{"title":"Yakka Strength","description":"\u003cp\u003eYakka Strength is one of the third-party brands sold through Muscle Market alongside our own Free Muscle range. This collection lists every Yakka Strength product we currently hold: five single-compound capsule listings and six multi-compound packs. Every pack in our data contains 60 capsules. The range covers a growth hormone secretagogue, a SARM, a selective oestrogen receptor modulator and two peptide-class compounds, and each compound has its own collection page where Yakka Strength can be compared with the other brands we stock.\u003c\/p\u003e\n\n\u003ch2\u003eWhat is in the Yakka Strength range\u003c\/h2\u003e\n\u003cp\u003eSingle-compound listings, each 60 capsules. Per-capsule strength is shown on the individual product page where the manufacturer states it.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMK-677 (Ibutamoren)\u003c\/strong\u003e: \u003ca href=\"\/products\/yakka-strength-yakka-strength-mk677\"\u003eYakka Strength MK-677\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/mk-677\"\u003eMK-677\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRAD-140 (Testolone)\u003c\/strong\u003e: \u003ca href=\"\/products\/yakka-strength-yakka-strength-rad140\"\u003eYakka Strength RAD-140\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/rad-140\"\u003eRAD-140\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnclomiphene\u003c\/strong\u003e: \u003ca href=\"\/products\/yakka-strength-yakka-strength-enclomiphene\"\u003eYakka Strength Enclomiphene\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/enclomiphene\"\u003eEnclomiphene\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBPC-157\u003c\/strong\u003e: \u003ca href=\"\/products\/yakka-strength-yakka-strength-bpc157-peptide-capsules\"\u003eYakka Strength BPC-157 Peptide Capsules\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTB-500 (Thymosin Beta-4 fragment)\u003c\/strong\u003e: \u003ca href=\"\/products\/yakka-strength-yakka-strength-tb500-peptide-capsules\"\u003eYakka Strength TB-500 Peptide Capsules\u003c\/a\u003e. Compound page: \u003ca href=\"\/collections\/tb-500\"\u003eTB-500\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMulti-compound packs, each 60 capsules, listed exactly as the manufacturer supplies them. The pairing is a product fact, not a suggestion of any protocol:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/products\/yakka-strength-yakka-strength-wolverine-stack-bpc157-tb500-capsule-peptide-bundle\"\u003eWolverine pack: BPC-157 and TB-500\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/products\/yakka-strength-yakka-strength-rad140-enclomiphene-bundle\"\u003eRAD-140 and Enclomiphene\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/products\/yakka-strength-yakka-strength-mk677-rad140\"\u003eMK-677 and RAD-140\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/products\/yakka-strength-yakka-strength-mk677-bpc157-capsule-bundle\"\u003eMK-677 and BPC-157\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/products\/yakka-strength-yakka-strength-mk677-tb500-capsule-bundle\"\u003eMK-677 and TB-500\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/products\/yakka-strength-yakka-strength-mk677-bpc157-tb500-capsule-bundle\"\u003eMK-677, BPC-157 and TB-500\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAll multi-compound packs across brands are grouped under \u003ca href=\"\/collections\/market-bundles\"\u003eBundles and Stacks\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow to compare listings\u003c\/h3\u003e\n\u003cp\u003eWhere a per-capsule strength is stated, multiply it by 60 for the total milligrams in the pack and compare cost per milligram with the same compound from another brand. Where the strength is not stated, that comparison is not possible and the batch certificate matters more. Our \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram article\u003c\/a\u003e explains the approach, and \u003ca href=\"\/blogs\/news\/mk-677-brands-compared\"\u003eMK-677 by brand\u003c\/a\u003e applies it to the compound this range has most of.\u003c\/p\u003e\n\n\u003ch2\u003eBatch testing and certificates of analysis\u003c\/h2\u003e\n\u003cp\u003eYakka Strength is a third-party manufacturer, so its batches are not covered by the Janoshik Analytical programme that tests every Free Muscle batch. For Yakka Strength products, a certificate of analysis is shown only where the manufacturer supplies one for the specific batch we hold. Where no certificate is available, the listing does not claim one. A batch certificate should name the batch, confirm the identity of the compound and state its measured purity; a generic PDF with no batch number is not evidence about the pack you receive. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e sets out what is available per brand.\u003c\/p\u003e\n\n\u003ch2\u003eLegal status in the UK\u003c\/h2\u003e\n\u003cp\u003eNone of these compounds is a licensed medicine, none has been assessed by the MHRA, and none is an authorised food supplement. They are supplied to adults aged 18 or over for laboratory research only and are not for human consumption. RAD-140 and MK-677 are named on the World Anti-Doping Agency prohibited list, enclomiphene falls under its category for selective oestrogen receptor modulators, TB-500 is listed as a thymosin beta-4 derivative, and BPC-157 falls under the category for substances with no current approval for human use, so all are prohibited in sport at all times. Background on the SARM class is in our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eDelivery and returns\u003c\/h2\u003e\n\u003cp\u003eEvery order ships with free tracked UK delivery in plain packaging. Orders placed before 2pm Monday to Friday are processed the same working day. EU delivery takes 3 to 7 working days. Unopened items can be returned within 30 days. Full details are on our \u003ca href=\"\/pages\/shipping\"\u003eshipping page\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee page\u003c\/a\u003e. Customers must be 18 or over.\u003c\/p\u003e\n\n\u003ch2\u003eRelated reading\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677 (Ibutamoren): what the research says\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/bpc-157-what-research-shows\"\u003eBPC-157: what the research actually shows, and what it does not\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/why-post-cycle-therapy-pct-matters\"\u003eWhy post-cycle therapy (PCT) matters\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eHow to read a certificate of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003eCompound pages: \u003ca href=\"\/collections\/mk-677\"\u003eMK-677\u003c\/a\u003e, \u003ca href=\"\/collections\/rad-140\"\u003eRAD-140\u003c\/a\u003e, \u003ca href=\"\/collections\/enclomiphene\"\u003eEnclomiphene\u003c\/a\u003e, \u003ca href=\"\/collections\/tb-500\"\u003eTB-500\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cem\u003eAll products in this collection are sold for laboratory research use only. They have not been evaluated by the MHRA, EMA or FDA, are not medicines or food supplements, and are not for human consumption. Buyers must be 18 or over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"yakka-strength-yakka-strength-bpc157-peptide-capsules","title":"Yakka Strength BPC-157 Peptide Capsules","description":"\u003cp\u003eYakka Strength BPC-157 Peptide Capsules is a 60-capsule pack of the synthetic pentadecapeptide BPC-157, manufactured by Yakka Strength and stocked by Free Muscle through the \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range. No per-capsule peptide content is stated in the manufacturer information we hold, so we do not quote a strength. The product is supplied to adults aged 18 and over for laboratory research only. Below: the evidence, the UK and sport rules, and how to judge a certificate for this pack.\u003c\/p\u003e\n\u003ch2\u003eAbout BPC-157\u003c\/h2\u003e\n\u003cp\u003eBPC-157 (Body Protection Compound 157, also written BPC157 or PL 14736) is a synthetic 15-amino-acid peptide whose sequence, GEPPPGKPADDAGLV, is derived from a protein found in human gastric juice. It was developed by a research group at the University of Zagreb and has been studied since the early 1990s, almost entirely in rodents. Being a peptide, it belongs to neither the SARM nor the steroid class, although shops often list it beside both.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIdentifier\u003c\/th\u003e\n\u003cth\u003eBPC-157\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e137525-51-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC62H98N16O22\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e1419.5 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSequence (one-letter code)\u003c\/td\u003e\n\u003ctd\u003eGEPPPGKPADDAGLV\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInChIKey\u003c\/td\u003e\n\u003ctd\u003eHEEWEZGQMLZMFE-RKGINYAYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePubChem CID\u003c\/td\u003e\n\u003ctd\u003e9941957\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003eWhat the published research reports\u003c\/h3\u003e\n\u003cp\u003eA 2011 study of rat Achilles tendon reported that BPC-157 increased outgrowth of tendon explants and the migration and survival of tendon fibroblasts in culture, and linked this to activation of the FAK-paxillin signalling pathway. That work came from Chang Gung University in Taiwan, one of the few laboratories outside Zagreb to publish on the peptide. A 2016 review by the originating group summarised its own rodent findings on the gut, brain and vascular system. Reviewers have noted as a limitation that most of the evidence comes from that one research network.\u003c\/p\u003e\n\u003cp\u003eThe first formal pharmacokinetic study appeared only in 2022, from a group in Xi'an, China, preparing BPC-157 for clinical development. In rats and beagle dogs given the peptide intravenously or by intramuscular injection, the intact peptide had an elimination half-life of under 30 minutes, and absolute bioavailability after intramuscular injection was roughly 14 to 19 per cent in rats and 45 to 51 per cent in dogs. Radiolabelled peptide was broken quickly into small fragments and then single amino acids, excreted mainly in urine and bile. The oral route was not tested.\u003c\/p\u003e\n\u003cp\u003eThere are no published, peer-reviewed randomised controlled trials of BPC-157 in humans, and no pharmacokinetic data on oral capsules in people. The animal findings above are not claims about this product. More in \u003ca href=\"\/blogs\/news\/bpc-157-what-research-shows\"\u003eBPC-157: what the research actually shows\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCompound: BPC-157\u003c\/li\u003e\n\u003cli\u003eBrand: Yakka Strength\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStrength per capsule: not stated in the manufacturer information we hold\u003c\/li\u003e\n\u003cli\u003eTotal per pack: cannot be calculated without a stated strength\u003c\/li\u003e\n\u003cli\u003eCertificate of analysis: depends on the batch; displayed only if the manufacturer has provided one for our current stock\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBecause no per-capsule content is stated, this pack cannot be compared on milligrams with brands that do. A batch certificate, if available, may give a measured content. See \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003ehow to compare by milligram\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eBPC-157 in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eThree kinds of UK search lead here: whether BPC-157 can be bought (\"BPC 157 UK buy\"), whether that is lawful (\"BPC 157 UK legal\", \"BPC 157 UK NHS\"), and how to tell a careful seller from a careless one.\u003c\/p\u003e\n\u003ch3\u003eThe legal position\u003c\/h3\u003e\n\u003cp\u003eBPC-157 is not a licensed medicine in the UK: it has no MHRA marketing authorisation, is not an authorised food supplement, and cannot lawfully be sold for human consumption. It is not a controlled drug under the Misuse of Drugs Act 1971, and it may be supplied only as a research material. Free Muscle supplies it on that basis, to adults aged 18 or over, for laboratory research only. With no licensed product containing it anywhere, the NHS does not prescribe it. In sport it is banned at all times (see detection, below). Buyers are responsible for the rules that apply to them, including any anti-doping code. The same applies across our \u003ca href=\"\/collections\/peptides\"\u003eresearch peptides\u003c\/a\u003e range.\u003c\/p\u003e\n\u003ch3\u003eWhat a careful UK listing shows\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA named manufacturer and a traceable seller\u003c\/strong\u003e, meaning a registered UK company you can contact.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA printed lot number\u003c\/strong\u003e, without which no test result can be tied to the capsules.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate for that lot\u003c\/strong\u003e, not one sample report reused for years.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated peptide content per capsule\u003c\/strong\u003e, so packs can be compared.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-only terms\u003c\/strong\u003e: an 18+ restriction, no directions for use and no promised outcomes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTracked delivery in plain packaging\u003c\/strong\u003e, with a written returns policy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhere this listing stands\u003c\/h3\u003e\n\u003cp\u003eFreeMuscle LTD is a UK company based in Scunthorpe, the manufacturer is named, sales are restricted to adults and the page gives no directions for use. Every order goes by free tracked UK delivery in plain packaging; orders placed before 2pm Monday to Friday are processed the same working day, and unopened items can be returned within 30 days. Two points rest with the manufacturer: a Yakka Strength certificate is shown only where one has been supplied for the batch we hold, and no per-capsule content is stated, so the strength point is not met. \"BPC 157 UK reviews\" and Reddit threads cannot fill either gap, since a review records one buyer's impression, not what a lot contained. More checks are in our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eBPC-157 is sold as capsules, tablets, freeze-dried powder in vials and ready-mixed liquids, and \"BPC 157 capsules vs injection\" is among the most searched comparisons. The molecule is the same in each; what differs is how studies delivered it and how each format behaves as a material.\u003c\/p\u003e\n\u003cp\u003eMost rodent experiments injected BPC-157 into the abdominal cavity, and some from the Zagreb group dissolved it in the animals' drinking water. The 2022 pharmacokinetic study measured only intravenous and intramuscular injection, so no published figure exists for how much intact peptide, if any, reaches the blood after a capsule is swallowed. The general obstacle is digestion: pepsin and the intestinal proteases exist to cut peptide bonds, and a 15-residue chain is a typical substrate. The originating group describes BPC-157 as stable in human gastric juice, a finding from its own laboratory that no published human study has tested.\u003c\/p\u003e\n\u003cp\u003eAs materials, the formats differ mainly in handling. A lyophilised vial is dry and comparatively stable until reconstituted; in solution, hydrolysis and microbial growth become concerns, and each measured volume is only as accurate as the mixing and drawing. Ready-mixed liquids carry those issues from the start. A capsule holds a fixed fill of dry powder blended with a filler, so its consistency depends on how evenly the batch was mixed, which only a per-capsule content test can confirm. Searches such as \"BPC 157 capsules 1000mcg\" reflect labels that state strength in micrograms; none is stated for this pack. None of this suggests that any format produces an effect. Both routes are examined in \u003ca href=\"\/blogs\/news\/bpc-157-capsules-vs-injection-what-studies-used\"\u003eBPC-157 capsules vs injection: what the studies used\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eBPC-157 compared with TB-500\u003c\/h2\u003e\n\u003cp\u003eTB-500 is the peptide most often searched alongside this one (\"TB 500 vs BPC 157\", \"BPC 157 and TB 500\"). The two are often sold side by side, but they are unrelated molecules with different origins, evidence and regulatory treatment.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eBPC-157\u003c\/th\u003e\n\u003cth\u003eTB-500\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOrigin\u003c\/td\u003e\n\u003ctd\u003e15-residue sequence from a protein in gastric juice\u003c\/td\u003e\n\u003ctd\u003eSynthetic peptide derived from thymosin beta-4, a 43-residue actin-binding protein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIdentity\u003c\/td\u003e\n\u003ctd\u003eGEPPPGKPADDAGLV, 1419.5 g\/mol\u003c\/td\u003e\n\u003ctd\u003eCharacterised by anti-doping chemists as the acetylated fragment Ac-LKKTETQ; full thymosin beta-4 is about 4,963 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMain research setting\u003c\/td\u003e\n\u003ctd\u003eRodent gut, tendon, ligament and vascular models, mostly from one Zagreb group\u003c\/td\u003e\n\u003ctd\u003eAnimal wound, cornea and heart models, mostly using the full protein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman data\u003c\/td\u003e\n\u003ctd\u003eNo randomised controlled trial\u003c\/td\u003e\n\u003ctd\u003eSmall early trials of full-length thymosin beta-4 applied to the eye or skin; none of the fragment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eUnlicensed research compound\u003c\/td\u003e\n\u003ctd\u003eUnlicensed research compound\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS0, non-approved substances; banned at all times\u003c\/td\u003e\n\u003ctd\u003eS2, where thymosin beta-4 and its derivatives are named among growth factor modulators; banned at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThe proposed mechanisms differ too. The Zagreb group's 2016 review lists the FAK-paxillin, Egr-1 and JAK-2 pathways as implicated in BPC-157's animal effects, whereas thymosin beta-4's best-established role is holding a reserve of unpolymerised actin, which governs how cells move. Neither has been confirmed in controlled human studies. No human trial has compared the two, so neither can be ranked above the other, and we publish no guidance on using them together.\u003c\/p\u003e\n\u003cp\u003eBrands held are in the \u003ca href=\"\/collections\/tb-500\"\u003eTB-500 collection\u003c\/a\u003e, including \u003ca href=\"\/products\/yakka-strength-yakka-strength-tb500-peptide-capsules\"\u003eYakka Strength TB-500 capsules\u003c\/a\u003e, and the evidence is summarised in the \u003ca href=\"\/blogs\/news\/tb-500-thymosin-beta-4-research-guide\"\u003eTB-500 and thymosin beta-4 research guide\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eYakka Strength manufactures this product, so any certificate of analysis comes from them. We show a COA only where the manufacturer has supplied one for the batch we hold, and if there is none, we say so rather than substitute a generic PDF. Free Muscle-brand batches, including our own \u003ca href=\"\/collections\/bpc-150\"\u003eBPC-150 capsules\u003c\/a\u003e, are independently assayed at Janoshik Analytical; that does not extend to Yakka Strength. On a peptide capsule certificate, these are the lines to read:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity (HPLC or LC-MS).\u003c\/strong\u003e HPLC matches a peak to a BPC-157 reference standard, which is suggestive rather than conclusive. LC-MS weighs the molecule: C62H98N16O22 has a monoisotopic mass of about 1418.7, usually seen as a doubly charged ion near m\/z 710.4 or a singly charged one near m\/z 1419.7.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity (%).\u003c\/strong\u003e The BPC-157 peak's share of the chromatogram. It grades how clean the peptide is, not how much each capsule holds; incomplete sequences left from synthesis are the usual impurities.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The measured peptide per capsule, the figure not stated for this pack. Peptide powders also carry water and counter-ions such as acetate, so a good certificate says whether it reports net peptide or total powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number.\u003c\/strong\u003e Must match the lot printed on the pack in hand.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLaboratory and test date.\u003c\/strong\u003e Identify who ran the analysis, so the result can be checked with them, and how old it is.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHere a missing field has a direct consequence. Without a content line, the certificate cannot supply the missing strength; without an identity method, a purity figure could describe any peptide; without a matching batch number, the report belongs to other material. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the lot number and we will say what exists for current stock. More at \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ereading a COA\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eBPC-157 is named as an example in section S0 (non-approved substances) of the WADA Prohibited List. S0 covers any pharmacological substance with no current approval for human therapeutic use by a government health authority, and applies at all times, in and out of competition, in every sport bound by the World Anti-Doping Code, UK Anti-Doping testing included. Strict liability applies: an athlete is responsible for any prohibited substance found in their sample, whatever its source or label.\u003c\/p\u003e\n\u003cp\u003eLaboratories have had a validated method since 2017, when the Salt Lake City anti-doping laboratory identified BPC-157 in confiscated vials. Its urine assay reached a limit of detection of 0.1 ng\/mL, the peptide stayed stable in urine for at least four days, and measuring a stable metabolite alongside it made the test more specific. No study has published how long after exposure BPC-157 remains detectable in human urine, so the accurate statement is: detectable, window not established. An unpublished window offers a tested athlete no protection, because the method exists and the ban never lapses.