabolic gene expression in mice, raised energy expenditure, and reduced fat mass in diet-induced obese mice (Solt et al., 2012). That is a mouse study; no human trial of SR9009 has been published, so its record is shorter than Cardarine's but also lacks Cardarine's two-year toxicology data, which is absence of information rather than reassurance. Cardarine, by contrast, has human lipid data and a carcinogenicity finding that ended its development.\u003c\/p\u003e\n\u003cp\u003eNeither compound is interchangeable with the other, neither is licensed, and both are sold here for laboratory research only. SR9009 listings, including \u003ca href=\"\/products\/imuscle-stenabolic-sr-9009-60-10mg\"\u003eiMuscle Stenabolic SR-9009\u003c\/a\u003e, are compared in the \u003ca href=\"\/collections\/sr9009\"\u003eSR9009 (Stenabolic) collection\u003c\/a\u003e, and the background is in \u003ca href=\"\/blogs\/news\/sr9009-stenabolic-research-guide\"\u003eSR9009 (Stenabolic): the research guide\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eThe Janoshik Analytical programme that assays every Free Muscle-brand batch, with certificates emailed on request, does not extend to this pack, because iMuscle manufactures it. Any certificate here is iMuscle's own, and we display one only when iMuscle has supplied it for the exact batch on our shelves. We will not pass off an undated or batch-free PDF as a certificate. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the product name and we will either send the document for current stock or tell you that none exists. Where one is available, these are the lines worth reading.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhat was tested.\u003c\/strong\u003e Look for GW-501516 or Cardarine by name, and preferably CAS 317318-70-0. A heading such as \"PPAR agonist\" or \"SARM\" could describe dozens of substances.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHow identity was shown.\u003c\/strong\u003e A matching retention time on HPLC against a reference standard is the basic check. Where LC-MS was run, the measured mass ought to fit C21H18F3NO3S2 at 453.5 g\/mol, which is harder to fake or misread.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity figure.\u003c\/strong\u003e Normally a percentage of total peak area on the chromatogram. A high number means few contaminants were seen; it does not reveal the milligram content of a capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMeasured milligrams.\u003c\/strong\u003e An assay result in mg per capsule is what tests iMuscle's 10 mg claim. Without it, the 600 mg pack total rests on the label alone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLot and date.\u003c\/strong\u003e Compare the lot on the report with the lot on the pot; a mismatch means the report describes other stock. The date tells you how long ago the sample was analysed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIssuing laboratory.\u003c\/strong\u003e A named laboratory can be asked to confirm that the report is genuine.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eA missing field is information in itself: whatever the certificate does not measure remains a label claim. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e explain the documents in more detail.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eGW-501516 has been on the WADA Prohibited List since January 2009, when it was first classed as a gene doping agent; it now sits in section S4 among the metabolic modulators and is prohibited in and out of competition (Thevis et al., 2010). Anti-doping rules apply strict liability, so an athlete is responsible for any prohibited substance in a sample regardless of how it got there, including through a mislabelled product.\u003c\/p\u003e\n\u003cp\u003eTesting does not rely on finding the unchanged compound. The Cologne anti-doping laboratory synthesised the two main urinary metabolites, a sulfoxide and a sulfone formed by oxidation of the sulphur atom, confirmed their structures by high-resolution mass spectrometry and NMR, and validated a routine screening method with a reported limit of detection of 0.1 ng\/ml in urine (Thevis et al., 2010). Numerous sanctions have followed.\u003c\/p\u003e\n\u003cp\u003eWe know of no verified published figure for how long Cardarine or its metabolites remain detectable after exposure, so the accurate statement for this product is: detectable, window not established. The lack of a published window is not evidence that the window is short.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eNo published stability study covers Cardarine capsules, so the expiry or best-before date printed by iMuscle is the working limit, and any certificate describes the batch on its test date rather than today.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep the original pot.\u003c\/strong\u003e The lot number on the label is what links the capsules to a certificate; capsules moved to another container lose that link.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCool, dry and dark.\u003c\/strong\u003e Store below room temperature where possible, away from radiators and sunny windowsills, and away from bathroom or kitchen humidity, which softens gelatine shells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep a record.\u003c\/strong\u003e Write down when the seal was broken, and give any aliquot sent for analysis its own label carrying the lot number.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCheck condition.\u003c\/strong\u003e If shells have cracked, turned sticky or changed colour, the contents may have changed too; quarantine them and send us the lot number.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLaboratory practice.\u003c\/strong\u003e Gloves for any opened capsule, a work area separate from food and drink, storage beyond the reach of children and pets, and disposal through the chemical waste route your local rules set out.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePPAR-delta\u003c\/strong\u003e: one of three peroxisome proliferator-activated receptors (alpha, gamma and delta); the delta form is widespread in muscle and is the receptor Cardarine binds.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eREV-ERB\u003c\/strong\u003e: a pair of nuclear receptors in the circadian clock machinery; the target of SR9009.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExercise mimetic\u003c\/strong\u003e: the description Narkar and colleagues applied in 2008, based on changes in mouse muscle, not on any human finding.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHDL cholesterol\u003c\/strong\u003e: high-density lipoprotein cholesterol, one of the blood lipid measures reported in the human trials.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCarcinogenicity study\u003c\/strong\u003e: a long-term animal study, usually two years in rodents, designed to detect tumour formation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase II trial\u003c\/strong\u003e: an early human study testing effects on a disease marker in a limited number of participants.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC\u003c\/strong\u003e: a technique that pumps a dissolved sample through a packed column so its components emerge at different times and can be measured.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLC-MS\u003c\/strong\u003e: liquid chromatography coupled to mass spectrometry, which adds a molecular mass to the identity check.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSulfoxide and sulfone\u003c\/strong\u003e: the oxidised forms of GW-501516 found in urine, which anti-doping laboratories screen for.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLimit of detection\u003c\/strong\u003e: the lowest concentration an analytical method can reliably distinguish from zero.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/cardarine\"\u003eAll brands of Cardarine we stock, compared\u003c\/a\u003e, including \u003ca href=\"\/products\/thoroughbred-labs-gw501516\"\u003eThoroughbred Labs GW-501516\u003c\/a\u003e and our own \u003ca href=\"\/products\/cardarine-gw-501516-10mg-free-muscle-60-capsules\"\u003eFree Muscle Cardarine 10mg\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/cardarine-gw-501516-what-happened-in-development\"\u003eCardarine (GW-501516): why development stopped and what the data show\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/sr9009\"\u003eSR9009 (Stenabolic)\u003c\/a\u003e and \u003ca href=\"\/collections\/weight-loss\"\u003emetabolic support\u003c\/a\u003e collections\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/pages\/lab-tests\"\u003eBatch testing and certificates of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It has not been evaluated by the MHRA, EMA or FDA. It is not a medicine, not a food supplement and not for human consumption. Sold only to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice, and descriptions of published studies are not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eNarkar VA, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008;134(3):405-15. PMID: 18674809.\u003c\/li\u003e\n\u003cli\u003eOlson EJ, et al. Lipid effects of peroxisome proliferator-activated receptor-delta agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. Arterioscler Thromb Vasc Biol. 2012;32(9):2289-94. PMID: 22814748.\u003c\/li\u003e\n\u003cli\u003eThevis M, et al. Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls. Anal Bioanal Chem. 2010;396(7):2479-91. PMID: 19946680.\u003c\/li\u003e\n\u003cli\u003eSolt LA, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012;485(7396):62-8. PMID: 22460951.\u003c\/li\u003e\n\u003c\/ol\u003e\n","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468978958562,"sku":null,"price":49.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/CARDARINE2_720x_d6eeb76e-e12e-4d4e-8613-f1d8572b8197.jpg?v=1789931398"},{"product_id":"imuscle-cardarine-gw501516-ligandrol","title":"iMuscle Cardarine GW-501516 + Ligandrol stack","description":"\u003cp\u003e\u003cstrong\u003eiMuscle Cardarine GW-501516 + Ligandrol\u003c\/strong\u003e is a two-compound bundle from iMuscle that pairs Cardarine (GW-501516) with LGD-4033 (Ligandrol), 60 capsules in total. iMuscle does not state the strength of either compound and we do not guess at it. The bundle simply offers both in one listing; we make no claim that the two do anything together. Supplied for laboratory research only, not for human consumption, to adults aged 18 and over.\u003c\/p\u003e\u003cp\u003eNothing here suggests they be studied or used together.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eCardarine (GW-501516)\u003c\/h3\u003e\u003cp\u003eCardarine, also written GW501516 or endurobol, is a synthetic PPAR-delta agonist developed by GlaxoSmithKline and Ligand for lipid disorders; it is not a SARM. A 2012 twelve-week human trial in 268 subjects with low HDL cholesterol recorded a rise in HDL and a fall in triglycerides, but was not designed to assess long-term safety (Olson et al., 2012). Clinical development was halted after two-year rodent carcinogenicity studies found tumours in multiple organs. Every brand we stock is on the \u003ca href=\"\/collections\/cardarine\"\u003eCardarine collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eLGD-4033 (Ligandrol)\u003c\/h3\u003e\u003cp\u003eLGD-4033, also called ligandrol or VK5211, is a non-steroidal selective androgen receptor modulator from Ligand Pharmaceuticals. In a 2013 placebo-controlled study, 76 healthy men aged 21 to 50 took LGD-4033 or placebo for 21 days. Lean body mass rose dose-dependently while fat mass did not change significantly; total testosterone, SHBG, HDL cholesterol and triglycerides fell dose-dependently, and free testosterone and FSH fell at the highest level only. Hormones and lipids returned to baseline after the study ended (Basaria et al., 2013). It was never approved. See the \u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033 collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eHow the two compounds differ\u003c\/h3\u003e\u003cp\u003eSharing a bundle does not make the two relatives. They bind different receptors, come from different chemical families and sit in different sections of the anti-doping list.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eProperty\u003c\/th\u003e\n\u003cth\u003eCardarine\u003c\/th\u003e\n\u003cth\u003eLGD-4033\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eClass\u003c\/td\u003e\n\u003ctd\u003ePPAR-delta agonist (not a SARM)\u003c\/td\u003e\n\u003ctd\u003eSelective androgen receptor modulator\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReceptor\u003c\/td\u003e\n\u003ctd\u003ePPAR-delta, a nuclear receptor governing fatty-acid oxidation genes\u003c\/td\u003e\n\u003ctd\u003eAndrogen receptor, the receptor testosterone activates\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e317318-70-0\u003c\/td\u003e\n\u003ctd\u003e1165910-22-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and molecular weight\u003c\/td\u003e\n\u003ctd\u003eC21H18F3NO3S2, 453.5 g\/mol\u003c\/td\u003e\n\u003ctd\u003eC14H12F6N2O, 338.25 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStereocentres\u003c\/td\u003e\n\u003ctd\u003eNone\u003c\/td\u003e\n\u003ctd\u003eTwo, marked (2R) and (1R) in the systematic name\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublished human data\u003c\/td\u003e\n\u003ctd\u003eLipid trials in people with low HDL cholesterol\u003c\/td\u003e\n\u003ctd\u003eOne 21-day placebo-controlled study in healthy men\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWhy development stopped or stalled\u003c\/td\u003e\n\u003ctd\u003eTumours in two-year rodent studies\u003c\/td\u003e\n\u003ctd\u003eNot approved; no long-term human data published\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA section\u003c\/td\u003e\n\u003ctd\u003eS4, hormone and metabolic modulators\u003c\/td\u003e\n\u003ctd\u003eS1, anabolic agents\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eNothing summarised above is a claim about this product, and no published study has examined these compounds together.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eCompounds: Cardarine (GW-501516) and LGD-4033 (Ligandrol)\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules in total across the bundle\u003c\/li\u003e\n\u003cli\u003eStrength per compound: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eBundle basis: two compounds in one listing; no combined effect is claimed\u003c\/li\u003e\n\u003cli\u003eUse: laboratory research only, not for human consumption, adults 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eWith no stated strength, total milligrams per pack cannot be calculated and we do not estimate it. The single-compound iMuscle listings carry a label strength; see \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCardarine and LGD-4033 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eTwo questions come up most often about these compounds in Britain: whether they can be bought lawfully, and how one listing can be told apart from another.\u003c\/p\u003e\u003ch3\u003eThe legal position for each compound\u003c\/h3\u003e\u003cp\u003eNeither Cardarine nor LGD-4033 is a licensed medicine in the UK (MHRA) or an authorised food supplement, so neither may be sold for people to take. They are not controlled drugs under the Misuse of Drugs Act 1971 and may be sold to adults for laboratory research, the only basis for this listing. Free Muscle gives no directions for use with either. Both are on the WADA Prohibited List, Cardarine under S4 (hormone and metabolic modulators) and LGD-4033 under S1 (anabolic agents), and are banned in tested sport at all times. Background: \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eWhy the label alone settles nothing\u003c\/h3\u003e\u003cp\u003eBoth compounds in this bundle turn up in the best-known analysis of products sold online. In 2016, researchers working with anti-doping laboratory methods bought 44 products marketed as SARMs (Van Wagoner et al., 2017). LGD-4033 was one of the three SARMs they detected, in the 23 products that contained any SARM. GW501516 was among the other unapproved drugs found in 17 further products. Four products held no active compound, eleven held substances not listed, and only 18 of the 44 contained the amount their label stated. For a two-compound bundle, that means two separate claims to confirm, not one.\u003c\/p\u003e\u003ch3\u003eWhat a checkable listing shows, and how this one compares\u003c\/h3\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eA named manufacturer and a named UK seller.\u003c\/strong\u003e Met: iMuscle makes the bundle, and FreeMuscle LTD, a UK company in Scunthorpe, sells and dispatches it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated strength for each compound.\u003c\/strong\u003e Not met: iMuscle states none, so we quote none.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate for each lot held.\u003c\/strong\u003e Shown only where iMuscle supplies one for the batch we hold; see the certificate section below.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-only terms.\u003c\/strong\u003e Met: no amounts, schedules or outcome claims, adults aged 18 and over.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTraceable, discreet delivery.\u003c\/strong\u003e Met: every UK order goes free and tracked in plain packaging.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA way to send it back.\u003c\/strong\u003e Met: any unopened item can come back within 30 days, as set out on the \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e pages.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003eStar ratings and forum threads record delivery experiences, not capsule contents. A longer checklist is in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eBoth compounds are also offered as liquids and loose powders. The molecule does not change with the format; what changes is where the quantity per unit is fixed, and so what a certificate can vouch for.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCapsules, as here.\u003c\/strong\u003e Powder is blended and portioned into shells before sealing, so the amount is set once, at manufacture, and an assay can report it directly. The unknown is how evenly the blend was mixed, since a single assay reports an average across the capsules sampled.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiquids.\u003c\/strong\u003e Sold by concentration, so every portion depends on measuring a volume accurately. A solution opened often can lose solvent and grow stronger.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePowder.\u003c\/strong\u003e Nothing is portioned in advance, so accuracy depends wholly on the balance and the person weighing.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInjectable versions of either are sometimes listed, but no human study we can cite gave either compound by injection; the 2013 LGD-4033 study describes it as an oral compound in its title. Neither is a peptide. At 453.5 and 338.25 g\/mol they are small synthetic molecules, so the argument that digestive enzymes break down swallowed peptides does not apply to them in the same way (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e). For this bundle, the capsule format's main strength, a stated figure per capsule that can be checked, is absent because iMuscle states none.\u003c\/p\u003e\u003ch2\u003eEach compound compared with its most-searched alternative\u003c\/h2\u003e\u003cp\u003eA bundle has no single comparison, so each compound is set against the one it is most often searched with: \"stenabolic vs cardarine\" and \"LGD 4033 vs RAD 140\".\u003c\/p\u003e\u003ch3\u003eCardarine compared with SR9009\u003c\/h3\u003e\u003cp\u003eSR9009, sold as stenabolic, is often treated as a sister compound of Cardarine, but the resemblance is commercial, not chemical. SR9009 (C20H24ClN3O4S, CAS 1379686-30-2) binds REV-ERB alpha and beta, receptors in the circadian clock, whereas Cardarine binds PPAR-delta. SR9009 came from an academic laboratory at the Scripps Research Institute and was first described in 2012 in mouse work; it has never entered a clinical trial, so it has no human lipid data like Cardarine's and no published two-year carcinogenicity studies either. That second gap is missing information, not reassurance. Neither is licensed anywhere; WADA lists both under S4. SR9009 brands are in the \u003ca href=\"\/collections\/sr9009\"\u003eSR9009 collection\u003c\/a\u003e, with background in the \u003ca href=\"\/blogs\/news\/sr9009-stenabolic-research-guide\"\u003eSR9009 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eLGD-4033 compared with RAD-140\u003c\/h3\u003e\u003cp\u003eRAD-140 (testolone, vosilasarm), from Radius Health, is like LGD-4033 a non-steroidal SARM that activates the androgen receptor and was never approved. Their clinical records point in different directions. LGD-4033 was given to healthy young men for three weeks with body composition and hormones among the outcomes. RAD-140's first-in-human phase 1 study enrolled 22 postmenopausal women with ER-positive, HER2-negative metastatic breast cancer to establish safety and a maximum tolerated level; raised liver enzymes (AST in 59% and ALT in 45%) were the most frequent adverse events (LoRusso et al., 2022). No trial has compared them, so claims that one is stronger rest on anecdote. WADA names both in section S1.2. RAD-140 brands are in the \u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 collection\u003c\/a\u003e, and its trial is covered in \u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand, so any certificate of analysis is the manufacturer's. We show one only where iMuscle supplies it for the batch we hold; a bundle may draw on a separate batch per compound, so ask for each by compound name. A generic PDF with no batch number is not a batch certificate. Free Muscle-brand batches are assayed by Janoshik Analytical, an independent laboratory, with the certificate sent on request by email; that programme does not cover iMuscle. See \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eBecause the bundle holds two compounds, expect two identity results, normally on two certificates. Read each against these points:\u003c\/p\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eName and CAS number.\u003c\/strong\u003e 317318-70-0 for Cardarine and 1165910-22-4 for LGD-4033. A heading of only \"SARM\" does not say which molecule was found.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity method.\u003c\/strong\u003e HPLC compares the sample's retention time with a reference standard. LC-MS adds a measured mass, which should match the molecular formula: a monoisotopic mass of about 453.07 for Cardarine and 338.09 for LGD-4033, usually seen as an ion about one mass unit above or below. Without an identity result, a purity figure could describe some other substance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIsomer, for LGD-4033 only.\u003c\/strong\u003e Its two stereocentres mean other isomers share its formula and mass, so a mass match alone does not prove the right form. Cardarine has no stereocentre, so the point does not arise for it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity percentage.\u003c\/strong\u003e Usually a share of the total HPLC peak area: how much of what was detected is the named compound. It does not give milligrams per capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e For most listings this tests a label claim. Here there is no label claim, so a measured figure would be the first statement of strength rather than a check on one.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number, test date and laboratory.\u003c\/strong\u003e The lot must match the container, the date shows the age of the result, and a named laboratory can be asked to confirm the report.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003eA missing field leaves its question open. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the lot numbers and we will tell you what documentation exists. See also \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eBoth compounds are banned in and out of competition. GW-501516 has been on the WADA list since January 2009, first categorised as a gene doping substance and now in section S4 (Thevis et al., 2010). LGD-4033 is named in section S1.2 among other anabolic agents. Anti-doping rules apply strict liability, so an athlete answers for any prohibited substance in a sample however it got there, and the 2017 analysis shows that a product's label is no guide to what it holds.\u003c\/p\u003e\u003cp\u003eTesting for Cardarine targets what the body makes of it as well as the parent molecule. The Cologne anti-doping laboratory synthesised the two main urinary metabolites, a sulfoxide and a sulfone formed at the sulphur atom, confirmed their structures and validated a routine urine screening method with a limit of detection of 0.1 ng\/ml (Thevis et al., 2010).\u003c\/p\u003e\u003cp\u003eNo verified study we can cite gives a detection window after capsules such as these, whose strength is not even stated. For both compounds the accurate statement is: detectable, window not established. The absence of a published window is not evidence that it is short.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eWe know of no published shelf-life study for Cardarine or LGD-4033 capsules, so we quote no shelf life. The expiry date printed by iMuscle is the working limit, and a certificate describes a batch only on its test date.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOne compound, one container.\u003c\/strong\u003e Keep each compound in its original labelled container. Capsules can look alike, and once mixed or decanted they can no longer be traced to a lot number or certificate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCool, dry and dark.\u003c\/strong\u003e A closed cupboard away from radiators, ovens and sunlit windows, with lids closed after every opening. Damp air softens capsule shells, so kitchens and bathrooms are poor choices.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep a log.\u003c\/strong\u003e Write the two lot numbers in a notebook with the dates each container was first opened; any portion sent away for testing needs its own tag naming compound, lot and date.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLaboratory practice.\u003c\/strong\u003e Gloves for opened capsules, no food or drink nearby, storage out of reach of children and pets, and disposal as chemical waste under local rules, not in household bins or drains.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eA sealed container keeps its 30-day return option; once opened, it no longer qualifies.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePPAR-delta\u003c\/strong\u003e: the delta member of the peroxisome proliferator-activated receptor family; Cardarine is a synthetic ligand of it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAndrogen receptor\u003c\/strong\u003e: the receptor testosterone activates, and the target of LGD-4033.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: selective androgen receptor modulator; LGD-4033 is one, Cardarine is not.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSHBG\u003c\/strong\u003e: sex hormone-binding globulin, a blood protein that carries testosterone and fell in the 2013 LGD-4033 study.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCarcinogenicity study\u003c\/strong\u003e: a toxicology test in which rats or mice are exposed for most of their lifespan and examined for tumours.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStereocentre\u003c\/strong\u003e: an atom allowing two mirror-image arrangements; LGD-4033 has two, Cardarine none.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC and LC-MS\u003c\/strong\u003e: separation of a dissolved sample on a column, read by a UV detector or by a mass spectrometer that also weighs each molecule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolite\u003c\/strong\u003e: a substance the body makes from another, such as Cardarine's sulfoxide and sulfone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLimit of detection\u003c\/strong\u003e: the smallest amount per millilitre a validated method can distinguish from a blank.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: the principle under which the presence of a banned substance in a sample is itself the violation, regardless of intent or how it got there.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/cardarine\"\u003eCardarine (GW-501516), all brands\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033 (Ligandrol), all brands\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-imuscle\"\u003eiMuscle brand collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eAll bundles\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/cardarine-gw-501516-what-happened-in-development\"\u003eCardarine (GW-501516): what happened in development\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/lgd-4033-ligandrol-research-guide\"\u003eLGD-4033 (ligandrol): the research guide\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eResearch use only. Not evaluated by the MHRA, EMA or FDA, not a food supplement, not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical or dosing advice or a suggestion that the compounds be combined.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eOlson EJ, et al. Lipid effects of peroxisome proliferator-activated receptor-delta agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. Arterioscler Thromb Vasc Biol. 2012;32(9):2289-94. PMID: 22814748.\u003c\/li\u003e\n\u003cli\u003eBasaria S, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95. PMID: 22459616.\u003c\/li\u003e\n\u003cli\u003eVan Wagoner RM, et al. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017;318(20):2004-2010. PMID: 29183075.\u003c\/li\u003e\n\u003cli\u003eThevis M, et al. Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls. Anal Bioanal Chem. 2010;396(7):2479-91. PMID: 19946680.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468978991330,"sku":null,"price":85.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/Combo4.jpg?v=1789931398"},{"product_id":"imuscle-cardarine-ibutamoren-andarine","title":"iMuscle Cardarine + Ibutamoren + Andarine stack","description":"\u003cp\u003e\u003cstrong\u003eiMuscle Cardarine + Ibutamoren + Andarine\u003c\/strong\u003e is a three-compound bundle from iMuscle that groups Cardarine (GW-501516), MK-677 (Ibutamoren) and Andarine (S-4), 60 capsules in total. iMuscle does not state the strength of any of the three and we do not guess at it. Free Muscle stocks it through the \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range and supplies it for laboratory research only, not for human consumption, to adults aged 18 and over.\u003c\/p\u003e\u003cp\u003eThe bundle simply places three compounds in one listing; we make no claim that they do anything together. The page takes each compound in turn: what it is, what research measured, its UK and sporting status, and what its batch certificate should show.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eCardarine (GW-501516)\u003c\/h3\u003e\u003cp\u003eCardarine, also written GW501516 or endurobol, is a synthetic PPAR-delta agonist developed by GlaxoSmithKline and Ligand for lipid disorders; it is not a SARM. A 2012 twelve-week human trial in subjects with low HDL cholesterol recorded a rise in HDL and a fall in triglycerides, but was not designed to assess long-term safety (Olson et al., 2012). Clinical development was halted after two-year rodent carcinogenicity studies found tumours in multiple organs. Every brand we stock is on the \u003ca href=\"\/collections\/cardarine\"\u003eCardarine collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eMK-677 (Ibutamoren)\u003c\/h3\u003e\u003cp\u003eMK-677, also called ibutamoren or L-163,191, is an oral ghrelin receptor agonist and growth hormone secretagogue, not a SARM. In a 2008 two-year randomised trial in 65 healthy older adults, fat-free mass rose by about 1.1 kg versus placebo, with increased appetite, fasting glucose, insulin resistance and oedema also recorded (Nass et al., 2008). It has never been approved. See the \u003ca href=\"\/collections\/mk-677\"\u003eMK-677 collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eAndarine (S-4)\u003c\/h3\u003e\u003cp\u003eAndarine, also called S-4, is an early non-steroidal selective androgen receptor modulator from GTx. The published evidence is almost entirely preclinical: in a 2007 study in ovariectomised rats, S-4 preserved bone mass and reduced body fat (Kearbey et al., 2007). It never reached late-stage human trials and has no approval anywhere. Reports of visual disturbance are widely repeated but have not been characterised in a published controlled trial. See the \u003ca href=\"\/collections\/andarine\"\u003eAndarine collection page\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eNothing summarised above is a claim about this product, and no published study has examined these compounds together.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eCompounds: Cardarine (GW-501516), MK-677 (Ibutamoren) and Andarine (S-4)\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules in total across the bundle\u003c\/li\u003e\n\u003cli\u003eStrength per compound: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eBundle basis: one listing for three compounds; no combined effect is claimed\u003c\/li\u003e\n\u003cli\u003eUse: laboratory research only, not for human consumption, adults 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eWith no stated strength, total milligrams per pack cannot be calculated and we do not estimate it. The single-compound iMuscle listings carry a label strength: \u003ca href=\"\/products\/imuscle-cardarine-gw501516-60-10mg\"\u003eiMuscle Cardarine GW-501516\u003c\/a\u003e, \u003ca href=\"\/products\/imuscle-ibutamoren-mk-677-60-10mg\"\u003eiMuscle Ibutamoren MK-677\u003c\/a\u003e and \u003ca href=\"\/products\/imuscle-andarine-s4-60-15mg\"\u003eiMuscle Andarine S-4\u003c\/a\u003e. How to set label strengths against each other is explained in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCardarine, MK-677 and Andarine in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"cardarine UK legal\", \"MK 677 UK buy\" and \"MK677 UK supplier\" ask two things: may each compound be sold in Britain, and how would a buyer know what a listing holds?\u003c\/p\u003e\u003ch3\u003eThe legal position, compound by compound\u003c\/h3\u003e\u003cp\u003eNone of the three is a licensed medicine in the UK (MHRA) or an authorised food supplement. They are not controlled drugs and may be sold to adults for laboratory research, the only basis for this listing. The limits concern what they may be sold as: not as a medicine or food, and not with directions for use or a promised result.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCompound\u003c\/th\u003e\n\u003cth\u003ePharmacological class\u003c\/th\u003e\n\u003cth\u003eUK medicine licence\u003c\/th\u003e\n\u003cth\u003eWADA Prohibited List\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCardarine\u003c\/td\u003e\n\u003ctd\u003ePPAR-delta agonist\u003c\/td\u003e\n\u003ctd\u003eNone\u003c\/td\u003e\n\u003ctd\u003eS4, hormone and metabolic modulators\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMK-677\u003c\/td\u003e\n\u003ctd\u003eGhrelin receptor agonist, growth hormone secretagogue\u003c\/td\u003e\n\u003ctd\u003eNone\u003c\/td\u003e\n\u003ctd\u003eS2, growth hormone secretagogues\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAndarine\u003c\/td\u003e\n\u003ctd\u003eSelective androgen receptor modulator\u003c\/td\u003e\n\u003ctd\u003eNone\u003c\/td\u003e\n\u003ctd\u003eS1, anabolic agents\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eAll three are banned in tested sport at all times. MK-677 has a page of its own on \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status in the UK\u003c\/a\u003e, and the SARM class is introduced in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eWhat official medicines laboratories have found\u003c\/h3\u003e\u003cp\u003eThese three compounds are among the molecules official medicines laboratories report most often. Over five years, the falsified medicines working group of the official medicines control laboratory network, whose contributors included a laboratory at the MHRA, pooled 354 results on 324 samples of SARMs, metabolic modulators and growth hormone secretagogues from 14 laboratories in 13 countries, most of them from illegal distribution (Barrios et al., 2025). Ibutamoren, ligandrol, ostarine, cardarine and andarine were the five molecules reported most often. About a quarter of the products were presented as dietary supplements, which the authors flagged because a buyer may not realise that an unapproved pharmaceutical is inside. A name on a pot is a claim; only analysis of the lot tests it.\u003c\/p\u003e\u003ch3\u003eWhat a checkable listing shows, and where this one stands\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA named manufacturer and a named UK seller.\u003c\/strong\u003e Made by iMuscle; sold and dispatched by FreeMuscle LTD, a UK company in Scunthorpe.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated strength for every compound.\u003c\/strong\u003e Not given by iMuscle for this bundle, so it does not meet this check; the single-compound listings above do.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch paperwork for each of the three compounds.\u003c\/strong\u003e iMuscle certificates appear here only when the manufacturer provides them for the stock on our shelves.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNo directions for use and no promised outcomes.\u003c\/strong\u003e None appear on this page; research use only, 18 and over.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTracked, discreet delivery.\u003c\/strong\u003e Free tracked UK delivery in plain packaging, orders placed before 2pm Monday to Friday processed the same working day, EU delivery in 3-7 working days (\u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA returns route.\u003c\/strong\u003e Unopened items within 30 days (\u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e).\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eReviews describe delivery, not contents. Our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e applies the same tests to any shop.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eEach compound is also sold as a research liquid (hence searches for \"MK677 UK liquid\") and as powder. None of the three is a peptide. Cardarine (molecular weight 453.5), MK-677 (528.7 as the free base) and andarine (441.4) are small synthetic molecules, and MK-677 was developed as an orally active ghrelin mimetic, which is how the 2008 trial gave it. Why swallowed peptides are a different case is covered in \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eWhat changes between formats is where the quantity per unit is fixed:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCapsules\u003c\/strong\u003e have their content fixed when powder is filled into shells. A measured figure per capsule is possible, but one pooled result averages away the spread between individual capsules, and in a bundle it must also be reported separately for each compound.