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eNo stability study of BPC-157 capsules has been published, so the printed expiry or best-before date, where there is one, is the limit to work to. General peptide chemistry still ranks the risks. Moisture comes first: it lets peptide bonds hydrolyse, clumps the powder and softens capsule shells, while very dry heat makes them brittle. Warmth speeds every degradation reaction, and light adds to it. Stability in gastric juice, as the originating group reports it, concerns hours in acid, not months on a shelf.\u003c\/p\u003e\n\u003cp\u003eIn practice, keep the tub sealed in a cool, dry place out of direct light, away from radiators, windowsills and steamy rooms. If it is kept in a fridge, let it reach room temperature before opening so condensation does not settle on the capsules, and leave any desiccant sachet in place. Note the date of first opening beside the batch number. Treat the pack as a laboratory reagent: gloves for opened capsules or loose powder, nowhere near food or drink, out of reach of children and animals, and waste disposed of as chemical waste rather than in household bins or drains. Keep capsules in the container that carries the lot number, or they can no longer be matched to a certificate.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePentadecapeptide\u003c\/strong\u003e: a peptide made of 15 amino acids; BPC-157 is one.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptide bond\u003c\/strong\u003e: the link between neighbouring amino acids, which both digestive enzymes and moisture can break.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBioavailability\u003c\/strong\u003e: the share of an administered amount that reaches the bloodstream unchanged.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLyophilised\u003c\/strong\u003e: freeze-dried, the usual state of peptide powder supplied in vials.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC\u003c\/strong\u003e: high-performance liquid chromatography, the separation technique behind most purity percentages; components leave the column at different times.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLC-MS\u003c\/strong\u003e: chromatography linked to a mass spectrometer, so every separated component is also weighed, which makes an identity result firmer.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNet peptide content\u003c\/strong\u003e: the proportion of a peptide powder that is peptide once water and counter-ions are excluded.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLimit of detection\u003c\/strong\u003e: the smallest amount an assay can distinguish from a blank sample.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThymosin beta-4\u003c\/strong\u003e: an actin-binding protein 43 amino acids long; TB-500 is sold as a synthetic peptide derived from it.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157 collection\u003c\/a\u003e: every brand we hold, set side by side on strength, pack size and testing\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eAll Yakka Strength products\u003c\/a\u003e stocked at Free Muscle\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/blogs\/news\/sarms-vs-peptides-choosing-by-goal\"\u003eSARMs vs peptides\u003c\/a\u003e, on how the two classes differ\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eSupplied for laboratory research use only and not for human consumption. This Yakka Strength product is neither a medicine nor a food supplement, and it has not been evaluated by the MHRA, EMA or FDA. Sales are limited to adults aged 18 and over, and nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eChang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-80. PMID: 21030672.\u003c\/li\u003e\n\u003cli\u003eSikiric P, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857-865. PMID: 27138887.\u003c\/li\u003e\n\u003cli\u003eHe L, et al. Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. Front Pharmacol. 2022;13:1026182. PMID: 36588717.\u003c\/li\u003e\n\u003cli\u003eCox HD, et al. Detection and in vitro metabolism of the confiscated peptides BPC 157 and MGF R23H. Drug Test Anal. 2017;9(10):1490-1498. PMID: 28035768.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982235362,"sku":null,"price":49.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-capsules-front-b_600x_dffe9978-e2cc-499d-ad58-1e67a4736cf9.png?v=1789931437"},{"product_id":"yakka-strength-yakka-strength-enclomiphene","title":"Yakka Strength Enclomiphene","description":"\u003cp\u003e\u003cstrong\u003eYakka Strength Enclomiphene\u003c\/strong\u003e is a Yakka Strength listing of enclomiphene, supplied as 60 capsules per pack; the manufacturer does not state a strength per capsule on the label. It is supplied through the Muscle Market range for laboratory research only, is not for human consumption, and is sold to adults aged 18 and over. This page sets out what the published research on enclomiphene reports, what the label documents, how it differs from clomifene, how to read a batch certificate for a Yakka Strength product, and where it stands in UK law and in sport.\u003c\/p\u003e\n\u003ch2\u003eAbout Enclomiphene\u003c\/h2\u003e\n\u003cp\u003eEnclomiphene is the trans-isomer of clomifene, a selective oestrogen receptor modulator (SERM). Clomifene as prescribed is a mixture of two isomers; enclomiphene is the one that blocks oestrogen receptors in the hypothalamus and pituitary, which reduces negative feedback and raises secretion of LH and FSH. It was developed by Repros Therapeutics under the name Androxal for secondary hypogonadism in men. Chemically it is a small synthetic molecule, formula C26H28ClNO, molecular weight 406.0 as the free base, CAS 15690-57-0, PubChem CID 1548953, also indexed as enclomifene, trans-clomifene and RMI 16,289.\u003c\/p\u003e\n\u003ch3\u003eWhat the trials measured\u003c\/h3\u003e\n\u003cp\u003eA 2013 phase IIB study enrolled 12 men with secondary hypogonadism who had previously used topical testosterone, randomising them to oral enclomiphene citrate or testosterone gel. Both groups reached similar morning testosterone values at six months, but only the enclomiphene group showed higher LH and FSH, and sperm concentrations rose in every man in that group who was measured. Testosterone fell back to pre-treatment values one month after the study ended.\u003c\/p\u003e\n\u003cp\u003eA 2014 randomised phase II trial in men with secondary hypogonadism reported that oral enclomiphene citrate raised serum testosterone into the normal range while sperm concentration was maintained, whereas topical testosterone lowered sperm counts. Two phase III trials published in 2016 reported the same pattern in obese hypogonadal men, with adverse events recorded in both arms.\u003c\/p\u003e\n\u003ch3\u003eLimits of the evidence and regulatory outcome\u003c\/h3\u003e\n\u003cp\u003eThese studies were small or short, sponsored by the developer, and measured blood hormones and semen counts in men with a diagnosed condition rather than symptoms or long-term outcomes. Despite those data, the US application did not succeed: the FDA raised concerns about the trials and did not approve it. A European application did not lead to an authorisation either, so enclomiphene is not an authorised medicine in the UK, the EU or the US. Clomifene, its parent, is prescription-only in the UK. Nothing above is a claim about this product.\u003c\/p\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eManufacturer: Yakka Strength\u003c\/li\u003e\n\u003cli\u003eCompound: Enclomiphene\u003c\/li\u003e\n\u003cli\u003eForm: Capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStrength: the manufacturer does not state the amount per capsule on the label, so we do not list one\u003c\/li\u003e\n\u003cli\u003eBatch certificate of analysis: shown where Yakka Strength supplies one for the batch we hold\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBecause no strength is stated, the total milligrams per pack cannot be worked out from the label, and cost per milligram cannot be compared with listings that do state one. Our guide to \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e explains the comparison for products where the figure is known.\u003c\/p\u003e\n\u003ch2\u003eEnclomiphene in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eSearches such as \"enclomiphene uk buy\" and \"enclomiphene uk legal\" come down to two questions. Can an adult in the UK obtain enclomiphene lawfully, and how can a buyer tell a documented listing from an undocumented one.\u003c\/p\u003e\n\u003ch3\u003eWhere enclomiphene sits in UK law\u003c\/h3\u003e\n\u003cp\u003eEnclomiphene is not a licensed medicine in the UK, holds no MHRA marketing authorisation, and is not an authorised food supplement. It is not a controlled drug. It is sold for laboratory research to adults aged 18 and over and is not for human consumption. Its position differs from its parent: clomifene is a prescription-only medicine, supplied only against a prescription for licensed uses, whereas enclomiphene on its own has no licence to be prescribed against. It is not a SARM either, although some sellers file it under that heading; it acts on oestrogen receptors, not androgen receptors. SERMs including clomifene are named under section S4 (hormone and metabolic modulators) of the WADA Prohibited List. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eresearch guide\u003c\/a\u003e covers the wider legal picture.\u003c\/p\u003e\n\u003ch3\u003eWhat a documented UK listing shows\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA named manufacturer\u003c\/strong\u003e and a seller that can be identified and contacted in the UK.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA milligram figure on the label\u003c\/strong\u003e, with enclomiphene specified as citrate or free base.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA batch or lot number on the pack\u003c\/strong\u003e that can be matched to paperwork.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for that batch\u003c\/strong\u003e, from a named laboratory, with a date.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use terms\u003c\/strong\u003e: sales restricted to adults, with no usage directions or outcome promises.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClear delivery and returns terms\u003c\/strong\u003e, published before purchase.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow this listing compares with that list\u003c\/h3\u003e\n\u003cp\u003eThe manufacturer is named on the pack and the seller is FreeMuscle LTD, a UK company in Scunthorpe. UK orders go by free tracked delivery in plain packaging, orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3-7 working days, and unopened items can be returned within 30 days under our \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e. Details are on the \u003ca href=\"\/pages\/shipping\"\u003eshipping page\u003c\/a\u003e. The point this listing does not meet is strength: Yakka Strength prints no milligram figure, so any content figure can only come from a batch certificate where the manufacturer supplies one. A buyer who needs a stated strength and a certificate for every batch can compare \u003ca href=\"\/products\/enclomiphene-25mg-60-capsules-free-muscle\"\u003eFree Muscle enclomiphene\u003c\/a\u003e, whose batches are assayed by Janoshik Analytical. A longer checklist is in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eSearches for \"enclomiphene tablets\" arise because clomifene is dispensed as tablets, while research enclomiphene appears as capsules, tablets and occasionally liquids. The active molecule is identical across these formats; what varies is how precisely each unit is filled and how well the material is protected from moisture, air and light.\u003c\/p\u003e\n\u003cp\u003eCapsules and tablets both start as a powder blend of the compound and an inactive filler. How close each unit is to its target depends on how evenly that blend was mixed before filling, and the only way to check is to assay several units from the same batch. A liquid holds the compound in solution, so its content is a concentration: accuracy depends on complete dissolution, on the measuring device and on the solvent not evaporating over time, which would slowly concentrate what is left. Dry solids generally degrade more slowly than solutions.\u003c\/p\u003e\n\u003cp\u003eEnclomiphene is not a peptide, so the enzymatic breakdown in the gut that limits peptides given by mouth, discussed in \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e, does not apply to it. The published trials all gave enclomiphene citrate by mouth, which describes their design and says nothing about the performance of this product. The citrate point also matters for labels: a milligram figure for the salt contains less enclomiphene base than the same figure for the free base, so a strength is only comparable once the form is stated.\u003c\/p\u003e\n\u003ch2\u003eEnclomiphene compared with clomifene\u003c\/h2\u003e\n\u003cp\u003e\"Enclomiphene vs clomiphene\" is the most-searched comparison for this compound. Clomiphene is the US spelling; clomifene is the UK and international name. The answer is a matter of chemistry, evidence and regulation rather than one being better than the other.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eEnclomiphene\u003c\/th\u003e\n\u003cth\u003eClomifene\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eWhat it is\u003c\/td\u003e\n\u003ctd\u003eA single geometric isomer, (E) or trans\u003c\/td\u003e\n\u003ctd\u003eA mixture of the (E) isomer and the (Z) isomer, zuclomiphene\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBehaviour of the isomers\u003c\/td\u003e\n\u003ctd\u003eThe shorter-lived, oestrogen-blocking component\u003c\/td\u003e\n\u003ctd\u003eAlso contains zuclomiphene, which is longer-lived and weakly oestrogenic\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman evidence\u003c\/td\u003e\n\u003ctd\u003ePhase II and phase III trials in men with secondary hypogonadism, sponsored by the developer\u003c\/td\u003e\n\u003ctd\u003eDecades of clinical use in female infertility; the 2019 detection study in healthy men\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eNot licensed; sold for research only\u003c\/td\u003e\n\u003ctd\u003ePrescription-only medicine\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eSection S4, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eNamed in section S4, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThe two isomers share a formula and a mass but differ in shape, and that shape difference changes how they bind the oestrogen receptor and how long they stay in the body. The case for developing enclomiphene alone rested on removing the slow-clearing zuclomiphene from the mixture. The trials in men compared enclomiphene with testosterone gel, not with clomifene, so there is no head-to-head human trial of the two. Clomifene is not stocked by Free Muscle, because it is a prescription medicine; the only related collection we hold is the \u003ca href=\"\/collections\/enclomiphene\"\u003eenclomiphene collection\u003c\/a\u003e, which lists every brand of enclomiphene we carry. A longer treatment of the trials, with their adverse findings, is in our \u003ca href=\"\/blogs\/news\/enclomiphene-vs-clomifene-research-guide\"\u003eenclomiphene vs clomifene research guide\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eYakka Strength is a third-party brand in the Muscle Market range, so the testing position differs from our own label. Every Free Muscle-brand batch is assayed by Janoshik Analytical, an independent laboratory, with the certificate sent on request by email. For Yakka Strength products we show a certificate of analysis only where the manufacturer supplies one for the specific batch we hold. A generic PDF with no batch number is not a batch certificate, and we do not present one as such. If you want to know whether a certificate is held for the current batch, ask through our contact page.\u003c\/p\u003e\n\u003cp\u003eWhen a certificate is available, these are the lines to read:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e HPLC compares the retention time of the main peak with a reference standard; LC-MS adds the measured mass. For enclomiphene the isomer matters: enclomiphene and zuclomiphene have the same mass, so identity should be confirmed against an (E)-isomer reference. A report that says only \"clomiphene\" does not show which isomer is present.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Usually an HPLC peak-area percentage. It describes the material tested, not how much is in each capsule, and zuclomiphene is the impurity most worth looking for.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay or content.\u003c\/strong\u003e With no strength on this label, a measured amount per capsule is the only source of that number; check which form, salt or base, it refers to.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number and test date.\u003c\/strong\u003e The batch must match the pack; the date shows how old the analysis is relative to the stock.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIssuing laboratory.\u003c\/strong\u003e A named laboratory can be asked to confirm that it issued the report.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor a third-party brand a missing field has a plain meaning. No identity line leaves the compound unconfirmed; purity without content leaves the strength unknown; no batch number means the document cannot be tied to the pack in hand. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e and the article on \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e cover the general method, and our \u003ca href=\"\/pages\/contact\"\u003econtact page\u003c\/a\u003e is the route for requesting what we hold.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eEnclomiphene is prohibited in sport at all times, in and out of competition. SERMs including clomifene are named under section S4 (hormone and metabolic modulators) of the WADA Prohibited List. Enclomiphene, as an isomer of clomifene, falls within that class. Strict liability applies, including to a mislabelled product.\u003c\/p\u003e\n\u003cp\u003eThe controlled detection study cited here concerns clomifene rather than isolated enclomiphene. In 2019 an anti-doping laboratory gave clomifene citrate to 12 healthy men aged 25 to 38 for a month. Serum testosterone, LH and FSH rose during treatment, drug concentrations varied widely between individuals, and zuclomiphene stayed detectable in urine from 121 to more than 261 days. That long window belongs to the zuclomiphene component. No verified study reports a urinary window for enclomiphene given alone, so for this product the accurate statement is: detectable, window not established.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eKeep the pack sealed in its original container until it is needed, with the lid closed, in a cool, dry and dark place away from heaters, sunny windows, kitchens and bathrooms. Moisture is the main threat to capsules: gelatine and plant shells absorb water, soften and can stick together, and damp powder degrades faster. Warmth accelerates both processes, and each opening of the container lets in humid air.\u003c\/p\u003e\n\u003cp\u003eNo published stability study covers enclomiphene in capsule form that we are aware of, so the expiry or best-before date on the pack is the working limit, and the batch number should be recorded alongside the date the pack was opened. Do not decant capsules into unlabelled containers or mix them with another batch, because that breaks the link between the material and its certificate. Standard laboratory practice applies: gloves when handling opened capsules or loose powder, no food or drink in the working area, clear labelling, storage out of reach of children and pets, and disposal as chemical waste rather than in household bins or drains.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSERM\u003c\/strong\u003e: a compound whose effect at the oestrogen receptor depends on the tissue, acting as a blocker in some and an activator in others.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGeometric isomers\u003c\/strong\u003e: molecules with the same atoms and formula but a different fixed arrangement around a double bond, labelled (E) and (Z).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eZuclomiphene\u003c\/strong\u003e: the (Z) or cis isomer of clomifene, cleared from the body much more slowly than enclomiphene.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree base and citrate salt\u003c\/strong\u003e: the molecule alone, and the molecule paired with citric acid; the salt weighs more per unit of active compound.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSecondary hypogonadism\u003c\/strong\u003e: a testosterone shortfall that originates in the brain's hormone signals, with the testes themselves intact.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGonadotrophins\u003c\/strong\u003e: LH (luteinising hormone) and FSH (follicle-stimulating hormone), released by the pituitary gland to regulate the testes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC and LC-MS\u003c\/strong\u003e: liquid chromatography methods; HPLC separates a sample into peaks, and LC-MS adds a measurement of each molecule's mass.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCertificate of analysis (COA)\u003c\/strong\u003e: a dated test report tied by number to a single manufactured batch.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: the anti-doping rule that an athlete is responsible for any prohibited substance in their sample, regardless of intent.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/enclomiphene\"\u003eAll brands of Enclomiphene we stock, compared\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eAll Yakka Strength products\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/products\/yakka-strength-yakka-strength-rad140-enclomiphene-bundle\"\u003eYakka Strength RAD-140 and Enclomiphene bundle\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/enclomiphene-vs-clomifene-research-guide\"\u003eEnclomiphene vs clomifene: what the trials report\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/pages\/lab-tests\"\u003eBatch testing and certificates of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It has not been evaluated by the MHRA, EMA or FDA. It is not a medicine, not a food supplement and not for human consumption. Sold only to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice, and descriptions of published studies are not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eKaminetsky J, et al. Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel. J Sex Med. 2013;10(6):1628-35. PMID: 23530575.\u003c\/li\u003e\n\u003cli\u003eWiehle RD, et al. Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. Fertil Steril. 2014;102(3):720-7. PMID: 25044085.\u003c\/li\u003e\n\u003cli\u003eKim ED, et al. Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement. BJU Int. 2016;117(4):677-85. PMID: 26496621.\u003c\/li\u003e\n\u003cli\u003eMiller GD, et al. Hypothalamic-Pituitary-Testicular Axis Effects and Urinary Detection Following Clomiphene Administration in Males. J Clin Endocrinol Metab. 2019;104(3):906-914. PMID: 30295816.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982268130,"sku":null,"price":74.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-compound-front_600x_40eb8bc1-a140-490f-b210-64855f4197d5.png?v=1789931438"},{"product_id":"yakka-strength-yakka-strength-mk677","title":"Yakka Strength MK-677","description":"\u003cp\u003eYakka Strength MK-677 is a pack of 60 capsules of ibutamoren, the orally active growth hormone secretagogue better known by its development code MK-677. Yakka Strength manufactures it, and Free Muscle stocks it in the \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range for laboratory research by adults aged 18 and over. No per-capsule strength is given in the product information we hold for this listing, so none is quoted here.\u003c\/p\u003e\n\u003ch2\u003eAbout MK-677\u003c\/h2\u003e\n\u003cp\u003eIbutamoren is also sold as MK-677, MK-0677, L-163,191, ibutamoren mesylate (its salt form) and Nutrobal. Merck designed it in the 1990s as a non-peptide molecule that reproduces the action of the growth hormone releasing peptides while remaining active when swallowed. It is not a SARM and does not target the androgen receptor. It activates the ghrelin receptor, GHS-R1a, which signals the pituitary to release growth hormone in pulses; the liver answers with more insulin-like growth factor 1 (IGF-1).\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIdentifier\u003c\/th\u003e\n\u003cth\u003eIbutamoren (free base)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e159634-47-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e528.7 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInChIKey\u003c\/td\u003e\n\u003ctd\u003eUMUPQWIGCOZEOY-JOCHJYFZSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePubChem CID\u003c\/td\u003e\n\u003ctd\u003e178024\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThese PubChem values describe the free base. The 2011 trial below used ibutamoren mesylate, a salt, and that distinction matters on a certificate.\u003c\/p\u003e\n\u003ch3\u003eWhat the published research reports\u003c\/h3\u003e\n\u003cp\u003eUnusually for a research compound, ibutamoren has a real human trial record. In a 1996 placebo-controlled study, 32 healthy volunteers aged 64 to 81 were assigned to placebo or once-daily oral ibutamoren for two and four weeks. Growth hormone rose because existing pulses grew larger, not more frequent, and at the highest of the three daily amounts tested, IGF-1 reached the range typical of young adults. Fasting glucose and prolactin also rose.\u003c\/p\u003e\n\u003cp\u003eThe longest trial, published in 2008, randomised 65 healthy adults aged 60 to 81. Over the first year, fat-free mass rose by 1.1 kg with ibutamoren and fell by 0.5 kg with placebo, but strength and function did not change, total fat mass and abdominal visceral fat did not differ, and body weight and limb fat rose more than with placebo. Adverse findings included increased appetite, mild transient swelling of the lower legs, muscle pain, a 0.3 mmol\/L rise in fasting glucose, reduced insulin sensitivity and higher cortisol. The authors judged the study too small and short to assess function.\u003c\/p\u003e\n\u003cp\u003eIbutamoren mesylate was also tested in a 2011 phase IIb trial in 123 older people recovering from hip fracture. IGF-1 went up and gait speed improved, while stair-climbing power and several other functional measures did not. Congestive heart failure in a small number of patients led to the trial being halted early, and the investigators concluded that the adverse-effect profile was unfavourable in that group. Merck did not take ibutamoren to approval. These findings describe study participants and are not claims about this product.\u003c\/p\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCompound: MK-677 (Ibutamoren)\u003c\/li\u003e\n\u003cli\u003eBrand and manufacturer: Yakka Strength\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStrength per capsule: not stated in the product information we hold\u003c\/li\u003e\n\u003cli\u003eTotal per pack: cannot be calculated without a stated strength\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWith no stated strength, neither milligrams per pack nor cost per milligram can be worked out, so this pack cannot be ranked against brands that print a figure (method: \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e). Only a batch certificate can supply a measured content.\u003c\/p\u003e\n\u003ch2\u003eMK-677 in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eThree of the commonest UK searches, \"MK 677 UK legal\", \"MK677 UK buy\" and \"MK677 UK supplier\", raise two questions: may it be bought here, and what separates a sound seller from a poor one.\u003c\/p\u003e\n\u003ch3\u003eThe legal position\u003c\/h3\u003e\n\u003cp\u003eUK law does not list ibutamoren as a controlled drug, but being uncontrolled is not the same as being approved. Without an MHRA marketing authorisation it cannot be marketed as a medicine, and as it is neither an authorised food supplement nor an authorised novel food, it cannot be marketed as food. It cannot lawfully be sold for human consumption. That leaves supply as a research compound for laboratory work: the only way Free Muscle lists it, and only to buyers aged 18 or over. In sport it is banned at all times (see detection, below), and buyers are responsible for the rules that apply to them, including any anti-doping code. Detail is on our \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status in the UK\u003c\/a\u003e page.\u003c\/p\u003e\n\u003ch3\u003eWhat a trustworthy UK listing shows\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA lot number printed on the pack\u003c\/strong\u003e, which is what links the contents to any test result.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA batch-specific certificate of analysis\u003c\/strong\u003e, rather than a generic or undated PDF.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated strength per capsule\u003c\/strong\u003e, ideally saying whether it means free base or mesylate salt.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA manufacturer's name\u003c\/strong\u003e, plus a UK seller with a registered company and a way to reach it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use terms\u003c\/strong\u003e: 18+ only, no usage directions, no promised outcomes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTracked delivery in plain packaging\u003c\/strong\u003e and a published returns policy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow this listing measures up\u003c\/h3\u003e\n\u003cp\u003eMeasured against that list, the seller, research-use and delivery points are met outright. FreeMuscle LTD is a UK company in Scunthorpe, the manufacturer is named, and every order goes by free tracked UK delivery in plain packaging. Orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3-7 working days, and unopened items can be returned within 30 days. The certificate point depends on the batch, because a Yakka Strength COA is shown only where the manufacturer supplies one. The strength point is not met: the product information we hold gives no figure. Price searches meet the same limit: prices change and appear on the listing itself, and a fair comparison is price per milligram, which needs a stated strength. More checks are in our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eSearches for \"MK 677 tablet\", \"MK677 tablets\" and \"MK677 UK liquid\" show that ibutamoren turns up in several formats: capsules, pressed tablets and so-called research liquids. The active molecule does not change between them; the way each unit's content is fixed, and how well that content holds up, does.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCapsules\u003c\/strong\u003e contain a set fill of powder, normally mixed with a bulking excipient. How evenly that blend was mixed decides how consistent each capsule is, and the shell keeps the dry powder largely away from air and moisture.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTablets\u003c\/strong\u003e add compression and binders to the same blending step, so their content is likewise fixed when they are made.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiquids\u003c\/strong\u003e depend on complete and lasting dissolution, and each drawn volume is only as accurate as the pipette used. In solution most compounds degrade faster than when dry, and if solvent evaporates the concentration creeps upward.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBecause ibutamoren is a small non-peptide molecule, the enzymatic digestion that limits peptides taken by mouth does not apply to it in the same way; it was designed to be orally active, and the 1996 and 2008 trials above gave it by mouth. Peptide secretagogues are in the opposite position (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e). None of this suggests any format produces an effect. The practical difference is verification: a capsule certificate can report content per capsule, a liquid one reports concentration.\u003c\/p\u003e\n\u003ch2\u003eMK-677 compared with ipamorelin\u003c\/h2\u003e\n\u003cp\u003eOf the related compounds, ipamorelin is the one most often searched against this one (\"ibutamoren vs ipamorelin\"). The two share a receptor, GHS-R1a, and a mode of action: each makes the pituitary release growth hormone it already holds. Almost everything else that can be documented about them differs.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eMK-677 (ibutamoren)\u003c\/th\u003e\n\u003cth\u003eIpamorelin\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical type\u003c\/td\u003e\n\u003ctd\u003eNon-peptide small molecule\u003c\/td\u003e\n\u003ctd\u003eSynthetic pentapeptide\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S\u003c\/td\u003e\n\u003ctd\u003eC38H49N9O5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e528.7 g\/mol\u003c\/td\u003e\n\u003ctd\u003e711.9 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOrigin\u003c\/td\u003e\n\u003ctd\u003eMerck, 1990s\u003c\/td\u003e\n\u003ctd\u003eNovo Nordisk, described 1998\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman trials\u003c\/td\u003e\n\u003ctd\u003eSeveral randomised trials, up to two years\u003c\/td\u003e\n\u003ctd\u003eFew, none measuring muscle or strength that we know of\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eUnlicensed research compound\u003c\/td\u003e\n\u003ctd\u003eUnlicensed research compound\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS2.2.4, named\u003c\/td\u003e\n\u003ctd\u003eS2.2.4, named\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eFirst, route: ibutamoren was built to survive the gut, whereas ipamorelin is a chain of five amino acids of the kind digestive enzymes break down, so oral ipamorelin products have no published clinical evidence behind them that we know of. Second, evidence: ibutamoren's trials measured body composition and recorded adverse effects, from raised glucose to the heart failure signal after hip fracture, while ipamorelin's human literature is thin. Third, status, where they converge: neither is licensed in the UK or a controlled drug, and WADA names both in section S2.2.4 as growth hormone secretagogues, prohibited at all times.\u003c\/p\u003e\n\u003cp\u003eA PubMed search for both names together returns reviews, chemistry and animal work but no head-to-head trial in people, so neither can be called stronger, and we do not rank research compounds by effect. Brands held are in the \u003ca href=\"\/collections\/ipamorelin\"\u003eipamorelin collection\u003c\/a\u003e, both are set against prescription somatropin in \u003ca href=\"\/blogs\/news\/mk-677-vs-ipamorelin-vs-hgh\"\u003eMK-677 vs ipamorelin vs somatropin\u003c\/a\u003e, and the peptide's own studies are summarised in the \u003ca href=\"\/blogs\/news\/ipamorelin-research-guide\"\u003eipamorelin research guide\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eYakka Strength manufactures this product, so a certificate of analysis (COA) for it can only come from them. We display one only when they have provided it for the batch in our stock, either linked here or emailed on request; where there is none, we state that plainly instead of posting a generic PDF. Free Muscle's own \u003ca href=\"\/collections\/mk-677-ibutamoren\"\u003eMK-677 capsules\u003c\/a\u003e (10mg, 12.5mg and 25mg) are assayed batch by batch at Janoshik Analytical, an independent laboratory; that does not extend to Yakka Strength. On a Yakka Strength certificate, read:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity (HPLC or LC-MS).\u003c\/strong\u003e HPLC infers identity from a peak matching a reference standard's retention time. LC-MS measures mass: ibutamoren gives a protonated ion near m\/z 529, whether the sample was free base or mesylate, because the salt partner separates in solution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity (%).\u003c\/strong\u003e An HPLC peak-area share. It grades the material, not the capsule, and gives no milligram figure.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule, and in which form.\u003c\/strong\u003e The line this product needs most. Methanesulfonic acid adds about 96 g\/mol, so free base is roughly 85 per cent of the mesylate salt by mass (528.7 divided by about 624.8); the two figures are not interchangeable.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number.\u003c\/strong\u003e Must match the lot on the pack in hand.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTest date and laboratory.\u003c\/strong\u003e Shows the result's age and who can confirm it.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eGaps have plain consequences here. Without identity, nothing confirms the capsules hold ibutamoren; purity with no content line leaves the amount per capsule unknown; a missing or different batch number means the report belongs to another batch. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the lot number and we will confirm what exists for current stock. See also \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eWADA bans ibutamoren at all times, in and out of competition. Section S2.2.4 (growth hormone releasing factors) names \"ibutamoren (MK-677)\" as an example of a growth hormone secretagogue, and every substance in section S2 is non-Specified. Because it is named on the list, WADA-accredited laboratories test for it, and strict liability applies: an athlete answers for any prohibited substance in their sample, whatever its source.\u003c\/p\u003e\n\u003cp\u003eFor urine, the usual sample, a PubMed search found metabolism studies in horses but no published human excretion study, so the accurate statement is: detectable, window not established. Hair has some human data. In a forensic study from Strasbourg, ibutamoren was measured at 1.3 pg\/mg in a male volunteer's hair collected four weeks after a single exposure (detection limit 0.1 pg\/mg), and at 224 pg\/mg in hair from a person who had taken it repeatedly for sporting purposes. Anyone subject to testing should assume exposure will be found.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eKeep the pack closed in its original container somewhere cool, dry and dark, away from radiators, sunny windows and kitchen steam. Humidity is the main threat: shells absorb water and soften or fuse, and damp powder breaks down faster, while hot, very dry air makes shells brittle. If the pack is refrigerated, let it reach room temperature before opening so condensation does not form inside, and leave any desiccant sachet in the tub.\u003c\/p\u003e\n\u003cp\u003eShelf-life data for ibutamoren capsules do not appear in any published literature we could find, so the printed expiry or best-before date, where there is one, sets the limit. Record when the pack was first opened alongside its batch number. Handle it as a laboratory reagent: gloves for opened capsules or loose powder, away from food and drink, out of reach of children and animals, any removed portion labelled with compound, batch and date, and waste disposed of as chemical waste, not in household bins or drains. Never decant capsules into an unlabelled container; the batch number on the original pack is the only link to a certificate.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth hormone secretagogue\u003c\/strong\u003e: the drug class ibutamoren belongs to, defined by causing the pituitary to secrete more of its own growth hormone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGHS-R1a\u003c\/strong\u003e: the receptor through which the stomach hormone ghrelin acts; ibutamoren and ipamorelin both activate it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1\u003c\/strong\u003e: insulin-like growth factor 1, a hormone whose blood level tracks growth hormone output, most of it produced by the liver.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePulsatile secretion\u003c\/strong\u003e: the pattern in which growth hormone leaves the pituitary as a series of peaks, not a constant flow.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIbutamoren mesylate\u003c\/strong\u003e: the methanesulfonic acid salt of ibutamoren, heavier than the free base.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree base\u003c\/strong\u003e: the molecule without a salt partner.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFat-free mass\u003c\/strong\u003e: body mass minus fat, including water, so it rises with fluid retention as well as tissue.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOedema\u003c\/strong\u003e: swelling from fluid collecting in tissues.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInsulin sensitivity\u003c\/strong\u003e: the degree to which muscle, liver and fat respond to insulin; lower sensitivity means glucose is cleared from the blood less readily.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLC-MS\u003c\/strong\u003e: a liquid chromatograph feeding a mass spectrometer, so each separated component is also weighed as ions; the firmer identity test.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003em\/z\u003c\/strong\u003e: mass-to-charge ratio, the value a mass spectrometer reports.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCertificate of analysis (COA)\u003c\/strong\u003e: one batch's laboratory results (identity, purity and content where measured), dated and carrying that batch's number.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection\u003c\/a\u003e: all brands held, with strength, pack size and testing set out for each\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eAll Yakka Strength products\u003c\/a\u003e at Free Muscle\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677 (ibutamoren): what the research says\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eNot for human consumption. This Yakka Strength pack is supplied for laboratory research use only; it is neither a licensed medicine nor a food supplement, and neither the MHRA nor the EMA or FDA has evaluated it. Orders are restricted to adults aged 18 and over, and nothing on this page amounts to medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eChapman IM, et al. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. J Clin Endocrinol Metab. 1996;81(12):4249-57. PMID: 8954023.\u003c\/li\u003e\n\u003cli\u003eNass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-11. PMID: 18981485.\u003c\/li\u003e\n\u003cli\u003eAdunsky A, et al. MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Arch Gerontol Geriatr. 2011;53(2):183-9. PMID: 21067829.\u003c\/li\u003e\n\u003cli\u003eKintz P, Gheddar L. Knowing the minimal detectable dose can facilitate the interpretation of a hair test result: II. Case example with ibutamoren (MK-677), a growth hormone secretagogue. Clin Chim Acta. 2026;578:120578. PMID: 40882886.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982300898,"sku":null,"price":64.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-capsules-front_600x_6e57c70d-5291-4057-8ead-6a5eefaa09ab.png?v=1789931440"},{"product_id":"yakka-strength-yakka-strength-mk677-bpc157-capsule-bundle","title":"Yakka Strength MK-677 \u0026 BPC-157 Capsule Bundle","description":"\u003cp\u003eThe Yakka Strength MK-677 and BPC-157 capsule bundle pairs ibutamoren (MK-677), an orally active growth hormone secretagogue, with BPC-157, a synthetic gastric pentadecapeptide, from the same manufacturer in one listing within our \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range. Yakka Strength lists the pack as 60 capsules and does not state a content per capsule, so we quote none. Supplied to adults for laboratory research only and not for human consumption.\u003c\/p\u003e\u003cp\u003eA bundle is a listing convenience only: it lets separately packaged products from one manufacturer be ordered in a single purchase. Nothing on this page claims that they act together or should be studied together, and Free Muscle publishes no stack or cycle guidance for any product.