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiquids\u003c\/strong\u003e carry a concentration, so the amount in any volume drawn depends on the measuring device, on the compound having fully dissolved and on solvent not evaporating after the bottle is opened.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePowders\u003c\/strong\u003e leave every portion to the buyer's own scales, so no label figure per unit exists to check.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eSalt form matters as well. MK-677 is often supplied as the mesylate salt, which is heavier than the free base, so a label should say which form its milligrams refer to. No study has compared formats for any of these three compounds, and nothing here suggests one form behaves differently in the body. With no strength stated, the usual advantage of a capsule, a checkable figure per unit, is not yet available here.\u003c\/p\u003e\u003ch2\u003eMK-677 compared with ipamorelin\u003c\/h2\u003e\u003cp\u003eMK-677 is the most searched of the three compounds in this bundle, and \"ibutamoren vs ipamorelin\" is the comparison that appears in its search suggestions. The two share a receptor and little else.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eMK-677 (in this bundle)\u003c\/th\u003e\n\u003cth\u003eIpamorelin\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical type\u003c\/td\u003e\n\u003ctd\u003eNon-peptide small molecule\u003c\/td\u003e\n\u003ctd\u003eSynthetic pentapeptide, Aib-His-D-2-Nal-D-Phe-Lys-NH2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and molecular weight\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S, 528.7\u003c\/td\u003e\n\u003ctd\u003eC38H49N9O5, 711.9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e159634-47-6\u003c\/td\u003e\n\u003ctd\u003e170851-70-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReceptor\u003c\/td\u003e\n\u003ctd\u003eGHS-R1a, the ghrelin receptor\u003c\/td\u003e\n\u003ctd\u003eGHS-R1a, the ghrelin receptor\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRoute in published human research\u003c\/td\u003e\n\u003ctd\u003eBy mouth\u003c\/td\u003e\n\u003ctd\u003eInjected or infused, as a peptide\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLength of human studies\u003c\/td\u003e\n\u003ctd\u003eRandomised trial of up to two years\u003c\/td\u003e\n\u003ctd\u003eShort pharmacology studies only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eUnlicensed; research use only\u003c\/td\u003e\n\u003ctd\u003eUnlicensed; research use only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS2, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eS2, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eBoth compounds mimic ghrelin, the stomach hormone that signals hunger, and both prompt the pituitary gland to release its own growth hormone rather than supplying any. The differences lie in the chemistry and in the depth of the record. MK-677 is a compact molecule absorbed from the gut, and its longest trial recorded increased appetite, raised fasting glucose, reduced insulin sensitivity and oedema alongside the change in fat-free mass. Ipamorelin is a chain of five amino acids, two of them in unusual forms, and has no human study of comparable length, so its long-term profile in people is unknown rather than favourable. No trial has given both compounds to the same participants, which means neither can be ranked against the other. Ipamorelin brands are on the \u003ca href=\"\/collections\/ipamorelin\"\u003eipamorelin collection page\u003c\/a\u003e; background is in the \u003ca href=\"\/blogs\/news\/ipamorelin-research-guide\"\u003eipamorelin research guide\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/mk-677-vs-ipamorelin-vs-hgh\"\u003eMK-677 vs ipamorelin vs HGH\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eFor the other two compounds, cardarine is often set against \u003ca href=\"\/collections\/sr9009\"\u003eSR9009\u003c\/a\u003e and andarine against \u003ca href=\"\/collections\/ostarine\"\u003eostarine\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eCertificates for this bundle come from iMuscle, not from us, and we display one only when iMuscle provides it for the batch in our stock. Because each of the three compounds may come from its own production lot, request paperwork by compound name. A PDF without a batch number is not a batch certificate. The Janoshik Analytical programme, under which an independent laboratory assays every Free Muscle-brand batch and the certificate is emailed on request, does not extend to iMuscle.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCompound\u003c\/th\u003e\n\u003cth\u003eCAS number\u003c\/th\u003e\n\u003cth\u003eFormula and molecular weight\u003c\/th\u003e\n\u003cth\u003ePoint to check\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCardarine\u003c\/td\u003e\n\u003ctd\u003e317318-70-0\u003c\/td\u003e\n\u003ctd\u003eC21H18F3NO3S2, 453.5\u003c\/td\u003e\n\u003ctd\u003eNo stereocentre, so there is no mirror-image form to rule out\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMK-677\u003c\/td\u003e\n\u003ctd\u003e159634-47-6\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S, 528.7 (free base)\u003c\/td\u003e\n\u003ctd\u003eWhether results are expressed as free base or mesylate salt\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAndarine\u003c\/td\u003e\n\u003ctd\u003e401900-40-1\u003c\/td\u003e\n\u003ctd\u003eC19H18F3N3O6, 441.4\u003c\/td\u003e\n\u003ctd\u003eThe (2S) form; its mirror image has the same mass\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e An HPLC retention time matched to a reference standard, or an LC-MS mass that fits the formula above. A certificate that names one compound says nothing about the other two.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Usually a percentage of HPLC peak area. It grades what the material is, not how much of it a capsule holds.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e For this bundle there is no label figure to compare it with, so a measured content would be the first statement of strength anyone has made, not a check on one.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLot, date and issuing laboratory.\u003c\/strong\u003e Compare the lot code with the label on your pot; the date shows the result's age, and a named laboratory can verify it.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eFor this brand, a missing field leaves a specific question open. No certificate means nothing independent confirms which compounds are present. Identity without content confirms presence, not quantity. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the lot numbers and we will tell you what documentation exists. See also \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eEach compound in this bundle sits in a different section of the WADA Prohibited List, applied in the UK by UK Anti-Doping: andarine in S1, MK-677 in S2 and cardarine in S4. All three are prohibited in and out of competition. Under strict liability an athlete answers for any prohibited substance in their sample, whatever its source.\u003c\/p\u003e\u003cp\u003eCardarine has the most detailed published detection work of the three. It entered the WADA list in January 2009, first categorised as a gene doping substance. The Cologne anti-doping laboratory then identified its two main urinary metabolites, a sulfoxide and a sulfone, and validated a urine screening method with a limit of detection of 0.1 ng\/ml that was brought into routine doping controls (Thevis et al., 2010). MK-677 and andarine are also screened for by accredited laboratories, but no verified study cited here gives a window for any of the three after capsules of unstated strength. The accurate answer for each is: detectable, window not established.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eWe know of no published shelf-life study for cardarine, MK-677 or andarine in capsule form, so no shelf life is stated here. Any expiry date iMuscle prints is the limit to work to, and a certificate describes a batch only on the day it was tested.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCheck on arrival.\u003c\/strong\u003e Confirm the seal is intact and note each lot number with the date received. Opening a container ends the 30-day return option, which covers unopened items only.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStore closed, cool, dry and dark.\u003c\/strong\u003e Humidity in kitchens and bathrooms can soften or crack capsule shells. Leave any desiccant sachet in place and close the lid straight after opening.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep each compound traceable.\u003c\/strong\u003e Do not decant, mix or relabel capsules. Once separated from the container, a capsule has no link to its lot number or certificate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHandle as laboratory chemicals.\u003c\/strong\u003e Gloves when handling opened capsules or powder, no food or drink in the work area, storage out of reach of children and pets, and disposal as chemical waste under local rules, never in household bins or drains.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePPAR-delta\u003c\/strong\u003e: a receptor inside the cell nucleus that controls genes for using fatty acids as fuel; cardarine was designed to switch it on.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGHS-R1a\u003c\/strong\u003e: the growth hormone secretagogue receptor, also called the ghrelin receptor, through which MK-677 and ipamorelin act.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth hormone secretagogue\u003c\/strong\u003e: any substance that prompts the pituitary gland to release growth hormone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: selective androgen receptor modulator; andarine is one, while cardarine and MK-677 are not.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCarcinogenicity study\u003c\/strong\u003e: a long-term animal study that looks for tumours; the finding that stopped cardarine's development.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree base and mesylate\u003c\/strong\u003e: the uncharged molecule and its heavier methanesulfonate salt; equal milligrams of each hold different amounts of ibutamoren.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLimit of detection\u003c\/strong\u003e: the lowest concentration a validated method can reliably report, a measure of sensitivity rather than time.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: in anti-doping, the principle that intent does not matter; a positive sample is a violation even when a product was mislabelled.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/cardarine\"\u003eCardarine (GW-501516), all brands\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/cardarine-gw-501516-what-happened-in-development\"\u003ecardarine: what happened in development\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren), all brands\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677: what the research says\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/andarine\"\u003eAndarine (S-4), all brands\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, compared above\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-imuscle\"\u003eiMuscle brand collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eAll bundles\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eResearch use only. Not evaluated by the MHRA, EMA or FDA, not a food supplement, not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical or dosing advice or a suggestion that the compounds be combined.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eOlson EJ, et al. Lipid effects of peroxisome proliferator-activated receptor-delta agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. Arterioscler Thromb Vasc Biol. 2012;32(9):2289-94. PMID: 22814748.\u003c\/li\u003e\n\u003cli\u003eNass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-11. PMID: 18981485.\u003c\/li\u003e\n\u003cli\u003eKearbey JD, et al. Selective androgen receptor modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res. 2007;24(2):328-35. PMID: 17063395.\u003c\/li\u003e\n\u003cli\u003eBarrios MM, et al. SARMs, Metabolic Modulators and Growth Hormone Secretagogues in Suspected Illegal Medicines, Bought as Sport Performance Enhancers: A Retro- and Prospective Study Within the GEON. Drug Test Anal. 2025;17(10):2078-2085. PMID: 40551438.\u003c\/li\u003e\n\u003cli\u003eThevis M, et al. Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls. Anal Bioanal Chem. 2010;396(7):2479-91. PMID: 19946680.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468979024098,"sku":null,"price":121.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/CardarineIbutamorenAndarine_f4b875eb-368c-4d5e-afbf-f01a1688b29e.jpg?v=1789931400"},{"product_id":"imuscle-cardarine-ostarine-mk2866","title":"iMuscle Cardarine + Ostarine MK-2866 stack","description":"\u003cp\u003e\u003cstrong\u003eiMuscle Cardarine + Ostarine MK-2866\u003c\/strong\u003e is a two-compound bundle from iMuscle that pairs Cardarine (GW-501516) with Ostarine (MK-2866), 60 capsules in total. iMuscle does not state the strength of either compound and we do not guess at it. The bundle is a pricing convenience for buying both in one listing; we make no claim that the two do anything together. Supplied for laboratory research only, not for human consumption, to adults aged 18 and over.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eCardarine (GW-501516)\u003c\/h3\u003e\u003cp\u003eCardarine, also written GW501516 or endurobol, is a synthetic PPAR-delta agonist developed by GlaxoSmithKline and Ligand for lipid disorders; it is not a SARM. A 2012 twelve-week human trial in subjects with low HDL cholesterol recorded a rise in HDL and a fall in triglycerides, but was not designed to assess long-term safety (Olson et al., 2012). Clinical development was halted after two-year rodent carcinogenicity studies found tumours in multiple organs. Every brand we stock is on the \u003ca href=\"\/collections\/cardarine\"\u003eCardarine collection page\u003c\/a\u003e, and the history is told in \u003ca href=\"\/blogs\/news\/cardarine-gw-501516-what-happened-in-development\"\u003ecardarine: what happened in development\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eOstarine (MK-2866)\u003c\/h3\u003e\u003cp\u003eOstarine, also called MK-2866 or enobosarm, is a non-steroidal selective androgen receptor modulator developed by GTx for muscle wasting and the most clinically studied SARM. In a 2011 placebo-controlled Phase 2 trial in 120 healthy elderly men and postmenopausal women, lean body mass rose by an average of 1.3 kg more than placebo over twelve weeks at the highest dose studied. HDL cholesterol fell in a dose-dependent way, eight participants had transient rises in the liver enzyme ALT, and one was withdrawn for this reason (Dalton et al., 2011). Later Phase 3 trials in people with cancer-related muscle loss did not lead to approval. See the \u003ca href=\"\/collections\/ostarine\"\u003eOstarine collection page\u003c\/a\u003e and the \u003ca href=\"\/blogs\/news\/ostarine-mk-2866-research-guide\"\u003eostarine research guide\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eNothing summarised above is a claim about this product, and we know of no published study that has examined these compounds together.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eCompounds: Cardarine (GW-501516) and Ostarine (MK-2866)\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules in total across the bundle\u003c\/li\u003e\n\u003cli\u003eStrength per compound: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eBundle basis: pricing convenience only; no combined effect is claimed\u003c\/li\u003e\n\u003cli\u003eUse: laboratory research only, not for human consumption, adults 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eWith no stated strength, total milligrams per pack cannot be calculated and we do not estimate it. The single-compound listings, \u003ca href=\"\/products\/imuscle-cardarine-gw501516-60-10mg\"\u003eiMuscle Cardarine GW-501516\u003c\/a\u003e and \u003ca href=\"\/products\/imuscle-ostarine-k2866-60-15mg\"\u003eiMuscle Ostarine MK-2866\u003c\/a\u003e, carry a label strength; see \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e for how to compare them.\u003c\/p\u003e\u003ch2\u003eCardarine and Ostarine in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"cardarine UK legal\", \"MK 2866 buy UK\" and \"cardarine UK reviews\" ask two things: is the purchase lawful, and will the seller send what the label says.\u003c\/p\u003e\u003ch3\u003eThe legal position\u003c\/h3\u003e\u003cp\u003eThis bundle contains Cardarine and Ostarine. Neither is a licensed medicine in the UK (MHRA) or an authorised food supplement. They are not controlled drugs and may be sold to adults for laboratory research, the only basis for this listing. Selling either with directions for human use, or with promises of physical results, could bring the product within the legal definition of a medicine, which is why this page gives neither. Both are on the WADA Prohibited List, Cardarine under S4 (hormone and metabolic modulators) and Ostarine under S1 (anabolic agents), and are banned in tested sport at all times. The class is introduced in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e, although only ostarine belongs to it.\u003c\/p\u003e\u003ch3\u003eSigns of a listing that can be checked\u003c\/h3\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eA manufacturer and a seller you can name.\u003c\/strong\u003e Here the maker is iMuscle and the seller is FreeMuscle LTD, a UK company based in Scunthorpe.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA batch number on every pot.\u003c\/strong\u003e Without one, no document can be matched to what arrived.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate for that batch, not a sample PDF.\u003c\/strong\u003e For iMuscle we show one only where the manufacturer supplies it for the batch we hold.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated strength.\u003c\/strong\u003e This is where the bundle falls short, because iMuscle does not state one; we say so rather than fill the gap.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNo usage directions or result claims.\u003c\/strong\u003e A listing that offers them is not selling for research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePlain, tracked delivery and a returns route.\u003c\/strong\u003e Every UK order ships free and tracked in plain packaging; orders placed before 2pm Monday to Friday are processed the same working day; EU delivery takes 3-7 working days; unopened items can be returned within 30 days. Details are on the \u003ca href=\"\/pages\/shipping\"\u003eshipping\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e pages.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003eReviews describe delivery and service; only a laboratory analysis of the lot can confirm what a capsule contains. A longer checklist sits in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e, and the other brands on this marketplace are introduced on the \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e page.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eSearches for \"ostarine liquid UK\", \"ostarine tablets UK\" and \"ostarine capsules UK\" show that buyers meet the same molecule in several formats. The format does not alter the chemistry; it alters how the amount in each unit is fixed and how easily a certificate can speak to it.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003cth\u003eWhere the amount is set\u003c\/th\u003e\n\u003cth\u003eWhat can drift\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCapsule\u003c\/td\u003e\n\u003ctd\u003eAt the factory, when powder is filled into shells\u003c\/td\u003e\n\u003ctd\u003eFill weight between capsules; a pooled assay reports the average\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTablet\u003c\/td\u003e\n\u003ctd\u003eAt the factory, when powder is blended with excipients and pressed\u003c\/td\u003e\n\u003ctd\u003eBlend uniformity; excipients add peaks to be explained on a chromatogram\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLiquid\u003c\/td\u003e\n\u003ctd\u003eBy the concentration written on the bottle\u003c\/td\u003e\n\u003ctd\u003eMeasuring accuracy of each portion, evaporation after opening, settling in the cold\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLoose powder\u003c\/td\u003e\n\u003ctd\u003eBy whoever weighs it\u003c\/td\u003e\n\u003ctd\u003eBalance accuracy and static cling at small masses\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eBoth compounds here are small synthetic molecules, not peptides: ostarine has a molecular weight of 389.3 and cardarine 453.5. The digestive breakdown that limits swallowed peptides, covered in \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e, is therefore not the relevant issue for either. We know of no study comparing retail formats of either compound. A capsule with a declared strength is simply the easiest format to check, and this bundle lacks that declaration.\u003c\/p\u003e\u003ch2\u003eOstarine compared with MK-677\u003c\/h2\u003e\u003cp\u003e\"MK 2866 vs MK 677\" is one of the most common comparison searches for ostarine, largely because the two codes look alike. The shared \"MK\" prefix is a development code and says nothing about how the molecules act. They sit in different drug classes, bind different receptors and fall under different sections of the WADA list.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFeature\u003c\/th\u003e\n\u003cth\u003eOstarine (in this bundle)\u003c\/th\u003e\n\u003cth\u003eMK-677\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eMK-2866, enobosarm, GTx-024\u003c\/td\u003e\n\u003ctd\u003eIbutamoren, L-163,191\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eClass\u003c\/td\u003e\n\u003ctd\u003eSelective androgen receptor modulator\u003c\/td\u003e\n\u003ctd\u003eGrowth hormone secretagogue, a non-peptide ghrelin mimetic\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTarget\u003c\/td\u003e\n\u003ctd\u003eAndrogen receptor\u003c\/td\u003e\n\u003ctd\u003eGhrelin receptor (growth hormone secretagogue receptor)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and molecular weight\u003c\/td\u003e\n\u003ctd\u003eC19H14F3N3O3, 389.3\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S, 528.7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMain human evidence\u003c\/td\u003e\n\u003ctd\u003ePhase 2 and Phase 3 trials in older adults and people with cancer-related muscle loss\u003c\/td\u003e\n\u003ctd\u003ePlacebo-controlled trials, including a two-year study in healthy older adults\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAdverse findings recorded\u003c\/td\u003e\n\u003ctd\u003eLower HDL cholesterol, transient liver enzyme rises\u003c\/td\u003e\n\u003ctd\u003eRaised fasting glucose, reduced insulin sensitivity, increased appetite, mild oedema\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLicensed as a medicine\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA section\u003c\/td\u003e\n\u003ctd\u003eS1, anabolic agents\u003c\/td\u003e\n\u003ctd\u003eS2, peptide hormones, growth factors, related substances and mimetics\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThe MK-677 row on adverse findings comes from the 2008 trial by Nass and colleagues, in which 65 healthy adults aged 60 to 81 were randomised to MK-677 or placebo. Growth hormone and IGF-1 rose into the young-adult range and fat-free mass increased by 1.1 kg against a 0.5 kg fall on placebo, but fasting glucose rose, insulin sensitivity fell, cortisol increased, and the gain in fat-free mass was not matched by any change in strength or function (Nass et al., 2008). Set that beside the ostarine trial above and the difference is one of route: ostarine acts at the androgen receptor directly, while MK-677 works upstream by prompting the pituitary to release growth hormone. Neither trial compared the two, and we know of no study that has.\u003c\/p\u003e\u003cp\u003eMK-677 brands are listed in the \u003ca href=\"\/collections\/mk-677\"\u003eMK-677 collection\u003c\/a\u003e, its evidence is summarised in \u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677 (ibutamoren): what the research says\u003c\/a\u003e, and its UK position is set out on the \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status\u003c\/a\u003e page. Cardarine, the other half of this bundle, is often mentioned alongside SR9009, which acts on a different receptor family altogether; see the \u003ca href=\"\/collections\/sr9009\"\u003eSR9009 collection\u003c\/a\u003e and the \u003ca href=\"\/blogs\/news\/sr9009-stenabolic-research-guide\"\u003eSR9009 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand, so any certificate of analysis is the manufacturer's. We show one only where iMuscle supplies it for the batch we hold. A bundle may draw on a separate batch per compound, so expect one certificate per compound and ask for each by name. A generic PDF with no batch number is not a batch certificate. Free Muscle-brand batches are assayed by Janoshik Analytical, an independent laboratory, with the certificate sent on request by email; that programme does not cover iMuscle. Our approach is set out on the \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\u003cp\u003eWork through each certificate in this order:\u003c\/p\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eMatch the lot.\u003c\/strong\u003e The batch number on the certificate must be the one printed on the pot in front of you. If they differ, the document describes other capsules.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCheck the identity method.\u003c\/strong\u003e HPLC compared against a reference standard, or LC-MS giving a mass consistent with the formula. For ostarine that is C19H14F3N3O3 (CAS 841205-47-8); for cardarine C21H18F3NO3S2 (CAS 317318-70-0). Ostarine has one stereocentre and the active form is (2S), which a mass alone cannot distinguish from its mirror image; cardarine has no stereocentre.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTreat purity as purity.\u003c\/strong\u003e A figure such as 99% describes how clean the detected material is, measured by peak area on a chromatogram. It is silent on how many milligrams sit in each capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLook for a content figure.\u003c\/strong\u003e A measured amount per capsule is the field that would matter most here, because there is no label strength to check it against.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWho tested it, and when.\u003c\/strong\u003e An unnamed laboratory cannot be asked to confirm a report, and an old test date says nothing about storage since.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003eWhere a field is absent, the certificate has simply not answered that question. Send the product name and both batch numbers through our \u003ca href=\"\/pages\/contact\"\u003econtact page\u003c\/a\u003e and we will say what paperwork iMuscle has provided. Further detail is in \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eBoth compounds are prohibited in and out of competition. Ostarine is listed in section S1 of the WADA Prohibited List as an anabolic agent and cardarine in section S4 among hormone and metabolic modulators. Anti-doping rules work on strict liability: a prohibited substance in a sample is the athlete's responsibility, whatever route it took, including a contaminated or mislabelled product.\u003c\/p\u003e\u003cp\u003eFor ostarine, sensitivity is well documented. Researchers at the German Sport University Cologne gave volunteers single and repeated oral amounts of 1, 10 and 50 micrograms, chosen to model supplement contamination rather than deliberate use, and analysed urine by LC-MS\/MS (Walpurgis et al., 2020). A single 1 microgram amount could still be found for up to nine days when ostarine was targeted, and up to five days for its glucuronide. Detection times lengthened as the amount rose, and varied widely between people.\u003c\/p\u003e\u003cp\u003eNo verified study we can cite gives a window after milligram amounts of ostarine, or any urinary window for cardarine after capsules of unstated strength. For both compounds in this bundle the accurate statement is: detectable, window not established. Anyone subject to an anti-doping code should regard any contact with either as a risk of an adverse finding.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eNo published shelf-life study of ostarine or cardarine capsules is available to cite, so we quote no shelf life and rely on the expiry date iMuscle prints on each pot.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOne compound, one pot.\u003c\/strong\u003e Keep cardarine and ostarine in their own original containers. Capsules from a bundle can look alike, and once decanted or mixed they cannot be traced back to a batch number or a certificate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTemperature and light.\u003c\/strong\u003e A cool cupboard away from heaters, ovens and direct sunlight.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMoisture.\u003c\/strong\u003e Replace the lid straight after opening and leave any desiccant sachet in place. Gelatin and plant-based shells absorb water, which can soften them and let the contents clump.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePaper trail.\u003c\/strong\u003e Keep a simple log for each pot: compound, batch number, date received, date opened. Any portion set aside for testing gets the same three details on its own label.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLaboratory practice.\u003c\/strong\u003e Wear gloves for opened capsules, keep food and drink away from the work area, store out of reach of children and pets, and dispose of unwanted material as chemical waste under local rules, not in household bins or drains.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eThe 30-day return option applies only while a pot is still sealed, so check the batch details against any certificate before opening.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: short for selective androgen receptor modulator. The label fits ostarine in this bundle but not cardarine, which does not act at the androgen receptor.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePPAR-delta\u003c\/strong\u003e: one of three peroxisome proliferator-activated receptors inside the cell nucleus; cardarine was designed to activate this subtype selectively.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGhrelin mimetic\u003c\/strong\u003e: a compound that copies the action of the hormone ghrelin at its receptor, as MK-677 does.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCarcinogenicity study\u003c\/strong\u003e: a regulatory toxicology test in which animals receive a substance for most of their lifespan and are examined for tumours; the cardarine findings came from studies of this kind.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHDL cholesterol\u003c\/strong\u003e: the lipoprotein fraction that rose in the cardarine lipid trial and fell in the ostarine Phase 2 trial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucuronide\u003c\/strong\u003e: a form of a compound the body links to glucuronic acid for excretion, often a target in urine testing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: under anti-doping codes, a positive sample is an offence in itself; intent and source affect only the sanction.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnantiomer\u003c\/strong\u003e: either of two mirror-image versions of a molecule with one stereocentre. Ostarine has two; cardarine has no mirror-image form.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChromatogram\u003c\/strong\u003e: the trace an HPLC run produces; each peak is a separated substance, and the main peak's share of the total area gives the purity figure.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/cardarine\"\u003eCardarine (GW-501516), all brands\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/ostarine\"\u003eOstarine (MK-2866), all brands\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/mk-677\"\u003eMK-677, all brands\u003c\/a\u003e and \u003ca href=\"\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-imuscle\"\u003eiMuscle brand collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eAll bundles\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/pages\/faq\"\u003eFrequently asked questions\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eResearch use only. Not evaluated by the MHRA, EMA or FDA, not a food supplement, not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical or dosing advice or a suggestion that the compounds be combined; research summaries describe findings in study participants, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eOlson EJ, et al. Lipid effects of peroxisome proliferator-activated receptor-delta agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. Arterioscler Thromb Vasc Biol. 2012;32(9):2289-94. PMID: 22814748.\u003c\/li\u003e\n\u003cli\u003eDalton JT, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle. 2011;2(3):153-161. PMID: 22031847.\u003c\/li\u003e\n\u003cli\u003eNass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-11. PMID: 18981485.\u003c\/li\u003e\n\u003cli\u003eWalpurgis K, et al. Elimination profiles of microdosed ostarine mimicking contaminated products ingestion. Drug Test Anal. 2020;12(11-12):1570-1580. PMID: 32959982.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468979056866,"sku":null,"price":82.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/Combo1_eea04d8f-0b97-4e11-94ad-6c34c7f253ae.jpg?v=1789931403"},{"product_id":"imuscle-cardarine-testolon-rad140","title":"iMuscle Cardarine + Testolone RAD-140 stack","description":"\u003cp\u003eThe iMuscle Cardarine and Testolone bundle pairs two research compounds from iMuscle in one listing: cardarine (GW-501516, endurobol), a PPAR-delta agonist, and testolone (RAD-140, vosilasarm), a selective androgen receptor modulator. iMuscle lists the pack as 60 capsules. The manufacturer does not state a strength per capsule on this listing, so we do not quote one. Supplied to adults aged 18 and over for laboratory research only, and not for human consumption.\u003c\/p\u003e\u003cp\u003eA bundle is a listing convenience only: it groups two compounds from one manufacturer under a single product listing. Nothing on this page claims that they act together or should be studied together, and Free Muscle publishes no stack or cycle guidance for any product. Each section below therefore treats cardarine first and RAD-140 second, as two unrelated substances that simply share a listing.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eCardarine (GW-501516)\u003c\/h3\u003e\u003cp\u003eCardarine is not a SARM but an agonist at the PPAR-delta nuclear receptor, which regulates genes for fatty-acid oxidation. GlaxoSmithKline developed it with Ligand as a candidate for lipid disorders. The first published study in people was a two-week 2007 trial in healthy volunteers kept in hospital and sedentary: HDL cholesterol was higher than with placebo, fasting triglycerides trended downwards without reaching statistical significance, and fat from a test meal was cleared faster (Sprecher et al., 2007). With 6 people on placebo and 18 on the compound, it could say nothing about long-term tolerability. Development was then discontinued after long-term rodent toxicology studies found tumours in several organs, a sponsor-reported finding that ended further human work. Cardarine has never been approved as a medicine. Compare brands on the \u003ca href=\"\/collections\/cardarine\"\u003eCardarine (GW-501516) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eTestolone (RAD-140)\u003c\/h3\u003e\u003cp\u003eTestolone (RAD-140) is a non-steroidal SARM designed by Radius Health and described in 2011 as potent and orally bioavailable, with its early characterisation carried out in rats and non-human primates (Miller et al., 2011). Human data are limited to a small early oncology study: 22 postmenopausal women with advanced ER-positive, HER2-negative breast cancer (LoRusso et al., 2022). Raised liver enzymes were the most frequent adverse events, AST in 59.1% of patients and ALT in 45.5%, alongside raised bilirubin, vomiting, dehydration and weight loss, and 16 of the 22 had at least one grade 3 or 4 event. The measured half-life was 44.7 hours. Published case reports describe drug-induced liver injury in adults who had taken products labelled as containing RAD-140; in one, a 52-year-old man's liver enzymes took about three months to return to normal (Barbara et al., 2020). It remains investigational and has never been approved as a medicine. Compare brands on the \u003ca href=\"\/collections\/rad-140\"\u003eTestolone (RAD-140) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eThese findings describe study participants and animals under trial conditions. None of them is a claim about the capsules in this bundle.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: iMuscle (third-party brand, Muscle Market)\u003c\/li\u003e\n\u003cli\u003eCompounds: cardarine (GW-501516), testolone (RAD-140)\u003c\/li\u003e\n\u003cli\u003eForm and pack size: 60 capsules, as listed by the manufacturer\u003c\/li\u003e\n\u003cli\u003eStrength per capsule: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eCOA: only where iMuscle supplies one for the batch held\u003c\/li\u003e\n\u003cli\u003eTerms: laboratory research only, adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eBecause no strength is printed, the usual comparison of total milligrams per pack, and of cost per milligram, cannot be made for this bundle. The method, for listings that do state a strength, is in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCardarine and RAD-140 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eBehind \"cardarine UK legal\", \"cardarine UK buy\" and \"testolone RAD 140 UK\" sit two questions: is the sale lawful, and how can a credible seller be told from a doubtful one.\u003c\/p\u003e\u003ch3\u003eThe legal position\u003c\/h3\u003e\u003cp\u003eNone of the compounds on this page is a licensed medicine in the United Kingdom, none has been assessed by the MHRA and none is an authorised food supplement. Cardarine and RAD-140 are not controlled substances in the UK, so they can be supplied to adults for laboratory research, which is the only basis on which Free Muscle sells them. The position in sport is stricter: RAD-140 falls under WADA section S1 (anabolic agents) and cardarine under S4 (hormone and metabolic modulators), and both are banned at all times, in and out of competition. Background: our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eWhat a credible UK listing shows, and where this one stands\u003c\/h3\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCheck\u003c\/th\u003e\n\u003cth\u003eWhy it matters\u003c\/th\u003e\n\u003cth\u003eThis listing\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eNamed manufacturer and UK seller\u003c\/td\u003e\n\u003ctd\u003eSomeone accountable for what is in the pack and for the sale\u003c\/td\u003e\n\u003ctd\u003eMade by iMuscle; sold and posted by FreeMuscle LTD of Scunthorpe, a UK company\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStated strength for each compound\u003c\/td\u003e\n\u003ctd\u003eWithout it, a certificate has no label figure to test\u003c\/td\u003e\n\u003ctd\u003eNot stated by iMuscle, so not quoted by us\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCertificate tied to a batch number\u003c\/td\u003e\n\u003ctd\u003eOnly a batch-specific result says anything about the pack you receive\u003c\/td\u003e\n\u003ctd\u003eShown only where iMuscle supplies one for the batch we hold\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResearch-only wording\u003c\/td\u003e\n\u003ctd\u003eA seller giving amounts or promising outcomes is marketing a product for people to take\u003c\/td\u003e\n\u003ctd\u003eNo amounts, schedules or outcome claims; 18 and over only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDiscreet, traceable delivery\u003c\/td\u003e\n\u003ctd\u003eA tracked parcel can be followed and a plain one draws no attention\u003c\/td\u003e\n\u003ctd\u003eSent free by tracked UK post in unmarked packaging; weekday orders placed by 2pm processed that day; 3-7 working days to the EU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eA returns route\u003c\/td\u003e\n\u003ctd\u003eShows the seller stands behind the order\u003c\/td\u003e\n\u003ctd\u003eUnopened items within 30 days, under our \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e terms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eReviews and \"cardarine UK reviews\" threads tell you how a parcel arrived, not what the capsules hold. A fuller supplier checklist is in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eBoth molecules are also sold as liquids, loose powder and occasionally injectables. The chemical is the same; what differs is how the quantity per unit is fixed and how well it holds.\u003c\/p\u003e\u003cp\u003eIn a capsule the amount is decided once, when powder is blended and filled into shells, so the figure can be checked by assaying a sample of capsules. The weak point is mixing: an assay reports an average, so a poorly blended batch can vary between shells. A liquid is sold as a concentration, so every measured portion depends on the accuracy of the volume drawn, and a solution that is opened repeatedly can lose solvent and become more concentrated, while a compound near its solubility limit can settle out in the cold. Powder has no preset portion; accuracy rests on the balance. As for injectable versions, both human studies cited here gave the compounds by mouth, and we know of no published injection study.\u003c\/p\u003e\u003cp\u003eNeither compound is a peptide. At molecular weights of 453.5 (cardarine) and 393.8 (RAD-140) they are small synthetic molecules, so the debate over whether stomach enzymes break down swallowed peptides, covered in \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e, does not apply to them in the same way. For this particular bundle, the main advantage of capsules, a printed figure per capsule that a laboratory can confirm, is missing because iMuscle prints none.\u003c\/p\u003e\u003ch2\u003eEach compound compared with its most-searched counterpart\u003c\/h2\u003e\u003cp\u003eSearchers pair each compound here with a different neighbour, \"stenabolic vs cardarine\" and \"RAD 140 vs RAD 150\", so the pairings are taken in turn.\u003c\/p\u003e\u003ch3\u003eCardarine compared with SR9009 (stenabolic)\u003c\/h3\u003e\u003cp\u003eThey are often shelved together, but share neither receptor nor chemical family. Cardarine binds PPAR-delta; SR9009 (C20H24ClN3O4S, CAS 1379686-30-2) binds REV-ERB alpha and beta, nuclear receptors that form part of the body clock. Cardarine went through industry clinical trials for lipid disorders before its tumour findings in rodents; SR9009 came out of academic research at the Scripps Research Institute and has never been given to people in a published trial. So SR9009 has no human data and no long-term carcinogenicity data, a gap in knowledge rather than a reassurance. Neither is licensed anywhere, and WADA lists both under S4 as metabolic modulators. SR9009 brands are in the \u003ca href=\"\/collections\/sr9009\"\u003eSR9009 (Stenabolic) collection\u003c\/a\u003e, with background in the \u003ca href=\"\/blogs\/news\/sr9009-stenabolic-research-guide\"\u003eSR9009 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eRAD-140 compared with RAD-150 (TLB-150)\u003c\/h3\u003e\u003cp\u003eRAD-150, also sold as TLB-150, is marketed as an ester of RAD-140: the same core molecule with a benzoate group attached. Closely related chemically, they differ sharply in evidence: RAD-140 has a peer-reviewed preclinical paper, a published first-in-human study and anti-doping research. RAD-150 has no peer-reviewed journal studies and no published data in people, so any claim that it is longer-lasting, milder or stronger than RAD-140 is untested. Neither has ever been approved as a medicine. RAD-140 is named in WADA section S1; RAD-150 is not named individually, but S1 also covers substances with a similar chemical structure or biological effect, so it is prohibited in sport as well. RAD-150 brands are in the \u003ca href=\"\/collections\/rad-150\"\u003eRAD-150 (TLB-150) collection\u003c\/a\u003e, with more in \u003ca href=\"\/blogs\/news\/rad-140-vs-rad-150-tlb-150\"\u003eRAD-140 vs RAD-150 (TLB-150)\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand sold through Muscle Market. For third-party brands we display a certificate of analysis only where the manufacturer supplies one for the exact batch we hold; if none is shown, none has been supplied and we do not substitute a generic document. Free Muscle-brand products, by contrast, are assayed batch by batch at Janoshik Analytical, with the certificate sent on request by email; that programme does not extend to iMuscle. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab testing page\u003c\/a\u003e explains what a certificate shows.\u003c\/p\u003e\u003cp\u003eTwo compounds need two identity results. Read each certificate field by field:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompound name and CAS number.\u003c\/strong\u003e Cardarine is CAS 317318-70-0 and RAD-140 is CAS 1182367-47-0.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity test.\u003c\/strong\u003e HPLC matches the sample against a reference standard by retention time; LC-MS also measures mass, which should correspond to 453.5 for cardarine (C21H18F3NO3S2) and 393.8 for RAD-140 (C20H16ClN5O2).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStereochemistry, for RAD-140.\u003c\/strong\u003e RAD-140 has two stereocentres, written (1R,2S) in its systematic name, so other isomers share its formula and mass. A mass match alone does not show the correct isomer. Cardarine has no stereocentre, so the question does not arise.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e A percentage, usually from chromatogram peak areas, of how much detected material is the named compound; other peaks are impurities. It is not a content per capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMeasured content.\u003c\/strong\u003e iMuscle prints no strength, so any milligram figure on a certificate would be new information about the pack, with no label value to hold it against.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLot code, date and issuer.\u003c\/strong\u003e Match the lot code to the one on your container, see how long ago the analysis was run, and note who ran it, since a named laboratory can be asked about its own report.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eTreat a blank field as an open question rather than a pass, and \u003ca href=\"\/pages\/contact\"\u003eget in touch\u003c\/a\u003e quoting the lot codes printed on the pack to learn what paperwork iMuscle has provided. See \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eFor anyone under anti-doping rules, both compounds are prohibited at all times. Under strict liability, a mislabelled or contaminated product is no defence.\u003c\/p\u003e\u003cp\u003eCardarine was added to the WADA list in January 2009, first classed as gene doping. The Cologne anti-doping laboratory then used human liver microsomes to reproduce its breakdown, synthesised the two main urinary metabolites, a sulfoxide and a sulfone, and validated a routine urine screening method able to detect 0.1 ng\/ml (Thevis et al., 2010). Testing therefore targets what the body makes from cardarine, not only the parent compound.\u003c\/p\u003e\u003cp\u003eRAD-140 is named in section S1, and anti-doping laboratories screen urine for SARMs. Its half-life in the 2022 cancer study was 44.7 hours, but a half-life describes how blood levels fall, not how long a laboratory can find traces in urine. We know of no verified study giving a detection window after capsule quantities of either compound, so for both the accurate statement is: detectable, window not established.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eWe are not aware of any published shelf-life study for cardarine or RAD-140 capsules, so no shelf life is quoted here. Treat the expiry date printed by iMuscle as the limit, and remember that a certificate describes the batch only as it stood on the day it was tested.\u003c\/p\u003e\u003cp\u003eBoth are solids held in capsule shells, and the main threats to them are moisture, heat and light. Humid air softens gelatin and lets the powder inside clump, so store the containers tightly closed in a cool, dark cupboard, well away from radiators, cookers, bathrooms and sunny windowsills. Keep capsules in their original labelled containers: loose capsules of similar appearance cannot be told apart afterwards, and once separated from the label they can no longer be linked to a batch number or certificate.\u003c\/p\u003e\u003cp\u003eLog each batch number with the date its seal was first broken. Handle opened capsules with gloves, away from food and drink, keep everything out of reach of children and pets, and dispose of unwanted material as chemical waste under local rules, never in household bins or drains. Opening a container also ends the 30-day return option, which covers unopened items only.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePPAR-delta\u003c\/strong\u003e: a nuclear receptor, full name peroxisome proliferator-activated receptor delta, switched on by cardarine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: a non-steroidal molecule built to act on the androgen receptor, such as RAD-140; cardarine belongs to a different class.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eREV-ERB alpha and beta\u003c\/strong\u003e: clock-linked nuclear receptors bound by SR9009, unrelated to PPAR-delta.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEster\u003c\/strong\u003e: a molecule made by joining an acid to an alcohol; RAD-150 is sold as RAD-140 joined to benzoic acid.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eER-positive, HER2-negative\u003c\/strong\u003e: a breast cancer type defined by oestrogen receptor presence and absence of HER2 protein excess, the population in the RAD-140 trial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAST and ALT\u003c\/strong\u003e: enzymes released from liver cells; blood levels above normal point to liver injury or stress.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCarcinogenicity study\u003c\/strong\u003e: lifelong animal exposure to a substance, run to see whether tumour rates rise.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSulfoxide and sulfone\u003c\/strong\u003e: oxidised forms of cardarine made in the body and used as targets in doping tests.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRetention time\u003c\/strong\u003e: the moment a substance emerges from a chromatography column; a sample emerging alongside its reference standard supports its identity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/cardarine\"\u003eCardarine (GW-501516) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (Testolone) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-imuscle\"\u003eiMuscle brand page\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eBundles collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/cardarine-gw-501516-what-happened-in-development\"\u003eCardarine (GW-501516): what happened in development\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eSupplied for laboratory research use only. Not a medicine, not evaluated by the MHRA, EMA or FDA, not a food supplement and not for human consumption. Buyers must be 18 or over. Nothing on this page is medical or dosing advice or a recommendation to use, stack or cycle any compound; research summaries describe findings in study participants or animals, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eSprecher DL, et al. Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. Arterioscler Thromb Vasc Biol. 2007;27(2):359-65. PMID: 17110604.\u003c\/li\u003e\n\u003cli\u003eMiller CP, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-9. PMID: 24900290.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003cli\u003eThevis M, et al. Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls. Anal Bioanal Chem. 2010;396(7):2479-91. PMID: 19946680.\u003c\/li\u003e\n\u003cli\u003eBarbara M, et al. Drug-Induced Liver Injury Associated With Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033). ACG Case Rep J. 2020;7(6):e00409. PMID: 33062783.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468979089634,"sku":null,"price":89.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/Combo10_1c630ed1-3aaf-4e68-872f-dc9700010877.jpg?v=1789931403"},{"product_id":"imuscle-ibutamoren-mk-677-60-10mg","title":"iMuscle Ibutamoren MK-677 — 60 caps, 10mg","description":"\u003cp\u003eiMuscle Ibutamoren MK-677 is supplied as 60 capsules stated at 10 mg each, a total of 600 mg of MK-677 per pack. MK-677, also called ibutamoren, L-163,191 or Nutrobal, is an oral growth hormone secretagogue with a genuine human trial record. iMuscle manufactures the product and Free Muscle stocks it through the \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range for laboratory research by adults aged 18 and over.\u003c\/p\u003e\u003ch2\u003eAbout MK-677\u003c\/h2\u003e\u003cp\u003eMK-677, or ibutamoren, is an orally active ghrelin mimetic developed by Merck under the code L-163,191, a synthetic small molecule rather than a peptide. It binds the GHS-R1a receptor in the hypothalamus and pituitary, prompting pulsatile growth hormone release and a sustained rise in IGF-1. PubChem lists the free base as CID 178024, CAS 159634-47-6, formula C27H36N4O5S, molecular weight 528.7.\u003c\/p\u003e\u003ch3\u003eWhat the published research reports\u003c\/h3\u003e\u003cp\u003eThe human literature is real but limited. In 1996 Chapman and colleagues reported that daily oral MK-677 in 32 healthy elderly volunteers, randomised against placebo, increased growth hormone pulse amplitude and raised IGF-1. Sampling every 20 minutes for 24 hours showed higher pulses and higher troughs between them, with no change in the number of pulses. IGF-binding protein 3 and fasting glucose rose; cortisol did not change. The study lasted four weeks at most and measured hormones only.\u003c\/p\u003e\u003cp\u003eSvensson and colleagues then randomised 24 otherwise healthy obese men aged 18 to 50 to MK-677 or placebo for eight weeks (Svensson et al., 1998). IGF-1 rose by about 40 per cent with MK-677, significantly more than with placebo, and fat-free mass increased, while total and visceral fat did not change significantly. Basal metabolic rate was higher at two weeks but not significantly at eight, and an oral glucose tolerance test showed impaired glucose handling at both points although fasting glucose was unchanged.\u003c\/p\u003e\u003cp\u003eThe longest trial followed 65 healthy adults aged 60 to 81 for up to two years, with its main end points at twelve months (Nass et al., 2008). Fat-free mass went up by an average of 1.1 kg on MK-677 and drifted down by 0.5 kg on placebo, but strength, physical function and abdominal visceral fat did not differ, and limb fat grew more. Increased appetite, oedema, muscle pain, reduced insulin sensitivity, a small rise in fasting glucose, higher cortisol and greater weight gain were recorded. The authors judged the study too small and too short to assess function.\u003c\/p\u003e\u003cp\u003eAcross the three trials, higher growth hormone and IGF-1 came with poorer glucose handling, and the one trial that measured strength and function found no change in either. MK-677 was never approved as a medicine. Nothing in these studies is a claim about this listing.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eCompound: MK-677 (Ibutamoren)\u003c\/li\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStated strength: 10 mg per capsule (manufacturer's label claim)\u003c\/li\u003e\n\u003cli\u003eStated total per pack: 600 mg\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eThe strength is the manufacturer's label claim; only a batch certificate confirms it. Because a figure is printed, this pack can be set against other brands of MK-677 on total milligrams, as explained in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e, provided each figure refers to the same form: free base or the heavier mesylate salt.\u003c\/p\u003e\u003ch2\u003eMK-677 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eUK searches for this compound ask three things: is it legal (\"MK 677 UK legal\"), where can it be bought (\"MK677 UK supplier\", \"MK 677 UK buy\") and can a seller be trusted (\"MK677 UK review\").\u003c\/p\u003e\u003ch3\u003eThe legal position\u003c\/h3\u003e\u003cp\u003eMK-677 is not a licensed medicine in the UK: it has no MHRA marketing authorisation, is not an authorised food supplement, and cannot lawfully be sold for human consumption. It is not a controlled drug either, which is why the question gets contradictory answers online; the restriction concerns what it may be sold as. Free Muscle supplies it to adults aged 18 or over for laboratory research only. It is prohibited at all times under section S2 (peptide hormones, growth factors and related substances) of the WADA Prohibited List. Buyers are responsible for the rules that apply to them, including any anti-doping code. See \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status in the UK\u003c\/a\u003e for more detail.\u003c\/p\u003e\u003ch3\u003eWhat a careful UK listing shows, and how this one compares\u003c\/h3\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCheck\u003c\/th\u003e\n\u003cth\u003eWhy it matters\u003c\/th\u003e\n\u003cth\u003eThis listing\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eNamed manufacturer and a UK seller\u003c\/td\u003e\n\u003ctd\u003eSomeone is answerable for contents and sale\u003c\/td\u003e\n\u003ctd\u003eMade by iMuscle; sold by FreeMuscle LTD, Scunthorpe\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStated strength and count\u003c\/td\u003e\n\u003ctd\u003eWithout both there is no pack total to compare\u003c\/td\u003e\n\u003ctd\u003e10 mg x 60 capsules = 600 mg (label claim)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLot number and a certificate for that lot\u003c\/td\u003e\n\u003ctd\u003eA certificate proves nothing unless the numbers match\u003c\/td\u003e\n\u003ctd\u003eiMuscle COA shown only where the manufacturer supplies one for the batch we hold\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResearch-use terms\u003c\/td\u003e\n\u003ctd\u003eDirections for use mean a product is being sold for consumption\u003c\/td\u003e\n\u003ctd\u003e18+ only; no quantities, timings or promised outcomes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTracked, discreet delivery\u003c\/td\u003e\n\u003ctd\u003eA traceable parcel is a record of the sale\u003c\/td\u003e\n\u003ctd\u003eFree tracked UK delivery in plain packaging; orders before 2pm Monday to Friday processed the same working day; EU 3-7 working days\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWritten returns policy\u003c\/td\u003e\n\u003ctd\u003eTerms are known before payment\u003c\/td\u003e\n\u003ctd\u003e30-day returns on unopened items\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThe certificate row varies for a third-party brand, so ask us before ordering if a current iMuscle certificate matters to your work. Forum and review searches meet a different limit: user reports describe sellers and parcels, but what a lot contains is a laboratory question. Prices change and appear on the listing, not in this text; cost per milligram is the fair measure. Our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e applies the same tests to any shop.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eMK-677 is also sold as tablets and research liquids, and is sometimes called a \"peptide\", which it is not. Every MK-677 trial cited here gave it by mouth, as the molecule was designed to be absorbed from the gut; none used an injectable form. Swallowed peptides, by contrast, are largely broken down by digestive enzymes (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e), which is why the human ipamorelin study below used an intravenous infusion.\u003c\/p\u003e\u003cp\u003eAmong solid forms, the question is how closely each unit matches the label. A capsule's content is fixed when powder, usually blended with a filler, is filled into shells, so an uneven blend lets one capsule differ from the next while the pack average stays right. Licensed medicines are tested for this as content uniformity, unit by unit; a research certificate reporting one pooled figure shows only the average. Tablets fix their content the same way at pressing.\u003c\/p\u003e\u003cp\u003eLiquids carry a concentration instead, so the amount in a measured volume depends on complete dissolution, on the measuring device and on solvent not evaporating after opening, and most compounds degrade faster in solution than dry. None of this implies that one form acts differently in the body; it concerns only what a label and a certificate can vouch for.\u003c\/p\u003e\u003ch2\u003eMK-677 compared with ipamorelin\u003c\/h2\u003e\u003cp\u003e\"Ibutamoren vs ipamorelin\" is the comparison most often searched for this compound. Both are GHS-R1a agonists that prompt the pituitary to release its own growth hormone; the human data show where they part.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eMK-677 (this product)\u003c\/th\u003e\n\u003cth\u003eIpamorelin\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical type\u003c\/td\u003e\n\u003ctd\u003eNon-peptide small molecule, C27H36N4O5S, 528.7, CAS 159634-47-6\u003c\/td\u003e\n\u003ctd\u003ePentapeptide Aib-His-D-2-Nal-D-Phe-Lys-NH2, C38H49N9O5, 711.9, CAS 170851-70-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRoute in human studies\u003c\/td\u003e\n\u003ctd\u003eBy mouth\u003c\/td\u003e\n\u003ctd\u003eIntravenous infusion\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTime course in people\u003c\/td\u003e\n\u003ctd\u003e24-hour growth hormone and IGF-1 raised during weeks of daily use\u003c\/td\u003e\n\u003ctd\u003eOne burst of growth hormone peaking at about 40 minutes; terminal half-life about two hours\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman research base\u003c\/td\u003e\n\u003ctd\u003eRandomised trials in older adults (up to two years) and obese men\u003c\/td\u003e\n\u003ctd\u003eA pharmacokinetic study in healthy men across five infusion rates\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eUnlicensed; research use only\u003c\/td\u003e\n\u003ctd\u003eUnlicensed; research use only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS2, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eS2, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThe time course is the sharpest contrast. In the study by Gobburu and colleagues, healthy men received ipamorelin as a 15-minute intravenous infusion; growth hormone rose in a single episode peaking at around 40 minutes and then declined, and the peptide's terminal half-life was about two hours (Gobburu et al., 1999). The MK-677 trials instead recorded raised 24-hour growth hormone and sustained IGF-1 during daily oral use. Different designs, routes and populations mean these profiles cannot rank the two, and we know of no trial giving both to the same people.\u003c\/p\u003e\u003cp\u003eA PubMed search returns no human study of ipamorelin taken by mouth, so its human pharmacology comes from infusion alone, whereas MK-677's comes from oral use. Our ipamorelin listing is on the \u003ca href=\"\/collections\/ipamorelin\"\u003eipamorelin collection page\u003c\/a\u003e; see also the \u003ca href=\"\/blogs\/news\/ipamorelin-research-guide\"\u003eipamorelin research guide\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/mk-677-vs-ipamorelin-vs-hgh\"\u003eMK-677 vs ipamorelin vs HGH\u003c\/a\u003e. None of this recommends either compound.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand, so any certificate of analysis (COA) for this product is the manufacturer's, not ours. A COA is shown only where iMuscle supplies one for the batch we hold; a generic document is not a substitute for a batch certificate. A real batch certificate carries the lot number printed on the pack, the test method (HPLC or LC-MS) and a purity figure. Free Muscle-brand compounds are assayed batch by batch at Janoshik Analytical; that programme does not cover iMuscle. Read an iMuscle certificate against this page:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e HPLC matches the sample's retention time to an ibutamoren reference standard; LC-MS adds a measured mass, about m\/z 529.25 for protonated C27H36N4O5S.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity, as a percentage.\u003c\/strong\u003e It grades the material, not the amount; a high figure is compatible with capsules holding well over or under 10 mg.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The line that tests the 10 mg claim; multiplied by 60, it gives the real pack total to set against 600 mg. It should say whether it is expressed as free base or mesylate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number and test date.\u003c\/strong\u003e These tie the result to your pot and show its age.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eFor this brand, a missing certificate leaves 10 mg and 600 mg as iMuscle's claim only; purity without content supports identity but not strength; a batch number that differs from your pot means another production run. In each case \u003ca href=\"\/pages\/contact\"\u003econtact us\u003c\/a\u003e with the lot number. See \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eIbutamoren is prohibited in and out of competition under section S2 of the WADA Prohibited List, named among the growth hormone secretagogues; in the UK the list is applied by UK Anti-Doping. Accredited laboratories screen urine for it and its metabolites, athletes have been sanctioned after positive findings, and strict liability makes an athlete responsible for whatever is in their sample. A research-use label on a product changes nothing in that respect.\u003c\/p\u003e\u003cp\u003eA PubMed search for ibutamoren in urine returns metabolism work in horses and hormone studies in volunteers, but no human excretion study that sets a detection window, so the accurate answer is: detectable, window not established. Windows quoted online without a study behind them deserve no weight, and blood half-life is no guide, because laboratories also target metabolites. Anyone bound by an anti-doping code should treat any exposure to MK-677 as a likely adverse finding and check the current list, which WADA revises every year.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eWe found no published stability study of ibutamoren capsules, so no shelf life is given here. Any date iMuscle prints on the pack is the limit, and a certificate describes the batch only as it was when tested.\u003c\/p\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eOn arrival.\u003c\/strong\u003e Check the seal and record the lot number and date of receipt; only unopened items can be returned within 30 days. On first opening, count the capsules and tell us the lot number if there are not 60.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIn storage.\u003c\/strong\u003e Keep the pack closed in its original container, cool, dry and away from light. Humidity softens, sticks or cracks capsule shells and speeds the breakdown of damp powder; leave any desiccant sachet in place.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIn use.\u003c\/strong\u003e Wear nitrile gloves, work away from food and drink, and never decant capsules or mix lots, because the lot number on the pack is the only link to its certificate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThroughout.\u003c\/strong\u003e Keep the product out of reach of children and pets, set aside discoloured, clumped or split capsules, and dispose of surplus as chemical waste, not in household bins or drains.\u003c\/li\u003e\n\u003c\/ol\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGhrelin mimetic\u003c\/strong\u003e: a compound that activates the ghrelin receptor as the stomach hormone ghrelin itself does.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGHS-R1a\u003c\/strong\u003e: the type 1a growth hormone secretagogue receptor; both compounds compared on this page are agonists at it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePulse amplitude\u003c\/strong\u003e: the height of each burst of growth hormone; MK-677 raised it without adding bursts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1 and IGFBP-3\u003c\/strong\u003e: insulin-like growth factor 1, produced largely by the liver when growth hormone rises, and the protein that carries most of it in blood.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOral glucose tolerance test\u003c\/strong\u003e: a measure of how blood glucose responds to a standard glucose drink; it can reveal impairment while fasting glucose looks normal.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFat-free mass\u003c\/strong\u003e: everything in the body that is not fat, bone and body water included, so it is not a measure of muscle alone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTerminal half-life\u003c\/strong\u003e: the time for blood concentration to halve once a compound has distributed; about two hours for infused ipamorelin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent uniformity\u003c\/strong\u003e: how closely individual units match the label claim, as opposed to the batch average.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRetention time\u003c\/strong\u003e: how long a compound takes to pass through an HPLC column, the basis of an HPLC identity match.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMesylate\u003c\/strong\u003e: a methanesulfonate salt; ibutamoren mesylate is heavier than the free base, so equal milligrams hold unequal amounts of ibutamoren.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/mk-677\"\u003eAll brands of MK-677 (Ibutamoren)\u003c\/a\u003e, compared on strength, pack size and batch testing\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/mk-677-ibutamoren\"\u003eFree Muscle's own MK-677\u003c\/a\u003e: 10mg, 12.5mg and 25mg, each batch assayed by Janoshik Analytical\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/ipamorelin\"\u003eIpamorelin\u003c\/a\u003e, the peptide compared above\u003c\/li\u003e\n\u003cli\u003eBackground reading: \u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003ethe MK-677 research review\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/mk-677-brands-compared\"\u003ehow MK-677 brands differ\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It is not a medicine or a food supplement, has not been evaluated by the MHRA, EMA or FDA, and is not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eChapman IM, et al. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. J Clin Endocrinol Metab. 1996;81(12):4249-57. PMID: 8954023.\u003c\/li\u003e\n\u003cli\u003eSvensson J, et al. Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. J Clin Endocrinol Metab. 1998;83(2):362-9. PMID: 9467542.\u003c\/li\u003e\n\u003cli\u003eNass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-11. PMID: 18981485.\u003c\/li\u003e\n\u003cli\u003eGobburu JV, et al. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res. 1999;16(9):1412-6. PMID: 10496658.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468979155170,"sku":null,"price":62.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/IBUTAMOREN_720x_2aaedf4d-7fbf-48ff-bed3-22513d927b2c.jpg?v=1789931405"},{"product_id":"imuscle-ligandrol-lgd4033-60-8mg","title":"iMuscle Ligandrol LGD-4033 — 60 caps, 8mg","description":"\u003cp\u003eiMuscle Ligandrol LGD-4033 is supplied as 60 capsules stated at 8 mg each, a total of 480 mg of LGD-4033 per pack. LGD-4033, also called ligandrol, is a non-steroidal selective androgen receptor modulator with a placebo-controlled human trial behind it. This iMuscle product is stocked by Free Muscle through Muscle Market for laboratory research by adults only.\u003c\/p\u003e\n\u003ch2\u003eAbout LGD-4033\u003c\/h2\u003e\n\u003cp\u003eLGD-4033, known as ligandrol and, in later development, as VK5211, is a non-steroidal selective androgen receptor modulator developed by Ligand Pharmaceuticals. It binds the androgen receptor with high affinity and was designed to act on muscle and bone while producing less effect on the prostate and skin than testosterone.\u003c\/p\u003e\n\u003cp\u003eIn a placebo-controlled study published in 2013, 76 healthy men aged 21 to 50 received placebo or one of three amounts of LGD-4033 for 21 days (Basaria et al., 2013). Lean body mass rose in a dose-dependent manner, while fat mass did not change significantly. The same study recorded dose-dependent falls in total testosterone, sex hormone-binding globulin, HDL cholesterol and triglycerides; free testosterone and follicle-stimulating hormone fell significantly at the highest amount only. Hormones and lipids returned to baseline after the study ended. Muscle strength and stair-climbing power were also measured, but the abstract reports no functional result, and the authors called for longer trials. Later development did not lead to approval.\u003c\/p\u003e\n\u003cp\u003eOutside clinical trials, the main evidence of harm comes from case reports. In 2020 physicians at Baylor College of Medicine described a 32-year-old man admitted with jaundice, itching and raised liver enzymes after taking a product sold over the counter as Ligandrol for about two weeks (Barbara et al., 2020). A liver biopsy showed cholestatic hepatitis with mild fibrosis, and his blood tests improved once he stopped. The product was never analysed, and the authors noted it may have contained other unapproved drugs. One case cannot show how often such injury occurs, and no long-term human data have been published. Nothing summarised here is a claim about this product.\u003c\/p\u003e\n\u003ch3\u003eChemical identity\u003c\/h3\u003e\n\u003cp\u003ePubChem records LGD-4033 under the identifiers below, which describe the molecule a certificate for this pack should report finding.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystematic name\u003c\/strong\u003e: 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number\u003c\/strong\u003e: 1165910-22-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula and molecular weight\u003c\/strong\u003e: C14H12F6N2O, 338.25 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInChIKey\u003c\/strong\u003e: OPSIVAKKLQRWKC-VXGBXAGGSA-N\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID\u003c\/strong\u003e: 44137686\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCompound: LGD-4033 (Ligandrol)\u003c\/li\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStated strength: 8 mg per capsule (manufacturer's label claim)\u003c\/li\u003e\n\u003cli\u003eStated total per pack: 480 mg\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe strength is the manufacturer's label claim; only a batch certificate confirms it. To compare brands of LGD-4033, use total milligrams per pack, as explained in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eLGD-4033 in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eSearches such as \"LGD 4033 UK buy\" and \"ligandrol UK\" ask two things: whether it can be bought lawfully here, and how to tell one listing from another.\u003c\/p\u003e\n\u003ch3\u003eThe legal position\u003c\/h3\u003e\n\u003cp\u003eLGD-4033 is not a licensed medicine in the UK: it has no MHRA marketing authorisation, is not an authorised food supplement, and cannot lawfully be sold for human consumption. It is not scheduled under the Misuse of Drugs Act, and Free Muscle supplies it only as a research compound, to adults aged 18 or over, for laboratory research. It is prohibited at all times under section S1 (anabolic agents) of the WADA Prohibited List. Buyers are responsible for the rules that apply to them, including any anti-doping code. Background on the class is in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eWhat a trustworthy listing shows, and where to find it here\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA strength and a count that multiply.\u003c\/strong\u003e Here, 8 mg by 60 capsules gives the 480 mg stated for the pack; a listing with no strength can be neither compared nor checked.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA named maker and seller.\u003c\/strong\u003e iMuscle manufactures this product; FreeMuscle LTD, a UK company in Scunthorpe, sells and dispatches it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate for the batch, not the brand.\u003c\/strong\u003e How this works for iMuscle stock is set out in the certificate section below.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use terms and an age limit.\u003c\/strong\u003e No instructions for use, no outcome claims, adults aged 18 or over only.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTracked, discreet delivery.\u003c\/strong\u003e Free tracked UK delivery in plain packaging; orders before 2pm Monday to Friday processed the same working day; EU delivery in 3-7 working days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReturns.\u003c\/strong\u003e Unopened items within 30 days, under our \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e terms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eA label proves little by itself: the doctors behind the 2020 liver injury report could not say what their patient's \"Ligandrol\" contained, and nor can anyone holding a pot without a batch certificate. Threads under \"ligandrol reddit\" record experiences, not contents. More checks are in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eProducts labelled LGD-4033 appear as capsules, tablets, liquids and loose powder. The molecule is the same in each; what differs is how the amount per unit is fixed and how it can be checked. No published study has compared the formats.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCapsules (this product).\u003c\/strong\u003e A blended powder is portioned into shells at manufacture, so the amount per capsule is fixed then and a certificate can report it directly against the 8 mg claim. Accuracy depends on even mixing, and one assay gives the average of the capsules tested, not the spread between them.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTablets.\u003c\/strong\u003e A similar blend compressed with binders, with the same dependence on mixing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiquids.\u003c\/strong\u003e Labelled in milligrams per millilitre. A certificate describes the solution on the day of testing; later accuracy depends on drawing exact volumes and on the compound staying dissolved, and solvent lost from a bottle opened often concentrates what remains.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLoose powder.\u003c\/strong\u003e Sold for weighing, which moves the whole question of accuracy onto the balance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSolutions suit very small quantities: the Cologne excretion study described below prepared its microgram amounts from an ethanol solution (Wagener et al., 2022). Because LGD-4033 is a small synthetic molecule rather than a peptide, the usual objection to swallowed peptides, breakdown by digestive enzymes, does not arise in the same way (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e), and the 2013 trial gave it by mouth. We know of no published human study of LGD-4033 given by injection.\u003c\/p\u003e\n\u003ch2\u003eLGD-4033 compared with RAD-140\u003c\/h2\u003e\n\u003cp\u003e\"LGD 4033 vs RAD 140\" and \"ligandrol vs RAD 140\" are the comparisons searched most often for this compound. Both are non-steroidal SARMs that activate the androgen receptor, and both began as drug candidates that never reached approval.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFeature\u003c\/th\u003e\n\u003cth\u003eLGD-4033 (this product)\u003c\/th\u003e\n\u003cth\u003eRAD-140\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eLigandrol, VK5211\u003c\/td\u003e\n\u003ctd\u003eTestolone, vosilasarm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDeveloper\u003c\/td\u003e\n\u003ctd\u003eLigand Pharmaceuticals, later licensed to Viking Therapeutics\u003c\/td\u003e\n\u003ctd\u003eRadius Health\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical family\u003c\/td\u003e\n\u003ctd\u003ePyrrolidinyl-benzonitrile with six fluorine atoms\u003c\/td\u003e\n\u003ctd\u003eChlorinated benzonitrile with an oxadiazole ring\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula, molecular weight, CAS\u003c\/td\u003e\n\u003ctd\u003eC14H12F6N2O, 338.25, 1165910-22-4\u003c\/td\u003e\n\u003ctd\u003eC20H16ClN5O2, 393.8, 1182367-47-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublished clinical trial\u003c\/td\u003e\n\u003ctd\u003ePlacebo-controlled study in 76 healthy men over 21 days (2013)\u003c\/td\u003e\n\u003ctd\u003ePhase 1 in women with advanced ER-positive, HER2-negative breast cancer (2022)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMain adverse findings in people\u003c\/td\u003e\n\u003ctd\u003eDose-related falls in testosterone, SHBG, HDL cholesterol and triglycerides; a biopsy-confirmed liver injury case\u003c\/td\u003e\n\u003ctd\u003eRaised liver enzymes and bilirubin common in the trial; liver injury case reports\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLicensed as a medicine\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eNamed in S1.2, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eNamed in S1.2, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThe two trials cannot be set side by side. LGD-4033 went to young, screened, healthy men for three weeks, with body composition and hormones among the outcomes; RAD-140 went to women with advanced cancer to find a tolerable amount for oncology, and muscle was not its question. No study has given the two compounds to comparable groups, so claims that one is \"stronger\" or \"milder\" rest on anecdote, and milligrams of two different molecules are no common currency either.\u003c\/p\u003e\n\u003cp\u003eIn law and in sport they stand together, as the last two rows show, and both are sold here for laboratory research only. RAD-140 brands are compared in the \u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (Testolone) collection\u003c\/a\u003e, and its trial and case reports are covered in \u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eBecause iMuscle is a third-party brand, a certificate of analysis (COA) for this pack is the manufacturer's document, not ours. A certificate is shown only where iMuscle has supplied one for the batch we hold; a generic document that names no batch is not a substitute. Free Muscle-brand compounds are assayed batch by batch at Janoshik Analytical, but that programme does not cover iMuscle. A real batch certificate is specific to one lot. Each part answers a different question, and each gap leaves that question open:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompound.\u003c\/strong\u003e It should name LGD-4033 or ligandrol, ideally with the CAS number. A certificate naming only \"SARM\" or another compound does not relate to this pack.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e HPLC matches the sample's peak to a reference standard; LC-MS adds a molecular mass that should fit C14H12F6N2O. Without identity, a purity figure could describe the wrong substance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIsomer.\u003c\/strong\u003e The (2R) and (1R) in the systematic name mark two stereocentres, so other isomers share the formula and mass. One, the epimer labelled M1, forms in the body and separates from LGD-4033 on chromatography (Wagener et al., 2022); mirror-image forms separate only by chiral methods, so a certificate naming none has not addressed them.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Usually an HPLC area percentage: how much of the detected material is LGD-4033. It says nothing about milligrams per capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The measured figure to set against 8 mg. Without it, the 480 mg on the label stays untested.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLot, date and laboratory.\u003c\/strong\u003e The lot must match your pot, the date shows the age of the result, and a named laboratory can be asked to confirm it. A different lot describes other stock.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eIf an iMuscle certificate leaves any of these gaps, \u003ca href=\"\/pages\/contact\"\u003econtact us\u003c\/a\u003e before relying on the batch. See also \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eLGD-4033 is named in section S1.2 (other anabolic agents) of the WADA Prohibited List and is banned in and out of competition. Under strict liability an athlete answers for any prohibited substance in their sample, whether it came from a research compound, a mislabelled product or a contaminated supplement. WADA reported 62 adverse analytical findings involving LGD-4033 in 2019, a number the Cologne authors described as the highest reported so far (Wagener et al., 2022).\u003c\/p\u003e\n\u003cp\u003eThe most detailed controlled detection data come from microgram amounts. At the German Sport University Cologne, groups of five healthy men took a single 1, 10 or 50 microgram amount, or the same amount on five consecutive days, and their urine was analysed by LC-HRMS\/MS with a limit of detection of 8 picograms per millilitre. After one 50 microgram amount, the longest-lasting metabolite, M5-a, gave its first negative sample only after 11 days. After five daily 50 microgram amounts, metabolite M5-b was still present in every sample when collection ended, 1,004 to 1,128 hours (about 42 to 47 days) after the last intake, so no end point could be set. The authors proposed the ratio of M1 to LGD-4033 for estimating when intake occurred.\u003c\/p\u003e\n\u003cp\u003eNo published study that we can cite establishes a detection window after milligram amounts such as the 8 mg stated per capsule here, so for this product the accurate statement is: detectable, window not established. The microgram results set no upper limit. Anyone subject to anti-doping rules should treat any contact with LGD-4033 as a risk of an adverse finding.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eWe are not aware of any published shelf-life study of LGD-4033 capsules. An expiry or best-before date printed by iMuscle is the limit, and a certificate describes the batch only as it stood on its test date.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eKeep the capsules in their original pot with the lid closed after every opening; the lot number on it is the only link to a certificate.\u003c\/li\u003e\n\u003cli\u003eChoose a cool, dry, dark cupboard away from ovens, radiators, sunny windows and bathrooms. Hard capsule shells soften and stick in damp air and turn brittle in hot, dry air.\u003c\/li\u003e\n\u003cli\u003eIf the pot has been somewhere cold, let it reach room temperature before opening, so condensation does not settle on the capsules.\u003c\/li\u003e\n\u003cli\u003eRecord when the seal was first broken alongside the lot number, and give any portion taken for analysis its own label showing compound, lot and date.\u003c\/li\u003e\n\u003cli\u003eWear gloves with opened capsules or loose powder, keep the material away from food and drink and out of reach of children and pets, and dispose of it as chemical waste, never in household bins or drains.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eReturns are accepted only on unopened items within 30 days, so a pack left sealed until needed keeps its return option.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAndrogen receptor\u003c\/strong\u003e: the protein inside cells that testosterone switches on; LGD-4033 binds the same receptor.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: a non-steroidal ligand of the androgen receptor, developed in the hope of anabolic action in muscle and bone with less action on the prostate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSHBG\u003c\/strong\u003e: sex hormone-binding globulin, the blood protein that carries much circulating testosterone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHDL cholesterol\u003c\/strong\u003e: cholesterol carried in high-density lipoproteins, a standard blood lipid measurement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase 1 trial\u003c\/strong\u003e: an early, usually small clinical study of how a compound is tolerated and handled by the body, before any larger trial examines efficacy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCholestatic liver injury\u003c\/strong\u003e: damage that impairs the flow of bile, typically causing jaundice and itching.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStereocentre\u003c\/strong\u003e: an atom whose attached groups can be arranged in two mirror-image ways; LGD-4033 has two.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpimer\u003c\/strong\u003e: an isomer differing from another at only one of several stereocentres.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolite\u003c\/strong\u003e: a substance the body makes from another; anti-doping tests target long-lasting ones.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLimit of detection\u003c\/strong\u003e: the lowest concentration a method can reliably detect.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdverse analytical finding\u003c\/strong\u003e: an anti-doping laboratory's report that a sample contains a prohibited substance, its metabolites or markers of its use; it starts the results-management process rather than concluding it.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/lgd-4033\"\u003eAll brands of LGD-4033 (Ligandrol)\u003c\/a\u003e, compared on strength, pack size and batch testing\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e stocked at Free Muscle\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/blogs\/news\/lgd-4033-ligandrol-research-guide\"\u003eLGD-4033 (ligandrol): trials, findings and UK status\u003c\/a\u003e, the full research guide\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/ostarine\"\u003eOstarine (MK-2866)\u003c\/a\u003e and \u003ca href=\"\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It is not a medicine, has not been evaluated by the MHRA, EMA or FDA, and is not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eBasaria S, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95. PMID: 22459616.\u003c\/li\u003e\n\u003cli\u003eBarbara M, et al. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J. 2020;7(6):e00370. PMID: 32637435.\u003c\/li\u003e\n\u003cli\u003eWagener F, et al. Investigations into the elimination profiles and metabolite ratios of micro-dosed selective androgen receptor modulator LGD-4033 for doping control purposes. Anal Bioanal Chem. 2022;414(2):1151-1162. PMID: 34734312.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468979482850,"sku":null,"price":44.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/LIGANDROL_720x_31d8619e-fb4e-4156-b614-1cc97bde668c.jpg?v=1789931406"},{"product_id":"imuscle-ligandrol-ibutamoren-ostarine","title":"iMuscle Ligandrol + Ibutamoren + Ostarine stack","description":"\u003cp\u003eThe iMuscle Ligandrol, Ibutamoren and Ostarine bundle groups three iMuscle research compounds in one listing: ligandrol (LGD-4033), ibutamoren (MK-677) and ostarine (MK-2866). Two are SARMs and one is a growth hormone secretagogue. iMuscle lists the pack as 60 capsules and states no per-capsule strength, so we do not invent one. Supplied to adults for laboratory research only, not for human consumption.\u003c\/p\u003e\n\u003cp\u003eA bundle is a listing convenience only: it lets separately packaged products from one manufacturer be ordered in a single purchase. Nothing on this page claims that they act together or should be studied together, and Free Muscle publishes no stack or cycle guidance for any product. Each compound is described in turn.\u003c\/p\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: iMuscle (third-party brand, Muscle Market)\u003c\/li\u003e\n\u003cli\u003eCompounds: ligandrol (LGD-4033), ibutamoren (MK-677), ostarine (MK-2866)\u003c\/li\u003e\n\u003cli\u003eForm and pack size: 60 capsules, as listed by the manufacturer\u003c\/li\u003e\n\u003cli\u003eStrength per capsule: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eCOA: only where iMuscle supplies one for the batch held\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over, for laboratory research only\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eiMuscle's single-compound listings do state strengths: \u003ca href=\"\/products\/imuscle-ligandrol-lgd4033-60-8mg\"\u003eiMuscle Ligandrol LGD-4033\u003c\/a\u003e is labelled 8 mg per capsule, \u003ca href=\"\/products\/imuscle-ostarine-k2866-60-15mg\"\u003eiMuscle Ostarine MK-2866\u003c\/a\u003e 15 mg and \u003ca href=\"\/products\/imuscle-ibutamoren-mk-677-60-10mg\"\u003eiMuscle Ibutamoren MK-677\u003c\/a\u003e 10 mg, each in packs of 60 capsules. They do not apply to this bundle.\u003c\/p\u003e\n\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\n\u003ch3\u003eLigandrol (LGD-4033)\u003c\/h3\u003e\n\u003cp\u003eLigandrol (LGD-4033, VK5211, anabolicum) is a non-steroidal SARM from Ligand Pharmaceuticals. Its main published placebo-controlled human study, a 21-day trial in 76 healthy men aged 21 to 50, reported dose-dependent gains in lean body mass with no significant change in fat mass, together with dose-dependent suppression of total testosterone, SHBG, HDL cholesterol and triglycerides, which returned to baseline after the study ended (Basaria 2013). It was never approved. WADA class S1. Compare brands on the \u003ca href=\"\/collections\/lgd-4033\"\u003eLigandrol (LGD-4033) collection page\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eMK-677 (Ibutamoren)\u003c\/h3\u003e\n\u003cp\u003eIbutamoren (MK-677, L-163,191, nutrobal) is not a SARM but an orally active ghrelin receptor (GHS-R1a) agonist, a growth hormone secretagogue. It has more human trial data than most compounds in this category. A two-year randomised trial in 65 healthy adults aged 60 to 81 reported, at its one-year primary analysis, sustained rises in growth hormone and IGF-1, about 1 kg more fat-free mass than placebo and no gain in strength or function, alongside increased appetite, mild fluid retention, muscle pain, higher fasting glucose and reduced insulin sensitivity (Nass 2008). Never approved. WADA class S2. Compare brands on the \u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection page\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eOstarine (MK-2866, enobosarm)\u003c\/h3\u003e\n\u003cp\u003eOstarine (MK-2866, enobosarm, GTx-024) is a non-steroidal selective androgen receptor modulator developed for muscle wasting, and the most clinically studied SARM. A 2011 phase II trial in healthy older adults reported more lean body mass than placebo over twelve weeks and a change in one physical function measure, with dose-related falls in HDL cholesterol and suppression of total testosterone in men (Dalton 2011). Later phase III trials in patients with cancer-related muscle wasting did not lead to approval, and it is not licensed anywhere. WADA class S1. Compare brands on the \u003ca href=\"\/collections\/ostarine\"\u003eOstarine (MK-2866, enobosarm) collection page\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eChemical identity of each compound\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCompound\u003c\/th\u003e\n\u003cth\u003ePubChem CID\u003c\/th\u003e\n\u003cth\u003eCAS number\u003c\/th\u003e\n\u003cth\u003eFormula\u003c\/th\u003e\n\u003cth\u003eMolecular weight\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eLigandrol (LGD-4033)\u003c\/td\u003e\n\u003ctd\u003e44137686\u003c\/td\u003e\n\u003ctd\u003e1165910-22-4\u003c\/td\u003e\n\u003ctd\u003eC14H12F6N2O\u003c\/td\u003e\n\u003ctd\u003e338.25\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIbutamoren (MK-677), free base\u003c\/td\u003e\n\u003ctd\u003e178024\u003c\/td\u003e\n\u003ctd\u003e159634-47-6\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S\u003c\/td\u003e\n\u003ctd\u003e528.7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOstarine (enobosarm)\u003c\/td\u003e\n\u003ctd\u003e11326715\u003c\/td\u003e\n\u003ctd\u003e841205-47-8\u003c\/td\u003e\n\u003ctd\u003eC19H14F3N3O3\u003c\/td\u003e\n\u003ctd\u003e389.3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThese summaries report what was measured in trial participants, each compound studied separately. No published study has examined the three together, and none of it is a claim about the capsules in this bundle.\u003c\/p\u003e\n\u003ch2\u003eLigandrol, ibutamoren and ostarine in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eTwo questions matter here: may these compounds change hands in Britain, and how does a checkable listing differ from one taken on trust?\u003c\/p\u003e\n\u003ch3\u003eThe legal position for each compound\u003c\/h3\u003e\n\u003cp\u003eNone of the compounds on this page is a licensed medicine in the United Kingdom, none has been assessed by the MHRA and none is an authorised food supplement. At the time of writing, none of the three is controlled under the Misuse of Drugs Act 1971. Free Muscle supplies them to adults aged 18 and over for laboratory research only. They are not for human consumption. LGD-4033 and ostarine fall under WADA class S1; MK-677 is listed under S2. For ibutamoren, see our \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status page\u003c\/a\u003e. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e covers the class.\u003c\/p\u003e\n\u003ch3\u003eWhy these three names attract scrutiny\u003c\/h3\u003e\n\u003cp\u003eOver five years, the falsified medicines working group of the European network of official medicines control laboratories, whose members include the MHRA laboratory in London, collected results on 324 samples from 14 laboratories in 13 countries (Barrios 2025). Ibutamoren, ligandrol and ostarine headed the list of the five molecules reported most often, and about a quarter of products had been presented as dietary supplements, which the authors noted leaves buyers unaware that a pharmaceutical substance is inside.\u003c\/p\u003e\n\u003cp\u003eLabels are the other problem. Of 44 products bought online as SARMs in 2016, only 23 contained a SARM at all, while 17 held a different unapproved drug, ibutamoren among them, and only 18 matched the amount on their label (Van Wagoner 2017). For a pack naming three compounds, each name is a separate claim needing its own evidence.\u003c\/p\u003e\n\u003ch3\u003eWhat a checkable UK listing shows\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eA stated amount per capsule for each compound.\u003c\/li\u003e\n\u003cli\u003eA printed batch number matching a certificate that covers every compound.\u003c\/li\u003e\n\u003cli\u003eA named UK seller, an 18+ restriction, plain packaging and tracked delivery.\u003c\/li\u003e\n\u003cli\u003eNo directions for human use and no promised outcomes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis bundle meets the seller-side points: it is sold and dispatched by FreeMuscle LTD in Scunthorpe, with free tracked UK delivery in plain packaging, same-day processing for orders placed before 2pm Monday to Friday, EU delivery in three to seven working days, and 30-day returns on unopened items (\u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e, \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e). It fails the strength point, because iMuscle states none. See our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eAll three compounds are also sold as liquids, tablets and powder. No study has compared formats for any of them, so the useful comparison concerns measurement, not effect.\u003c\/p\u003e\n\u003cp\u003eA capsule fixes its quantity once, at filling, before the container is sealed. A laboratory can then report milligrams per capsule directly. The weakness is variation between capsules, which depends on how evenly the powder was mixed and which a single averaged assay cannot show. A liquid fixes only a concentration. Every later portion depends on the measuring device and on solvent not evaporating from a bottle opened many times. Loose powder fixes nothing in advance and relies wholly on the balance used to weigh it.\u003c\/p\u003e\n\u003cp\u003eAll three are small synthetic molecules, not peptides, so the argument that swallowed peptides are largely digested, discussed in \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e, does not apply in the same way; each trial cited above gave the compound by mouth. One point is specific to ibutamoren: it is often sold as its mesylate salt, which weighs more than the free base in the table above, so any stated amount should say which form it counts. None of this is a claim about what a capsule does.\u003c\/p\u003e\n\u003ch2\u003eLigandrol, ostarine and MK-677 compared with RAD-140\u003c\/h2\u003e\n\u003cp\u003eRAD-140 (testolone) is not in this pack but is the compound most often compared with ligandrol, so it is included for reference.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eLigandrol\u003c\/th\u003e\n\u003cth\u003eOstarine\u003c\/th\u003e\n\u003cth\u003eMK-677\u003c\/th\u003e\n\u003cth\u003eRAD-140 (not in this pack)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eClass\u003c\/td\u003e\n\u003ctd\u003eNon-steroidal SARM\u003c\/td\u003e\n\u003ctd\u003eNon-steroidal SARM\u003c\/td\u003e\n\u003ctd\u003eNon-peptide growth hormone secretagogue\u003c\/td\u003e\n\u003ctd\u003eNon-steroidal SARM\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTarget\u003c\/td\u003e\n\u003ctd\u003eAndrogen receptor\u003c\/td\u003e\n\u003ctd\u003eAndrogen receptor\u003c\/td\u003e\n\u003ctd\u003eGhrelin receptor (GHS-R1a)\u003c\/td\u003e\n\u003ctd\u003eAndrogen receptor\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOriginal developer\u003c\/td\u003e\n\u003ctd\u003eLigand Pharmaceuticals\u003c\/td\u003e\n\u003ctd\u003eGTx\u003c\/td\u003e\n\u003ctd\u003eMerck\u003c\/td\u003e\n\u003ctd\u003eRadius Health\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMain published human data\u003c\/td\u003e\n\u003ctd\u003e21-day trial in 76 healthy men\u003c\/td\u003e\n\u003ctd\u003ePhase II trial in older adults; phase III trials in cancer patients\u003c\/td\u003e\n\u003ctd\u003eTwo-year randomised trial in 65 older adults\u003c\/td\u003e\n\u003ctd\u003eOne phase 1 trial in women with advanced breast cancer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLicensed anywhere\u003c\/td\u003e\n\u003ctd\u003eNo\u003c\/td\u003e\n\u003ctd\u003eNo\u003c\/td\u003e\n\u003ctd\u003eNo\u003c\/td\u003e\n\u003ctd\u003eNo\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA section\u003c\/td\u003e\n\u003ctd\u003eS1, anabolic agents\u003c\/td\u003e\n\u003ctd\u003eS1, anabolic agents\u003c\/td\u003e\n\u003ctd\u003eS2, growth hormone secretagogues\u003c\/td\u003e\n\u003ctd\u003eS1, anabolic agents\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eMK-2866 and MK-677 share only a development-code prefix, not a mechanism. Ostarine acts at the androgen receptor, the same target as testosterone. MK-677 never touches that receptor; it imitates ghrelin, prompting the pituitary to release growth hormone, which in turn raises IGF-1. Its recorded adverse findings on glucose, fluid and appetite reflect that different pathway.\u003c\/p\u003e\n\u003cp\u003eLigandrol and ostarine do share a target, and both trials recorded falls in testosterone and HDL cholesterol. The difference is the record: ostarine was taken through larger and longer trials in older adults and cancer patients, ligandrol, in the published record, mainly through one three-week study in healthy men. No trial compared them directly, so claims that one is stronger or milder rest on anecdote.\u003c\/p\u003e\n\u003cp\u003eRAD-140 is a third androgen receptor ligand, from a different chemical family. Its only clinical trial studied tolerability in cancer, where raised liver enzymes were frequent; our \u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 research summary\u003c\/a\u003e gives the detail. RAD-140 brands are compared on the \u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (Testolone) collection page\u003c\/a\u003e, and ibutamoren's nearest peptide counterpart is covered in \u003ca href=\"\/blogs\/news\/mk-677-vs-ipamorelin-vs-hgh\"\u003eMK-677 vs ipamorelin vs somatropin\u003c\/a\u003e. Nothing here ranks one compound above another.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eAny certificate for this pack comes from iMuscle, not from us. We show one only when iMuscle has supplied it for the precise batch on our shelves, and if nothing is shown, nothing has been supplied; a generic document never stands in. Janoshik Analytical testing of every batch, with certificates emailed on request, applies to Free Muscle-brand products only.\u003c\/p\u003e\n\u003cp\u003eThree compounds mean three identities to prove. Check each field:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number.\u003c\/strong\u003e Compare it character by character with the lot printed on your pack; a near miss is a different lot.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e HPLC compares a sample's peak with a reference standard; LC-MS adds a measured mass that should fit the formulas in the table above. Each compound needs its own result; one confirmed compound says nothing of the other two.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStereochemistry.\u003c\/strong\u003e Ligandrol has two stereocentres and ostarine one, so mirror-image forms share their formula and mass. Only a chiral method separates them.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Normally reported as a percentage of chromatogram peak area. A figure of 99 per cent describes the proportion of what was detected, never the milligrams inside a capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e With no stated strength, this measured figure would be the only statement of quantity for this bundle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTest date and laboratory.\u003c\/strong\u003e A named laboratory can confirm a report at source.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eA missing field has a specific meaning here. No certificate for the batch in stock means nothing independent confirms which compounds are present. Identity results without content figures confirm presence, not amount. Email us through the \u003ca href=\"\/pages\/contact\"\u003econtact page\u003c\/a\u003e with the product name and batch number and we will send what we hold, or say plainly that there is none. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab testing page\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e explain the methods.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eAll three compounds are prohibited at all times, in and out of competition, on the WADA Prohibited List, which UK Anti-Doping applies in the UK. Ligandrol and ostarine are named in section S1, anabolic agents; ibutamoren falls under section S2 as a growth hormone secretagogue. Under strict liability an athlete answers for any prohibited substance in their sample, whatever its source.\u003c\/p\u003e\n\u003cp\u003eAccredited anti-doping laboratories screen routinely for ligandrol and ostarine, and both have been the subject of published excretion studies using microgram amounts, summarised on the single-compound pages for \u003ca href=\"\/products\/imuscle-ligandrol-lgd4033-60-8mg\"\u003eiMuscle LGD-4033\u003c\/a\u003e and \u003ca href=\"\/products\/imuscle-ostarine-k2866-60-15mg\"\u003eiMuscle Ostarine\u003c\/a\u003e. Those studies set no upper limit and none used capsules like these. Ibutamoren is also within the scope of testing. A blood half-life is no guide to detection, because laboratories also target long-lived metabolites. For every compound in this bundle the accurate statement is: detectable, window not established. Anyone bound by an anti-doping code should treat this product as prohibited.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eNo published shelf-life study covers ligandrol, ibutamoren or ostarine in capsule form, so no shelf life is quoted here beyond any expiry date iMuscle prints. A certificate describes a batch only on its test date.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep every container as supplied.\u003c\/strong\u003e The lot number on each pot is its only link to a certificate, and loose capsules can look identical.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCool, dry and dark.\u003c\/strong\u003e A closed cupboard away from heat and sunlight. Close the lid after each opening and leave any desiccant inside.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep a log.\u003c\/strong\u003e Record the date received and the date each seal was broken beside the lot number, and label any sample drawn for analysis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInspect before use in the lab.\u003c\/strong\u003e Capsules that have clumped, softened or changed colour should be quarantined and reported to us with the lot number.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTreat it as bench material.\u003c\/strong\u003e Use gloves once a container is open, keep the work area free of food and drink, store it where children and pets cannot reach, and send surplus to chemical waste under local rules.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eReturns within 30 days apply to unopened items only.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: short for selective androgen receptor modulator. Two of the three compounds here qualify; ibutamoren sits in a different class altogether.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth hormone secretagogue\u003c\/strong\u003e: any substance that prompts the pituitary gland to release growth hormone; ibutamoren belongs to this class.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGhrelin and GHS-R1a\u003c\/strong\u003e: ghrelin is a hormone made mainly in the stomach; GHS-R1a is its receptor, which ibutamoren activates.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1\u003c\/strong\u003e: insulin-like growth factor 1, produced largely by the liver in response to growth hormone and measured as a marker of that axis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSHBG\u003c\/strong\u003e: the carrier protein that binds testosterone in blood; it fell in a dose-dependent manner in the 2013 LGD-4033 study.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCachexia\u003c\/strong\u003e: wasting of muscle and body weight in serious illness such as cancer; enobosarm's late-stage trials enrolled patients with it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMesylate\u003c\/strong\u003e: the methanesulfonate salt in which ibutamoren is commonly supplied; a milligram of salt holds less than a milligram of free base.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStereocentre\u003c\/strong\u003e: a point in a molecule where two mirror-image arrangements are possible, giving isomers of identical mass.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: the anti-doping principle that a prohibited substance in a sample counts against the athlete regardless of intent.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033 (Ligandrol) collection\u003c\/a\u003e and the \u003ca href=\"\/blogs\/news\/lgd-4033-ligandrol-research-guide\"\u003eligandrol research guide\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677 (ibutamoren): what the research says\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/ostarine\"\u003eOstarine (MK-2866) collection\u003c\/a\u003e and the \u003ca href=\"\/blogs\/news\/ostarine-mk-2866-research-guide\"\u003eostarine research guide\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-imuscle\"\u003eiMuscle brand page\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eBundles collection\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eSupplied for laboratory research use only. Not a medicine, not evaluated by the MHRA, EMA or FDA, and not for human consumption. Buyers must be 18 or over. Nothing on this page is medical or dosing advice or a recommendation to use, stack or cycle any compound; research summaries describe findings in study participants or animals, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eBasaria S, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95. PMID: 22459616.\u003c\/li\u003e\n\u003cli\u003eNass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-11. PMID: 18981485.\u003c\/li\u003e\n\u003cli\u003eDalton JT, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle. 2011;2(3):153-161. PMID: 22031847.\u003c\/li\u003e\n\u003cli\u003eBarrios MM, et al. SARMs, Metabolic Modulators and Growth Hormone Secretagogues in Suspected Illegal Medicines, Bought as Sport Performance Enhancers: A Retro- and Prospective Study Within the GEON. Drug Test Anal. 2025;17(10):2078-2085. PMID: 40551438.\u003c\/li\u003e\n\u003cli\u003eVan Wagoner RM, et al. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017;318(20):2004-2010. PMID: 29183075.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468979646690,"sku":null,"price":120.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/Combo2_720x_63c30469-21b1-4273-b023-bbca00a0d09a.jpg?v=1789931408"},{"product_id":"imuscle-ligandrol-testolon-yk-11","title":"iMuscle Ligandrol + Testolone + YK-11 stack","description":"\u003cp\u003eThe iMuscle Ligandrol, Testolone and YK-11 bundle places three androgen receptor compounds from one manufacturer in a single listing: ligandrol (LGD-4033), testolone (RAD-140) and YK-11. iMuscle lists the pack as 60 capsules and does not state a strength per capsule, so none is quoted here. Like every product on Free Muscle, it is supplied to adults for laboratory research only and is not for human consumption.\u003c\/p\u003e\u003cp\u003eA bundle is a listing convenience only: it lets separately packaged products from one manufacturer be ordered in a single purchase. Nothing on this page claims that they act together or should be studied together, and Free Muscle publishes no stack or cycle guidance for any product.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: iMuscle (third-party brand, \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e)\u003c\/li\u003e\n\u003cli\u003eCompounds: ligandrol (LGD-4033), testolone (RAD-140), YK-11\u003c\/li\u003e\n\u003cli\u003eForm and pack size: 60 capsules, as listed by the manufacturer\u003c\/li\u003e\n\u003cli\u003eStrength per capsule: not stated by the manufacturer for any of the three, so no per-capsule or per-pack total is given\u003c\/li\u003e\n\u003cli\u003eCOA: only where iMuscle supplies one for the batch held\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over, for laboratory research only\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eWhere a stated strength matters for a research record, iMuscle's single-compound listings carry one on the label: \u003ca href=\"\/products\/imuscle-ligandrol-lgd4033-60-8mg\"\u003eiMuscle Ligandrol LGD-4033\u003c\/a\u003e at 8 mg per capsule, \u003ca href=\"\/products\/imuscle-testolon-rad-140-60-10mg\"\u003eiMuscle Testolone RAD-140\u003c\/a\u003e at 10 mg and \u003ca href=\"\/products\/imuscle-yk-11-60-10mg\"\u003eiMuscle YK-11\u003c\/a\u003e at 10 mg, each in packs of 60.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eLigandrol (LGD-4033)\u003c\/h3\u003e\u003cp\u003eLigandrol (LGD-4033, VK5211, anabolicum) is a non-steroidal SARM from Ligand Pharmaceuticals (PubChem CID 44137686, CAS 1165910-22-4, formula C14H12F6N2O, molecular weight 338.25). The only published placebo-controlled human study, a 21-day phase I trial in 76 healthy young men, reported a dose-dependent rise in lean body mass with no significant change in fat mass, together with dose-dependent falls in total testosterone, SHBG, HDL cholesterol and triglycerides, which returned to baseline after stopping (Basaria 2013). It was never approved. WADA class S1. Compare brands on the \u003ca href=\"\/collections\/lgd-4033\"\u003eLigandrol (LGD-4033) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eTestolone (RAD-140)\u003c\/h3\u003e\u003cp\u003eTestolone (RAD-140, vosilasarm) is a non-steroidal SARM designed by Radius Health and characterised in rats and non-human primates (Miller 2011; PubChem CID 44200882, CAS 1182367-47-0, formula C20H16ClN5O2, molecular weight 393.8). Human data are limited to a small early oncology study. That first-in-human phase 1 trial recruited 22 postmenopausal women with ER-positive, HER2-negative metastatic breast cancer and gave the compound by mouth. Liver findings led its adverse-event list, with AST raised in 59.1 per cent of participants, ALT in 45.5 per cent and bilirubin in 27.3 per cent, and 16 women had at least one grade 3 or 4 event (LoRusso 2022). It assessed tolerability and tumour response, not muscle. Published case reports describe drug-induced liver injury in adults who had taken products labelled as containing RAD-140, in one case alongside LGD-4033 (Barbara 2020). It has never been approved as a medicine. WADA class S1. Compare brands on the \u003ca href=\"\/collections\/rad-140\"\u003eTestolone (RAD-140) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eYK-11\u003c\/h3\u003e\u003cp\u003eYK-11 is a steroidal compound, structurally unlike the other SARMs here (PubChem CID 119058028, CAS 1370003-76-1, formula C25H34O6, molecular weight 430.5). In a 2011 reporter-gene study it behaved as a partial androgen receptor agonist in cultured cells (Kanno 2011). Most later work is also in cells. A 2023 study in male rats reported raised oxidative stress and impaired mitochondrial markers in the hippocampus after five weeks of exposure (Dahleh 2023). There is no formal toxicology programme, no human data and no clinical development. WADA class S1. Compare brands on the \u003ca href=\"\/collections\/yk-11\"\u003eYK-11 collection page\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eEvery study above looked at one compound on its own. Nothing has been published on LGD-4033, RAD-140 and YK-11 in combination, and none of these findings is a claim about this product.