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eMK-677 (Ibutamoren)\u003c\/h3\u003e\u003cp\u003eIbutamoren (MK-677, L-163,191, nutrobal) is not a SARM but an orally active ghrelin receptor (GHS-R1a) agonist, a growth hormone secretagogue. In a placebo-controlled trial in 65 healthy adults aged 60 to 81, growth hormone and IGF-1 rose over one year; fat-free mass rose by about 1.1 kg while it fell by about 0.5 kg on placebo, with no change in strength or function. Reported adverse findings included increased appetite, mild leg oedema, higher fasting glucose, reduced insulin sensitivity and raised cortisol. Never approved. WADA class S2. Compare brands on the \u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eBPC-157\u003c\/h3\u003e\u003cp\u003eBPC-157 is a synthetic fifteen-amino-acid peptide based on a sequence from a human gastric protein. Almost all published work is rodent and cell research, largely from one Croatian group, covering animal models of gut, tendon, muscle and vascular injury. No controlled human trial has been published, and oral absorption of any peptide is unproven. WADA lists it under S0 (non-approved substances). Compare brands on the \u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157 collection page\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eThe first formal pharmacokinetic study of BPC-157, published in 2022 by a group in Xi'an, gave the peptide to rats and beagle dogs by intravenous and intramuscular injection. The unchanged peptide had an elimination half-life under 30 minutes, bioavailability after intramuscular injection was roughly 14-19% in rats and 45-51% in dogs, and radiolabelled material was quickly broken into small fragments and single amino acids, excreted mainly in urine and bile. The study included no oral arm, so it says nothing directly about capsules; it does show how short-lived the intact molecule was even when injected.\u003c\/p\u003e\u003ch3\u003eChemical identifiers\u003c\/h3\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eProperty\u003c\/th\u003e\n\u003cth\u003eIbutamoren\u003c\/th\u003e\n\u003cth\u003eBPC-157\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical class\u003c\/td\u003e\n\u003ctd\u003eSpiroindoline small molecule\u003c\/td\u003e\n\u003ctd\u003eLinear peptide of 15 residues\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePeptide bonds\u003c\/td\u003e\n\u003ctd\u003eNone in the backbone\u003c\/td\u003e\n\u003ctd\u003eFourteen\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S\u003c\/td\u003e\n\u003ctd\u003eC62H98N16O22\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e528.7 g\/mol\u003c\/td\u003e\n\u003ctd\u003e1419.5 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e159634-47-6\u003c\/td\u003e\n\u003ctd\u003e137525-51-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePubChem CID\u003c\/td\u003e\n\u003ctd\u003e178024\u003c\/td\u003e\n\u003ctd\u003e9941957\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eFigures are from PubChem; an identity result on a certificate should match them. BPC-157 here is in capsule form. Our article \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003eDo oral peptides actually work?\u003c\/a\u003e covers why oral absorption of peptides remains unproven.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: Yakka Strength (third-party brand, Muscle Market)\u003c\/li\u003e\n\u003cli\u003eCompounds: ibutamoren (MK-677) and BPC-157\u003c\/li\u003e\n\u003cli\u003eForm and pack size: 60 capsules, as listed by the manufacturer\u003c\/li\u003e\n\u003cli\u003eContent per capsule: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eCOA: only where Yakka Strength supplies one for the batch held\u003c\/li\u003e\n\u003cli\u003eBuyers: adults aged 18 and over, for laboratory research only\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eBecause no milligram figure is given for either compound, the total content of the pack cannot be worked out, and the bundle cannot be compared with single packs on cost per milligram. Our guide to \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e explains the method for listings that do state strength. Yakka Strength also sells \u003ca href=\"\/products\/yakka-strength-yakka-strength-mk677\"\u003eMK-677\u003c\/a\u003e and \u003ca href=\"\/products\/yakka-strength-yakka-strength-bpc157-peptide-capsules\"\u003eBPC-157 capsules\u003c\/a\u003e as separate listings.\u003c\/p\u003e\u003ch2\u003eMK-677 and BPC-157 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"MK677 UK buy\", \"MK 677 UK legal\" and \"BPC 157 capsules UK\" ask whether a purchase is lawful and how to tell a documented seller from an undocumented one.\u003c\/p\u003e\u003ch3\u003eLegal status, compound by compound\u003c\/h3\u003e\u003cp\u003e\u003cstrong\u003eMK-677.\u003c\/strong\u003e Ibutamoren has never been authorised as a medicine in the UK or anywhere else, and it is not listed under the Misuse of Drugs Act. Our \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status page\u003c\/a\u003e sets out the position in more detail.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBPC-157.\u003c\/strong\u003e The peptide has no marketing authorisation in any country and is not a controlled drug in the UK. It is not an authorised food supplement, so capsule packaging does not make it a food product.\u003c\/p\u003e\u003cp\u003eNone of the compounds on this page is a licensed medicine in the United Kingdom, none has been assessed by the MHRA and none is an authorised food supplement. Free Muscle supplies them to adults aged 18 and over for laboratory research only. They are not for human consumption. MK-677 falls under WADA class S2 and BPC-157 under S0. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e has more background.\u003c\/p\u003e\u003ch3\u003eSigns of a well-documented listing\u003c\/h3\u003e\u003cp\u003eWhatever the compound, the same questions separate a seller who can account for its stock from one who cannot:\u003c\/p\u003e\u003col\u003e\n\u003cli\u003eIs the manufacturer named, and does each container carry a lot or batch number?\u003c\/li\u003e\n\u003cli\u003eIs there a certificate of analysis for that lot, from a named laboratory, rather than a generic document reused across batches?\u003c\/li\u003e\n\u003cli\u003eIs the strength stated, or does the listing say plainly that it is not?\u003c\/li\u003e\n\u003cli\u003eIs sale restricted to adults, with no dosing directions or promised results?\u003c\/li\u003e\n\u003cli\u003eIs the seller a traceable UK business with published delivery and returns terms?\u003c\/li\u003e\n\u003c\/ol\u003e\u003ch3\u003eHow this listing measures up\u003c\/h3\u003e\u003cp\u003eFreeMuscle LTD is a UK company based in Scunthorpe. Every order goes by free tracked UK delivery in plain packaging, orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3-7 working days, and unopened items may be returned within 30 days (see \u003ca href=\"\/pages\/shipping\"\u003eshipping\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eour guarantee\u003c\/a\u003e). The manufacturer is named. Two points depend on Yakka Strength: the label states no content per capsule for either compound, so question three is answered by that disclosure rather than a figure, and a certificate is displayed only where the manufacturer supplies one for the batch we hold. The \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e goes through each check in more depth.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eBoth compounds are sold as capsules, tablets and liquids, and BPC-157 also as freeze-dried powder for reconstitution. The molecule is identical in each; what differs is the route research used and how well the material keeps.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eIbutamoren\u003c\/strong\u003e was built as a non-peptide precisely so that it would survive being swallowed. The randomised human trials, including the one-year study summarised above, gave it by mouth, so a capsule matches the route that was studied.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBPC-157\u003c\/strong\u003e is different. Most rodent studies gave it by injection into the abdominal cavity, with a smaller number adding it to drinking water, and the 2022 pharmacokinetic study used only intravenous and intramuscular routes. No study has measured blood levels in people after an oral dose. A fifteen-residue chain is exactly the kind of substrate that stomach and intestinal enzymes are there to break down. The question of routes is covered at length in \u003ca href=\"\/blogs\/news\/bpc-157-capsules-vs-injection-what-studies-used\"\u003eBPC-157 capsules vs injection: what the studies used\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eOn stability, dry formats generally hold up better than solutions, in which hydrolysis and microbial contamination can start. On consistency, a capsule's content is set when powder is blended and filled, so only a content test on individual capsules shows whether fill is even; a liquid depends on full dissolution and accurate measuring. Neither point implies that any format produces an effect.\u003c\/p\u003e\u003ch2\u003eBPC-157 compared with TB-500\u003c\/h2\u003e\u003cp\u003eBPC-157 is often listed alongside TB-500, but they are unrelated molecules with separate literatures.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eBPC-157\u003c\/th\u003e\n\u003cth\u003eTB-500\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOrigin\u003c\/td\u003e\n\u003ctd\u003eSequence taken from a protein in human gastric juice\u003c\/td\u003e\n\u003ctd\u003eSynthetic fragment of thymosin beta-4, a 43-residue actin-binding protein found in most cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSize\u003c\/td\u003e\n\u003ctd\u003e15 residues, 1419.5 g\/mol\u003c\/td\u003e\n\u003ctd\u003eA short fragment of a protein of about 4,963 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMain research base\u003c\/td\u003e\n\u003ctd\u003eRodent and cell models, mostly from one group\u003c\/td\u003e\n\u003ctd\u003ePreclinical and early clinical work on the full thymosin beta-4 protein; little on the fragment itself\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman trials\u003c\/td\u003e\n\u003ctd\u003eNo controlled trial published\u003c\/td\u003e\n\u003ctd\u003eEarly trials of full thymosin beta-4 in skin, eye and heart; none of TB-500 as sold\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eUnlicensed, research use only\u003c\/td\u003e\n\u003ctd\u003eUnlicensed, research use only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA section\u003c\/td\u003e\n\u003ctd\u003eS0, non-approved substances\u003c\/td\u003e\n\u003ctd\u003eS2, named with thymosin beta-4 and its derivatives\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThe proposed mechanisms also differ. BPC-157 work has concentrated on gut, tendon and vascular injury models in animals, while thymosin beta-4 binds actin, part of the cell skeleton, and a 2012 review described its study in wound, corneal and cardiac repair models and ongoing or planned clinical trials. Findings for the full protein cannot be assumed to apply to the fragment sold as TB-500, and neither literature can be assumed to transfer to the other peptide. No trial has compared the two. The \u003ca href=\"\/collections\/tb-500\"\u003eTB-500 collection\u003c\/a\u003e lists the brands we hold, and the \u003ca href=\"\/blogs\/news\/tb-500-thymosin-beta-4-research-guide\"\u003eTB-500 and thymosin beta-4 research guide\u003c\/a\u003e summarises its studies. For MK-677 the closest relative is ipamorelin, compared in \u003ca href=\"\/blogs\/news\/mk-677-vs-ipamorelin-vs-hgh\"\u003eMK-677 vs ipamorelin vs somatropin\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eYakka Strength is a third-party brand sold through Muscle Market. For third-party brands we display a certificate of analysis only where the manufacturer supplies one for the exact batch we hold; if none is shown, none has been supplied and we do not substitute a generic document. Free Muscle-brand products, by contrast, are assayed batch by batch at Janoshik Analytical, with the certificate sent on request by email. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab testing page\u003c\/a\u003e explains what a certificate shows.\u003c\/p\u003e\u003cp\u003eA two-compound bundle should come with two results, one per container. When reading either, check these lines in order:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSample description.\u003c\/strong\u003e The report should name ibutamoren or BPC-157 and describe the sample as capsules. A report headed only with the bundle name leaves open which material was tested.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity method.\u003c\/strong\u003e HPLC compares the time at which a peak leaves the column with a reference standard. LC-MS adds a mass measurement, which is more specific. For ibutamoren the expected mass corresponds to 528.7 g\/mol; for BPC-157, 1419.5 g\/mol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e The target compound's percentage share of what the instrument detected. It describes cleanliness, not how much is in each capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay or content.\u003c\/strong\u003e A milligram figure per capsule would supply what the Yakka Strength label leaves blank. With BPC-157, see whether it is expressed as net peptide or as total powder weight.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number, date and laboratory.\u003c\/strong\u003e Set the report's lot code beside the one on the container; a mismatch ends the check there. A dated report from a named laboratory can be followed up.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eWhat a missing field means is straightforward. No identity line: nothing confirms the compound. No content line: the strength remains unknown, as it is on this label. No matching batch number: the report describes other material. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the batch numbers from your containers and we will tell you what exists for current stock. Our article on \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e covers the same lines in more detail.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eBoth compounds are prohibited at all times, in and out of competition, under the World Anti-Doping Code, which UK Anti-Doping enforces for British sport. Ibutamoren appears in section S2 among growth hormone secretagogues. BPC-157 is named in section S0, which covers pharmacological substances with no current approval for human therapeutic use. The anti-doping rule of strict liability means an athlete is responsible for any prohibited substance found in a sample, whatever a label said and whatever the intention.\u003c\/p\u003e\u003cp\u003eNone of the references on this page establishes how long either stays detectable in human urine or blood after exposure, so the accurate statement is: detectable, window not established. The short half-life measured in animals for intact BPC-157 is not a detection window, because testing can target metabolites as well as the parent molecule. Anyone subject to testing should treat exposure to either compound as incompatible with competition.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eNo stability study has been published for either compound in capsule form, so the manufacturer's expiry or best-before date, where printed, is the limit to work to. The two molecules have different weak points. BPC-157, as a peptide, is vulnerable to moisture, because water slowly hydrolyses peptide bonds, and to heat, which speeds that reaction. Ibutamoren has no peptide backbone, but is still best kept from damp, heat and direct light, and capsule shells themselves soften in humidity and turn brittle in dry heat.\u003c\/p\u003e\u003cp\u003eKeep each container tightly closed in a cool, dry and dark place, with any desiccant sachet left inside. If containers are kept in a fridge, allow them to reach room temperature before opening so that condensation does not form on the contents. Keep each compound in its original labelled container so the lot number stays with it. As laboratory reagents they should be handled with gloves once capsules are opened, kept apart from food and drink, stored out of reach of children and animals, and disposed of as chemical waste rather than in household rubbish or drains.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGhrelin\u003c\/strong\u003e: a hormone released mainly by the stomach; its receptor is the target of ibutamoren.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGHS-R1a\u003c\/strong\u003e: the growth hormone secretagogue receptor type 1a, the ghrelin receptor.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth hormone secretagogue\u003c\/strong\u003e: any compound whose action is to trigger growth hormone release from pituitary stores rather than to replace the hormone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1\u003c\/strong\u003e: insulin-like growth factor 1; its blood level is the usual marker researchers use to track growth hormone activity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePentadecapeptide\u003c\/strong\u003e: from the Greek for fifteen; BPC-157 is so called because its chain has fifteen amino acids.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHalf-life\u003c\/strong\u003e: the time taken for the concentration of a substance in blood to fall by half.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBioavailability\u003c\/strong\u003e: the fraction of a dose that reaches the circulation unchanged.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHydrolysis\u003c\/strong\u003e: breakdown of a chemical bond by water; the main route by which peptides degrade in storage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC and LC-MS\u003c\/strong\u003e: laboratory methods that separate a sample; LC-MS also measures molecular mass.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay\u003c\/strong\u003e: a measurement of how much of a compound a sample contains, as distinct from its purity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: the anti-doping principle that an athlete is responsible for any prohibited substance in a sample.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157 collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/tb-500\"\u003eTB-500 collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eYakka Strength brand page\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/peptides\"\u003ePeptides collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eBundles collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003eResearch articles: \u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677: what the research says\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/bpc-157-what-research-shows\"\u003eBPC-157: what research shows\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eSupplied for laboratory research use only. Not a medicine, not evaluated by the MHRA, EMA or FDA, and not for human consumption. Buyers must be 18 or over. Nothing on this page is medical or dosing advice or a recommendation to use, stack or cycle any compound; research summaries describe findings in study participants or animals, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eNass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-11. PMID: 18981485.\u003c\/li\u003e\n\u003cli\u003eSikiric P, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857-865. PMID: 27138887.\u003c\/li\u003e\n\u003cli\u003eHe L, et al. Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. Front Pharmacol. 2022;13:1026182. PMID: 36588717.\u003c\/li\u003e\n\u003cli\u003eGoldstein AL, et al. Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. PMID: 22074294.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982366434,"sku":null,"price":111.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-capsule-bundle-front-g_600x_c5de8613-da5f-4500-939b-b383c4161ef4.png?v=1789931442"},{"product_id":"yakka-strength-yakka-strength-mk677-tb500-capsule-bundle","title":"Yakka Strength MK-677 \u0026 TB-500 Capsule Bundle","description":"\u003cp\u003eThe Yakka Strength MK-677 and TB-500 capsule bundle lists ibutamoren (MK-677), a growth hormone secretagogue, together with TB-500, a synthetic fragment of thymosin beta-4, from one manufacturer in a single order through our \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range. Yakka Strength lists the pack as 60 capsules. No content per capsule is stated by the manufacturer on this listing, so we do not quote one. Supplied to adults for laboratory research only and not for human consumption.\u003c\/p\u003e\u003cp\u003eA bundle is a listing convenience only: it lets separately packaged products from one manufacturer be ordered in a single purchase. Nothing on this page claims that they act together or should be studied together, and Free Muscle publishes no stack or cycle guidance for any product.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eMK-677 (Ibutamoren)\u003c\/h3\u003e\u003cp\u003eIbutamoren (MK-677, L-163,191, nutrobal) is not a SARM but an orally active ghrelin receptor (GHS-R1a) agonist, a growth hormone secretagogue. Unusually for this market it has real human data. A one-year randomised trial in healthy older adults reported sustained rises in growth hormone and IGF-1, a 1.1 kg rise in fat-free mass against a 0.5 kg fall with placebo, but no change in strength or function, alongside increased appetite, mild leg swelling from fluid retention, muscle pain, higher fasting glucose, reduced insulin sensitivity and a rise in cortisol. Never approved. WADA class S2. Compare brands on the \u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eA later phase IIb trial tested the compound, under the code MK-0677, in 123 older patients recovering from hip fracture. Blood IGF-1 rose clearly against placebo and gait speed improved modestly, but most other measures of physical function did not change, and the study was stopped early after a small number of patients developed congestive heart failure. The authors concluded that the compound had an unfavourable safety profile in that population.\u003c\/p\u003e\u003ch3\u003eTB-500 (Thymosin Beta-4 fragment)\u003c\/h3\u003e\u003cp\u003eTB-500 is the market name for a synthetic fragment of thymosin beta-4, a 43-amino-acid actin-binding peptide made in the body. Reviews of thymosin beta-4 cover preclinical wound, corneal and cardiac repair models and early clinical trials of the full peptide. TB-500 itself has no published human data. WADA names thymosin beta-4 and its derivatives, including TB-500, under S2. Compare brands on the \u003ca href=\"\/collections\/tb-500\"\u003eTB-500 (Thymosin Beta-4 fragment) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eWhat TB-500 actually contains was settled analytically rather than clinically. In 2012 the Ghent anti-doping laboratory examined a product sold as TB-500 by high-resolution mass spectrometry and found the acetylated 17-23 fragment of thymosin beta-4, Ac-LKKTETQ, a seven-residue peptide, instead of the whole protein. So a TB-500 label and the thymosin beta-4 literature need not describe the same molecule.