\u003c\/p\u003e\u003ch2\u003eLGD-4033, RAD-140 and YK-11 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003ch3\u003eThe legal position\u003c\/h3\u003e\u003cp\u003eNone of the compounds on this page is a licensed medicine in the United Kingdom, none has been assessed by the MHRA and none is an authorised food supplement, so none may lawfully be sold for human consumption. Free Muscle supplies them to adults aged 18 and over for laboratory research only.\u003c\/p\u003e\u003cp\u003eLGD-4033 and RAD-140 are non-steroidal and, at the time of writing, are not controlled drugs in the UK. YK-11 needs a closer look. Its carbon skeleton is that of a steroid, and anabolic steroids are Class C controlled drugs in the UK, so its position is less settled than that of the other two. Anyone ordering is responsible for the rules that apply to them and their institution. All three compounds fall under WADA class S1 (anabolic agents). Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e has more background.\u003c\/p\u003e\u003ch3\u003eWhat a trustworthy UK listing shows\u003c\/h3\u003e\u003cp\u003eThese points separate a documented product from an undocumented one:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eA stated amount of every compound per capsule, so that a certificate has a figure to be checked against.\u003c\/li\u003e\n\u003cli\u003eA batch or lot number printed on the pot, matching the number on the certificate.\u003c\/li\u003e\n\u003cli\u003eA certificate for that batch that covers each compound named on the label, not only the first one.\u003c\/li\u003e\n\u003cli\u003eA named UK company with an address, and an 18+ restriction at checkout.\u003c\/li\u003e\n\u003cli\u003ePlain packaging and tracked delivery.\u003c\/li\u003e\n\u003cli\u003eNo instructions for taking the product and no outcome photographs or promises.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eHow this listing compares\u003c\/h3\u003e\u003cp\u003eMeasured against that list, this bundle falls short on the first point: iMuscle gives no strength, and we will not invent one. A certificate appears only where iMuscle supplies one for the batch in stock. The remaining points are met by us as the seller. FreeMuscle LTD is a UK company based in Scunthorpe; UK delivery is free, tracked and in plain packaging; orders placed before 2pm Monday to Friday are processed the same working day; EU delivery takes 3 to 7 working days; and unopened items can be returned within 30 days. Details are on the \u003ca href=\"\/pages\/shipping\"\u003eshipping page\u003c\/a\u003e and the \u003ca href=\"\/pages\/guarantee\"\u003eguarantee page\u003c\/a\u003e, and our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e sets out each check in more depth.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eAll three compounds circulate as capsules, tablets and liquids, and \"YK11 injectable\" and \"RAD 140 liquid UK\" are both common searches. No published study has compared these formats for LGD-4033, RAD-140 or YK-11, so the useful differences are about measurement and keeping the material intact, not about effect.\u003c\/p\u003e\u003cp\u003eIn a capsule the amount is fixed at the filling stage, and a content assay of finished capsules can then confirm it. That only works if a target figure exists, which is exactly what this bundle lacks. The listing also does not break the 60 capsules down by compound, so if the split matters to your records, ask us before ordering. A liquid is labelled in milligrams per millilitre; its accuracy then rests on how exactly volumes are measured, whether the compound stays in solution, and whether solvent evaporates from a bottle opened many times, which concentrates what is left.\u003c\/p\u003e\u003cp\u003eNone of the three is a peptide. They are small synthetic molecules, so the objection raised against swallowed peptides, that digestive enzymes break them down (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e), does not apply in the same way. Both published human trials in this family, for LGD-4033 and for RAD-140, gave the compound by mouth. We are aware of no published human study of any of the three given by injection, and YK-11 has never been given to people in a published study at all.\u003c\/p\u003e\u003ch2\u003eLigandrol compared with ostarine\u003c\/h2\u003e\u003cp\u003eRAD-140 is already covered above, so this section sets ligandrol beside ostarine, a compound not in this bundle.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eLigandrol (LGD-4033)\u003c\/th\u003e\n\u003cth\u003eOstarine (MK-2866)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eVK5211, anabolicum\u003c\/td\u003e\n\u003ctd\u003eEnobosarm, GTx-024\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDeveloper\u003c\/td\u003e\n\u003ctd\u003eLigand Pharmaceuticals\u003c\/td\u003e\n\u003ctd\u003eGTx, Inc.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and molecular weight\u003c\/td\u003e\n\u003ctd\u003eC14H12F6N2O, 338.25\u003c\/td\u003e\n\u003ctd\u003eC19H14F3N3O3, 389.3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e1165910-22-4\u003c\/td\u003e\n\u003ctd\u003e841205-47-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTarget\u003c\/td\u003e\n\u003ctd\u003eAndrogen receptor\u003c\/td\u003e\n\u003ctd\u003eAndrogen receptor\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eKey published human trial\u003c\/td\u003e\n\u003ctd\u003e21-day phase I, 76 healthy young men\u003c\/td\u003e\n\u003ctd\u003e12-week phase II, 120 men over 60 and postmenopausal women\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMain recorded findings\u003c\/td\u003e\n\u003ctd\u003eLean body mass rose with dose; fat mass unchanged; testosterone, SHBG and HDL fell\u003c\/td\u003e\n\u003ctd\u003eLean body mass rose with dose versus placebo; adverse events at similar rates across groups\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eApproved as a medicine\u003c\/td\u003e\n\u003ctd\u003eNo\u003c\/td\u003e\n\u003ctd\u003eNo\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA class\u003c\/td\u003e\n\u003ctd\u003eS1, anabolic agents\u003c\/td\u003e\n\u003ctd\u003eS1, anabolic agents\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eBoth are non-steroidal and both target the androgen receptor, but they come from different chemical families: ligandrol is built on a fluorinated pyrrolidine ring, while ostarine is an aryl-propionamide with two cyano groups. The trials also asked different questions. The ligandrol study was short and in young men, and its main purpose was tolerability and pharmacokinetics. The ostarine study ran four times longer, in older adults, and was sponsored and run by the developer, which also reported changes in a physical function measure and in insulin resistance (Dalton 2011). Neither trial was designed to show long-term safety, and neither compound has been approved anywhere. Nothing here ranks one compound above the other.\u003c\/p\u003e\u003cp\u003eOstarine brands are compared on the \u003ca href=\"\/collections\/ostarine\"\u003eostarine collection page\u003c\/a\u003e and the \u003ca href=\"\/blogs\/news\/ostarine-mk-2866-research-guide\"\u003eostarine research guide\u003c\/a\u003e covers its trials. For testolone the comparison searched most often is with RAD-150, the benzoate ester sold as TLB-150; see the \u003ca href=\"\/collections\/rad-150\"\u003eRAD-150 collection\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/rad-140-vs-rad-150-tlb-150\"\u003eRAD-140 vs RAD-150\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand sold through Muscle Market. For third-party brands we display a certificate of analysis only where the manufacturer supplies one for the exact batch we hold; if none is shown, none has been supplied and we do not substitute a generic document. Free Muscle-brand products, by contrast, are assayed batch by batch at Janoshik Analytical, with the certificate sent on request by email. That Janoshik testing does not extend to iMuscle.\u003c\/p\u003e\u003cp\u003eIf a certificate is available for this bundle, read it field by field:\u003c\/p\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number.\u003c\/strong\u003e Compare it character by character with the lot code on your pot; the certificate only speaks for that lot.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e HPLC compares the retention time of each peak with a reference standard; LC-MS adds a mass reading. The expected molecular weights are 338.25 for LGD-4033, 393.8 for RAD-140 and 430.5 for YK-11. Each compound should have its own result.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Usually given as the percentage of total peak area on the HPLC trace. With three compounds, check that each is reported separately and that any unknown peaks are listed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent.\u003c\/strong\u003e Milligrams found per capsule. For this listing this would be the only figure anywhere stating how much of each compound is present.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLaboratory and test date.\u003c\/strong\u003e A named laboratory and a date let the result be traced at source and show how old it is.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003eA gap on the certificate has a plain meaning here. No certificate for the batch held means nothing independent confirms what the capsules contain. A certificate naming only ligandrol says nothing about testolone or YK-11. Identity without content confirms that a compound is present but not how much. To ask for what we hold, email us via the \u003ca href=\"\/pages\/contact\"\u003econtact page\u003c\/a\u003e with the product name and batch number. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab testing page\u003c\/a\u003e and the guide on \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e explain the methods further.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eLGD-4033, RAD-140 and YK-11 are all on the WADA Prohibited List under S1, anabolic agents, and are banned at all times, in and out of competition. UK Anti-Doping applies that list in the UK. Anti-doping rules work on strict liability: a prohibited substance found in an athlete's sample counts against them regardless of how it got there or what the product label said, so anyone subject to testing should treat this bundle as prohibited.\u003c\/p\u003e\u003cp\u003eAccredited laboratories screen for SARMs and for their urinary metabolites, not only the parent compound. For that reason a blood half-life, such as the 44.7 hours measured for RAD-140 in the oncology trial (LoRusso 2022), is not a detection window. This page cites no study that sets a detection window for any of the three, so the accurate answer for each is: detectable, window not established.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eNo stability study has been published for capsules of LGD-4033, RAD-140 or YK-11, so we give no shelf life beyond any date iMuscle prints on the pack. What can be controlled is exposure to heat, humidity and light.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eKeep the pots sealed, at cool room temperature, in a dry cupboard away from sunlight and radiators.\u003c\/li\u003e\n\u003cli\u003eOpen one pot at a time, reseal it promptly, and keep any moisture-absorbing sachet in with the capsules.\u003c\/li\u003e\n\u003cli\u003eDo not decant capsules into other containers; once separated from the labelled pot they can no longer be tied to a batch number or certificate.\u003c\/li\u003e\n\u003cli\u003eIf shells turn soft, split or change colour, quarantine that pot and send us the batch number.\u003c\/li\u003e\n\u003cli\u003eWear gloves when handling, keep the pots well clear of kitchens, children and pets, and send surplus material for disposal as laboratory chemical waste.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: selective androgen receptor modulator, a compound designed to activate the androgen receptor in some tissues more than others.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePartial agonist\u003c\/strong\u003e: a compound that activates a receptor but produces a weaker maximum response than the body's own hormone, as reported for YK-11 in cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLean body mass\u003c\/strong\u003e: body weight minus fat, usually measured by a DEXA scan; the main outcome in the ligandrol and ostarine trials.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSHBG\u003c\/strong\u003e: sex hormone-binding globulin, a blood protein that carries testosterone; it fell in the ligandrol trial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHDL cholesterol\u003c\/strong\u003e: the lipoprotein fraction usually regarded as protective, which also fell in the ligandrol trial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAST and ALT\u003c\/strong\u003e: liver enzymes that rise in the blood when liver cells are damaged.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase I and phase II\u003c\/strong\u003e: early clinical trial stages that test tolerability and first signs of an effect, not long-term safety.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC\u003c\/strong\u003e: high-performance liquid chromatography; a sample is pushed through a packed column and its components emerge at different times as separate peaks.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLC-MS\u003c\/strong\u003e: a chromatography run coupled to a mass spectrometer, so each separated peak also gets a measured mass, a stronger identity check than retention time alone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWADA S1\u003c\/strong\u003e: the anabolic agents section of the World Anti-Doping Agency Prohibited List.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033 (Ligandrol) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (Testolone) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/yk-11\"\u003eYK-11 collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/ostarine\"\u003eOstarine (MK-2866) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-imuscle\"\u003eiMuscle brand page\u003c\/a\u003e and \u003ca href=\"\/collections\/market-bundles\"\u003eBundles collection\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/lgd-4033-ligandrol-research-guide\"\u003eLGD-4033 (ligandrol) research guide\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/yk-11-what-is-known\"\u003eYK-11: what is known\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eSupplied for laboratory research use only. Not a medicine, not evaluated by the MHRA, EMA or FDA, and not for human consumption. Buyers must be 18 or over. Nothing on this page is medical or dosing advice or a recommendation to use, stack or cycle any compound; research summaries describe findings in study participants or animals, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eBasaria S, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95. PMID: 22459616.\u003c\/li\u003e\n\u003cli\u003eMiller CP, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-9. PMID: 24900290.\u003c\/li\u003e\n\u003cli\u003eKanno Y, et al. (17alpha,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor. Biol Pharm Bull. 2011;34(3):318-23. PMID: 21372378.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003cli\u003eDalton JT, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle. 2011;2(3):153-61. PMID: 22031847.\u003c\/li\u003e\n\u003cli\u003eBarbara M, et al. Drug-Induced Liver Injury Associated With Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033). ACG Case Rep J. 2020;7(6):e00409. PMID: 33062783.\u003c\/li\u003e\n\u003cli\u003eDahleh MMM, et al. YK11 induces oxidative stress and mitochondrial dysfunction in hippocampus: The interplay between a selective androgen receptor modulator (SARM) and exercise. J Steroid Biochem Mol Biol. 2023;233:106364. PMID: 37468001.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468979843298,"sku":null,"price":119.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/Combo5_7fdb5057-d6a3-4b23-a7bb-b8cc28b4f448.jpg?v=1789931410"},{"product_id":"imuscle-ostarine-k2866-60-15mg","title":"iMuscle Ostarine MK-2866 — 60 caps, 15mg","description":"\u003cp\u003eiMuscle Ostarine MK-2866 is a pack of 60 capsules stated at 15 mg each, 900 mg of ostarine in total. Ostarine, also known as enobosarm, MK-2866 or GTx-024, is the most clinically studied compound in the SARM class, having reached Phase 3 trials without approval. iMuscle manufactures it and Free Muscle stocks it in the Muscle Market range for research use by adults aged 18 and over.\u003c\/p\u003e\u003ch2\u003eAbout Ostarine (MK-2866)\u003c\/h2\u003e\u003cp\u003eOstarine is a non-steroidal selective androgen receptor modulator developed by GTx Inc. for muscle wasting and, later, for breast cancer.\u003c\/p\u003e\u003cp\u003eA 2011 Phase 2 trial in 120 healthy elderly men and postmenopausal women reported a placebo-adjusted increase in lean body mass of about 1.3 kg at the 3 mg dose over 12 weeks, alongside improved stair-climb performance, and also recorded falls in HDL cholesterol and modest suppression of testosterone (Dalton et al., 2011). A 2013 randomised Phase 2 trial in patients with cancer-related muscle wasting again found increases in lean body mass (Dobs et al., 2013), but the subsequent Phase 3 POWER trials did not meet their co-primary endpoints and enobosarm was not approved. It remains unlicensed as a medicine in every country.\u003c\/p\u003e\u003cp\u003eThe adverse findings carry as much weight as the lean mass figure. In the full 2011 report, HDL cholesterol fell with dose, by 27 per cent at the highest dose; in men, SHBG and total testosterone fell, though free testosterone did not change significantly; and eight participants had transient rises in the liver enzyme ALT, one of whom was withdrawn. Outside trials, physicians at the University of British Columbia described a previously healthy man in his early forties admitted with jaundice after two months of taking ostarine bought online, without medical supervision (Bedi et al., 2021). A liver biopsy showed moderate to severe cholestasis consistent with drug-induced liver injury, and his blood tests improved gradually over the following months. He had also been taking two prescribed medicines, and the report describes no analysis of the product. One case cannot show how often such injury occurs, and no long-term human data exist.\u003c\/p\u003e\u003cp\u003eThe findings above describe the compound in clinical research and case reports and are not claims about this listing. The later breast cancer trial and the wider literature are covered in the \u003ca href=\"\/blogs\/news\/ostarine-mk-2866-research-guide\"\u003eostarine research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eCompound: Ostarine (MK-2866)\u003c\/li\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStated strength: 15 mg per capsule (manufacturer's label claim)\u003c\/li\u003e\n\u003cli\u003eStated total per pack: 900 mg\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eThe strength is the manufacturer's label claim; only a batch certificate confirms it. To compare brands of Ostarine, use total milligrams per pack, as explained in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eOstarine in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eBehind \"ostarine UK\", \"MK 2866 buy UK\" and \"ostarine UK sale\" sit two questions: is buying it here lawful, and what separates one listing from another?\u003c\/p\u003e\u003ch3\u003eThe legal position\u003c\/h3\u003e\u003cp\u003eOstarine is not a licensed medicine in the UK: it has no MHRA marketing authorisation, is not an authorised food supplement, and cannot lawfully be sold for human consumption. It is not a controlled drug under the Misuse of Drugs Act 1971, and Free Muscle supplies it to adults aged 18 or over for laboratory research only. It is prohibited at all times under section S1 (anabolic agents) of the WADA Prohibited List. Buyers are responsible for the rules that apply to them, including any anti-doping code. Background on the class is in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eSix things a UK listing should show\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLabel figures that can be tested.\u003c\/strong\u003e A strength per capsule and a count, as listed above; without them a listing can be neither checked nor compared.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWho makes it and who sells it.\u003c\/strong\u003e The manufacturer is iMuscle; the seller is FreeMuscle LTD, a UK company based in Scunthorpe.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA lot number that leads to a certificate.\u003c\/strong\u003e The number printed on the pot ties the capsules to an analysis; how this works for iMuscle stock is set out in the certificate section below.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSold for research, to adults.\u003c\/strong\u003e The page gives no directions for use and promises nothing about outcomes, and every buyer must be 18 or over.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDelivery that can be followed.\u003c\/strong\u003e Every UK order travels free, tracked and in plain packaging; orders placed before 2pm Monday to Friday are processed the same working day, and EU delivery takes 3-7 working days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA way back.\u003c\/strong\u003e Unopened items can be returned within 30 days, on the terms given on our \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e pages.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eReviews and \"ostarine UK reddit\" threads can say how fast a parcel arrived, not what the capsules contained; only a laboratory can say that. A longer checklist is in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003e\"Ostarine tablets UK\", \"ostarine capsules UK\" and \"ostarine liquid UK\" are all searched. Ostarine is a small synthetic molecule with a molecular weight of 389.3, not a peptide, so the usual objection to swallowed peptides, breakdown by digestive enzymes, does not apply in the same way (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e); the Cologne excretion study described below gave it by mouth. The forms differ in how the amount per unit is fixed and how far a certificate can confirm it; no published study has compared them.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003cth\u003eHow the amount is set\u003c\/th\u003e\n\u003cth\u003eWhat a certificate can confirm\u003c\/th\u003e\n\u003cth\u003eMain weakness\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCapsules (this product)\u003c\/td\u003e\n\u003ctd\u003eA powder blend is filled into shells at manufacture\u003c\/td\u003e\n\u003ctd\u003eMeasured content per capsule against the 15 mg label figure\u003c\/td\u003e\n\u003ctd\u003eUniformity between capsules depends on how well the blend was mixed, which an assay of pooled capsules does not reveal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTablets\u003c\/td\u003e\n\u003ctd\u003eA blend is compressed with binders and fillers\u003c\/td\u003e\n\u003ctd\u003eContent per tablet\u003c\/td\u003e\n\u003ctd\u003eThe same reliance on mixing, plus uneven content if tablets are split\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLiquids\u003c\/td\u003e\n\u003ctd\u003eDissolved to a stated concentration in milligrams per millilitre\u003c\/td\u003e\n\u003ctd\u003eConcentration of the solution on the day it was tested\u003c\/td\u003e\n\u003ctd\u003eThe quantity per millilitre can drift after testing, through inaccurate measuring, the compound coming out of solution, or evaporation from a bottle opened repeatedly\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLoose powder\u003c\/td\u003e\n\u003ctd\u003eNot portioned at all\u003c\/td\u003e\n\u003ctd\u003eIdentity and purity of the powder\u003c\/td\u003e\n\u003ctd\u003eEvery quantity must be weighed, so accuracy rests on the balance\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eNone of this is a claim that one form works better than another; it concerns only how a stated quantity can be verified.\u003c\/p\u003e\u003ch2\u003eOstarine compared with LGD-4033\u003c\/h2\u003e\u003cp\u003e\"Ligandrol vs ostarine\" sets ostarine against another member of its class; \"MK 2866 vs MK 677\", a pairing with an unrelated growth hormone secretagogue, is answered in the questions below. Ostarine and LGD-4033 are both non-steroidal SARMs that activate the androgen receptor, and both began as drug candidates that were never approved.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFeature\u003c\/th\u003e\n\u003cth\u003eOstarine (this product)\u003c\/th\u003e\n\u003cth\u003eLGD-4033\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eEnobosarm, MK-2866, GTx-024\u003c\/td\u003e\n\u003ctd\u003eLigandrol, VK5211\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOriginator\u003c\/td\u003e\n\u003ctd\u003eGTx Inc.\u003c\/td\u003e\n\u003ctd\u003eLigand Pharmaceuticals\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical family\u003c\/td\u003e\n\u003ctd\u003eAryl-propionamide with one stereocentre, the (2S) form\u003c\/td\u003e\n\u003ctd\u003ePyrrolidinyl-benzonitrile with two stereocentres\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and molecular weight\u003c\/td\u003e\n\u003ctd\u003eC19H14F3N3O3, 389.3\u003c\/td\u003e\n\u003ctd\u003eC14H12F6N2O, 338.25\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e841205-47-8\u003c\/td\u003e\n\u003ctd\u003e1165910-22-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFurthest clinical stage\u003c\/td\u003e\n\u003ctd\u003ePhase 3 (the POWER trials in cancer-related muscle wasting)\u003c\/td\u003e\n\u003ctd\u003ePhase 1: one placebo-controlled trial in 76 healthy men aged 21 to 50, lasting 21 days (2013)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAdverse findings reported in people\u003c\/td\u003e\n\u003ctd\u003eFalls in HDL cholesterol, SHBG and total testosterone; transient ALT rises; a biopsy-proven case of cholestatic liver injury\u003c\/td\u003e\n\u003ctd\u003eTotal testosterone, SHBG, HDL cholesterol and triglycerides fell as the dose rose; one biopsy-confirmed report of cholestatic liver injury\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLicensed as a medicine\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS1.2, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eS1.2, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThe table invites a head-to-head reading the evidence cannot support. Ostarine's Phase 2 trials enrolled older adults and people with cancer over roughly twelve to sixteen weeks; the only LGD-4033 trial enrolled young, healthy men for three weeks. No study has given both compounds to comparable participants, so any ranking by strength or tolerability has no trial behind it, and a milligram of one molecule is not equivalent to a milligram of the other.\u003c\/p\u003e\u003cp\u003eWhat they share is status: unlicensed everywhere, sold here for laboratory research only, and prohibited under the same WADA section. Brands of LGD-4033 are compared in the \u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033 (Ligandrol) collection\u003c\/a\u003e, and its trial is summarised in \u003ca href=\"\/blogs\/news\/lgd-4033-ligandrol-research-guide\"\u003eLGD-4033 (ligandrol): trials, findings and UK status\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand, so any certificate of analysis (COA) for this pack is the manufacturer's, not ours. Where iMuscle supplies a COA for the batch we hold, we show it; where none exists for the batch in stock, we say so rather than show a generic document. Free Muscle-brand compounds are assayed batch by batch at Janoshik Analytical; that programme does not cover iMuscle. When a certificate is available, check each field against the table.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eField\u003c\/th\u003e\n\u003cth\u003eWhat it should show for this product\u003c\/th\u003e\n\u003cth\u003eWhat a gap means\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCompound\u003c\/td\u003e\n\u003ctd\u003eOstarine, enobosarm or MK-2866, ideally with CAS 841205-47-8\u003c\/td\u003e\n\u003ctd\u003eIt does not describe this pot\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIdentity\u003c\/td\u003e\n\u003ctd\u003eHPLC against a reference standard, or LC-MS showing a mass consistent with C19H14F3N3O3 (molecular weight 389.3)\u003c\/td\u003e\n\u003ctd\u003eWithout identity, a purity figure could belong to a different substance\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStereochemistry\u003c\/td\u003e\n\u003ctd\u003eThe (2S) form that PubChem records under InChIKey JNGVJMBLXIUVRD-SFHVURJKSA-N\u003c\/td\u003e\n\u003ctd\u003eIts mirror image has the same mass and is resolved only by a chiral method, so a certificate naming none has not addressed it\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003eA percentage, usually from HPLC peak area\u003c\/td\u003e\n\u003ctd\u003eNothing is known about impurities or breakdown products\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eContent per capsule\u003c\/td\u003e\n\u003ctd\u003eA measured figure in milligrams to set against the 15 mg label claim\u003c\/td\u003e\n\u003ctd\u003eThe 900 mg per pack stays an untested label claim\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBatch number\u003c\/td\u003e\n\u003ctd\u003eThe same lot as printed on your pot\u003c\/td\u003e\n\u003ctd\u003eThe certificate describes other stock\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTest date and laboratory\u003c\/td\u003e\n\u003ctd\u003eA date and a named laboratory that can confirm the report\u003c\/td\u003e\n\u003ctd\u003eThe result cannot be traced\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eWhere a field is blank on the certificate for our current batch, ask us through the \u003ca href=\"\/pages\/contact\"\u003econtact page\u003c\/a\u003e what is known before relying on that batch. Further detail is in \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and on our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eOstarine is named in section S1.2 (other anabolic agents) of the WADA Prohibited List, banned in and out of competition, and is the SARM most frequently detected in anti-doping analyses. Under strict liability an athlete answers for any prohibited substance in their sample, whatever its source, and supplements contaminated with minute amounts of ostarine have become a major concern for athletes and the authorities that manage results.\u003c\/p\u003e\u003cp\u003eThat concern prompted a controlled study at the German Sport University Cologne, where single and repeated oral amounts of 1, 10 and 50 micrograms of ostarine were given and urine was analysed by LC-MS\/MS (Walpurgis et al., 2020). A single 1 microgram amount could be detected for up to nine days, depending on whether ostarine itself or its glucuronide was the target, while hydroxylated metabolites gave considerably shorter windows. Peak urine levels and detection times rose with the amount given and varied widely between individuals.\u003c\/p\u003e\u003cp\u003eNo verified study we can cite gives a detection window after milligram quantities such as the 15 mg stated per capsule here, so the accurate statement for this product is: detectable, window not established. Because detection time increased with the amount, the microgram figures are not an upper limit. Anyone subject to an anti-doping code should treat any contact with ostarine as a risk of an adverse finding.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eWe can cite no published stability study of ostarine capsules, so we quote no shelf life. Work to the expiry date on the iMuscle pot; a certificate reflects the batch only on its test date.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eContainer.\u003c\/strong\u003e Keep the capsules in the original pot, closed fully after each opening; the pot carries the lot number, and decanting into an unlabelled container breaks the link to any certificate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConditions.\u003c\/strong\u003e A cool, dry, dark place away from heat and direct sunlight. Kitchens and bathrooms are poor choices, as capsule shells take up moisture and can soften or stick together.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecords.\u003c\/strong\u003e Note the lot number and the date the seal was broken, and label any sample taken for analysis with compound, lot and date.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHandling.\u003c\/strong\u003e Use gloves with opened capsules or loose powder, keep the material away from food and drink and out of reach of children and pets, and dispose of it as chemical waste rather than in household bins or drains.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eBreaking the seal also ends the 30-day return option, which applies to unopened items only.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnobosarm\u003c\/strong\u003e: the International Nonproprietary Name for ostarine, used in clinical publications; MK-2866 and GTx-024 are development codes for the same molecule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSelective androgen receptor modulator (SARM)\u003c\/strong\u003e: a non-steroidal androgen receptor activator whose developers aimed for effects on muscle and bone with less action on the prostate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAryl-propionamide\u003c\/strong\u003e: the chemical family ostarine belongs to, which also includes andarine (S-4) and S-23.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLean body mass\u003c\/strong\u003e: body weight minus fat, measured in the ostarine trials by dual-energy X-ray absorptiometry (DXA); it includes water and organs as well as muscle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCo-primary endpoint\u003c\/strong\u003e: one of the main outcomes, set in advance, that a trial must meet to count as a success; the POWER trials fell short on theirs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSHBG\u003c\/strong\u003e: sex hormone-binding globulin, which binds testosterone in the blood, so total testosterone tends to fall when SHBG does.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eALT\u003c\/strong\u003e: alanine aminotransferase, a liver enzyme whose blood level rises when liver cells are damaged.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCholestasis\u003c\/strong\u003e: reduced flow of bile from the liver, which can cause jaundice; the pattern seen in the ostarine case report.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucuronide\u003c\/strong\u003e: a compound joined to glucuronic acid by the body so it can be excreted in urine; anti-doping methods can target it.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/ostarine\"\u003eAll brands of Ostarine (MK-2866)\u003c\/a\u003e, compared on strength, pack size and batch testing\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/ostarine-mk-2866-research-guide\"\u003eOstarine (MK-2866): the most-studied SARM, what trials found\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e stocked at Free Muscle\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033 (Ligandrol)\u003c\/a\u003e and \u003ca href=\"\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It is not a medicine, has not been evaluated by the MHRA, EMA or FDA, and is not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eDalton JT, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle. 2011;2(3):153-161. PMID: 22031847.\u003c\/li\u003e\n\u003cli\u003eDobs AS, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol. 2013;14(4):335-45. PMID: 23499390.\u003c\/li\u003e\n\u003cli\u003eBedi H, et al. Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator. ACG Case Rep J. 2021;8(1):e00518. PMID: 34368386.\u003c\/li\u003e\n\u003cli\u003eWalpurgis K, et al. Elimination profiles of microdosed ostarine mimicking contaminated products ingestion. Drug Test Anal. 2020;12(11-12):1570-1580. PMID: 32959982.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468980039906,"sku":null,"price":41.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/OSTABOLON_720x_038c6b35-a391-48d6-a65a-43cf847f030f.jpg?v=1789931412"},{"product_id":"imuscle-ostarine-andarine-cardarine","title":"iMuscle Ostarine + Andarine + Cardarine stack","description":"\u003cp\u003eThe iMuscle Ostarine, Andarine and Cardarine bundle groups three research compounds from one manufacturer into a single listing: ostarine (MK-2866), andarine (S-4) and cardarine (GW-501516). iMuscle lists the pack as 60 capsules and does not state a strength per capsule, so we do not quote one. Supplied to adults for laboratory research only, not for human consumption.\u003c\/p\u003e\u003cp\u003eA bundle is a listing convenience only: it lets separately packaged products from one manufacturer be ordered in a single purchase. Nothing on this page claims that they act together or should be studied together, and Free Muscle publishes no stack or cycle guidance for any product.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eOstarine (MK-2866, enobosarm)\u003c\/h3\u003e\u003cp\u003eOstarine (MK-2866, enobosarm, GTx-024) is a non-steroidal selective androgen receptor modulator developed for muscle wasting, and one of the most clinically studied SARMs. A 2011 phase II trial in healthy older adults reported more lean body mass than placebo over twelve weeks, alongside dose-related falls in HDL cholesterol and, in men, lower SHBG and total testosterone. Phase III cancer cachexia trials reported lean mass gains but missed their physical function endpoints, and it was never approved. WADA class S1. Compare brands on the \u003ca href=\"\/collections\/ostarine\"\u003eOstarine (MK-2866, enobosarm) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eAndarine (S-4)\u003c\/h3\u003e\u003cp\u003eAndarine (S-4, GTx-007) is an earlier aryl-propionamide SARM from the same programme as ostarine. Its evidence is preclinical: in ovariectomised rats it prevented bone loss and reduced body fat in a 2007 study. No controlled human trial has been published and no regulator has approved it. WADA class S1. Compare brands on the \u003ca href=\"\/collections\/andarine\"\u003eAndarine (S-4) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eCardarine (GW-501516)\u003c\/h3\u003e\u003cp\u003eCardarine (GW-501516, endurobol) is not a SARM but an agonist at the PPAR-delta nuclear receptor, which regulates fatty-acid oxidation genes. In a small two-week 2007 study of 24 healthy volunteers, HDL cholesterol rose relative to placebo and fat clearance after a test meal improved, while fasting triglycerides only trended lower. Development was later discontinued after long-term rodent toxicology studies reportedly found tumours in several organs, a sponsor-reported finding that ended further human work. Never approved; prohibited by WADA as a metabolic modulator under section S4. Compare brands on the \u003ca href=\"\/collections\/cardarine\"\u003eCardarine (GW-501516) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eThese summaries describe what was measured in trial participants and laboratory animals. None of it is a claim about the capsules in this bundle.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: iMuscle (third-party brand, Muscle Market)\u003c\/li\u003e\n\u003cli\u003eCompounds: ostarine (MK-2866), andarine (S-4), cardarine (GW-501516)\u003c\/li\u003e\n\u003cli\u003eForm and pack size: 60 capsules, as listed by the manufacturer\u003c\/li\u003e\n\u003cli\u003eStrength per capsule: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eCOA: only where iMuscle supplies one for the batch held\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eOstarine, andarine and cardarine in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"ostarine UK buy\", \"cardarine UK legal\" and \"andarine UK\" reduce to two questions. Can these compounds lawfully change hands in Britain, and how can a buyer tell a checkable listing from one that asks to be taken on trust?\u003c\/p\u003e\u003ch3\u003eWhere the law stands\u003c\/h3\u003e\u003cp\u003eNone of the three appears in the schedules of the Misuse of Drugs Act 1971, so none is a controlled drug. None holds a UK marketing authorisation from the MHRA, so none may be sold or promoted as a medicine, and none is an authorised food supplement or novel food, so none may be sold for eating. What remains is supply as a chemical for laboratory research, to adults, with no directions for use and no promised outcome. That is the only basis on which Free Muscle lists this bundle. In sport the position is stricter: ostarine and andarine are prohibited at all times under WADA section S1, and cardarine under section S4.\u003c\/p\u003e\u003ch3\u003eWhy the listing matters more than the compound name\u003c\/h3\u003e\u003cp\u003eA 2017 study in \u003cem\u003eJAMA\u003c\/em\u003e bought 44 products sold online as SARMs and analysed them with methods accredited for anti-doping work (Van Wagoner et al., 2017). Only 23 contained a SARM at all. A further 17 contained another unapproved drug, among them GW501516 and SR9009; four contained no active compound; eleven held something not named on the label; and in just 18 did the measured amount match the label. The lesson for this bundle is direct: the name on a pot is a claim, and only an analysis of the lot tests it.\u003c\/p\u003e\u003ch3\u003eWhat a checkable UK listing shows, and where this one stands\u003c\/h3\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCheck\u003c\/th\u003e\n\u003cth\u003eThis bundle\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eNamed manufacturer and named seller\u003c\/td\u003e\n\u003ctd\u003eMade by iMuscle; sold and dispatched by FreeMuscle LTD, a UK company in Scunthorpe\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eA stated strength for each compound\u003c\/td\u003e\n\u003ctd\u003eNot stated by the manufacturer, so none is quoted here\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eA certificate tied to the lot in stock\u003c\/td\u003e\n\u003ctd\u003eShown only where iMuscle supplies one for the batch held\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNo directions for use or outcome claims\u003c\/td\u003e\n\u003ctd\u003eNone given; research use only, 18 and over\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTracked, discreet delivery\u003c\/td\u003e\n\u003ctd\u003eFree tracked UK delivery in plain packaging; orders before 2pm Monday to Friday processed the same working day; EU delivery in 3-7 working days\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eA returns route\u003c\/td\u003e\n\u003ctd\u003eUnopened items within 30 days, see \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThis bundle meets the seller-side checks but not the strength check, because the manufacturer has not published one; the single-compound listings in each collection are the alternative where a stated strength matters. Reviews can report delivery times, not what a capsule contains. A fuller checklist is in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e, and the class is introduced in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eAll three compounds are also sold as liquids and loose powders, hence searches such as \"ostarine liquid UK\". The chemistry does not change with the format; what changes is where the amount per unit is fixed and how it can be checked.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCapsules.\u003c\/strong\u003e The amount is set when powder is filled into shells, before the container is sealed, so a certificate can report a measured figure per capsule. Its blind spot is variation from one capsule to the next, which a pooled assay averages away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiquids.\u003c\/strong\u003e The label gives a concentration, so every portion depends on the accuracy of a dropper or syringe. Solvent loss from a bottle opened often raises the concentration, and a compound held near its solubility limit can settle out in the cold. A certificate for a liquid describes the bottle only as it was when sampled.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLoose powder.\u003c\/strong\u003e Nothing is portioned in advance, so accuracy rests entirely on the balance used to weigh it.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eNone of the three is a peptide. Ostarine (molecular weight 389.3), andarine (441.4) and cardarine (453.5) are small synthetic molecules, so the usual objection to swallowed peptides, breakdown by digestive enzymes, does not apply to them in the same way; the background is in \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e. No published study compares formats for any of the three, so nothing here suggests one format works better than another. A capsule with a stated strength is simply the easiest format to verify, and this bundle lacks one.\u003c\/p\u003e\u003ch2\u003eCardarine compared with SR9009 (stenabolic)\u003c\/h2\u003e\u003cp\u003e\"Stenabolic vs cardarine\" is the comparison searched most often for the one non-SARM in this bundle. The two are often mistaken for relatives, but they act on different receptors and have very different evidence behind them.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFeature\u003c\/th\u003e\n\u003cth\u003eCardarine (in this bundle)\u003c\/th\u003e\n\u003cth\u003eSR9009\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eGW-501516, GW1516, endurobol\u003c\/td\u003e\n\u003ctd\u003eStenabolic, SR-9009\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTarget\u003c\/td\u003e\n\u003ctd\u003ePPAR-delta, a nuclear receptor controlling genes for fatty-acid use\u003c\/td\u003e\n\u003ctd\u003eREV-ERB alpha and beta, nuclear receptors in the circadian clock\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOrigin\u003c\/td\u003e\n\u003ctd\u003eA drug-development programme at Glaxo Wellcome, later GlaxoSmithKline\u003c\/td\u003e\n\u003ctd\u003eA laboratory probe from the Scripps Research Institute, first described in 2012\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman data\u003c\/td\u003e\n\u003ctd\u003eSmall, short controlled studies in volunteers, including the two-week 2007 lipid study\u003c\/td\u003e\n\u003ctd\u003eNo clinical study; almost all data from injected mice and cultured cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReason development stopped\u003c\/td\u003e\n\u003ctd\u003eTumours in long-term rodent toxicology studies\u003c\/td\u003e\n\u003ctd\u003eNever entered clinical development\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLicensed as a medicine\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS4, metabolic modulators (PPAR-delta agonists), prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eS4, metabolic modulators (listed as an example of an AMPK activator), prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThe practical difference is the depth of the record. Cardarine reached people under trial conditions, so there are measured lipid changes and a documented reason for its abandonment. SR9009 has neither: its reputation as an \"exercise mimetic\" rests on mouse work, and its oral bioavailability in humans has not been established. No study has compared the two directly. They do meet in two places. The 2017 \u003cem\u003eJAMA\u003c\/em\u003e analysis found both inside products labelled as SARMs, and both fall under the same WADA section. The development history of cardarine is covered in \u003ca href=\"\/blogs\/news\/cardarine-gw-501516-what-happened-in-development\"\u003ecardarine: what happened in development\u003c\/a\u003e; SR9009 brands are listed in the \u003ca href=\"\/collections\/sr9009\"\u003eSR9009 collection\u003c\/a\u003e and explained in the \u003ca href=\"\/blogs\/news\/sr9009-stenabolic-research-guide\"\u003eSR9009 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eFor the two SARMs in the bundle, the searched comparisons are \"andarine vs ostarine\" and \"ligandrol vs ostarine\". The first is set out on the \u003ca href=\"\/products\/imuscle-andarine-s4-60-15mg\"\u003eiMuscle Andarine S-4\u003c\/a\u003e page and the second on the \u003ca href=\"\/products\/imuscle-ostarine-k2866-60-15mg\"\u003eiMuscle Ostarine MK-2866\u003c\/a\u003e page, with LGD-4033 brands in the \u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033 collection\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand, so any certificate of analysis (COA) for this bundle is the manufacturer's. We display one only where iMuscle supplies it for the exact batch we hold, and we never substitute a generic document. Free Muscle-brand products are assayed batch by batch at Janoshik Analytical, with the certificate emailed on request; that programme does not extend to iMuscle. A bundle raises one extra point: three compounds means three identities to confirm, normally on three certificates, one per lot.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCompound\u003c\/th\u003e\n\u003cth\u003eCAS\u003c\/th\u003e\n\u003cth\u003eFormula and molecular weight\u003c\/th\u003e\n\u003cth\u003eStereochemistry to check\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOstarine\u003c\/td\u003e\n\u003ctd\u003e841205-47-8\u003c\/td\u003e\n\u003ctd\u003eC19H14F3N3O3, 389.3\u003c\/td\u003e\n\u003ctd\u003eThe (2S) form; its mirror image has the same mass\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAndarine\u003c\/td\u003e\n\u003ctd\u003e401900-40-1\u003c\/td\u003e\n\u003ctd\u003eC19H18F3N3O6, 441.4\u003c\/td\u003e\n\u003ctd\u003eThe (2S) form; same issue as ostarine\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCardarine\u003c\/td\u003e\n\u003ctd\u003e317318-70-0\u003c\/td\u003e\n\u003ctd\u003eC21H18F3NO3S2, 453.5\u003c\/td\u003e\n\u003ctd\u003eNone; the molecule has no stereocentre\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eOn each certificate, look for these fields:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e HPLC against a reference standard, or LC-MS giving a mass that fits the formula above. Without it, a purity figure could belong to a different substance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Usually an HPLC peak-area percentage. It shows what share of the detected material is the named compound, not how many milligrams a capsule holds.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e A measured milligram figure. For this bundle there is no label strength to compare it with, so the certificate would be the first statement of strength rather than a check on one.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number, test date and laboratory.\u003c\/strong\u003e The lot on the certificate must match the lot on the container, and a named laboratory can be asked to confirm the report is genuine.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eIf any field is missing, the matching question stays open. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the lot numbers and we will say what documentation exists. Further detail is in \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and on our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eAll three compounds are on the WADA Prohibited List and banned in and out of competition. Ostarine and andarine sit in section S1.2, other anabolic agents. Cardarine has been on the list since January 2009, first as a gene doping substance and now in section S4 among metabolic modulators (Kintz et al., 2020). Anti-doping rules apply strict liability, so an athlete answers for any prohibited substance found in a sample whatever its source, including a mislabelled product.\u003c\/p\u003e\u003cp\u003eAccredited anti-doping laboratories screen urine for all three, and hair analysis can in principle reach further back. In 2020, forensic toxicologists in Strasbourg reported the first identification of GW501516 in human hair, at 32 and 22 pg\/mg in two consecutive 2 cm segments from one male user, and noted that this was not expected for a molecule carrying a carboxylic acid group (Kintz et al., 2020).\u003c\/p\u003e\u003cp\u003eWhat no verified study gives is a detection window after capsules like these, whose strength is not even stated. For every compound in this bundle, the accurate position is: detectable, window not established. Anyone bound by an anti-doping code should treat any contact with these compounds as a risk of an adverse finding.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eWe can cite no published shelf-life study for ostarine, andarine or cardarine in capsule form, so we quote no shelf life. Work to the expiry date printed on each iMuscle container, and remember that a certificate describes a batch only on its test date.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep the products apart.\u003c\/strong\u003e Leave each compound in its own labelled container. Capsules of different compounds can look alike, and once mixed or decanted they can no longer be matched to a lot number or a certificate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCool, dry and dark.\u003c\/strong\u003e A closed cupboard away from radiators, ovens and sunny windowsills. Close the lid after every opening; capsule shells take up moisture, so bathrooms and kitchens are poor places for them.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecord as you go.\u003c\/strong\u003e Note each lot number and the date its seal was broken. Label any sample taken for analysis with compound, lot and date.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHandle as laboratory chemicals.\u003c\/strong\u003e Gloves for opened capsules or powder, no food or drink nearby, out of reach of children and pets, and disposal as chemical waste under local rules rather than in household bins or drains.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eOpening a container also ends the 30-day return option, which applies to unopened items only.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: selective androgen receptor modulator, a non-steroidal compound that activates the androgen receptor; ostarine and andarine are SARMs, cardarine is not.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAryl-propionamide\u003c\/strong\u003e: the chemical family shared by ostarine and andarine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePPAR-delta\u003c\/strong\u003e: peroxisome proliferator-activated receptor delta, the nuclear receptor cardarine binds.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eREV-ERB\u003c\/strong\u003e: a pair of circadian clock receptors targeted by SR9009, unrelated to PPAR-delta.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic modulator\u003c\/strong\u003e: the WADA category in section S4 that covers PPAR-delta agonists and AMPK activators.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCachexia\u003c\/strong\u003e: the muscle and weight loss that accompanies cancer and other chronic illness, the condition ostarine's phase III trials targeted.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStereocentre\u003c\/strong\u003e: an atom that allows two mirror-image forms of a molecule; ostarine and andarine each have one, cardarine has none.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC and LC-MS\u003c\/strong\u003e: liquid chromatography, alone or linked to mass spectrometry, used to identify a compound and measure its purity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/ostarine\"\u003eOstarine (MK-2866) collection\u003c\/a\u003e and the \u003ca href=\"\/blogs\/news\/ostarine-mk-2866-research-guide\"\u003eostarine research guide\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/andarine\"\u003eAndarine (S-4) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/cardarine\"\u003eCardarine (GW-501516) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/sr9009\"\u003eSR9009 collection\u003c\/a\u003e and \u003ca href=\"\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-imuscle\"\u003eiMuscle brand page\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eBundles collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eComparing listings by price per milligram\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eSupplied for laboratory research use only. Not a medicine, not evaluated by the MHRA, EMA or FDA, and not for human consumption. Buyers must be 18 or over. Nothing on this page is medical or dosing advice or a recommendation to use, stack or cycle any compound; research summaries describe findings in study participants or animals, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eDalton JT, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle. 2011;2(3):153-161. PMID: 22031847.\u003c\/li\u003e\n\u003cli\u003eKearbey JD, et al. Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res. 2007;24(2):328-35. PMID: 17063395.\u003c\/li\u003e\n\u003cli\u003eSprecher DL, et al. Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. Arterioscler Thromb Vasc Biol. 2007;27(2):359-65. PMID: 17110604.\u003c\/li\u003e\n\u003cli\u003eVan Wagoner RM, et al. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017;318(20):2004-2010. PMID: 29183075.\u003c\/li\u003e\n\u003cli\u003eKintz P, et al. Testing for GW501516 (cardarine) in human hair using LC\/MS-MS and confirmation by LC\/HRMS. Drug Test Anal. 2020;12(7):980-986. PMID: 32298044.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468980105442,"sku":null,"price":104.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/Combo8.jpg?v=1789931413"},{"product_id":"imuscle-s-23-60-15mg","title":"iMuscle S-23 — 60 caps, 15mg","description":"\u003cp\u003eiMuscle S-23 is a pack of 60 capsules stated at 15 mg each, 900 mg of S-23 in total. S-23 is a potent non-steroidal selective androgen receptor modulator that was studied in rats as a candidate for hormonal male contraception. It has never been tested in a published clinical trial; the only human data come from anti-doping excretion studies. Free Muscle stocks this iMuscle product through Muscle Market for laboratory research by adults aged 18 and over.\u003c\/p\u003e\u003ch2\u003eAbout S-23\u003c\/h2\u003e\u003cp\u003eS-23 is a non-steroidal selective androgen receptor modulator from the same aryl-propionamide family as andarine and ostarine. It was investigated not for muscle wasting but as a candidate for hormonal male contraception, because of how effectively it suppressed the pituitary-gonadal axis in animals.\u003c\/p\u003e\u003cp\u003eThe key paper is a 2009 preclinical characterisation in rats (Jones et al., 2009). S-23 bound the androgen receptor with an inhibitory constant of about 1.7 nanomolar and behaved as a full agonist in cell assays. In the animals it increased levator ani muscle weight and, when combined with an oestrogen, suppressed spermatogenesis and produced infertility that reversed once treatment stopped. The same work recorded a strong decrease in luteinising hormone and follicle-stimulating hormone. In castrated rats it acted on the prostate as well as on muscle, though at higher amounts, while in intact rats prostate size fell as luteinising hormone was suppressed. No clinical trial of S-23 has been published, and no clinical development has been reported. Its suppressive effect on the animals' own reproductive hormones is therefore its best-documented property. These rodent findings are not claims about this listing.\u003c\/p\u003e\u003ch3\u003eName and chemical identity\u003c\/h3\u003e\u003cp\u003eS-23 never reached clinical development, so it is known only by its series code, also written S23, and is easily confused with S-22 (an early code for ostarine) and S-4 (andarine). A certificate for this pack should match these PubChem identifiers:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystematic name\u003c\/strong\u003e: (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number\u003c\/strong\u003e: 1010396-29-8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula and molecular weight\u003c\/strong\u003e: C18H13ClF4N2O3, 416.8 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInChIKey\u003c\/strong\u003e: SSFVOEAXHZGTRJ-KRWDZBQOSA-N\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID\u003c\/strong\u003e: 24892822\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eCompound: S-23\u003c\/li\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStated strength: 15 mg per capsule (manufacturer's label claim)\u003c\/li\u003e\n\u003cli\u003eStated total per pack: 900 mg\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eThe strength is the manufacturer's label claim; only a batch certificate confirms it. To compare brands of S-23, use total milligrams per pack, as explained in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eS-23 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"S23 SARM UK\" and \"S-23 SARM for sale\" ask two things: whether S-23 can be bought lawfully in Britain, and how to tell a listing that can be checked from one that must be taken on trust.\u003c\/p\u003e\u003ch3\u003eThe legal position\u003c\/h3\u003e\u003cp\u003eS-23 is not a licensed medicine in the UK: it has no MHRA marketing authorisation, and no regulator anywhere has granted one. Nor is it an authorised food supplement, so it cannot lawfully be sold for human consumption, although it is not a controlled substance. Free Muscle supplies it to adults aged 18 or over for laboratory research only. WADA prohibits it at all times under section S1 (anabolic agents) of its Prohibited List. Buyers are responsible for the rules that bind them, including any anti-doping code and, for EU orders, local import rules. The wider class is covered in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eWhat a listing should show, and what this one shows\u003c\/h3\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCheck\u003c\/th\u003e\n\u003cth\u003eWhy it matters for S-23\u003c\/th\u003e\n\u003cth\u003eThis listing\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCompound named precisely\u003c\/td\u003e\n\u003ctd\u003eA certificate can only be matched to an exact name\u003c\/td\u003e\n\u003ctd\u003eS-23, with the identifiers above\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStrength and capsule count\u003c\/td\u003e\n\u003ctd\u003eNeeded for a pack total and a price per milligram\u003c\/td\u003e\n\u003ctd\u003e15 mg by 60 capsules, 900 mg per pack (label claim)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCertificate for the batch sold\u003c\/td\u003e\n\u003ctd\u003eThe only evidence of what the capsules contain\u003c\/td\u003e\n\u003ctd\u003eShown only where iMuscle supplies one for the batch we hold; otherwise we say none exists\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eA named seller\u003c\/td\u003e\n\u003ctd\u003eSomeone accountable for the sale\u003c\/td\u003e\n\u003ctd\u003eFreeMuscle LTD, a UK company based in Scunthorpe\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eResearch-only terms\u003c\/td\u003e\n\u003ctd\u003eDirections or promised results signal a sale for consumption\u003c\/td\u003e\n\u003ctd\u003eLaboratory research, adults 18+, no directions or outcome claims\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDelivery and returns\u003c\/td\u003e\n\u003ctd\u003eShows who holds the parcel, and on what terms\u003c\/td\u003e\n\u003ctd\u003eFree tracked UK delivery on every order, in plain packaging; same-day processing for orders before 2pm Monday to Friday; EU delivery in 3-7 working days; unopened items returnable within 30 days\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eA label alone proves little. Anti-doping researchers in Cologne name contaminated dietary supplements as one route by which SARMs have reached athletes' samples (Alhalabi et al., 2025): a tub can carry a substance it does not declare. Reviews of \"S23\" record what writers felt, not what they took. Full terms are on our \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e pages, and further checks are in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eBesides capsules, S-23 circulates as tablets and as liquids labelled in milligrams per millilitre. The molecule does not change between them; what changes is where the stated amount is fixed and what a certificate can confirm. No published study has compared formats of S-23.\u003c\/p\u003e\u003cp\u003eIn a capsule or tablet the amount per unit is fixed at the factory, so a laboratory can report milligrams per capsule, the figure that tests the 15 mg claim here, although a pooled assay gives only the average and unit-to-unit variation shows only when capsules are tested singly. A liquid's certificate reports concentration on the test date, and the amount in any portion then depends on how accurately a volume is drawn, whether the compound stays dissolved in the cold, and solvent lost from a bottle opened many times.\u003c\/p\u003e\u003cp\u003eAs a small synthetic molecule rather than a peptide, S-23 is not open in the same way to the objection that digestive enzymes break swallowed peptides apart (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e). The oral excretion studies described under detection below gave it by mouth, one as a tablet, and we know of no published study of it by injection. A dry powder in a shell is also kept from the water and solvents in which breakdown usually runs fastest, though that is general chemistry, not a measured result for S-23.\u003c\/p\u003e\u003ch2\u003eS-23 compared with RAD-140\u003c\/h2\u003e\u003cp\u003e\"S23 vs RAD140\" is the comparison searched most often for this compound, usually as a question about which is stronger. Chemistry and regulation answer part of it; the rest has never been studied.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFeature\u003c\/th\u003e\n\u003cth\u003eS-23 (this product)\u003c\/th\u003e\n\u003cth\u003eRAD-140\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical family\u003c\/td\u003e\n\u003ctd\u003eAryl-propionamide, like andarine and ostarine\u003c\/td\u003e\n\u003ctd\u003eA different scaffold built around a 1,3,4-oxadiazole ring\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula, molecular weight, CAS\u003c\/td\u003e\n\u003ctd\u003eC18H13ClF4N2O3, 416.8, 1010396-29-8\u003c\/td\u003e\n\u003ctd\u003eC20H16ClN5O2, 393.8, 1182367-47-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurpose of the research\u003c\/td\u003e\n\u003ctd\u003eHormonal male contraception, in rats (2009)\u003c\/td\u003e\n\u003ctd\u003eAnabolic androgen action in preclinical models (Radius Health, 2011); later breast cancer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStudies in people\u003c\/td\u003e\n\u003ctd\u003eNo clinical trial; anti-doping excretion studies only\u003c\/td\u003e\n\u003ctd\u003eOne Phase 1 trial in 22 women with advanced breast cancer; anti-doping excretion studies\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBest-documented effects\u003c\/td\u003e\n\u003ctd\u003eStrong LH and FSH suppression; with an oestrogen, reversible loss of sperm production (rats)\u003c\/td\u003e\n\u003ctd\u003eRaised AST, ALT and bilirubin, the most frequent adverse events in that trial (LoRusso et al., 2022)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLicensed as a medicine\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS1.2, prohibited as a SARM\u003c\/td\u003e\n\u003ctd\u003eS1.2, named among the examples\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eS-23's reputation for strength rests on the 2009 cell work, where it bound the receptor tightly and switched it on fully; Radius Health likewise called RAD-140 potent. Those results come from different laboratories, assays and species, and no study has tested the two side by side, so no ranking is supported. Receptor potency would in any case say nothing about effects or risks in a person.\u003c\/p\u003e\u003cp\u003eThe evidence is unequal: RAD-140 has adverse events and blood levels recorded in supervised patients, while S-23 has rat pharmacology and urine data from anti-doping volunteers. No equivalence between their milligram labels has been established, and both are sold here for laboratory research only. RAD-140 brands, including \u003ca href=\"\/products\/imuscle-testolon-rad-140-60-10mg\"\u003eiMuscle Testolone RAD-140\u003c\/a\u003e, are compared in the \u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (Testolone) collection\u003c\/a\u003e, and its research record is set out in \u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand, so any certificate of analysis (COA) is the manufacturer's, not ours. Where iMuscle has supplied one for the batch we hold, we show it; where none exists, we say so rather than show a generic document. Our Janoshik Analytical batch testing covers Free Muscle-brand compounds only, not iMuscle. At a minimum, a real batch certificate carries the lot number printed on the pack, the test method (HPLC or LC-MS) and a purity figure; a full S-23 certificate lets you check each of these:\u003c\/p\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe right compound.\u003c\/strong\u003e S-23 by name, ideally with CAS 1010396-29-8. A report for S-22, S-4 or an unnamed \"SARM\" does not describe this pot.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity, with the method stated.\u003c\/strong\u003e HPLC matches a peak to an S-23 reference standard; LC-MS adds a mass that should fit C18H13ClF4N2O3 (416.8 g\/mol). With one chlorine atom, S-23 should also give a companion signal two mass units higher, roughly a third the height of the main one.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e The percentage of chromatogram peak area that is S-23. A high figure says the material is clean, not that each capsule holds 15 mg.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e A measured milligram figure to set against the 15 mg label claim; sixty times it is the real pack total.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhich mirror-image form.\u003c\/strong\u003e S-23 is the (2S) form. Its mirror image has the same formula and mass, which ordinary HPLC and LC-MS cannot tell apart; unless a chiral method is named, this has not been checked.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLot number, test date and laboratory.\u003c\/strong\u003e The lot must match your pot; the date shows the result's age; a named laboratory can confirm it issued the report.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003eIf an iMuscle document falls short on any of these, \u003ca href=\"\/pages\/contact\"\u003econtact us\u003c\/a\u003e with your lot number and we will tell you what exists for the stock we hold. See also \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eS-23 falls under section S1.2 (other anabolic agents) of the WADA Prohibited List, which covers SARMs as a class, and is banned in and out of competition. It lay behind five adverse analytical findings reported in 2022 (Alhalabi et al., 2025), and under strict liability an athlete answers for any prohibited substance in their sample, however it got there.\u003c\/p\u003e\u003cp\u003eOral excretion studies give detection times. At the Institute of Legal Medicine in Strasbourg, a single volunteer took one oral amount in the milligram range; unchanged S-23 was found in hydrolysed urine from 2 hours to 28 days afterwards, as was a hydroxylated metabolite (Ameline et al., 2022). At the German Sport University Cologne, volunteers took single and repeated amounts of 1, 10 or 50 micrograms, the scale of a contaminated product. With a method able to detect 1 picogram per millilitre, a single microgram was traced for an average of up to 253 hours, about ten days, and a single 50 micrograms for up to 544 hours, about 23 days; 18 metabolites were identified (Alhalabi et al., 2025).\u003c\/p\u003e\u003cp\u003eThose figures come from one person and from small groups given very small amounts. Detection after repeated or larger milligram quantities has not been studied, so for this product: detectable, window not established. Anyone subject to anti-doping rules should treat any contact with S-23 as a risk of an adverse finding.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eWe know of no published stability study of S-23 in any form, so iMuscle's printed expiry or best-before date is the working limit, and a certificate describes the batch on its test date, not on the day the pot is opened.\u003c\/p\u003e\u003cp\u003eKeep the capsules in their original pot with the lid closed, because its lot number links them to any certificate. Store it cool, dry and dark, in a cupboard rather than a kitchen, bathroom or windowsill; humidity softens shells and makes powder cake. Let a cold pot reach room temperature before opening it so condensation does not form inside. Shells that have darkened, gone soft or fused together suggest the contents have changed since the batch was tested; keep that pot apart and \u003ca href=\"\/pages\/contact\"\u003etell us\u003c\/a\u003e its lot number.\u003c\/p\u003e\u003cp\u003eWear gloves whenever a capsule is opened or powder is spilled, and work away from food and drink. Label anything taken out of the pot with compound, lot and date. Store the pot where children and pets cannot reach it, and treat unwanted material as chemical waste under local rules rather than tipping it into a household bin or drain. Unopened items can be returned within 30 days, so a pot left sealed keeps that option open.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAryl-propionamide\u003c\/strong\u003e: the structural series of S-23, ostarine (S-22) and andarine (S-4), source of the S-numbered codes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull agonist\u003c\/strong\u003e: a compound that activates a receptor as completely as the body's own hormone, as S-23 did in 2009 cell assays; some related SARMs are only partial agonists.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInhibitory constant (Ki)\u003c\/strong\u003e: how tightly a compound binds a receptor in a competition assay; lower means tighter, about 1.7 nanomolar for S-23.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLevator ani\u003c\/strong\u003e: a small androgen-sensitive pelvic muscle weighed in rat studies as a marker of anabolic activity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLH and FSH\u003c\/strong\u003e: luteinising hormone and follicle-stimulating hormone, released by the pituitary gland to drive testosterone and sperm production in the testes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpermatogenesis\u003c\/strong\u003e: sperm production in the testes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReference standard\u003c\/strong\u003e: material of certified identity used as the benchmark for identifying and measuring a sample.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHydrolysed urine\u003c\/strong\u003e: urine treated with an enzyme that strips attached groups such as glucuronic acid, freeing a compound and its metabolites for measurement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdverse analytical finding\u003c\/strong\u003e: a laboratory's formal report that a prohibited substance or its metabolite is present in an athlete's sample.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: the anti-doping rule that athletes answer for whatever is found in their sample, whatever its source.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/s-23\"\u003eAll brands of S-23\u003c\/a\u003e, compared on strength, pack size and batch testing\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e stocked at Free Muscle\u003c\/li\u003e\n\u003cli\u003eRelated SARMs: \u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (Testolone)\u003c\/a\u003e, \u003ca href=\"\/collections\/andarine\"\u003eAndarine (S-4)\u003c\/a\u003e, \u003ca href=\"\/collections\/ostarine\"\u003eOstarine (MK-2866)\u003c\/a\u003e and \u003ca href=\"\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It is not a medicine, has not been evaluated by the MHRA, EMA or FDA, and is not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eJones A, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):385-95. PMID: 18772237.\u003c\/li\u003e\n\u003cli\u003eAmeline A, et al. In vitro characterization of S-23 metabolites produced by human liver microsomes, and subsequent application to urine after a controlled oral administration. J Pharm Biomed Anal. 2022;212:114660. PMID: 35182830.\u003c\/li\u003e\n\u003cli\u003eAlhalabi H, et al. Investigations Into the Urinary Metabolite Elimination Profile of the Selective Androgen Receptor Modulator S-23 in Studies Mimicking Contaminated Product Ingestion for Doping Control Purposes. Biomed Chromatogr. 2025;39(6):e70090. PMID: 40277337.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468980138210,"sku":null,"price":58.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/S-23_800x_0f998b39-6402-4c4a-9f31-a7dfe2de1826.jpg?v=1789931414"},{"product_id":"imuscle-stenabolic-sr-9009-60-10mg","title":"iMuscle Stenabolic SR-9009 — 60 caps, 10mg","description":"\u003cp\u003e\u003cstrong\u003eiMuscle Stenabolic SR-9009, 60 caps, 10mg\u003c\/strong\u003e is an iMuscle listing of SR9009, labelled at 10 mg per capsule, 60 capsules per pack. It is supplied through the \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range for laboratory research only, is not for human consumption, and is sold to adults aged 18 and over. Below: what the published research on SR9009 reports, what the label documents, where the compound stands in UK law and in sport, how to read a batch certificate for it, and how batch certificates are handled for iMuscle products.\u003c\/p\u003e\n\u003ch2\u003eAbout SR9009\u003c\/h2\u003e\n\u003cp\u003eSR9009, sold under the name Stenabolic, is a synthetic agonist of REV-ERB alpha and REV-ERB beta, nuclear receptors that connect the circadian clock to the expression of metabolic genes. It was developed at the Scripps Research Institute by Burris and colleagues. It is not a SARM and has no described activity at the androgen receptor.\u003c\/p\u003e\n\u003cp\u003ePubChem records it as CID 57394020, CAS number 1379686-30-2, molecular formula C20H24ClN3O4S and molecular weight 437.9, with InChIKey MMJJNHOIVCGAAP-UHFFFAOYSA-N. Its systematic name is ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate. These identifiers are what any certificate of analysis should be checked against.