\u003c\/p\u003e\u003ch3\u003eAt a glance\u003c\/h3\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eIbutamoren (MK-677)\u003c\/th\u003e\n\u003cth\u003eTB-500\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical class\u003c\/td\u003e\n\u003ctd\u003eSpiro-piperidine small molecule, no peptide bonds\u003c\/td\u003e\n\u003ctd\u003ePeptide, usually the acetylated seven-residue fragment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula (PubChem)\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S, 528.7 g\/mol, CAS 159634-47-6\u003c\/td\u003e\n\u003ctd\u003eParent protein C212H350N56O78S, about 4,963 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTarget\u003c\/td\u003e\n\u003ctd\u003eGhrelin receptor on the pituitary\u003c\/td\u003e\n\u003ctd\u003eBinds G-actin inside cells (parent protein)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman trial data\u003c\/td\u003e\n\u003ctd\u003eYes, randomised, taken by mouth\u003c\/td\u003e\n\u003ctd\u003eNone for TB-500; limited for the full protein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA section\u003c\/td\u003e\n\u003ctd\u003eS2\u003c\/td\u003e\n\u003ctd\u003eS2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: Yakka Strength (third-party brand, Muscle Market)\u003c\/li\u003e\n\u003cli\u003eCompounds: ibutamoren (MK-677) and TB-500 (thymosin beta-4 fragment)\u003c\/li\u003e\n\u003cli\u003eForm and pack size: 60 capsules, as listed by the manufacturer\u003c\/li\u003e\n\u003cli\u003eContent per capsule: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eWhich TB-500 molecule: not stated on the label\u003c\/li\u003e\n\u003cli\u003eCOA: only where Yakka Strength supplies one for the batch held\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eBecause neither compound carries a stated content, milligrams per pack cannot be worked out and the bundle cannot be compared with single packs on cost per milligram; our \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram guide\u003c\/a\u003e sets out the method for products that do state a strength. The same manufacturer's \u003ca href=\"\/products\/yakka-strength-yakka-strength-mk677\"\u003eMK-677 capsules\u003c\/a\u003e and \u003ca href=\"\/products\/yakka-strength-yakka-strength-tb500-peptide-capsules\"\u003eTB-500 capsules\u003c\/a\u003e are also listed on their own.\u003c\/p\u003e\u003ch2\u003eMK-677 and TB-500 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"MK677 UK buy\" and \"MK 677 UK legal\" ask two things: is the purchase lawful, and can the seller show what is in the container.\u003c\/p\u003e\u003ch3\u003eWhere the law stands\u003c\/h3\u003e\u003cp\u003eNone of the compounds on this page is a licensed medicine in the United Kingdom, none has been assessed by the MHRA and none is an authorised food supplement. MK-677 and TB-500 are not controlled substances in the UK, but that is not approval: neither may lawfully be marketed for people to take. Free Muscle supplies them to adults aged 18 and over for laboratory research only. They are not for human consumption. Both MK-677 and TB-500 fall under WADA class S2. See our \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status page\u003c\/a\u003e. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e has more background.\u003c\/p\u003e\u003ch3\u003eSigns of a listing worth trusting\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated strength for each compound\u003c\/strong\u003e, or an open statement that the manufacturer gives none.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe exact molecule named\u003c\/strong\u003e: for TB-500 that means saying whether it is the Ac-LKKTETQ fragment or full thymosin beta-4.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA lot number printed on each container\u003c\/strong\u003e and repeated on the certificate that goes with it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate per compound per batch\u003c\/strong\u003e, from a named laboratory, not a single report headed with the bundle name.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-only wording\u003c\/strong\u003e: 18+, no instructions, no promised outcomes, no before-and-after images.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA UK company you can write to\u003c\/strong\u003e, tracked delivery, plain packaging and a published returns policy.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eHow this listing measures up\u003c\/h3\u003e\u003cp\u003eThe seller side is met. FreeMuscle LTD is a UK company based in Scunthorpe; every order ships by free tracked UK delivery in plain packaging, orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3-7 working days, and unopened items can be returned within 30 days. The product side depends on Yakka Strength. The label names both compounds but states no content for either and does not say which TB-500 molecule is used, so those checks are not met from the label alone. A certificate is shown only where the manufacturer supplies one for the batch we hold. The full set of checks is in our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eIn the UK research market ibutamoren is found as capsules, tablets and liquid (\"MK677 UK liquid\" is a frequent search), while TB-500 is most often sold as freeze-dried powder in vials, with capsules a more recent format. The molecule is the same; the evidence behind each route is not.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eIbutamoren.\u003c\/strong\u003e Merck designed it as a non-peptide precisely so that it would remain active when swallowed, and both trials summarised above gave it by mouth. A capsule is therefore the route its literature actually studied. In a liquid, hydrolysis, evaporation and incomplete dissolution can shift the concentration; a capsule fixes its fill at manufacture, so its consistency rests on how evenly the powder was blended.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTB-500.\u003c\/strong\u003e Here the capsule is the unusual choice. The thymosin beta-4 programmes used injection or direct application to eye, skin or heart tissue, and no published study has given either the full protein or the Ac-LKKTETQ fragment by mouth and measured it in blood. Peptides face digestive enzymes that cut the bonds between amino acids. Our article \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003eDo oral peptides actually work?\u003c\/a\u003e sets out what is and is not known about oral peptide absorption. None of this implies that any format produces an effect.\u003c\/p\u003e\u003ch2\u003eTB-500 compared with BPC-157, and MK-677 with ipamorelin\u003c\/h2\u003e\u003cp\u003eEach compound in this bundle has one relative it is searched against far more than any other: \"TB 500 vs BPC 157\" and \"ibutamoren vs ipamorelin\".\u003c\/p\u003e\u003ch3\u003eTB-500 and BPC-157\u003c\/h3\u003e\u003cp\u003eThe two peptides are often shelved together, but they share neither origin nor mechanism. TB-500 traces back to thymosin beta-4, a protein that sits inside cells and holds single actin units in reserve. BPC-157 is a 15-amino-acid sequence taken from a protein found in gastric juice, and nearly all of its published work comes from rodent gut, tendon and blood vessel models. Neither peptide has a published controlled human trial. The clearest practical difference is definition: BPC-157 is one fixed sequence, so identity testing is simple, whereas \"TB-500\" has been applied to more than one molecule, so a certificate has to say which it found. The two also sit in different parts of the WADA list, TB-500 under S2 and BPC-157 under S0 for non-approved substances. Brands we hold are in the \u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157 collection\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eMK-677 and ipamorelin\u003c\/h3\u003e\u003cp\u003eHere the comparison is closer, because both act at the same ghrelin receptor and prompt the pituitary to release growth hormone it already stores. The differences are structure and evidence. Ibutamoren is a small molecule tested by mouth in randomised human trials, with the adverse findings described above. Ipamorelin is a five-residue peptide developed by Novo Nordisk in the 1990s, studied mostly by injection and with a far thinner human literature. Neither is licensed in the UK and WADA lists both under S2. Brands are in the \u003ca href=\"\/collections\/ipamorelin\"\u003eipamorelin collection\u003c\/a\u003e, and the \u003ca href=\"\/blogs\/news\/mk-677-vs-ipamorelin-vs-hgh\"\u003eMK-677 vs ipamorelin vs somatropin\u003c\/a\u003e article covers the question in depth.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eYakka Strength is a third-party brand sold through Muscle Market. For third-party brands we display a certificate of analysis only where the manufacturer supplies one for the exact batch we hold; if none is shown, none has been supplied and we do not substitute a generic document. Free Muscle-brand products, by contrast, are assayed batch by batch at Janoshik Analytical, with the certificate sent on request by email. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab testing page\u003c\/a\u003e explains what a certificate shows.\u003c\/p\u003e\u003cp\u003eExpect two reports, one per compound, and read each against its own container.\u003c\/p\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e HPLC compares a peak with a reference standard; LC-MS also measures the mass, which is the firmer evidence. Ibutamoren, at 528.7 g\/mol, should appear as a protonated ion close to m\/z 529. For TB-500 the mass tells you which molecule is present: the Ac-LKKTETQ fragment weighs roughly 889 g\/mol, while full thymosin beta-4 is near 4,963 g\/mol and shows as a cluster of multiply charged ions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity (%).\u003c\/strong\u003e The main compound's share of the chromatogram. It measures how clean the material is, not how much is in each capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay.\u003c\/strong\u003e Milligrams found per capsule, the one figure that would replace the missing label strength; peptide results may be given as net peptide or as gross powder weight.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number.\u003c\/strong\u003e It has to match the lot printed on that container; a different number means the report describes other stock.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTest date and laboratory.\u003c\/strong\u003e The test date should fall after the batch was made, and the laboratory should be named so the report can be checked with it.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003eFor this brand, a missing identity line leaves the TB-500 question open, a missing content line leaves both strengths unknown, and a report headed only \"MK-677 and TB-500 bundle\" cannot show which compound was tested. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the lot numbers and we will say what exists for current stock. See also \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eBoth compounds are prohibited at all times, in and out of competition, under the World Anti-Doping Code, which UK Anti-Doping applies in this country. Ibutamoren is named in section S2 among the growth hormone secretagogues; TB-500 falls under the same section through the entry for thymosin beta-4 and its derivatives. Under strict liability a competitor is answerable for anything found in their sample. A research-use label or a certificate of analysis offers no defence in an anti-doping case.\u003c\/p\u003e\u003cp\u003eAnti-doping laboratories have worked on TB-500 for over a decade. The 2012 Ghent study that identified the Ac-LKKTETQ fragment also proposed an LC-MS\/MS strategy for finding it in plasma and urine. No study cited on this page reports how long either ibutamoren or TB-500 remains detectable in human urine after exposure, so the accurate statement for both is: detectable, window not established. Anyone who is subject to testing should assume that contact with either compound will be found.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eNo published stability study covers either compound in capsule form, so the expiry or best-before date printed by the manufacturer, where one is given, is the limit to work within. The two compounds are vulnerable in different ways. For ibutamoren the main risks come from the capsule itself: humidity softens gelatin and clumps powder. TB-500 is a peptide, so water is the bigger concern, since it breaks peptide bonds over time; the full thymosin beta-4 protein also carries a methionine that oxidises easily, a reaction light can accelerate.\u003c\/p\u003e\u003cp\u003eIn practice: keep the containers sealed in a cool, dry, dark cupboard, away from bathrooms and radiators. Leave any desiccant sachet in place. If stock is kept in a fridge, allow the container to reach room temperature before opening so moisture does not condense on the capsules. Store each compound in its own labelled container so that it stays tied to its lot number and certificate. Treat the contents as laboratory reagents: wear gloves when handling opened capsules, keep them apart from food and drink and out of reach of children and pets, and dispose of unwanted material as chemical waste rather than in household bins or drains.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIbutamoren\u003c\/strong\u003e: the international name for MK-677, also coded L-163,191 and MK-0677.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGhrelin receptor (GHS-R1a)\u003c\/strong\u003e: the receptor on pituitary cells that ibutamoren and ipamorelin activate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1\u003c\/strong\u003e: insulin-like growth factor 1, whose blood level rose in both ibutamoren trials.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase IIb trial\u003c\/strong\u003e: a mid-stage study of a candidate medicine in patients with the target condition.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThymosin beta-4\u003c\/strong\u003e: a 43-amino-acid protein present in most cells; TB-500 products are based on it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAc-LKKTETQ\u003c\/strong\u003e: the acetylated seven-residue fragment (positions 17 to 23) of thymosin beta-4 found in TB-500 by anti-doping analysts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eG-actin\u003c\/strong\u003e: single, unpolymerised units of actin, the protein that builds a cell's internal scaffolding.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMass spectrometry\u003c\/strong\u003e: weighing ionised molecules, reported as m\/z, to confirm what a sample is.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNet peptide content\u003c\/strong\u003e: the share of a peptide powder that is the peptide itself, excluding water and counter-ions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWADA S2\u003c\/strong\u003e: the Prohibited List section for peptide hormones, growth factors, related substances and mimetics.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/tb-500\"\u003eTB-500 (Thymosin Beta-4) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eYakka Strength brand page\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/peptides\"\u003ePeptides collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eBundles collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003eResearch articles: \u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677: what the research says\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/tb-500-thymosin-beta-4-research-guide\"\u003eTB-500 and thymosin beta-4 research guide\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eSupplied for laboratory research use only. Not a medicine, not evaluated by the MHRA, EMA or FDA, and not for human consumption. Buyers must be 18 or over. Nothing on this page is medical or dosing advice or a recommendation to use, stack or cycle any compound; research summaries describe findings in study participants or animals, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eNass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-11. PMID: 18981485.\u003c\/li\u003e\n\u003cli\u003eAdunsky A, et al. MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Arch Gerontol Geriatr. 2011;53(2):183-9. PMID: 21067829.\u003c\/li\u003e\n\u003cli\u003eGoldstein AL, et al. Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. PMID: 22074294.\u003c\/li\u003e\n\u003cli\u003eEsposito S, et al. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012;4(9):733-8. PMID: 22962027.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982595810,"sku":null,"price":116.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-capsule-bundle-front-f_600x_561eea53-9aa9-4013-b614-e55dc15f7cf3.png?v=1789931444"},{"product_id":"yakka-strength-yakka-strength-mk677-bpc157-tb500-capsule-bundle","title":"Yakka Strength MK-677 + BPC-157 + TB-500 Capsule Bundle","description":"\u003cp\u003eThe Yakka Strength MK-677, BPC-157 and TB-500 capsule bundle brings together one growth hormone secretagogue, ibutamoren (MK-677), and two research peptides, BPC-157 and TB-500, all from the same manufacturer and stocked in our \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range. Yakka Strength lists the pack as 60 capsules and states no content per capsule, so we quote none. Supplied to adults for laboratory research only, not for human consumption.\u003c\/p\u003e\u003cp\u003eA bundle is a listing convenience only: it lets products from one manufacturer be ordered in a single purchase. Nothing on this page claims that they act together or should be studied together, and Free Muscle publishes no stack or cycle guidance for any product.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eMK-677 (Ibutamoren)\u003c\/h3\u003e\u003cp\u003eIbutamoren (MK-677, L-163,191, nutrobal) is not a SARM but an orally active ghrelin receptor (GHS-R1a) agonist, a growth hormone secretagogue. Unusually for this market it has real human data. A two-year randomised trial in healthy older adults reported, at one year, sustained rises in growth hormone and IGF-1, about 1 kg more fat-free mass than placebo and no gain in strength or function, alongside increased appetite, fluid retention, higher fasting glucose and reduced insulin sensitivity. Never approved. WADA class S2. Compare brands on the \u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eBPC-157\u003c\/h3\u003e\u003cp\u003eBPC-157 is a synthetic fifteen-amino-acid peptide based on a sequence from a human gastric protein. Almost all published work is rodent and cell research, largely from one Croatian group, covering animal models of gut, tendon, muscle and vascular injury. No controlled human trial has been published, and oral absorption of any peptide is unproven. WADA lists it under S0 (non-approved substances). Compare brands on the \u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157 collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eTB-500 (Thymosin Beta-4 fragment)\u003c\/h3\u003e\u003cp\u003eTB-500 is the trade name for a synthetic fragment of thymosin beta-4, a 43-amino-acid actin-binding peptide present in most human and animal cells. Reviews of thymosin beta-4 cover preclinical wound, corneal and cardiac repair models and early clinical trials of the full peptide. TB-500 itself has no published human data. WADA names thymosin beta-4 and its derivatives, including TB-500, under S2. Compare brands on the \u003ca href=\"\/collections\/tb-500\"\u003eTB-500 (Thymosin Beta-4 fragment) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eThe three molecules side by side\u003c\/h3\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIdentifier\u003c\/th\u003e\n\u003cth\u003eIbutamoren\u003c\/th\u003e\n\u003cth\u003eBPC-157\u003c\/th\u003e\n\u003cth\u003eThymosin beta-4 (parent of TB-500)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eType\u003c\/td\u003e\n\u003ctd\u003eNon-peptide small molecule\u003c\/td\u003e\n\u003ctd\u003e15-residue peptide\u003c\/td\u003e\n\u003ctd\u003e43-residue protein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S\u003c\/td\u003e\n\u003ctd\u003eC62H98N16O22\u003c\/td\u003e\n\u003ctd\u003eC212H350N56O78S\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e528.7 g\/mol\u003c\/td\u003e\n\u003ctd\u003e1419.5 g\/mol\u003c\/td\u003e\n\u003ctd\u003eabout 4,963 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e159634-47-6\u003c\/td\u003e\n\u003ctd\u003e137525-51-0\u003c\/td\u003e\n\u003ctd\u003enone in our PubChem record\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePubChem CID\u003c\/td\u003e\n\u003ctd\u003e178024\u003c\/td\u003e\n\u003ctd\u003e9941957\u003c\/td\u003e\n\u003ctd\u003e45382195\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThe size gap, roughly tenfold, shapes how each is delivered, identified and detected. The two peptides are in capsule form. Oral absorption of peptides is unproven, a point covered in our article \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003eDo oral peptides actually work?\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: Yakka Strength (third-party brand, Muscle Market)\u003c\/li\u003e\n\u003cli\u003eCompounds: ibutamoren (MK-677), BPC-157, TB-500\u003c\/li\u003e\n\u003cli\u003eForm and pack size: 60 capsules, as listed by the manufacturer\u003c\/li\u003e\n\u003cli\u003eContent per capsule: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eCOA: only where Yakka Strength supplies one for the batch held\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over, for laboratory research only\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eWithout a stated content for any of the three compounds, milligrams per pack cannot be calculated, so this bundle cannot be set against single-compound packs on cost per milligram (the method is explained in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e). Yakka Strength also lists \u003ca href=\"\/products\/yakka-strength-yakka-strength-mk677\"\u003eMK-677\u003c\/a\u003e, \u003ca href=\"\/products\/yakka-strength-yakka-strength-bpc157-peptide-capsules\"\u003eBPC-157\u003c\/a\u003e and \u003ca href=\"\/products\/yakka-strength-yakka-strength-tb500-peptide-capsules\"\u003eTB-500\u003c\/a\u003e singly.\u003c\/p\u003e\u003ch2\u003eMK-677, BPC-157 and TB-500 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"MK677 UK buy\", \"BPC 157 UK legal\" and \"BPC157 TB500 UK\" ask two things: can these be bought lawfully here, and does the seller document what it sells?\u003c\/p\u003e\u003ch3\u003eThe legal position for each compound\u003c\/h3\u003e\u003cp\u003eNone of the compounds on this page is a licensed medicine in the United Kingdom, none has been assessed by the MHRA and none is an authorised food supplement. None is a controlled drug either, which is why they can be supplied at all, but lack of control is not approval: they cannot lawfully be sold for human consumption under any heading. Free Muscle supplies them to adults aged 18 and over for laboratory research only. None is available on prescription. MK-677 and TB-500 fall under WADA class S2, and BPC-157 under S0. Buyers are responsible for the rules that apply to them, including any anti-doping code. See our \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status page\u003c\/a\u003e. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e has more background.\u003c\/p\u003e\u003ch3\u003eWhat a bundle listing should document\u003c\/h3\u003e\u003cp\u003eEvery claim on a bundle has to hold for each compound separately. A well-documented UK bundle listing shows:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEach compound named properly\u003c\/strong\u003e, with the manufacturer identified.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA lot number on every container\u003c\/strong\u003e, since a certificate can only be tied to material that carries its number.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA separate certificate for each compound\u003c\/strong\u003e; a report on the MK-677 capsules proves nothing about the peptides, and the reverse.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated content per capsule for each compound\u003c\/strong\u003e, or a clear note that the manufacturer gives none.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSale terms that match research supply\u003c\/strong\u003e: an 18+ restriction and no directions or outcome claims.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA traceable UK company\u003c\/strong\u003e, tracked delivery, plain packaging and published returns terms.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eWhere this listing stands\u003c\/h3\u003e\u003cp\u003eFreeMuscle LTD is a UK company in Scunthorpe, the manufacturer is named, and every order goes by free tracked UK delivery in plain packaging. Orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3-7 working days, and unopened items can be returned within 30 days. The compound points rest with Yakka Strength. The label states no content for any of the three, so that check is not met, and a certificate is shown only where the manufacturer supplies one for the batch we hold. Reviews and forum threads cannot close either gap: they record impressions, not measured content. Our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e sets out the full list of checks.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eAll three compounds circulate as capsules, tablets and liquids, and the two peptides also as freeze-dried powder in vials. The molecule is the same in each; what differs is whether research used that route and how the material keeps.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIbutamoren\u003c\/strong\u003e is the exception in this bundle. It was designed by Merck as a non-peptide so that it would remain active when swallowed, and the controlled trials cited here gave it by mouth.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBPC-157\u003c\/strong\u003e was mostly given by injection into the abdominal cavity in rodent work, with some studies adding it to drinking water. No study has measured blood levels in people after a capsule, and the question is examined in \u003ca href=\"\/blogs\/news\/bpc-157-capsules-vs-injection-what-studies-used\"\u003eBPC-157 capsules vs injection: what the studies used\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTB-500 and thymosin beta-4\u003c\/strong\u003e were studied by injection or local application to eye, skin or heart tissue. No oral study of either has been published.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eFor the peptides the obstacle is digestion: pepsin, trypsin, chymotrypsin and brush-border peptidases split peptide bonds, and short linear chains are routine substrates. Ibutamoren has no peptide bonds for them to cut.\u003c\/p\u003e\u003cp\u003eDry formats generally keep better than solutions, where hydrolysis and microbial growth can start. A capsule's content is fixed at blending and filling, so its consistency depends on the blend, which only a per-capsule content test shows; a liquid's depends on complete dissolution and accurate measuring. None of this implies that any format produces an effect.\u003c\/p\u003e\u003ch2\u003eMK-677 compared with ipamorelin\u003c\/h2\u003e\u003cp\u003eThe compound most often searched against MK-677 is ipamorelin (\"ibutamoren vs ipamorelin\"). The two peptides in this bundle act by unrelated mechanisms, whereas ipamorelin shares MK-677's receptor, which makes it the useful reference point.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eIbutamoren (MK-677)\u003c\/th\u003e\n\u003cth\u003eIpamorelin\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStructure\u003c\/td\u003e\n\u003ctd\u003eNon-peptide small molecule\u003c\/td\u003e\n\u003ctd\u003eFive-residue peptide, Aib-His-D-2-Nal-D-Phe-Lys-NH2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and weight\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S, 528.7 g\/mol\u003c\/td\u003e\n\u003ctd\u003eC38H49N9O5, 711.9 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDeveloper\u003c\/td\u003e\n\u003ctd\u003eMerck, 1990s\u003c\/td\u003e\n\u003ctd\u003eNovo Nordisk, described in 1998\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReceptor\u003c\/td\u003e\n\u003ctd\u003eGhrelin receptor, GHS-R1a\u003c\/td\u003e\n\u003ctd\u003eThe same receptor\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRoute in published studies\u003c\/td\u003e\n\u003ctd\u003eBy mouth, in randomised human trials\u003c\/td\u003e\n\u003ctd\u003eInjection in the original animal pharmacology\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eUnlicensed research compound\u003c\/td\u003e\n\u003ctd\u003eUnlicensed research compound\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS2, growth hormone secretagogues\u003c\/td\u003e\n\u003ctd\u003eS2, growth hormone secretagogues\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eMechanism is where they meet. Both bind the ghrelin receptor on the pituitary and release growth hormone the gland already holds, rather than supplying hormone from outside. The 1998 paper from Novo Nordisk that introduced ipamorelin described it as the first selective secretagogue: in conscious swine it released growth hormone with a potency similar to the older peptide GHRP-6, but unlike GHRP-6 and GHRP-2 it did not raise ACTH or cortisol beyond the levels seen with growth hormone releasing hormone. That is an animal finding, not a human one.\u003c\/p\u003e\u003cp\u003eEvidence is where they part. Ibutamoren has randomised human trials with recorded adverse findings; ipamorelin's human literature is much thinner, and a PubMed search combining the two names returns no randomised trial comparing them, so neither can be ranked above the other. Brands held are in the \u003ca href=\"\/collections\/ipamorelin\"\u003eipamorelin collection\u003c\/a\u003e, the two are set against prescription somatropin in \u003ca href=\"\/blogs\/news\/mk-677-vs-ipamorelin-vs-hgh\"\u003eMK-677 vs ipamorelin vs somatropin\u003c\/a\u003e, and the peptide's own studies are in the \u003ca href=\"\/blogs\/news\/ipamorelin-research-guide\"\u003eipamorelin research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eYakka Strength is a third-party brand sold through Muscle Market. For third-party brands we display a certificate of analysis only where the manufacturer supplies one for the exact batch we hold; if none is shown, none has been supplied and we do not substitute a generic document. Free Muscle-brand products, by contrast, are assayed batch by batch at Janoshik Analytical, with the certificate sent on request by email. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab testing page\u003c\/a\u003e explains what a certificate shows.\u003c\/p\u003e\u003cp\u003eThree compounds means three results. Read each against its container:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhich compound.\u003c\/strong\u003e A result headed only with the bundle name cannot show which of the three was measured.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity, by HPLC or LC-MS.\u003c\/strong\u003e HPLC matches a peak to a reference standard's retention time; LC-MS also weighs it, which is firmer. The expected masses differ widely: ibutamoren gives a protonated ion near m\/z 529, BPC-157 has a molecular weight of about 1419.5, and TB-500 should match the mass of the fragment stated on the report, far below the full 4,963 g\/mol protein.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity (%).\u003c\/strong\u003e The compound's share of the chromatogram: cleanliness, not quantity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The only line that can supply the figure this label leaves out. For peptides, check whether it reports net peptide or total powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number, test date and laboratory.\u003c\/strong\u003e Check the number against the lot printed on that compound's container; a named laboratory and a dated report can be checked, an anonymous one cannot.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eWithout an identity line nothing confirms the compound; without a content line the strength stays unknown; without a matching batch number the report describes other material. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the batch numbers and we will say what exists for current stock. See also \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eAll three compounds are prohibited at all times, in and out of competition, under the World Anti-Doping Code, which UK Anti-Doping applies in this country. They sit in different sections. Ibutamoren is named among the growth hormone secretagogues in S2. TB-500 falls under S2 because the list names thymosin beta-4 and its derivatives. BPC-157 is named in S0, the section for substances with no current approval for human therapeutic use. Strict liability applies: an athlete answers for any prohibited substance in a sample, whatever the label said.\u003c\/p\u003e\u003cp\u003eFor BPC-157, the Salt Lake City anti-doping laboratory published a validated urine method in 2017 with a limit of detection of 0.1 ng\/mL, found the peptide stable in urine for at least four days, and made the test more specific by measuring a stable metabolite alongside it. None of the studies cited on this page sets out how long any of the three compounds remains detectable in human urine after exposure, so the accurate statement for each is: detectable, window not established. Anyone subject to testing should assume that exposure to any compound in this bundle will be found.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eNo published stability study covers any of these compounds in capsule form, so the expiry or best-before date printed by the manufacturer, where there is one, is the limit to work to. For the two peptides, moisture is the main threat, because water hydrolyses peptide bonds. Full thymosin beta-4 also contains a methionine residue, which oxidises readily, a process light can speed up. For all three, damp softens capsule shells and clumps powder, while dry heat makes shells brittle.\u003c\/p\u003e\u003cp\u003eKeep each container closed in a cool, dry, dark cupboard, away from radiators and steamy rooms, with any desiccant left in place. If containers are refrigerated, let them reach room temperature before opening so condensation does not form inside. Keep the contents in the original, lot-numbered packaging and note the date of first opening. Handle the contents as laboratory reagents: gloves for opened capsules, separation from food and drink, storage out of reach of children and animals, and disposal as chemical waste rather than in household bins or drains.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth hormone secretagogue\u003c\/strong\u003e: a substance that causes the pituitary gland to release more of its own growth hormone; ibutamoren and ipamorelin are both examples.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGHS-R1a\u003c\/strong\u003e: the receptor for the stomach hormone ghrelin, found on the pituitary and elsewhere; ibutamoren binds it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1\u003c\/strong\u003e: insulin-like growth factor 1, a hormone made mainly in the liver whose blood level follows growth hormone output.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePentadecapeptide\u003c\/strong\u003e: a peptide of 15 amino acids, which is how BPC-157 is described.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThymosin beta-4\u003c\/strong\u003e: the full 43-residue actin-binding protein from which the TB-500 fragment is taken.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptidase\u003c\/strong\u003e: any enzyme that splits a peptide chain; pepsin and trypsin are two of the digestive ones.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRetention time\u003c\/strong\u003e: the point at which a compound emerges from an HPLC column; a match with a reference standard supports, but does not prove, identity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eS0 and S2\u003c\/strong\u003e: WADA list sections; S0 catches substances with no human therapeutic approval, S2 covers peptide hormones, growth factors and their releasing agents.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: under the anti-doping code, a banned substance in a sample counts as a violation regardless of intent or labelling.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157 collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/tb-500\"\u003eTB-500 (Thymosin Beta-4) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/ipamorelin\"\u003eIpamorelin collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eYakka Strength brand page\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eBundles collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003eResearch articles: \u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677\u003c\/a\u003e, \u003ca href=\"\/blogs\/news\/bpc-157-what-research-shows\"\u003eBPC-157\u003c\/a\u003e, \u003ca href=\"\/blogs\/news\/tb-500-thymosin-beta-4-research-guide\"\u003eTB-500\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eSupplied for laboratory research use only. Not a medicine, not evaluated by the MHRA, EMA or FDA, and not for human consumption. Buyers must be 18 or over. Nothing on this page is medical or dosing advice or a recommendation to use, stack or cycle any compound; research summaries describe findings in study participants or animals, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eNass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-11. PMID: 18981485.\u003c\/li\u003e\n\u003cli\u003eSikiric P, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857-865. PMID: 27138887.\u003c\/li\u003e\n\u003cli\u003eGoldstein AL, et al. Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. PMID: 22074294.\u003c\/li\u003e\n\u003cli\u003eRaun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-61. PMID: 9849822.\u003c\/li\u003e\n\u003cli\u003eCox HD, et al. Detection and in vitro metabolism of the confiscated peptides BPC 157 and MGF R23H. Drug Test Anal. 2017;9(10):1490-1498. PMID: 28035768.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982628578,"sku":null,"price":165.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-capsule-bundle-front-e_600x_43ada6d6-ab80-4b0e-8fc1-9c7c88a8813d.png?v=1789931445"},{"product_id":"yakka-strength-yakka-strength-mk677-rad140","title":"Yakka Strength MK-677 + RAD-140","description":"\u003cp\u003eThe Yakka Strength MK-677 and RAD-140 bundle lists a growth hormone secretagogue, ibutamoren (MK-677), alongside a selective androgen receptor modulator, testolone (RAD-140), in one order from a single manufacturer. Yakka Strength lists the pack as 60 capsules. No strength per capsule is stated by the manufacturer on this listing, so none is quoted here. Supplied to adults for laboratory research only and not for human consumption, through the \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range.\u003c\/p\u003e\u003cp\u003eThis bundle exists purely for ordering convenience: two separately packaged Yakka Strength products bought in one transaction. No claim is made here that the two compounds interact or belong in the same study, and Free Muscle publishes no stack or cycle guidance for any product.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003cp\u003eThe two molecules share a format and a manufacturer, and little else: one prompts the pituitary through the ghrelin receptor, the other binds the androgen receptor in tissue. PubChem identifiers:\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIdentifier\u003c\/th\u003e\n\u003cth\u003eMK-677\u003c\/th\u003e\n\u003cth\u003eRAD-140\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eIbutamoren, L-163,191, Nutrobal\u003c\/td\u003e\n\u003ctd\u003eTestolone, vosilasarm, EP0062\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eClass\u003c\/td\u003e\n\u003ctd\u003eGrowth hormone secretagogue\u003c\/td\u003e\n\u003ctd\u003eNon-steroidal SARM\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e159634-47-6\u003c\/td\u003e\n\u003ctd\u003e1182367-47-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC27H36N4O5S\u003c\/td\u003e\n\u003ctd\u003eC20H16ClN5O2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e528.7 g\/mol\u003c\/td\u003e\n\u003ctd\u003e393.8 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePubChem CID\u003c\/td\u003e\n\u003ctd\u003e178024\u003c\/td\u003e\n\u003ctd\u003e44200882\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA class\u003c\/td\u003e\n\u003ctd\u003eS2\u003c\/td\u003e\n\u003ctd\u003eS1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003ch3\u003eMK-677 (Ibutamoren)\u003c\/h3\u003e\u003cp\u003eIbutamoren (MK-677, L-163,191, nutrobal) is not a SARM but an orally active ghrelin receptor (GHS-R1a) agonist, a growth hormone secretagogue. Unusually for this market it has real human data. A one-year randomised trial in healthy older adults reported sustained rises in growth hormone and IGF-1, a mean fat-free mass gain of 1.1 kg against a 0.5 kg fall with placebo and no change in strength or function, alongside increased appetite, fluid retention, higher fasting glucose and reduced insulin sensitivity. Never approved. WADA class S2. Compare brands on the \u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eTestolone (RAD-140)\u003c\/h3\u003e\u003cp\u003eTestolone (RAD-140) is a non-steroidal SARM designed by Radius Health, characterised in preclinical animal models. Human data are limited to a small early oncology study, and it has not been approved for any use. That first-in-human trial, published in 2022, enrolled 22 postmenopausal women with advanced hormone receptor-positive breast cancer. Raised liver enzymes were its most frequent adverse events, and 16 of the 22 women had an event graded 3 or 4. Sex hormone-binding globulin fell and prostate-specific antigen rose in most participants tested, a sign of androgen receptor activity well beyond muscle, and the elimination half-life was measured at 44.7 hours.\u003c\/p\u003e\u003cp\u003ePublished case reports describe drug-induced liver injury in adults who had taken products labelled RAD-140. In one, from a Veterans Affairs hospital in California, a 24-year-old man presented with jaundice and itching; biopsy showed a cholestatic pattern of injury, and it resolved after the product was stopped. It has never been approved as a medicine. WADA class S1. Compare brands on the \u003ca href=\"\/collections\/rad-140\"\u003eTestolone (RAD-140) collection page\u003c\/a\u003e. None of these findings, for either compound, is a claim about this product.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: Yakka Strength (third-party brand, Muscle Market)\u003c\/li\u003e\n\u003cli\u003eCompounds: ibutamoren (MK-677) and testolone (RAD-140)\u003c\/li\u003e\n\u003cli\u003eForm and pack size: 60 capsules, as listed by the manufacturer\u003c\/li\u003e\n\u003cli\u003eStrength per capsule: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eCOA: only where Yakka Strength supplies one for the batch held\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eBecause neither compound carries a printed milligram figure, the total per pack cannot be worked out and the bundle cannot be set against single-compound listings on \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e. A measured content can only come from a batch certificate, covered further down.\u003c\/p\u003e\u003ch2\u003eMK-677 and RAD-140 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"mk677 rad140 uk\", \"rad140 for sale uk\" and \"mk 677 uk legal\" ask two things: may these compounds lawfully be bought in Britain, and how is a reliable listing recognised? For a bundle, each answer is needed twice.\u003c\/p\u003e\u003ch3\u003eWhere each compound stands\u003c\/h3\u003e\u003cp\u003eNeither ibutamoren nor RAD-140 is a controlled drug in the UK, but uncontrolled is not the same as approved. None of the compounds on this page is a licensed medicine in the United Kingdom, none has been assessed by the MHRA and none is an authorised food supplement. Free Muscle supplies them to adults aged 18 and over for laboratory research only. They are not for human consumption. MK-677 falls under WADA class S2 and RAD-140 under S1, and both are banned in sport at all times. See our \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status page\u003c\/a\u003e. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e has more background on RAD-140 and its class.\u003c\/p\u003e\u003ch3\u003eWhat a sound listing shows for a two-compound pack\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA lot number on every pack\u003c\/strong\u003e, since two products usually mean two batches.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate for each compound\u003c\/strong\u003e, each carrying the lot number of its own pack.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated strength per capsule\u003c\/strong\u003e for both compounds, and for ibutamoren whether that figure is free base or mesylate salt.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWho made it and who sells it\u003c\/strong\u003e: a named manufacturer, plus a registered UK company you can contact.