\u003c\/p\u003e\n\u003ch2\u003eWhat the published research reports\u003c\/h2\u003e\n\u003cp\u003eIn a 2012 study published in Nature, mice given SR9009 by injection showed altered circadian behaviour, and the circadian pattern of metabolic gene expression in liver, muscle and fat changed, with increased energy expenditure. Diet-induced obese mice treated with the agonist lost fat mass and showed improved dyslipidaemia and hyperglycaemia (Solt et al., 2012). A 2013 mouse study led from the Institut Pasteur de Lille, with the Scripps group as co-authors, linked REV-ERB alpha to mitochondrial number in skeletal muscle and reported that pharmacological activation of the receptor increased exercise capacity in mice (Woldt et al., 2013). In 2019 a group at the University of Pennsylvania reported that SR9009 changed cell proliferation and metabolism in cells lacking REV-ERB altogether, showing that some of its effects are off-target (Dierickx et al., 2019).\u003c\/p\u003e\n\u003cp\u003eThe animal studies used injection, and there are no published human trials or human pharmacokinetic data, so the behaviour of an oral capsule is unknown. It has never been approved as a medicine. Two further papers matter for anyone assessing SR9009 bought online. A Ghent University doping control laboratory confirmed SR9009 in a black market product bought over the internet and described eight metabolites formed by human liver enzymes in the test tube (Geldof et al., 2016). A 2017 analysis of 44 products sold online as SARMs found that 17 contained another unapproved drug, SR9009 among them, and that in only 18 of the 44 (41%) did the amount of active compound match the label (Van Wagoner et al., 2017). Nothing above is a claim about this product.\u003c\/p\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eManufacturer: iMuscle\u003c\/li\u003e\n\u003cli\u003eCompound: SR9009 (Stenabolic)\u003c\/li\u003e\n\u003cli\u003eForm: Capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStrength: 10 mg per capsule, as stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eTotal in pack: 600 mg (10 mg x 60 capsules)\u003c\/li\u003e\n\u003cli\u003eBatch certificate of analysis: shown where iMuscle supplies one for the batch we hold\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe 600 mg total is a label figure, calculated from the manufacturer's stated strength and capsule count. It becomes a measured figure only when a batch certificate reports content per capsule. Our guide to \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e shows how to compare it with other SR9009 listings.\u003c\/p\u003e\n\u003ch2\u003eSR9009 in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eThe searches \"SR9009 UK\", \"stenabolic UK\" and \"SR9009 UK sarms\" hide two questions: may it lawfully be sold here, and how do you tell a sound listing from a poor one. SR9009 is not a licensed medicine in the UK, has not been assessed by the MHRA, and is not an authorised food supplement. It is not a controlled drug. It is sold for laboratory research to adults aged 18 and over and is not for human consumption. Any seller offering instructions for taking it is marketing it outside that research basis.\u003c\/p\u003e\n\u003cp\u003eIn sport the position is stricter. SR9009 is named on the WADA Prohibited List under section S4 (hormone and metabolic modulators) alongside GW1516 and is prohibited at all times. Anyone subject to anti-doping rules should consult the current list. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eresearch guide\u003c\/a\u003e covers the wider legal picture for compounds sold next to SARMs.\u003c\/p\u003e\n\u003cp\u003eThe 2017 finding that SR9009 turned up in products labelled as something else is the best reason to judge an SR9009 listing on documents rather than on ratings or forum posts. The points worth checking, and how this listing answers each:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eNamed manufacturer and compound identifiers.\u003c\/strong\u003e This listing: iMuscle, with CAS 1379686-30-2 and the molecular formula given above, so a certificate can be matched to SR9009 and not to its sister compound SR9011.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrength and count on the label.\u003c\/strong\u003e iMuscle states 10 mg in each of 60 capsules.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate tied to the stock on sale.\u003c\/strong\u003e This listing: shown only where iMuscle supplies one for the batch we hold, and we say plainly when there is none.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWho is selling, and to whom.\u003c\/strong\u003e Here the seller is FreeMuscle LTD, registered in the UK and based in Scunthorpe; buyers must be 18 or over, and unopened items may be returned within 30 days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHow it travels.\u003c\/strong\u003e Every UK order goes out free with tracking, in plain packaging. Anything ordered by 2pm on a weekday is processed that day, and parcels to the EU take 3-7 working days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNo usage guidance.\u003c\/strong\u003e This listing gives none, and neither does anything else on this site.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eDelivery and returns terms are set out on our \u003ca href=\"\/pages\/shipping\"\u003eshipping\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e pages. The \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e applies the same tests to any shop, including this one.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eSR9009 is offered in three formats across the market: filled capsules like these, liquids in which the compound is dissolved or suspended, and loose powder. None of them has been studied for SR9009 in people. The published mouse studies used injected solutions prepared in the laboratory, so no commercial format, capsule or liquid, reproduces the conditions of that research. What differs is how each fixes the amount per unit.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCapsule fill.\u003c\/strong\u003e The stated 10 mg is blended with an inert filler and dosed into each shell by weight. Variation comes from blend uniformity and fill weight, and a laboratory can open and assay individual capsules to check both.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiquid.\u003c\/strong\u003e The label states a concentration, often in a carrier that is not identified. The figure holds only while the compound stays evenly dissolved or suspended, and any volume drawn off depends on how accurately it is measured.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePowder.\u003c\/strong\u003e Accuracy moves entirely to the researcher's balance and technique, and a certificate describes the bulk material only.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe search \"SR9009 peptide\" reflects a common confusion. SR9009 is not a peptide: it has no amino acid chain for digestive enzymes to cut, which is the main obstacle for peptides given by mouth (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003eDo oral peptides work?\u003c\/a\u003e). That does not mean oral SR9009 is well absorbed. With no human pharmacokinetic study published, the fraction of an oral amount reaching the circulation in people is simply unknown, and we do not suggest otherwise. For this pack, the useful property of the capsule format is that it gives a countable unit that a laboratory can test.\u003c\/p\u003e\n\u003ch2\u003eSR9009 compared with Cardarine\u003c\/h2\u003e\n\u003cp\u003e\"Stenabolic vs cardarine\" is a frequent search, because the two are sold next to each other and both appear in section S4 of the WADA list. The overlap largely ends there. The table sets out where they differ.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eQuestion\u003c\/th\u003e\n\u003cth\u003eSR9009 (Stenabolic)\u003c\/th\u003e\n\u003cth\u003eCardarine (GW-501516)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eReceptor it was designed for\u003c\/td\u003e\n\u003ctd\u003eREV-ERB alpha and beta, circadian clock receptors\u003c\/td\u003e\n\u003ctd\u003ePPAR-delta, a fatty acid metabolism receptor\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWho made it and why\u003c\/td\u003e\n\u003ctd\u003eAn academic research tool for probing the clock\u003c\/td\u003e\n\u003ctd\u003eA pharmaceutical candidate for blood lipid disorders\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHighest level of evidence\u003c\/td\u003e\n\u003ctd\u003eMouse and cell studies only\u003c\/td\u003e\n\u003ctd\u003eShort human lipid trials\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eKnown specificity problem\u003c\/td\u003e\n\u003ctd\u003eEffects in cells with no REV-ERB (2019)\u003c\/td\u003e\n\u003ctd\u003eDevelopment halted over rodent tumour findings\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOral data in people\u003c\/td\u003e\n\u003ctd\u003eNone published\u003c\/td\u003e\n\u003ctd\u003eGiven by mouth in human trials\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK position\u003c\/td\u003e\n\u003ctd\u003eUnlicensed, research use only, 18+\u003c\/td\u003e\n\u003ctd\u003eUnlicensed, research use only, 18+\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSport\u003c\/td\u003e\n\u003ctd\u003eWADA S4, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eWADA S4, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003ePut in plain terms, Cardarine is a failed drug candidate with some human data and a serious toxicology history, while SR9009 is a laboratory probe that was never taken into people at all. Neither is a SARM. The 2019 off-target finding also means that effects attributed to REV-ERB in SR9009 studies may partly come from other targets. We make no claim about either compound used together with any other. The \u003ca href=\"\/collections\/cardarine\"\u003eCardarine collection\u003c\/a\u003e lists the brands we hold, and our article on \u003ca href=\"\/blogs\/news\/cardarine-gw-501516-what-happened-in-development\"\u003ewhy Cardarine development stopped\u003c\/a\u003e gives its history. People also search \"SR9009 vs SR9011\": SR9011 is the sister compound described in the same 2012 paper, with a similar target and no human data either. We do not stock it.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eCertificates work differently for our own label and for iMuscle. Every Free Muscle-brand batch goes to Janoshik Analytical, an independent laboratory, and the certificate is emailed on request. iMuscle is an outside manufacturer stocked through Muscle Market, so for this product a certificate of analysis appears only when iMuscle provides one for the particular batch on our shelves. We do not pass off a generic PDF without a batch number as a batch certificate. Send us the product name by email and we will forward whatever we hold for the current batch, or tell you directly that nothing is held.\u003c\/p\u003e\n\u003cp\u003eIf an iMuscle certificate is available for this batch, read it in this order:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity\u003c\/strong\u003e: the compound named should be SR9009, not SR9011 or a generic \"Stenabolic\" with no structure. HPLC identifies it by comparing retention time with a reference standard; LC-MS adds a mass, which should fit the 437.9 molecular weight given above.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity\u003c\/strong\u003e: a percentage from HPLC peak areas. It tells you how much of the detected material is SR9009, not how many milligrams a capsule holds.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule\u003c\/strong\u003e: the measured amount in one capsule, which is the figure to set against the stated 10 mg.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number\u003c\/strong\u003e: must match the code on the pack you received.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLaboratory and test date\u003c\/strong\u003e: name the analyst and show whether the result is recent enough to cover this stock.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor this brand, gaps mean specific things. No certificate means this listing makes no documented claim about identity, purity or content beyond the manufacturer's label. Purity with no content figure confirms the molecule but leaves the 10 mg unverified. A batch number that does not match your pack means the certificate describes different stock, and you should \u003ca href=\"\/pages\/contact\"\u003econtact us\u003c\/a\u003e. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e and the article on \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e cover the methods in more depth.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eFor athletes, the regulatory point is simple: SR9009 is in section S4 of the WADA Prohibited List and is banned in and out of competition, and under strict liability a positive sample counts regardless of how the substance got there, including through a mislabelled product. The 2016 Ghent study identified eight human liver metabolites of SR9009 so that screens could look for breakdown products as well as the parent compound, and it recommended adding SR9009 to routine screening. When the authors searched 1,511 stored doping control urine results, they found neither SR9009 nor its metabolites in those routine samples.\u003c\/p\u003e\n\u003cp\u003eNo verified study has measured how long SR9009 or its metabolites remain detectable in human urine after exposure. The honest answer for this capsule product is therefore: detectable, window not established. Anyone subject to anti-doping rules should treat it as prohibited.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eNo stability study of SR9009 in capsule form has been published, so the manufacturer's expiry date, where iMuscle prints one, is the only product-specific guide. General laboratory practice for small organic compounds applies: protect from heat, moisture and light.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLeave the capsules in the tub they arrived in: the batch code printed on it is the only link to a certificate.\u003c\/li\u003e\n\u003cli\u003eStore somewhere cool, dry and dark, away from radiators, windowsills and steamy rooms; capsule shells soften in humid air and turn brittle in very dry air.\u003c\/li\u003e\n\u003cli\u003eLog the batch number, date received and date opened.\u003c\/li\u003e\n\u003cli\u003eWear nitrile gloves when handling opened capsules or spilled powder, and clean surfaces afterwards.\u003c\/li\u003e\n\u003cli\u003eSurplus or out-of-date capsules belong in a chemical waste stream, never in household bins or down a drain.\u003c\/li\u003e\n\u003cli\u003eStore on a shelf that children and pets cannot reach, and never in a fridge or cupboard used for food.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eREV-ERB alpha and beta\u003c\/strong\u003e: nuclear receptors that repress clock and metabolic genes on a daily cycle; SR9009 was designed to activate them.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCircadian clock\u003c\/strong\u003e: the internal roughly 24-hour cycle of gene activity found in most cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAgonist\u003c\/strong\u003e: a molecule that binds a receptor and switches it on.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOff-target effect\u003c\/strong\u003e: an action of a compound that does not go through its intended receptor, as shown for SR9009 in 2019.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSR9011\u003c\/strong\u003e: a closely related REV-ERB agonist described alongside SR9009 in 2012; not stocked here.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePharmacokinetics\u003c\/strong\u003e: the study of what the body does to a substance over time, from uptake to elimination; no human data exist for SR9009.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiver microsomes\u003c\/strong\u003e: fractions of liver cells holding drug-metabolising enzymes, used in the test tube to predict metabolites.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolite\u003c\/strong\u003e: a product the body forms by altering a substance, often the target of anti-doping tests.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReference standard\u003c\/strong\u003e: a highly characterised sample of a compound that a laboratory uses to confirm identity and quantity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRetention time\u003c\/strong\u003e: the point at which a compound emerges from an HPLC column; a sample and a standard of the same substance should emerge together.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: under anti-doping rules, a finding in a sample stands against the athlete whether or not they knew the substance was there.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/sr9009\"\u003eAll brands of SR9009 we stock, compared\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/sr9009-stenabolic-research-guide\"\u003eSR9009 (Stenabolic): REV-ERB agonist research and the bioavailability problem\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/cardarine\"\u003eCardarine\u003c\/a\u003e and the wider \u003ca href=\"\/collections\/sarms\"\u003eSARMs range\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/pages\/lab-tests\"\u003eBatch testing and certificates of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It has not been evaluated by the MHRA, EMA or FDA. It is not a medicine, not a food supplement and not for human consumption. Sold only to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice, and descriptions of published studies are not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSolt LA, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012;485(7396):62-8. PMID: 22460951.\u003c\/li\u003e\n\u003cli\u003eWoldt E, et al. Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med. 2013;19(8):1039-46. PMID: 23852339.\u003c\/li\u003e\n\u003cli\u003eDierickx P, et al. SR9009 has REV-ERB-independent effects on cell proliferation and metabolism. Proc Natl Acad Sci U S A. 2019;116(25):12147-12152. PMID: 31127047.\u003c\/li\u003e\n\u003cli\u003eGeldof L, et al. In Vitro Metabolic Studies of REV-ERB Agonists SR9009 and SR9011. Int J Mol Sci. 2016;17(10):1676. PMID: 27706103.\u003c\/li\u003e\n\u003cli\u003eVan Wagoner RM, et al. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017;318(20):2004-2010. PMID: 29183075.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468980170978,"sku":null,"price":63.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/STENABOLIC_3333x_3eb916f3-0538-401c-8e12-157d57e3440a.jpg?v=1789931416"},{"product_id":"imuscle-testolon-rad-140-60-10mg","title":"iMuscle Testolone RAD-140 — 60 caps, 10mg","description":"\u003cp\u003eiMuscle Testolone RAD-140 comes as 60 capsules stated at 10 mg each, giving 600 mg of RAD-140 per pack. RAD-140, or testolone, is a non-steroidal selective androgen receptor modulator with a single published clinical trial. iMuscle manufactures the product; Free Muscle stocks it in the Muscle Market range and ships it from the UK to adults for laboratory research only.\u003c\/p\u003e\u003ch2\u003eAbout RAD-140\u003c\/h2\u003e\u003cp\u003eRAD-140 is a synthetic, non-steroidal selective androgen receptor modulator, commonly called testolone. Like other SARMs it binds the androgen receptor, but it has no steroid ring system and its structure is unrelated to testosterone. Radius Health described its discovery in 2011 as a potent, orally bioavailable SARM and reported its characterisation in several preclinical animal models of anabolic androgen action (Miller et al., 2011).\u003c\/p\u003e\u003cp\u003eRAD-140 later entered a Phase 1 oncology trial in women with ER-positive, HER2-negative advanced breast cancer, published in 2022 (LoRusso et al., 2022). Twenty-two heavily pretreated patients took part. The adverse events recorded most often were raised AST (59%), ALT (45%) and bilirubin (27%), and grade 3 or 4 events occurred in 16 of the 22. Outside clinical research, published case reports link RAD-140 to cholestatic liver injury, including a biopsy-supported case in a 24-year-old man that resolved after exposure stopped (Leung et al., 2022).\u003c\/p\u003e\u003cp\u003eThe only other structured human data come from anti-doping research: a 2022 Cologne study gave adult male volunteers microgram amounts to chart how RAD-140 is excreted, covered under detection below (Wagener et al., 2022). No published trial has measured muscle, strength or body composition in healthy adults. The research described here relates to the molecule in laboratory and clinical settings and is not a claim about this listing.\u003c\/p\u003e\u003ch3\u003eChemical identity\u003c\/h3\u003e\u003cp\u003eIdentifiers from PubChem, against which a laboratory result can be checked:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystematic name\u003c\/strong\u003e: 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number\u003c\/strong\u003e: 1182367-47-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula and molecular weight\u003c\/strong\u003e: C20H16ClN5O2, 393.8 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInChIKey\u003c\/strong\u003e: XMBUPPIEVAFYHO-KPZWWZAWSA-N\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID\u003c\/strong\u003e: 44200882\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOther names\u003c\/strong\u003e: testolone, vosilasarm, EP0062\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eCompound: RAD-140 (Testolone)\u003c\/li\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStated strength: 10 mg per capsule (manufacturer's label claim)\u003c\/li\u003e\n\u003cli\u003eStated total per pack: 600 mg\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eThe strength is the manufacturer's label claim; only a batch certificate confirms it. To compare brands of RAD-140, use total milligrams per pack, as explained in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e. Of the RAD-140 listings we stock, only this one and the Free Muscle-brand pack state a per-capsule strength; the Yakka Strength and Thoroughbred Labs listings do not.\u003c\/p\u003e\u003ch2\u003eRAD-140 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eUK searches such as \"RAD140 for sale UK\" and \"testolone RAD 140 UK\" raise two practical questions: what the law allows, and what evidence a listing should offer.\u003c\/p\u003e\u003ch3\u003eLegal status\u003c\/h3\u003e\u003cp\u003eNo UK medicines licence exists for RAD-140: the MHRA has never granted it a marketing authorisation, and no regulator elsewhere has licensed it either. Nor is it an authorised food supplement, so selling it for human consumption would be unlawful. It is not a controlled drug. Free Muscle supplies it only as a research compound, to adults aged 18 or over, for laboratory use. WADA prohibits it at all times under section S1 (anabolic agents) of its Prohibited List. Buyers are responsible for the rules that apply to them, including any anti-doping code. Background on the class is in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eWhy a label proves little on its own\u003c\/h3\u003e\u003cp\u003eThe case for checking is empirical. A US anti-doping laboratory, working with the US Anti-Doping Agency, bought 44 products sold online as SARMs and analysed them: in 26 the amount of active compound differed substantially from the label, and 17 contained a different unapproved drug altogether, among them ibutamoren, GW501516 and SR9009 (Van Wagoner et al., 2017). It concerned US websites in 2016, not this product.\u003c\/p\u003e\u003ch3\u003eQuestions to ask of any listing, answered for this one\u003c\/h3\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eQuestion\u003c\/th\u003e\n\u003cth\u003eThis iMuscle listing\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eIs a strength printed, with a capsule count?\u003c\/td\u003e\n\u003ctd\u003eYes: 10 mg per capsule, 60 capsules, 600 mg per pack (manufacturer's claim)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWho makes it?\u003c\/td\u003e\n\u003ctd\u003eiMuscle\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWho sells it, and from where?\u003c\/td\u003e\n\u003ctd\u003eFreeMuscle LTD, a UK company based in Scunthorpe\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIs there a certificate for the batch sold?\u003c\/td\u003e\n\u003ctd\u003eShown only where iMuscle supplies one for the batch we hold\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAre the terms research-only?\u003c\/td\u003e\n\u003ctd\u003eYes: laboratory research, adults 18+, no directions for use and no promised outcomes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHow does it travel?\u003c\/td\u003e\n\u003ctd\u003eFree tracked delivery on every UK order, in plain packaging; same-day processing for orders before 2pm Monday to Friday; 3-7 working days to the EU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCan it be returned?\u003c\/td\u003e\n\u003ctd\u003eUnopened items, within 30 days\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eOnly the certificate depends on the manufacturer. Personal accounts under \"RAD 140 UK reddit\" or \"best RAD 140 UK\" describe experiences, not the contents of a pack; only a batch certificate measures those. More checks are in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand, so any certificate of analysis (COA) for this product is the manufacturer's, not ours. A COA is shown only where iMuscle supplies one for the batch we hold; a generic document is not a substitute for a batch certificate. Free Muscle-brand compounds are assayed batch by batch at Janoshik Analytical; that programme does not cover iMuscle. A genuine batch certificate names its method, HPLC or LC-MS; check an iMuscle certificate in this order:\u003c\/p\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompound named.\u003c\/strong\u003e It should say RAD-140, or a synonym such as testolone or vosilasarm. A certificate for RAD-150, or for an unnamed \"SARM\", is not a certificate for this product.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity result.\u003c\/strong\u003e A chromatogram alone shows that something eluted where a RAD-140 reference standard does; a mass spectrum shows a molecule of the right mass, for protonated RAD-140 an ion at m\/z 394.1065 (Wagener et al., 2022).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e A share of chromatogram peak area. It describes how clean the material is; a capsule could meet a high purity figure and still hold far more or far less than 10 mg.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The measured figure to set against the 10 mg claim; sixty times it is the real pack total. One assay gives the average of the capsules tested, not the spread between them.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLot number, test date and laboratory.\u003c\/strong\u003e The lot must match your pack; the date shows how old the result is.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003ePurity without a content figure leaves the 10 mg claim, and with it the 600 mg total, unconfirmed. A result with no stated method cannot be weighed. A lot number that is missing, or differs from the one on your pot, means the certificate concerns another production run. In any of those cases, \u003ca href=\"\/pages\/contact\"\u003eask us\u003c\/a\u003e before relying on the batch. See also \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eTestolone tablets and RAD-140 \"research liquids\" are also on the market, and searches such as \"RAD 140 tablets\" and \"RAD 140 liquid UK\" reflect that. Whatever the format, the molecule is RAD-140; what varies is how reliably the printed amount reaches each unit, and no one has published a comparison for this compound.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003cth\u003eWhat the label figure relies on\u003c\/th\u003e\n\u003cth\u003eWhat its certificate should state\u003c\/th\u003e\n\u003cth\u003eStorage sensitivity\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCapsule (this product)\u003c\/td\u003e\n\u003ctd\u003eUniform mixing of the powder and a consistent fill in every shell\u003c\/td\u003e\n\u003ctd\u003eMilligrams per capsule, to set against 10 mg\u003c\/td\u003e\n\u003ctd\u003eMoisture: shells soften and the powder clumps\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTablet\u003c\/td\u003e\n\u003ctd\u003eUniform mixing, then pressing with binders and sometimes a coating\u003c\/td\u003e\n\u003ctd\u003eMilligrams per tablet\u003c\/td\u003e\n\u003ctd\u003eMoisture and breakage\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLiquid\u003c\/td\u003e\n\u003ctd\u003eComplete dissolution, a solution that stays stable, and accurate measuring of every volume drawn\u003c\/td\u003e\n\u003ctd\u003eMilligrams per millilitre, on the test date\u003c\/td\u003e\n\u003ctd\u003eChemical change in solution; evaporation concentrates what remains\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eBecause RAD-140 is a small molecule rather than a peptide, the question that dominates debate over swallowed peptides, whether digestive enzymes break them down, does not arise in the same way (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e). Both human studies gave it by mouth; we know of no published study of RAD-140 by injection.\u003c\/p\u003e\u003ch2\u003eRAD-140 compared with RAD-150 (TLB-150)\u003c\/h2\u003e\u003cp\u003e\"RAD 140 vs RAD 150\", also searched as \"TLB 150 vs RAD 140\", is the comparison most often made for this compound.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFeature\u003c\/th\u003e\n\u003cth\u003eRAD-140 (this product)\u003c\/th\u003e\n\u003cth\u003eRAD-150 (TLB-150)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eRelationship\u003c\/td\u003e\n\u003ctd\u003eParent molecule\u003c\/td\u003e\n\u003ctd\u003eBenzoate ester of RAD-140, recorded in PubChem as \"TLB 150 Benzoate\" (CID 68547459)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and molecular weight\u003c\/td\u003e\n\u003ctd\u003eC20H16ClN5O2, 393.8\u003c\/td\u003e\n\u003ctd\u003eC27H20ClN5O3, 497.9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWhere it appears in print\u003c\/td\u003e\n\u003ctd\u003ePeer-reviewed journals since 2011\u003c\/td\u003e\n\u003ctd\u003eA patent, US 8,629,167 (compound 87); no journal papers\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIC50 for androgen receptor binding, patent assay\u003c\/td\u003e\n\u003ctd\u003e2 nM\u003c\/td\u003e\n\u003ctd\u003e130 nM\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStudies in people\u003c\/td\u003e\n\u003ctd\u003eOne cancer trial and one anti-doping excretion study\u003c\/td\u003e\n\u003ctd\u003eNo published study\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA Prohibited List\u003c\/td\u003e\n\u003ctd\u003eListed by name in S1.2\u003c\/td\u003e\n\u003ctd\u003eAbsent from the examples; covered by the section's open wording\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThe binding figures come from the patent, as deposited in PubChem, not from a journal, and describe the intact molecules in a commercial binding kit. On them the ester bound the receptor about 65 times more weakly than RAD-140. A living system may split an ester back to its parent, so this does not settle what RAD-150 does there, but it argues against the ester being a stronger ligand in its own right. Claims that it lasts longer or acts more strongly are unmeasured, and whether, and how fast, it becomes RAD-140 in the body is unknown.\u003c\/p\u003e\u003cp\u003eThe heavier formula matters for labels too: roughly a fifth of the ester's mass comes from the added benzoate portion, so a milligram figure for RAD-150 and the 600 mg on this pack do not describe the same quantity of the RAD-140 structure. Legally the two are alike: neither is a licensed medicine or an authorised food, and both are sold here for laboratory research only. WADA names RAD140 in S1.2; RAD-150 is absent, but the section introduces its examples with \"including, but not limited to\", so absence is no exemption. Brands held are in the \u003ca href=\"\/collections\/rad-150\"\u003eRAD-150 (TLB-150) collection\u003c\/a\u003e; the chemistry is set out in \u003ca href=\"\/blogs\/news\/rad-140-vs-rad-150-tlb-150\"\u003eRAD-140 vs RAD-150 (TLB-150)\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eRAD-140 is named, as RAD140, under S1.2 (other anabolic agents) of the WADA Prohibited List, banned at all times. Under strict liability an adverse analytical finding stands against the athlete whatever its source, be it a research compound, a mislabelled product or a contaminated supplement.\u003c\/p\u003e\u003cp\u003eIts persistence in urine has been measured, though only after very small amounts. At the German Sport University Cologne, six excretion studies, each with five adult male volunteers, used single or five daily amounts of 1, 10 or 50 micrograms, and their urine was analysed by LC-HRMS\/MS (Wagener et al., 2022). Unchanged RAD-140 outlasted all six metabolites tracked in every group. After one 50 microgram amount it was found up to 696 hours later, about 29 days; after five daily amounts of 50 micrograms, up to 912 hours, about 38 days, after the last. Part of the aim was to help laboratories judge whether a finding reflects deliberate use or contamination.\u003c\/p\u003e\u003cp\u003eEvery figure above comes from microgram exposures. How long RAD-140 remains detectable after milligram quantities, such as the 10 mg stated per capsule here, has not been reported that we know of, so for this product: detectable, window not established. The Cologne results set no upper limit, and anyone subject to testing should regard any contact with RAD-140 as a positive-test risk.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eShelf life for RAD-140 capsules has not been established in any published study we know of. Work to iMuscle's printed expiry or best-before date, where there is one, and to the age of any certificate.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep the original pot.\u003c\/strong\u003e A certificate refers to the lot number printed on it, so capsules moved to another container can no longer be matched to one. Close the lid straight after each opening.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCool, dry and dark.\u003c\/strong\u003e A cupboard away from radiators, kettles and bathrooms. Humidity is the chief threat: shells absorb water and turn soft and sticky, and moisture that reaches the powder can hasten chemical breakdown.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNo temperature swings.\u003c\/strong\u003e A cold pot brought into a warm room gathers condensation; let it reach room temperature before opening.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecords.\u003c\/strong\u003e Note when the seal was first broken, and label anything removed from the pot with compound, lot and date.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHandling.\u003c\/strong\u003e Gloves for opened capsules or spilled powder, no eating or drinking nearby, storage beyond the reach of children and animals, and disposal through chemical waste routes rather than household bins or drains.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: selective androgen receptor modulator, a label for non-steroidal molecules developed to switch on the androgen receptor in some tissues, chiefly muscle and bone, while sparing others.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReference standard\u003c\/strong\u003e: material of known identity and purity, run alongside a sample for comparison.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC\u003c\/strong\u003e: high-performance liquid chromatography; the sample is pushed through a packed column and each component shows as a peak on the chromatogram, whose areas give the purity figure.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLC-MS\u003c\/strong\u003e: the same separation followed by a mass spectrometer, which identifies each component by its mass.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtonated molecule\u003c\/strong\u003e: a molecule carrying one extra hydrogen ion, the form in which LC-MS registers RAD-140, at m\/z 394.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay\u003c\/strong\u003e: the test of how much RAD-140 a capsule holds, as opposed to how clean it is.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEster\u003c\/strong\u003e: an acid joined to an alcohol group by a bond that water can break; RAD-150 is RAD-140 joined in this way to benzoic acid.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdverse analytical finding\u003c\/strong\u003e: the formal term for a laboratory report of a prohibited substance in an athlete's sample.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: the rule that athletes answer for any prohibited substance in their sample, however it got there.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMarketing authorisation\u003c\/strong\u003e: a regulator's permission, in the UK from the MHRA, to sell a product as a medicine; RAD-140 has none.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/rad-140\"\u003eAll brands of RAD-140 (Testolone)\u003c\/a\u003e, compared on strength, pack size and batch testing\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e stocked at Free Muscle\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/free-muscle-rad-140-testolone-10mg\"\u003eFree Muscle RAD-140 Testolone 10mg\u003c\/a\u003e, the own-brand pack, Janoshik-assayed batch by batch\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e, from animal studies to case reports\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It is not a medicine, has not been evaluated by the MHRA, EMA or FDA, and is not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eMiller CP, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-9. PMID: 24900290.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003cli\u003eVan Wagoner RM, et al. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017;318(20):2004-2010. PMID: 29183075.\u003c\/li\u003e\n\u003cli\u003eWagener F, et al. Human In Vivo Metabolism and Elimination Behavior of Micro-Dosed Selective Androgen Receptor Modulator RAD140 for Doping Control Purposes. Metabolites. 2022;12(7):666. PMID: 35888790.\u003c\/li\u003e\n\u003cli\u003eLeung K, et al. RAD-140 Drug-Induced Liver Injury. Ochsner J. 2022;22(4):361-365. PMID: 36561105.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468980203746,"sku":null,"price":49.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/TESTOLON.jpg?v=1789931418"},{"product_id":"imuscle-testolon-yk11-ibutamoren","title":"iMuscle Testolone + YK-11 + Ibutamoren stack","description":"\u003cp\u003e\u003cstrong\u003eiMuscle Testolone + YK-11 + Ibutamoren stack\u003c\/strong\u003e is a 60-capsule combined listing from iMuscle, labelled as containing three research compounds: YK-11, Testolone (RAD-140) and Ibutamoren (MK-677). The manufacturer does not state the amount of each compound per capsule on the label. It is supplied through the \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range for laboratory research only, is not for human consumption, and is sold to adults aged 18 and over. Each compound is covered in turn below.