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use terms\u003c\/strong\u003e: 18+ only, no directions for use, no promised outcomes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTracked delivery in plain packaging\u003c\/strong\u003e and a stated returns policy.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eHow this bundle measures up\u003c\/h3\u003e\u003cp\u003eSeveral points are met in full. The manufacturer is named, and the seller is FreeMuscle LTD, a UK company based in Scunthorpe. Orders go by free tracked UK delivery in plain packaging, those placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3-7 working days, and unopened items can be returned within 30 days. The certificate point is batch-dependent, because a Yakka Strength COA appears only where the manufacturer has supplied one, and a bundle needs one for each compound. The strength point is not met for either. No forum review can close that gap. A fuller checklist is in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eBoth compounds turn up as capsules, pressed tablets and so-called research liquids, which is why \"rad 140 tablets\", \"rad 140 liquid uk\" and \"mk677 uk liquid\" are all common searches. The molecule is the same in each; what differs is where measurement error enters and what degrades the material.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003cth\u003eHow the amount per unit is set\u003c\/th\u003e\n\u003cth\u003eMain stability concern\u003c\/th\u003e\n\u003cth\u003eWhat a certificate can report\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCapsule\u003c\/td\u003e\n\u003ctd\u003ePowder blend filled into a shell at manufacture; uniformity depends on mixing\u003c\/td\u003e\n\u003ctd\u003eHumidity softening the shell or dampening the powder\u003c\/td\u003e\n\u003ctd\u003eContent per capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTablet\u003c\/td\u003e\n\u003ctd\u003ePowder compressed with binders at manufacture\u003c\/td\u003e\n\u003ctd\u003eHumidity and crumbling\u003c\/td\u003e\n\u003ctd\u003eContent per tablet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLiquid\u003c\/td\u003e\n\u003ctd\u003eConcentration of a solution, then the volume drawn\u003c\/td\u003e\n\u003ctd\u003eBreakdown in solution, precipitation, solvent loss\u003c\/td\u003e\n\u003ctd\u003eConcentration per millilitre\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eNeither compound is a peptide. Ibutamoren (528.7 g\/mol) and RAD-140 (393.8 g\/mol) are small synthetic molecules, and both were developed to work when swallowed: the ibutamoren trials gave it by mouth, and RAD-140 was described as orally bioavailable in animals before its oral phase 1 study. The digestive breakdown that undermines peptide capsules (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e) is therefore not the relevant question here. What matters instead is consistency: a capsule's content is fixed once, at the factory, while a liquid's depends on full dissolution and accurate measuring. None of this means any format produces an effect.\u003c\/p\u003e\u003ch2\u003eMK-677 and RAD-140 compared with their nearest relatives\u003c\/h2\u003e\u003cp\u003eFor this bundle, two comparisons dominate the searches: \"rad 140 vs rad 150\" for the SARM and \"ibutamoren vs ipamorelin\" for the secretagogue. Both are answered here on chemistry, evidence and regulation only.\u003c\/p\u003e\u003ch3\u003eRAD-140 compared with RAD-150\u003c\/h3\u003e\u003cp\u003eRAD-150, also sold as TLB-150, is not a separate development programme. PubChem records it as TLB 150 benzoate (CID 68547459, C27H20ClN5O3, 497.9 g\/mol), which is RAD-140 with a benzoate group attached as an ester. A PubMed search under RAD-150, TLB-150 and related spellings returns no study of it. Because the benzoate adds weight, only about 79 per cent of the ester by mass is the RAD-140 part, so a milligram figure on one label cannot be read across to the other. Claims that the ester lasts longer or acts more strongly have not been measured in any published work. RAD-140 is named in section S1.2 of the WADA list; RAD-150 is not named, but that section explicitly includes substances not listed by name. Brands held are on the \u003ca href=\"\/collections\/rad-150\"\u003eRAD-150 (TLB-150) collection page\u003c\/a\u003e, and the chemistry is covered in \u003ca href=\"\/blogs\/news\/rad-140-vs-rad-150-tlb-150\"\u003eRAD-140 vs RAD-150\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eMK-677 compared with ipamorelin\u003c\/h3\u003e\u003cp\u003eIbutamoren and ipamorelin act on the same receptor, GHS-R1a, and both cause the pituitary to release growth hormone it already stores. Ibutamoren is a non-peptide small molecule; ipamorelin is a synthetic chain of five amino acids (C38H49N9O5, 711.9 g\/mol) that digestive enzymes would be expected to break down. Ibutamoren has randomised human trials measuring body composition and adverse effects, while the human literature on ipamorelin is thin, and PubMed holds no head-to-head trial of the two. Neither is licensed in the UK, and both fall within WADA section S2. Ipamorelin brands are on the \u003ca href=\"\/collections\/ipamorelin\"\u003eipamorelin collection page\u003c\/a\u003e, with a wider comparison in \u003ca href=\"\/blogs\/news\/mk-677-vs-ipamorelin-vs-hgh\"\u003eMK-677 vs ipamorelin vs HGH\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eYakka Strength is a third-party brand sold through Muscle Market. For third-party brands we display a certificate of analysis only where the manufacturer supplies one for the exact batch we hold; if none is shown, none has been supplied and we do not substitute a generic document. Free Muscle-brand products, by contrast, such as our \u003ca href=\"\/collections\/mk-677-ibutamoren\"\u003eown MK-677 capsules\u003c\/a\u003e and \u003ca href=\"\/products\/free-muscle-rad-140-testolone-10mg\"\u003eFree Muscle RAD-140 Testolone 10mg\u003c\/a\u003e, are assayed batch by batch at Janoshik Analytical, with the certificate sent on request by email. For this bundle, full documentation means two reports, one per compound. On each, look at:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e HPLC infers identity from a peak appearing at the same retention time as a reference standard. LC-MS is firmer because it weighs the molecule: ibutamoren gives a protonated ion near m\/z 529 and RAD-140 one near m\/z 394. RAD-140 also contains a chlorine atom, so its spectrum shows a companion peak two mass units higher at roughly a third of the height; ibutamoren, with no chlorine, lacks it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity (%).\u003c\/strong\u003e The share of the detected signal belonging to the named compound. It grades the material, not the capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The field this bundle most needs, since neither label states a strength. For ibutamoren, check whether the figure refers to free base or the heavier mesylate salt.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number.\u003c\/strong\u003e Each certificate must match the lot on its own pack; an MK-677 report says nothing about the RAD-140 capsules.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTest date and laboratory.\u003c\/strong\u003e These show the result's age and its issuer.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eEach gap has a specific meaning here. A report for only one compound leaves the other unverified. Purity without a content line leaves the amount per capsule unknown. A missing or different lot number means the document belongs to another batch. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the lot numbers and we will say exactly what exists for current stock. See our \u003ca href=\"\/pages\/lab-tests\"\u003elab testing page\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eBoth compounds are on the WADA Prohibited List and banned at all times, in and out of competition. RAD-140 is named as an example in section S1.2, other anabolic agents. Ibutamoren sits in section S2, among the growth hormone secretagogues, a section whose substances are all non-Specified. Accredited anti-doping laboratories screen for both, and strict liability applies: an athlete answers for any prohibited substance in their sample, whatever its source, including a product bought for another purpose.\u003c\/p\u003e\u003cp\u003eNo published study gives a detection window for the capsules in this bundle, for either compound, so the accurate statement is: detectable, window not established. Controlled excretion studies would not transfer directly to capsules of unstated content in any case. The 44.7-hour half-life from the RAD-140 oncology trial describes blood levels in patients and is not a urine detection window. Anyone subject to testing should assume that any exposure to either compound could be found.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eStore the two packs separately in their original containers, lids closed between openings, in a cool, dry, dark cupboard away from radiators and steam. Moisture does the most harm: capsule shells take up water and go soft or stick together, and damp powder degrades more quickly.\u003c\/p\u003e\u003cp\u003eWe have found no published stability data for either compound in capsule form, so the expiry or best-before date printed on each pack, where there is one, marks the limit. Write the opening date next to each lot number. Never combine capsules from the two packs in a single container: only the original labels link each capsule to its compound and certificate. Treat both as laboratory reagents: gloves for opened capsules or loose powder, away from food and drink, out of reach of children and animals, any portion removed labelled with compound, lot and date, and waste disposed of as chemical waste, not in household bins or drains.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth hormone secretagogue\u003c\/strong\u003e: the class ibutamoren belongs to; such compounds prompt growth hormone release rather than supplying the hormone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGHS-R1a\u003c\/strong\u003e: the ghrelin receptor, activated by both ibutamoren and ipamorelin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGF-1\u003c\/strong\u003e: insulin-like growth factor 1, the hormone trials track as a downstream marker of raised growth hormone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: selective androgen receptor modulator; RAD-140 is one, built without the steroid ring system of testosterone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBenzoate ester\u003c\/strong\u003e: the product of linking benzoic acid to a hydroxyl group; PubChem describes RAD-150 this way, built on RAD-140.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree base and mesylate\u003c\/strong\u003e: ibutamoren without a salt partner, and its heavier methanesulfonic acid salt.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCholestasis\u003c\/strong\u003e: a slowing or blockage of bile flow from the liver, the pattern seen in the RAD-140 case report cited here.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003em\/z\u003c\/strong\u003e: mass-to-charge ratio, the value a mass spectrometer reports for each ion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: under anti-doping codes, a positive sample is a rule violation whether or not the athlete intended to take the substance.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (Testolone) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eYakka Strength brand page\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eBundles collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677 (Ibutamoren): what the research says\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eBoth compounds in this Yakka Strength bundle are supplied for laboratory research use only. Neither is a medicine or a food supplement, neither has been evaluated by the MHRA, EMA or FDA, and neither is for human consumption. Buyers must be 18 or over. Nothing here is medical or dosing advice or a recommendation to use, stack or cycle any compound; the research summaries describe findings in study participants or animals, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eNass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-11. PMID: 18981485.\u003c\/li\u003e\n\u003cli\u003eMiller CP, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-9. PMID: 24900290.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003cli\u003eLeung K, et al. RAD-140 Drug-Induced Liver Injury. Ochsner J. 2022;22(4):361-365. PMID: 36561105.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982694114,"sku":null,"price":69.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-capsules-front-a_600x_a7c6f61a-2c4e-4759-b8fb-73a5c0dbf2fe.png?v=1789931447"},{"product_id":"yakka-strength-yakka-strength-rad140","title":"Yakka Strength RAD-140","description":"\u003cp\u003eYakka Strength RAD-140 is a 60-capsule pack of the selective androgen receptor modulator RAD-140, also known as testolone, manufactured by Yakka Strength and stocked by Free Muscle as part of the Muscle Market range. Yakka Strength does not state a per-capsule strength on the label, so we do not quote one.\u003c\/p\u003e\u003ch2\u003eAbout RAD-140\u003c\/h2\u003e\u003cp\u003eRAD-140 is a non-steroidal selective androgen receptor modulator (SARM). It was designed by Radius Health as an orally active compound that binds the androgen receptor and, in preclinical work, showed a stronger effect on skeletal muscle than on the prostate. The 2011 characterisation paper described it as potent and orally bioavailable and reported its activity in several preclinical animal models of anabolic androgen action. Animal results do not show how it behaves in people.\u003c\/p\u003e\u003cp\u003eClinical data are limited to a single first-in-human Phase 1 study in 22 postmenopausal women with ER-positive, HER2-negative metastatic breast cancer, published in 2022. The investigators described the safety profile as acceptable, but raised liver enzymes (AST in 59.1 per cent of participants, ALT in 45.5 per cent) and raised bilirubin were the most frequent treatment-emergent adverse events, and 16 of the 22 had a grade 3 or 4 event. The same study measured an elimination half-life of 44.7 hours. Sex hormone-binding globulin fell in all 18 participants in whom it was measured and prostate-specific antigen rose in 16 of 20, markers that the androgen receptor was being engaged well beyond muscle.\u003c\/p\u003e\u003cp\u003eRAD-140 has never been approved as a medicine anywhere in the world. Nothing in these studies is a claim about this product.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIdentifier\u003c\/th\u003e\n\u003cth\u003eRAD-140\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eTestolone, vosilasarm, EP0062\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e1182367-47-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC20H16ClN5O2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e393.8 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInChIKey\u003c\/td\u003e\n\u003ctd\u003eXMBUPPIEVAFYHO-KPZWWZAWSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePubChem CID\u003c\/td\u003e\n\u003ctd\u003e44200882\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eIdentifiers are from PubChem. The formula and molecular weight are the values to check a mass-spectrometry result against.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eCompound: RAD-140 (Testolone)\u003c\/li\u003e\n\u003cli\u003eBrand and manufacturer: Yakka Strength\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStrength per capsule: not stated by the manufacturer on the label\u003c\/li\u003e\n\u003cli\u003eTotal per pack: cannot be calculated without a stated strength\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eWith no printed milligram figure, this pack cannot be set against RAD-140 brands that state one; for those, the method is in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003ehow to compare by milligram\u003c\/a\u003e. A measured content, where a batch certificate gives one, is covered below.\u003c\/p\u003e\u003ch2\u003eRAD-140 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"RAD 140 UK\" and \"RAD140 for sale UK\" ask two things: is buying it lawful, and how is a sound listing told apart from a poor one.\u003c\/p\u003e\u003ch3\u003eThe legal position\u003c\/h3\u003e\u003cp\u003eRAD-140 is not a controlled drug in the UK. It sits outside both routes by which a substance can be sold for people: the MHRA has never granted it a marketing authorisation, so it cannot be sold as a medicine, and it is not an authorised food supplement, so it cannot be sold as food. What remains is sale as a research compound for laboratory work, the only basis on which Free Muscle lists it, and only to buyers aged 18 or over. WADA bans it at all times, so a tested athlete stands in a different position from a laboratory buyer. Buyers are responsible for the rules that apply to them. Background on the class is in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eWhy the listing matters\u003c\/h3\u003e\u003cp\u003eResearchers at LGC in Fordham, Cambridgeshire, bought a range of products sold to UK consumers as SARMs and analysed them by high-resolution mass spectrometry. One contained no active ingredient, others contained prohibited substances not declared on the label, and where a SARM was present the measured amount differed from the packaging. The paper also notes that neither the European Medicines Agency nor the US Food and Drug Administration has approved any SARM. Because a label alone guarantees nothing, a trustworthy UK listing shows:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA batch or lot number\u003c\/strong\u003e on the pack that can be matched to a certificate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for that batch\u003c\/strong\u003e, with identity, purity and a test date.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated strength per capsule\u003c\/strong\u003e, so the total per pack can be worked out and checked.\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eA named manufacturer and a traceable UK seller.\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use terms\u003c\/strong\u003e: an 18+ restriction and no usage instructions or outcome claims.\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eTracked delivery in plain packaging.\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eHow this listing measures up\u003c\/h3\u003e\u003cp\u003eOn most points, not all. The manufacturer is named, and the seller is FreeMuscle LTD, a UK company in Scunthorpe. Every order goes by free tracked UK delivery in plain packaging, orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3-7 working days, and unopened items can be returned within 30 days. The gap is the third point: with no strength on the label, only a batch certificate can supply a content figure. Forum and Reddit threads found by searches like \"RAD 140 UK review\" cannot show what a given pack contained. More checks are in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eRAD-140 is sold as capsules, pressed tablets and \"research liquids\", hence searches for \"RAD 140 tablets\" and \"RAD 140 liquid UK\". The molecule is the same in each; what differs is how well each format holds it and how precisely each unit is measured.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCapsules.\u003c\/strong\u003e A weighed or volume-filled quantity of powder, usually blended with a filler, is sealed in a shell. The amount per unit is fixed at manufacture, so its accuracy depends on how evenly the blend was mixed and filled. A dry powder in a closed shell is the least exposed of the three formats to moisture and oxygen.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTablets.\u003c\/strong\u003e Powder is compressed with binders. The content per unit is also fixed at manufacture and depends on the same blending step, with compression adding further excipients.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiquids.\u003c\/strong\u003e The content per millilitre depends on the compound dissolving completely and staying in solution, and every measured volume is only as accurate as the dropper or pipette used. Compounds in solution are generally more open to degradation than dry solids, and concentration drifts if solvent evaporates.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eRAD-140 is a small molecule of about 394 daltons, not a peptide, so the digestion problem that limits peptides given by mouth does not apply to it (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e). Its discoverers described it as orally bioavailable in animal models, and the published human data concern oral administration only. None of this says that any form produces an effect. For laboratory purposes the practical difference is verification: a capsule certificate can report content per unit, a liquid certificate reports concentration, and either has to match its own batch.\u003c\/p\u003e\u003ch2\u003eRAD-140 compared with RAD-150\u003c\/h2\u003e\u003cp\u003e\"RAD 140 vs RAD 150\" is the comparison most often searched for this compound. RAD-150, also sold as TLB-150, is not a separate drug programme. PubChem records it as TLB 150 benzoate (CID 68547459): RAD-140 with a benzoate group joined as an ester to its hydroxyl group. It appears as a numbered compound in US patent 8,629,167, but a PubMed search under RAD-150, TLB-150 and related names returns no study of it.