\u003c\/p\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eManufacturer: iMuscle\u003c\/li\u003e\n\u003cli\u003eCompounds named on the label: YK-11, Testolone (RAD-140) and Ibutamoren (MK-677)\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStrength: not stated by the manufacturer for any of the three compounds, so no per-capsule or per-pack figure is given\u003c\/li\u003e\n\u003cli\u003eBatch certificate of analysis: shown where iMuscle supplies one for the batch we hold\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over, for laboratory research only\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eiMuscle also sells each compound on its own with a stated strength: \u003ca href=\"\/products\/imuscle-yk-11-60-10mg\"\u003eiMuscle YK-11\u003c\/a\u003e, \u003ca href=\"\/products\/imuscle-testolon-rad-140-60-10mg\"\u003eiMuscle Testolone RAD-140\u003c\/a\u003e and \u003ca href=\"\/products\/imuscle-ibutamoren-mk-677-60-10mg\"\u003eiMuscle Ibutamoren MK-677\u003c\/a\u003e are each labelled 10 mg per capsule, 60 capsules.\u003c\/p\u003e\n\u003ch2\u003eThe three compounds in this pack\u003c\/h2\u003e\n\u003ch3\u003eYK-11\u003c\/h3\u003e\n\u003cp\u003eYK-11 is a synthetic steroidal compound, a 19-nortestosterone derivative carrying a methoxyethylidene group, that is marketed as a SARM. It was first described by Kanno and colleagues at Toho University in Japan (PubChem CID 119058028, CAS 1370003-76-1, C25H34O6).\u003c\/p\u003e\n\u003cp\u003eIn a 2011 cell-culture study using a reporter-gene assay, YK-11 acted as a partial agonist of the androgen receptor and activated it without the receptor's N\/C-terminal interaction that dihydrotestosterone induces (Kanno 2011). A 2013 study in mouse C2C12 myoblast cells reported that YK-11 increased follistatin expression and promoted myogenic differentiation through the androgen receptor, the origin of the myostatin-inhibitor description (Kanno 2013). Those are the founding primary studies; there are no human trials or toxicology data, and later work has been limited to a few rodent studies and doping-control metabolism research. It has never been approved as a medicine.\u003c\/p\u003e\n\u003ch3\u003eRAD-140 (Testolone)\u003c\/h3\u003e\n\u003cp\u003eRAD-140, also listed as testolone and vosilasarm, is a non-steroidal selective androgen receptor modulator designed by Radius Health (PubChem CID 44200882, CAS 1182367-47-0, C20H16ClN5O2). Its human data come from a single clinical trial. A first-in-human phase 1 study enrolled 22 postmenopausal women with oestrogen receptor-positive, HER2-negative metastatic breast cancer and gave RAD-140 by mouth (LoRusso 2022). The most frequent adverse events were raised AST in 59.1 per cent of participants, raised ALT in 45.5 per cent and raised bilirubin in 27.3 per cent, and 16 of the 22 had a grade 3 or 4 adverse event. The measured half-life was 44.7 hours. The trial assessed tolerability and tumour response, not muscle or strength, and RAD-140 has not been approved as a medicine anywhere.\u003c\/p\u003e\n\u003ch3\u003eMK-677 (Ibutamoren)\u003c\/h3\u003e\n\u003cp\u003eMK-677, or ibutamoren, is a non-peptide growth hormone secretagogue developed by Merck under the code L-163,191 (PubChem CID 178024, CAS 159634-47-6, C27H36N4O5S). It mimics ghrelin at the GHS-R1a receptor, prompting the pituitary to release growth hormone, and it raises IGF-1. Randomised trials in older adults and in obese men recorded higher growth hormone and IGF-1 together with poorer glucose handling, and in the older adults increased appetite and mild oedema (Nass 2008; Svensson 1998); those trials are summarised in \u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677 (ibutamoren): what the research says\u003c\/a\u003e. It was never approved as a medicine.\u003c\/p\u003e\n\u003cp\u003eEach compound was studied on its own. No published study has examined YK-11, RAD-140 and MK-677 together, in cells, animals or people. We do not advise on combining compounds; the listing is described as the manufacturer presents it. Nothing above is a claim about this product.\u003c\/p\u003e\n\u003ch2\u003eYK-11, RAD-140 and MK-677 in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eNone of the three compounds is a licensed medicine in the UK. None holds an MHRA marketing authorisation, none is an authorised food supplement, and none may lawfully be sold for human consumption. Free Muscle supplies this pack to adults aged 18 and over for laboratory research only.\u003c\/p\u003e\n\u003cp\u003eThe three do not sit in identical positions. YK-11 is a steroid, and because anabolic steroids are Class C controlled drugs in the UK its status is less clear-cut than that of RAD-140, a non-steroidal SARM with no steroid backbone. MK-677 acts on the growth hormone axis; its UK position is set out on our \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status page\u003c\/a\u003e. All three are prohibited in sport. Buyers are responsible for the rules that apply to them, and our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e covers the wider legal picture.\u003c\/p\u003e\n\u003ch3\u003eWhat to check before buying a multi-compound pack\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eEvery compound named precisely, with a separate stated amount per capsule for each. A list of names alone does not say how much of anything is present.\u003c\/li\u003e\n\u003cli\u003eA printed lot number that ties the pack to a named laboratory's certificate.\u003c\/li\u003e\n\u003cli\u003eA certificate that identifies and quantifies each compound, not only the one in the product title.\u003c\/li\u003e\n\u003cli\u003eA named UK company, an 18+ restriction, plain packaging and tracked delivery.\u003c\/li\u003e\n\u003cli\u003eNo instructions for human use, no stacking advice and no promises of outcomes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow this listing measures up\u003c\/h3\u003e\n\u003cp\u003eiMuscle does not state per-capsule amounts, so this listing fails the first check, and we do not fill the gap with an estimate. A certificate is shown only where iMuscle supplies one for the batch we hold. Orders ship from FreeMuscle LTD in Scunthorpe with free tracked UK delivery in plain packaging, orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3 to 7 working days, and unopened items can be returned within 30 days (\u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e, \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e). Our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e explains each test.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eYK-11, RAD-140 and MK-677 are each sold separately as capsules, liquids and powder. No study has compared these forms for any of the three, so the points here concern what can be measured and kept stable, not effect. This pack is a single capsule said to hold all three.\u003c\/p\u003e\n\u003cp\u003ePutting three compounds in one fill changes the measurement problem. In a blend, the amount of each compound depends on how evenly the powders were mixed before filling, and a minor component that is poorly mixed can vary from capsule to capsule even when the total fill weight is consistent. Only a content assay of finished capsules, reporting each compound separately, shows the actual ratio.\u003c\/p\u003e\n\u003cp\u003eThe chemistry points the same way. All three are small molecules rather than peptides, so the digestion argument made about peptides taken by mouth, discussed in \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003eDo oral peptides actually work?\u003c\/a\u003e, does not apply to them. YK-11 carries an orthoester-derived group that its main metabolism study called arguably labile (Piper 2018), which makes a water-free fill easier to keep stable than a solution. MK-677 is often supplied as its mesylate salt, which weighs more than the free base, so a label amount should say which form it refers to. None of this is a claim about what a capsule does.\u003c\/p\u003e\n\u003ch2\u003eYK-11 compared with RAD-140 and MK-677, and where RAD-150 fits\u003c\/h2\u003e\n\u003cp\u003eA common question is how the three compounds differ, and how RAD-140 relates to RAD-150. The table uses only points that published sources support.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eYK-11\u003c\/th\u003e\n\u003cth\u003eRAD-140\u003c\/th\u003e\n\u003cth\u003eMK-677\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical family\u003c\/td\u003e\n\u003ctd\u003eSteroidal, 19-nor skeleton\u003c\/td\u003e\n\u003ctd\u003eNon-steroidal SARM\u003c\/td\u003e\n\u003ctd\u003eNon-peptide ghrelin mimetic\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMain target\u003c\/td\u003e\n\u003ctd\u003eAndrogen receptor, partial agonist in cell assays\u003c\/td\u003e\n\u003ctd\u003eAndrogen receptor\u003c\/td\u003e\n\u003ctd\u003eGhrelin receptor (GHS-R1a)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and molecular weight\u003c\/td\u003e\n\u003ctd\u003eC25H34O6, 430.5\u003c\/td\u003e\n\u003ctd\u003eC20H16ClN5O2, 393.8\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S, 528.7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDeveloped by\u003c\/td\u003e\n\u003ctd\u003eAcademic group, Toho University\u003c\/td\u003e\n\u003ctd\u003eRadius Health\u003c\/td\u003e\n\u003ctd\u003eMerck, as L-163,191\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublished human data\u003c\/td\u003e\n\u003ctd\u003eNone\u003c\/td\u003e\n\u003ctd\u003eOne phase 1 trial, 22 women with metastatic breast cancer\u003c\/td\u003e\n\u003ctd\u003eRandomised trials in older adults and obese men\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAdverse findings in people\u003c\/td\u003e\n\u003ctd\u003eNot studied\u003c\/td\u003e\n\u003ctd\u003eRaised liver enzymes and bilirubin\u003c\/td\u003e\n\u003ctd\u003ePoorer glucose handling, appetite, oedema\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA section\u003c\/td\u003e\n\u003ctd\u003eS1, anabolic agents\u003c\/td\u003e\n\u003ctd\u003eS1, anabolic agents\u003c\/td\u003e\n\u003ctd\u003eS2, growth hormone secretagogues\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eTwo of the three share a target. YK-11 and RAD-140 both act at the androgen receptor, though they come from unrelated chemical families, while MK-677 works on a separate system, the growth hormone and IGF-1 axis. On human evidence, MK-677 has the most trial data, RAD-140 a single oncology study, and YK-11 none. Nothing here ranks one above another for any purpose.\u003c\/p\u003e\n\u003cp\u003eRAD-150, also sold as TLB-150, is not in this pack. PubChem records it as the benzoate ester of RAD-140; it appears in a Radius Health patent but has no peer-reviewed study, so claims that it acts for longer are inference. It is stocked separately on the \u003ca href=\"\/collections\/rad-150\"\u003eRAD-150 collection page\u003c\/a\u003e, and \u003ca href=\"\/blogs\/news\/rad-140-vs-rad-150-tlb-150\"\u003eRAD-140 vs RAD-150 (TLB-150)\u003c\/a\u003e sets out the chemistry. For MK-677 the most searched comparison is with ipamorelin, a peptide acting at the same ghrelin receptor; see the \u003ca href=\"\/collections\/ipamorelin\"\u003eipamorelin collection\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/mk-677-vs-ipamorelin-vs-hgh\"\u003eMK-677 vs ipamorelin vs somatropin\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eiMuscle is a third-party brand in the Muscle Market range, so any certificate for this pack is the manufacturer's, not ours. We show one only where iMuscle supplies it for the specific batch we hold, and a generic PDF with no batch number is not a batch certificate, so we do not present one as such. Janoshik Analytical testing of every batch applies to Free Muscle-brand products only, not to iMuscle. A three-compound certificate has more to prove; check these fields.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number\u003c\/strong\u003e: the same number as the one printed on your pack.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity of each compound\u003c\/strong\u003e: a method such as HPLC against reference standards or LC-MS, with a separate result for YK-11 (C25H34O6, 430.5), RAD-140 (C20H16ClN5O2, 393.8) and MK-677 (C27H36N4O5S, 528.7 as the free base). A certificate that confirms only one of them says nothing about the other two.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule for each compound\u003c\/strong\u003e: because iMuscle states no strengths, these figures would be the only statement of how much of each is present.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity\u003c\/strong\u003e: in a blend a single percentage is ambiguous, because three main peaks are expected. Look for each compound reported separately, with any unidentified peaks listed on their own.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTest date and laboratory\u003c\/strong\u003e: a named lab and date allow the result to be confirmed at source.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor this listing a missing field has a specific meaning. With no certificate for the batch in stock, nothing independent confirms which compounds are present or in what amounts. With identity results but no content figures, the certificate confirms presence, not quantity. Email us through the \u003ca href=\"\/pages\/contact\"\u003econtact page\u003c\/a\u003e with the product name and batch number and we will send what we hold, or say plainly that there is none. See \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eEvery compound in this pack is prohibited at all times, in and out of competition, on the WADA Prohibited List, which UK Anti-Doping applies in the UK. YK-11 and RAD-140 fall under section S1, anabolic agents, where RAD-140 is named; MK-677 falls under section S2 as a growth hormone secretagogue. Under strict liability an athlete answers for any prohibited substance found in their sample, whatever a label says.\u003c\/p\u003e\n\u003cp\u003eFor YK-11 there is direct evidence. The Cologne anti-doping laboratory followed deuterium-labelled YK-11 through urine. The parent compound never appeared, but fourteen metabolites did. Free metabolites were gone by 24 hours, whereas forms bound to glucuronic acid or sulfate remained measurable past 48 hours, and two of them were built into the laboratory's screen for anabolic agents (Piper 2018). That is one study, not a detection window. RAD-140 and MK-677 are screened for by accredited laboratories as well; this page cites no study that sets a window for either, so the accurate answer for both is detectable, window not established. A blood half-life is no guide to detection, since laboratories also target metabolites.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eNo stability study has been published for YK-11, RAD-140 or MK-677 capsules, singly or combined, so no shelf life is given here beyond any date iMuscle prints on the pack. A blend is only as stable as its least stable component. The ester and orthoester-derived groups of YK-11 can be split by water, which makes moisture the main avoidable risk for the whole capsule.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eStore the sealed container cool, dry and out of direct light.\u003c\/li\u003e\n\u003cli\u003eReplace the lid straight after opening and leave any desiccant sachet in place.\u003c\/li\u003e\n\u003cli\u003eKeep capsules in their own labelled pot; once moved or mixed, they lose their link to any certificate.\u003c\/li\u003e\n\u003cli\u003eNote the date received alongside the batch number.\u003c\/li\u003e\n\u003cli\u003eSet aside soft, sticky or discoloured capsules and contact us with the batch number.\u003c\/li\u003e\n\u003cli\u003eWear gloves, work away from food, drink, children and pets, and treat any surplus as chemical waste.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eOnly unopened items can be returned within 30 days.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAndrogen receptor\u003c\/strong\u003e: the receptor inside cells that testosterone switches on; YK-11 and RAD-140 both bind it, from different chemical starting points.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: selective androgen receptor modulator; RAD-140 is one, while YK-11 is a steroid sold under the same label.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth hormone secretagogue\u003c\/strong\u003e: MK-677's class, meaning any substance that triggers growth hormone release from the pituitary gland.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGHS-R1a\u003c\/strong\u003e: the receptor for the hunger hormone ghrelin, which MK-677 mimics.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1\u003c\/strong\u003e: insulin-like growth factor 1, the hormone the liver releases when growth hormone rises; MK-677 trials tracked it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAST and ALT\u003c\/strong\u003e: liver enzymes whose blood levels rise when liver cells are damaged; the most frequent adverse findings in the RAD-140 phase 1 trial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase 1 trial\u003c\/strong\u003e: first-in-human testing that asks how well a compound is tolerated and how the body handles it, not whether it works.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMesylate salt\u003c\/strong\u003e: a form of a compound paired with methanesulfonic acid that weighs more than the free base.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlend uniformity\u003c\/strong\u003e: how evenly several powders are mixed before capsule filling, which decides whether each capsule holds the same ratio of compounds.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: the rule under which a prohibited substance in an athlete's sample counts against them whether or not they knew it was there.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/yk-11\"\u003eAll brands of YK-11 we stock, compared\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (Testolone) collection\u003c\/a\u003e and \u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e and \u003ca href=\"\/collections\/market-bundles\"\u003eMuscle Market bundles\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/yk-11-what-is-known\"\u003eYK-11: a steroidal compound sold as a SARM, what is actually known\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (Testolone): what the research says\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/pages\/lab-tests\"\u003eBatch testing and certificates of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It has not been evaluated by the MHRA, EMA or FDA. It is not a medicine, not a food supplement and not for human consumption. Sold only to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice, and descriptions of published studies are not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eKanno Y, et al. (17alpha,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor. Biol Pharm Bull. 2011;34(3):318-23. PMID: 21372378.\u003c\/li\u003e\n\u003cli\u003eKanno Y, et al. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. Biol Pharm Bull. 2013;36(9):1460-5. PMID: 23995658.\u003c\/li\u003e\n\u003cli\u003ePiper T, et al. Studies on the in vivo metabolism of the SARM YK11: Identification and characterization of metabolites potentially useful for doping controls. Drug Test Anal. 2018;10(11-12):1646-56. PMID: 30379415.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003cli\u003eNass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-11. PMID: 18981485.\u003c\/li\u003e\n\u003cli\u003eSvensson J, et al. Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. J Clin Endocrinol Metab. 1998;83(2):362-9. PMID: 9467542.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468980367586,"sku":null,"price":133.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/Combo6_720x_99821e6c-59bc-47ce-b643-d4c07517bcfa.jpg?v=1789931420"},{"product_id":"imuscle-yk-11-60-10mg","title":"iMuscle YK-11 — 60 caps, 10mg","description":"\u003cp\u003eiMuscle YK-11 is supplied as 60 capsules stated at 10 mg each, giving 600 mg of YK-11 per pack. YK-11 is a steroidal partial agonist of the androgen receptor that is commonly sold alongside SARMs and is described in cell studies as a follistatin inducer. iMuscle manufactures it and Free Muscle stocks it in the Muscle Market range for laboratory research by adults only.\u003c\/p\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCompound: YK-11\u003c\/li\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStated strength: 10 mg per capsule (manufacturer's label claim)\u003c\/li\u003e\n\u003cli\u003eStated total per pack: 600 mg\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe strength is the manufacturer's label claim; only a batch certificate confirms it. To compare brands of YK-11, use total milligrams per pack: dividing the listed price by the 600 mg stated here gives the cost per stated milligram, as explained in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eAbout YK-11\u003c\/h2\u003e\n\u003cp\u003eYK-11 is often grouped with SARMs, but it is a steroidal molecule: a 19-nor-pregnane derivative with a methyl ester side chain. It was described in 2011 by a group at Toho University in Japan, who showed in cell assays that it acts as a partial agonist at the androgen receptor, activating the receptor less fully than DHT (Kanno 2011).\u003c\/p\u003e\n\u003cp\u003eThe claim that YK-11 is a myostatin inhibitor comes from a 2013 study in C2C12 mouse myoblast cells, in which YK-11 increased expression of follistatin, a protein that binds myostatin, and promoted myogenic differentiation more than DHT did in that model (Kanno 2013). Both papers are cell-culture work. No human clinical trial of YK-11 has been published, so its pharmacokinetics, hormonal effects and liver tolerance in people are unknown.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIdentifier\u003c\/th\u003e\n\u003cth\u003eYK-11\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e1370003-76-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC25H34O6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e430.5 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInChIKey\u003c\/td\u003e\n\u003ctd\u003eKCQHQCDHFVGNMK-PQUNLUOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePubChem CID\u003c\/td\u003e\n\u003ctd\u003e119058028\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003eAnimal and metabolism studies\u003c\/h3\u003e\n\u003cp\u003eWork in living animals is recent and sparse, and much of the published in vivo work concerns metabolism for doping control (Piper 2018). One study followed rats for five weeks, with and without swimming exercise, to look for unwanted effects in the brain (Dahleh 2024). Animals given YK-11 retained an aversive memory task less well, showed weaker BDNF signalling in the hippocampus, had a cytokine balance tilted towards inflammation and showed activation of proteins that drive programmed cell death. Exercise offset part of this. One rat study cannot say what happens in people, but its findings point towards harm rather than benefit.\u003c\/p\u003e\n\u003cp\u003eThe cell and animal findings summarised here are not claims about this product.\u003c\/p\u003e\n\u003ch2\u003eYK-11 in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eYK-11 is not a licensed medicine in the UK, and it has never been licensed in any other country: it has no MHRA marketing authorisation, is not an authorised food supplement, and cannot lawfully be sold for human consumption. Free Muscle supplies it to adults aged 18 or over for laboratory research only. Because it is a synthetic steroid, its status under the Misuse of Drugs Act is less clear-cut than that of non-steroidal SARMs, and buyers should take their own advice. It is prohibited at all times in sport, as the detection section below explains. Buyers are responsible for the rules that apply to them, including any anti-doping code. Background on the class is in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eWhat a trustworthy UK listing shows\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eThe compound named precisely, ideally with its CAS number, not a nickname.\u003c\/li\u003e\n\u003cli\u003eA stated strength per capsule and a capsule count, so total content can be worked out.\u003c\/li\u003e\n\u003cli\u003eA batch number on the pack, and a certificate of analysis carrying that number from a named laboratory.\u003c\/li\u003e\n\u003cli\u003eA plain statement when no certificate exists for the batch in stock, instead of a generic PDF.\u003c\/li\u003e\n\u003cli\u003eA named UK company, an 18+ restriction, plain packaging and tracked delivery.\u003c\/li\u003e\n\u003cli\u003eNo instructions for human use and no outcome promises.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow this listing measures up\u003c\/h3\u003e\n\u003cp\u003eThe 10 mg and 60-capsule figures are iMuscle's label claim, not a figure we have assayed. A certificate is shown only where iMuscle supplies one for the batch we hold, and we tell you when there is none. Testing is the real difference from Free Muscle's own-brand \u003ca href=\"\/products\/yk-11-10mg\"\u003eYK-11 10 mg\u003c\/a\u003e, which carries the same label strength and capsule count but is assayed batch by batch at Janoshik Analytical. Orders ship from FreeMuscle LTD in Scunthorpe by free tracked UK delivery in plain packaging; orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3 to 7 working days, and unopened items can be returned within 30 days (\u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e, \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e). Our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e covers each test in more detail.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eYK-11 is offered as capsules, as solutions in dropper bottles and as loose powder, and injectable versions are widely searched for. No study has compared these forms and none has been evaluated in a clinical trial, so the differences below concern what can be measured and kept stable, not effect. This listing is capsules.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003cth\u003eWhat fixes the amount per unit\u003c\/th\u003e\n\u003cth\u003eWhat a certificate can confirm\u003c\/th\u003e\n\u003cth\u003eMain stability concern\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCapsule\u003c\/td\u003e\n\u003ctd\u003eFill weight set at manufacture\u003c\/td\u003e\n\u003ctd\u003eContent per capsule and purity, if finished capsules are tested\u003c\/td\u003e\n\u003ctd\u003eHumidity once the container is opened\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSolution\u003c\/td\u003e\n\u003ctd\u003eConcentration, and whether the compound stays evenly dissolved\u003c\/td\u003e\n\u003ctd\u003eConcentration per millilitre on the test date\u003c\/td\u003e\n\u003ctd\u003eConstant contact with solvent\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePowder\u003c\/td\u003e\n\u003ctd\u003eWeighing by the researcher\u003c\/td\u003e\n\u003ctd\u003ePurity of the bulk material\u003c\/td\u003e\n\u003ctd\u003eHumidity and handling losses\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInjectable\u003c\/td\u003e\n\u003ctd\u003eConcentration, carrier and sterility\u003c\/td\u003e\n\u003ctd\u003eUsually concentration only; sterility needs separate testing\u003c\/td\u003e\n\u003ctd\u003eNo published characterisation for YK-11\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eTwo points follow from the chemistry. First, the Cologne anti-doping group described the orthoester-derived group on the D-ring of YK-11 as arguably labile and found no unchanged YK-11 in urine after administration (Piper 2018). Groups that break down readily in the body are also exposed to hydrolysis in a solution containing water or acid, one reason a dry fill is the easier form to store and assay. Second, YK-11 is not a peptide but a small steroid, so the argument that peptides are largely digested when swallowed, discussed in \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003eDo oral peptides actually work?\u003c\/a\u003e, does not apply. That is a point about chemistry, not a claim about what a capsule does. Fill accuracy is itself a manufacturing variable, which is why the certificate section below asks whether finished capsules or raw powder were tested.\u003c\/p\u003e\n\u003ch2\u003eYK-11 compared with RAD-140\u003c\/h2\u003e\n\u003cp\u003eRAD-140 (testolone) is the compound most often set beside YK-11, and iMuscle sells both in the same format: \u003ca href=\"\/products\/imuscle-testolon-rad-140-60-10mg\"\u003eiMuscle Testolone RAD-140\u003c\/a\u003e is also labelled 10 mg per capsule, 60 capsules. Identical label arithmetic hides two different molecules with very different evidence bases.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eYK-11\u003c\/th\u003e\n\u003cth\u003eRAD-140\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical class\u003c\/td\u003e\n\u003ctd\u003eSteroid, 19-nor-pregnane derivative\u003c\/td\u003e\n\u003ctd\u003eNon-steroidal SARM\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and molecular weight\u003c\/td\u003e\n\u003ctd\u003eC25H34O6, 430.5\u003c\/td\u003e\n\u003ctd\u003eC20H16ClN5O2, 393.8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOrigin\u003c\/td\u003e\n\u003ctd\u003eAcademic group, Toho University, 2011\u003c\/td\u003e\n\u003ctd\u003ePharmaceutical programme, Radius Health\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAction at the androgen receptor\u003c\/td\u003e\n\u003ctd\u003ePartial agonist in cell assays; induced follistatin in mouse muscle cells\u003c\/td\u003e\n\u003ctd\u003eAgonist designed for tissue selectivity, characterised in rats and monkeys\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublished human data\u003c\/td\u003e\n\u003ctd\u003eNo clinical trial\u003c\/td\u003e\n\u003ctd\u003eOne phase 1 study in 22 women with advanced breast cancer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMain adverse findings\u003c\/td\u003e\n\u003ctd\u003eMemory, inflammatory and cell-death changes in rat hippocampus\u003c\/td\u003e\n\u003ctd\u003eRaised liver enzymes, the most frequent adverse events in the phase 1 study\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eNot a licensed medicine; steroid structure makes its drugs-law status less clear-cut\u003c\/td\u003e\n\u003ctd\u003eNot a licensed medicine; research use only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eSection S1, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eSection S1, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThe evidence gap is the main difference. RAD-140's human data come from one oncology study in patients with advanced disease (LoRusso 2022), yet that study still produced a measured half-life and a documented liver-enzyme signal. YK-11 has neither, so any statement about how it behaves in people rests on nothing published. The regulatory picture differs for a structural reason: a steroid backbone brings YK-11 closer to the anabolic steroids that UK drugs law already controls, whereas RAD-140 is chemically unrelated to them. Neither compound is approved anywhere, both are banned in sport, and nothing here ranks one above the other for any purpose. Brands of RAD-140 are compared on the \u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 collection page\u003c\/a\u003e, and its research is summarised in \u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (Testolone): what the research says\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eiMuscle is a third-party brand, so any certificate of analysis is the manufacturer's, not ours. Where iMuscle supplies a COA for the batch we hold, we show it or send it by email on request; where none exists for the batch in stock, we say so rather than show a generic document. Free Muscle-brand compounds are assayed batch by batch at Janoshik Analytical; that programme does not cover iMuscle. When an iMuscle certificate is available, these are the fields to check.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch or lot number\u003c\/strong\u003e: the same number as the one printed on your pack.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity\u003c\/strong\u003e: the method (HPLC against a YK-11 reference standard, LC-MS, or both) and a result consistent with C25H34O6, molecular weight 430.5. YK-11 has a defined E geometry at its side-chain double bond, and an isomer would share its mass, so a retention-time match to a reference standard is stronger evidence than mass alone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity\u003c\/strong\u003e: the main peak as a percentage of everything the HPLC detected. The remainder may be synthesis by-products or breakdown products.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule\u003c\/strong\u003e: the milligrams found in finished capsules, to set against the stated 10 mg; a raw-powder result is not the same measurement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTest date and laboratory\u003c\/strong\u003e: when and by whom the analysis was run.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor this brand, a missing field has a specific meaning. With no certificate for the batch in stock, nothing independent confirms identity, purity or content, and the 10 mg figure stays a label claim. Without a content figure, a certificate confirms what the material is but not the fill; without a batch number, it cannot be tied to your pack; without a named laboratory, it cannot be checked with the lab that issued it. Email us through the \u003ca href=\"\/pages\/contact\"\u003econtact page\u003c\/a\u003e with the product name and the batch number on your pack and we will tell you what we hold. See \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eYK-11 is prohibited at all times, in and out of competition, under section S1 (anabolic agents) of the WADA Prohibited List, which UK Anti-Doping applies in the UK. Under the strict liability principle of the anti-doping code, an athlete is responsible for any prohibited substance found in their sample, whatever the product label said.\u003c\/p\u003e\n\u003cp\u003eLaboratories can find it. In an elimination study with deuterium-labelled YK-11, the Cologne anti-doping laboratory identified fourteen urinary metabolites and no unchanged YK-11 in urine. Unconjugated metabolites had gone within 24 hours, while glucuronide and sulfate conjugates were still traceable after more than 48 hours, and two glucuronidated metabolites were added to the laboratory's routine screen for anabolic agents (Piper 2018). The study itself was prompted by the detection of YK-11 in a seized black-market product.\u003c\/p\u003e\n\u003cp\u003eThose timings describe how long metabolites were traced in one study; they are not a detection window. With no published human pharmacokinetic study, there is no established half-life for YK-11 in people and the full window is unknown. The reliable statement is that YK-11 is detectable.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eNo stability study of YK-11 capsules has been published, so storage practice rests on general chemistry and the manufacturer's label. Water can cleave the ester and orthoester-derived groups in the molecule, and heat and light degrade most organic research materials.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eKeep the capsules in the original closed container, cool, dry and away from direct sunlight and heat.\u003c\/li\u003e\n\u003cli\u003eClose the lid promptly and leave any desiccant sachet in place; humidity is the main avoidable threat.\u003c\/li\u003e\n\u003cli\u003eKeep the label intact: the batch number links the capsules to any certificate and to any quality query.\u003c\/li\u003e\n\u003cli\u003eRecord the date of receipt and any printed expiry date; without one, a certificate's test date is the only dated reference.\u003c\/li\u003e\n\u003cli\u003eSoft, sticky, discoloured or clumped capsules suggest moisture damage; note the batch number and contact us.\u003c\/li\u003e\n\u003cli\u003eKeep out of reach of children and pets, handle with gloves in a clean area free of food and drink, and dispose of unwanted material under local chemical-waste rules.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIf you might return the item, leave it sealed: returns are accepted within 30 days on unopened items only.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePartial agonist\u003c\/strong\u003e: a ligand whose maximum effect at a receptor stays below that of a reference hormone; for YK-11 in cell assays the reference was DHT.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDHT (dihydrotestosterone)\u003c\/strong\u003e: a potent androgen made from testosterone in tissues such as skin and prostate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e19-nor steroid\u003c\/strong\u003e: a steroid missing the carbon atom usually found at position 19, the skeleton YK-11 shares with nandrolone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFollistatin\u003c\/strong\u003e: a glycoprotein that captures myostatin and activin outside the cell; the 2013 C2C12 study reported a rise in its expression, the basis of the myostatin-inhibitor label.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eC2C12 cells\u003c\/strong\u003e: a mouse muscle precursor line that fuses into muscle-like fibres in culture.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHydrolysis\u003c\/strong\u003e: cleavage of a chemical bond by water, the main storage risk for the ester and orthoester-derived groups in YK-11.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLabel claim\u003c\/strong\u003e: the amount a manufacturer prints per capsule, here 10 mg, unconfirmed until a content assay is run.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRetention time\u003c\/strong\u003e: how long a compound takes to pass through an HPLC column, compared against a reference standard to support identity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConjugated metabolite\u003c\/strong\u003e: a breakdown product linked to glucuronic acid or sulfate for excretion; these were the longest-traced YK-11 markers in the Cologne study.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/yk-11\"\u003eAll brands of YK-11\u003c\/a\u003e, compared on strength, pack size and batch testing\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e stocked at Free Muscle\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/yk-11-what-is-known\"\u003eYK-11: a steroidal compound sold as a SARM, what is actually known\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (testolone)\u003c\/a\u003e and the full \u003ca href=\"\/collections\/sarms\"\u003eSARMs range\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It is not a medicine, has not been evaluated by the MHRA, EMA or FDA, and is not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eKanno Y, et al. (17alpha,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor. Biol Pharm Bull. 2011;34(3):318-23. PMID: 21372378.\u003c\/li\u003e\n\u003cli\u003eKanno Y, et al. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. Biol Pharm Bull. 2013;36(9):1460-5. PMID: 23995658.\u003c\/li\u003e\n\u003cli\u003ePiper T, et al. Studies on the in vivo metabolism of the SARM YK11: Identification and characterization of metabolites potentially useful for doping controls. Drug Test Anal. 2018;10(11-12):1646-56. PMID: 30379415.\u003c\/li\u003e\n\u003cli\u003eDahleh MMM, et al. From gains to gaps? How Selective Androgen Receptor Modulator (SARM) YK11 impact hippocampal function: In silico, in vivo, and ex vivo perspectives. Chem Biol Interact. 2024;394:110971. PMID: 38521455.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468980400354,"sku":null,"price":53.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/YK11_720x_d356e17a-105c-480a-834b-d0c2826f4875.jpg?v=1789931421"}],"url":"https:\/\/freemuscle.co.uk\/collections\/brand-imuscle.oembed","provider":"Free Muscle","version":"1.0","type":"link"}