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eRAD-140\u003c\/th\u003e\n\u003cth\u003eRAD-150 (TLB-150)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical type\u003c\/td\u003e\n\u003ctd\u003eNon-steroidal SARM\u003c\/td\u003e\n\u003ctd\u003eBenzoate ester of RAD-140\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula\u003c\/td\u003e\n\u003ctd\u003eC20H16ClN5O2\u003c\/td\u003e\n\u003ctd\u003eC27H20ClN5O3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e393.8\u003c\/td\u003e\n\u003ctd\u003e497.9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eComputed XLogP3\u003c\/td\u003e\n\u003ctd\u003e3.1\u003c\/td\u003e\n\u003ctd\u003e5.4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAnimal studies\u003c\/td\u003e\n\u003ctd\u003ePreclinical animal data, 2011\u003c\/td\u003e\n\u003ctd\u003eNone published\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman studies\u003c\/td\u003e\n\u003ctd\u003eOne Phase 1 trial (22 women); anti-doping excretion studies\u003c\/td\u003e\n\u003ctd\u003eNone\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eUnlicensed; research compound\u003c\/td\u003e\n\u003ctd\u003eUnlicensed; research compound\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eNamed in S1.2\u003c\/td\u003e\n\u003ctd\u003eNot named; within S1.2 wording\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThree things follow from the structure. The RAD-140 portion makes up about 79 per cent of the ester by mass, so label milligrams of the two are not interchangeable figures. The ester is markedly more fat-soluble on computed values. And an ester bond can be split by water, which makes humidity and heat more relevant to its storage. Claims that RAD-150 is longer-acting or stronger have never been measured, and whether it is converted to RAD-140 in a living system has not been reported.\u003c\/p\u003e\u003cp\u003eIn sport, RAD-140 is named in section S1.2 of the WADA Prohibited List; RAD-150 is not, but S1.2 opens with the words \"including, but not limited to\", so an unnamed SARM derivative is not outside it. Brands held are in the \u003ca href=\"\/collections\/rad-150\"\u003eRAD-150 (TLB-150) collection\u003c\/a\u003e, and the chemistry is set out at length in \u003ca href=\"\/blogs\/news\/rad-140-vs-rad-150-tlb-150\"\u003eRAD-140 vs RAD-150 (TLB-150)\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eAny certificate of analysis (COA) for this product is Yakka Strength's, since they make it. Our rule for their stock: a COA appears only when the manufacturer has supplied one for the batch we hold. If one exists for the current batch it is linked here or sent by email on request; if not, we say so rather than substitute a generic PDF. Free Muscle-brand batches, such as \u003ca href=\"\/products\/free-muscle-rad-140-testolone-10mg\"\u003eFree Muscle RAD-140 Testolone 10mg\u003c\/a\u003e, are independently assayed at Janoshik Analytical; that does not extend to Yakka Strength. Where a Yakka Strength certificate exists, read these fields.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e Confirms the sample is RAD-140. By HPLC, identity rests on the main peak matching the retention time of a reference standard. LC-MS is stronger: RAD-140 gives a protonated molecule at m\/z 394, the ion anti-doping chemists track in urine, while an ion near m\/z 498, calculated for RAD-150, would point to the ester.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Usually an HPLC area percentage, the share of detected material that is RAD-140. It describes the compound, not the capsule, and says nothing about how much RAD-140 each capsule holds.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The key line for this product, since the label states no strength: a measured milligram figure per capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number.\u003c\/strong\u003e Must match the lot printed on the pack.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTest date and laboratory.\u003c\/strong\u003e The date shows how old the result is; the laboratory name allows the report to be checked with its issuer.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eFor this brand, a missing field has a specific meaning. No identity result leaves the compound unconfirmed; purity without content leaves the strength unknown; no batch number means the document does not verify the pack in hand. If a field is missing, \u003ca href=\"\/pages\/contact\"\u003econtact us\u003c\/a\u003e and we will say what exists for the current stock. Method is covered in \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ereading a COA\u003c\/a\u003e and on our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eRAD-140 is prohibited at all times, in and out of competition, under section S1.2 (other anabolic agents) of the WADA Prohibited List, where it is named as an example of a SARM. Anti-doping rules apply strict liability: an athlete is responsible for any prohibited substance found in their sample, whatever its source.\u003c\/p\u003e\u003cp\u003eThe most detailed human elimination data come from a 2022 study at the German Sport University Cologne. In six controlled excretion studies, each with five adult male volunteers given very small amounts of RAD-140, urine was analysed by LC-HRMS\/MS. Concentrations peaked two to six hours after administration and then fell slowly. Unchanged RAD-140 remained detectable for up to 29 days after a single administration of the largest amount studied, and it accumulated when administration was repeated on consecutive days. The parent compound was detectable for longest, and several metabolites were described in human urine for the first time. The authors framed the work partly around contaminated supplements, which can also cause positive findings.\u003c\/p\u003e\u003cp\u003eNo published study gives a detection window for the quantities in commercial capsules, so for this product the accurate statement is: detectable, window not established. For anyone in a tested sport, any exposure carries the risk of a positive test.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eKeep the pack sealed in its original container, closed between openings, in a cool, dry cupboard away from direct light and heat. Moisture is the main risk to capsules: capsule shells, gelatine ones in particular, soften and stick together in humid air and turn brittle when very dry, and damp powder degrades faster than dry. Heat speeds up both. Do not decant capsules into unlabelled containers: the batch number on the original pack is what ties the contents to a certificate.\u003c\/p\u003e\u003cp\u003eWe are not aware of published stability data for RAD-140 in capsule form, so the expiry or best-before date on the pack, where printed, is the limit to work within. Note the date the pack was first opened next to the batch number. Ordinary laboratory good practice applies: wear gloves when handling opened capsules or powder, work away from food and drink, keep the pack out of reach of children and animals, label any sample taken from the pack with compound, batch and date, and dispose of unwanted material as chemical waste, not via household bins or drains.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: selective androgen receptor modulator, a non-steroidal androgen receptor ligand designed to act more on muscle and bone than on the prostate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAndrogen receptor\u003c\/strong\u003e: the nuclear receptor activated by testosterone and dihydrotestosterone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTestolone and vosilasarm\u003c\/strong\u003e: other names for RAD-140; testolone is an informal market name, vosilasarm the non-proprietary name used in reference databases such as PubChem.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEster\u003c\/strong\u003e: a compound formed by joining an acid to an alcohol group; RAD-150 is the benzoic acid ester of RAD-140.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHalf-life\u003c\/strong\u003e: the time taken for the concentration of a compound in the blood to fall by half.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase 1 trial\u003c\/strong\u003e: the first stage of human testing, focused on tolerability and pharmacokinetics in a small group.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC\u003c\/strong\u003e: high-performance liquid chromatography, which separates a sample into its components; the usual basis of a purity figure.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLC-MS\u003c\/strong\u003e: liquid chromatography with mass spectrometry, which also measures molecular mass and so gives firmer proof of identity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCertificate of analysis (COA)\u003c\/strong\u003e: a laboratory report on one specific batch, carrying its batch number and test date.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWADA S1.2\u003c\/strong\u003e: the Prohibited List section for other anabolic agents, including SARMs, banned at all times.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMHRA\u003c\/strong\u003e: the Medicines and Healthcare products Regulatory Agency.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (Testolone) collection\u003c\/a\u003e: every brand we stock, side by side on strength, pack size and batch testing\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eAll Yakka Strength products\u003c\/a\u003e stocked at Free Muscle\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/sarms\"\u003eSARMs\u003c\/a\u003e, the wider range\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e, including the reported side effects\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eYakka Strength RAD-140 is supplied for laboratory research use only. It is not a medicine or a food supplement, has not been evaluated by the MHRA, EMA or FDA, and is not for human consumption. Sale is restricted to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eMiller CP, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-9. PMID: 24900290.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003cli\u003eLeaney AE, et al. Analysis of supplements available to UK consumers purporting to contain selective androgen receptor modulators. Drug Test Anal. 2021;13(1):122-127. PMID: 32748554.\u003c\/li\u003e\n\u003cli\u003eWagener F, et al. Human In Vivo Metabolism and Elimination Behavior of Micro-Dosed Selective Androgen Receptor Modulator RAD140 for Doping Control Purposes. Metabolites. 2022;12(7):666. PMID: 35888790.\u003c\/li\u003e\n\u003cli\u003eBasaria S, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95. PMID: 22459616.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982792418,"sku":null,"price":64.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-capsule-frontview_600x_279ef740-de0d-47fe-83d8-e2ad3e157ee7.png?v=1789931448"},{"product_id":"yakka-strength-yakka-strength-rad140-enclomiphene-bundle","title":"Yakka Strength RAD-140 \u0026 Enclomiphene Bundle","description":"\u003cp\u003eThe Yakka Strength RAD-140 and Enclomiphene bundle lists two research compounds from one manufacturer together: testolone (RAD-140), a selective androgen receptor modulator, and enclomiphene, a selective oestrogen receptor modulator. Yakka Strength lists the pack as 60 capsules and does not state a strength per capsule, so we do not quote one. Supplied to adults for laboratory research only and not for human consumption.\u003c\/p\u003e\u003cp\u003eA bundle is a listing convenience only: it lets products from one manufacturer be ordered in a single purchase. Nothing on this page claims that they act together or should be studied together, and Free Muscle publishes no stack or cycle guidance for any product. Each compound is covered on its own below.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eTestolone (RAD-140)\u003c\/h3\u003e\u003cp\u003eTestolone (RAD-140) is a non-steroidal SARM designed by Radius Health and characterised in preclinical animal models. Human data are limited to a small early oncology study. Published case reports describe drug-induced liver injury in adults who had taken products labelled RAD-140. It has never been approved as a medicine. WADA class S1. Compare brands on the \u003ca href=\"\/collections\/rad-140\"\u003eTestolone (RAD-140) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eA 2011 paper by its developers described it as potent and orally bioavailable in several preclinical models. The oncology study, published in 2022, enrolled 22 postmenopausal women with ER-positive, HER2-negative metastatic breast cancer, all heavily pretreated. The most frequent treatment-emergent adverse events were raised AST (59.1 per cent of participants), raised ALT (45.5 per cent) and raised bilirubin (27.3 per cent), with vomiting, dehydration and reduced appetite each at 27.3 per cent; 16 of the 22 had a grade 3 or 4 event. These were seriously ill, monitored patients, so the findings do not transfer to anyone else.\u003c\/p\u003e\u003ch3\u003eEnclomiphene\u003c\/h3\u003e\u003cp\u003eEnclomiphene is the trans-isomer of clomiphene, a selective oestrogen receptor modulator acting at the hypothalamus and pituitary. In a 2014 phase II trial in men with secondary hypogonadism it raised serum testosterone while sperm counts were maintained, unlike the topical testosterone comparator. It has not been approved as a medicine in the United States and it is not a licensed medicine in the UK. WADA class S4. Compare brands on the \u003ca href=\"\/collections\/enclomiphene\"\u003eEnclomiphene collection page\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eBy blocking oestrogen feedback in the brain, a SERM lets more luteinising hormone (LH) and follicle-stimulating hormone (FSH) reach the testes, whereas testosterone applied from outside turns both down. In the 2014 trial LH, FSH, morning testosterone and oestradiol rose with enclomiphene. The outcomes were blood hormones and semen counts in men with a diagnosed condition, not symptoms, and the sponsor was the company developing the compound.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIdentifier\u003c\/th\u003e\n\u003cth\u003eRAD-140\u003c\/th\u003e\n\u003cth\u003eEnclomiphene\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eTestolone, vosilasarm, EP0062\u003c\/td\u003e\n\u003ctd\u003eEnclomifene, trans-clomifene, RMI 16,289\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e1182367-47-0\u003c\/td\u003e\n\u003ctd\u003e15690-57-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC20H16ClN5O2\u003c\/td\u003e\n\u003ctd\u003eC26H28ClNO\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e393.8 g\/mol\u003c\/td\u003e\n\u003ctd\u003e406.0 g\/mol (free base)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePubChem CID\u003c\/td\u003e\n\u003ctd\u003e44200882\u003c\/td\u003e\n\u003ctd\u003e1548953\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eIdentifiers are taken from PubChem. None of the research summarised above is a claim about this product.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: Yakka Strength (third-party brand, Muscle Market)\u003c\/li\u003e\n\u003cli\u003eCompounds: testolone (RAD-140) and enclomiphene\u003c\/li\u003e\n\u003cli\u003eForm and pack size: 60 capsules, as listed by the manufacturer\u003c\/li\u003e\n\u003cli\u003eStrength per capsule: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eCOA: only where Yakka Strength supplies one for the batch held\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over, for laboratory research only\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eThe listing gives one figure, 60 capsules, without a split by compound, so the pack labels are the reference. With no stated strength, milligrams per pack cannot be calculated or compared; for listings that state one, see \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eRAD-140 and enclomiphene in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"enclomiphene UK buy\", \"enclomiphene UK legal\" and \"rad 140 UK sale\" ask two things: may an adult in the UK lawfully buy these compounds, and what separates a careful listing from a careless one.\u003c\/p\u003e\u003ch3\u003eThe legal position, compound by compound\u003c\/h3\u003e\u003cp\u003eNone of the compounds on this page is a licensed medicine in the United Kingdom, none has been assessed by the MHRA and none is an authorised food supplement. Neither is a controlled drug. Free Muscle supplies them to adults aged 18 and over for laboratory research only. They are not for human consumption. RAD-140 falls under WADA class S1 and enclomiphene under S4. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e has more background.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRAD-140\u003c\/strong\u003e has never held a marketing authorisation anywhere.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnclomiphene\u003c\/strong\u003e sits in a different position because its parent, clomifene, is a prescription-only medicine in the UK. The isolated isomer was refused authorisation by the European Medicines Agency in 2018. Nothing here is an alternative to care from a doctor.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eWhat a careful UK listing shows\u003c\/h3\u003e\u003cp\u003eFor a bundle, each point applies once per compound:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA lot number printed on each pack\u003c\/strong\u003e that the paperwork can be checked against.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA laboratory report for each compound\u003c\/strong\u003e naming that lot, dated, with identity and purity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated strength per capsule\u003c\/strong\u003e, and for enclomiphene, whether the figure refers to the citrate salt or the free base.\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eA named manufacturer and a traceable UK seller.\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use terms\u003c\/strong\u003e: 18+, no usage instructions or promised outcomes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTracked delivery in plain packaging\u003c\/strong\u003e and a stated returns policy.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eHow this bundle measures up\u003c\/h3\u003e\u003cp\u003eThe manufacturer is named, and the seller is FreeMuscle LTD, a UK company based in Scunthorpe. Every UK order travels by free tracked delivery in plain packaging; orders placed before 2pm Monday to Friday are processed the same working day; EU delivery takes 3-7 working days; and unopened items may be returned within 30 days under our \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e. The listing does not meet the strength point: Yakka Strength states no milligram figure, so for either compound a content figure can only come from a batch certificate, where the manufacturer has supplied one. A fuller checklist is in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e, and delivery terms are on our \u003ca href=\"\/pages\/shipping\"\u003eshipping page\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eRAD-140 is sold as capsules, tablets and research liquids, and clomifene as tablets, hence searches for \"enclomiphene tablets\" and \"RAD 140 liquid UK\". The molecule is the same in every format; what differs is protection and measurement.\u003c\/p\u003e\u003cp\u003eA capsule holds a blend of powder and filler measured at manufacture. Unit accuracy rests on how evenly the blend was mixed, which only an assay of several capsules can confirm. Tablets share that blending step. A liquid depends on the compound fully dissolving and staying dissolved: its content is a concentration, every measured volume is only as precise as the dropper, and evaporation of the solvent slowly raises the concentration. Dry solids generally resist hydrolysis and oxidation better than solutions.\u003c\/p\u003e\u003cp\u003eNeither compound is a peptide. RAD-140 (about 394 daltons) and enclomiphene (about 406 daltons as the free base) are small synthetic molecules, so the breakdown by digestive enzymes that limits peptides taken by mouth, discussed in \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e, does not arise. The published human studies of both used oral administration. That describes study design, not any effect of these capsules. For enclomiphene there is one further point: the trials used the citrate salt, which weighs more than the free base, so a milligram figure only means something once the label or certificate says which form it counts.\u003c\/p\u003e\u003ch2\u003eRAD-140 compared with RAD-150, and enclomiphene compared with clomifene\u003c\/h2\u003e\u003cp\u003eEach compound has one dominant comparison search, \"rad 140 vs rad 150\" and \"enclomiphene vs clomiphene\", answered separately here as chemistry and regulation.\u003c\/p\u003e\u003ch3\u003eRAD-140 and RAD-150 (TLB-150)\u003c\/h3\u003e\u003cp\u003eRAD-150, sold also as TLB-150, is not a separate development programme. PubChem lists it as TLB 150 benzoate (CID 68547459), formula C27H20ClN5O3, molecular weight 497.9: the RAD-140 molecule with a benzoate ester on its hydroxyl group. A PubMed search under its market names returns no study of it; RAD-140 has the animal and Phase 1 data above.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMass\u003c\/strong\u003e: a milligram of the heavier ester carries roughly four fifths of a milligram of RAD-140, so label figures are not interchangeable.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClaims\u003c\/strong\u003e: that RAD-150 lasts longer or acts more strongly is untested, and its conversion to RAD-140 in the body is unreported.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStatus\u003c\/strong\u003e: both are unlicensed research compounds in the UK, and both fall within WADA section S1.2, which bans SARMs \"including, but not limited to\" those it names.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eRAD-150 brands held are listed in the \u003ca href=\"\/collections\/rad-150\"\u003eRAD-150 (TLB-150) collection\u003c\/a\u003e, and the chemistry is set out in \u003ca href=\"\/blogs\/news\/rad-140-vs-rad-150-tlb-150\"\u003eRAD-140 vs RAD-150 (TLB-150)\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eEnclomiphene and clomifene\u003c\/h3\u003e\u003cp\u003eClomifene (spelt clomiphene in the US) is a mixture of two geometric isomers of one molecule: enclomiphene, the (E) or trans isomer, and zuclomiphene, the (Z) or cis isomer. They share a formula but differ in shape, and zuclomiphene is cleared far more slowly. Clomifene is a prescription-only medicine in the UK, licensed for female infertility, and FDA-approved for ovulation induction. Enclomiphene alone has controlled trials in men with secondary hypogonadism but no UK, EU or US approval. WADA section S4 names clomifene among anti-oestrogenic substances, and both isomers are prohibited at all times. Our \u003ca href=\"\/blogs\/news\/enclomiphene-vs-clomifene-research-guide\"\u003eenclomiphene vs clomifene guide\u003c\/a\u003e covers the trials and adverse findings, and single-compound enclomiphene listings, including \u003ca href=\"\/products\/enclomiphene-25mg-60-capsules-free-muscle\"\u003eFree Muscle enclomiphene\u003c\/a\u003e, are in the \u003ca href=\"\/collections\/enclomiphene\"\u003eenclomiphene collection\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eYakka Strength is a third-party brand sold through Muscle Market. For third-party brands we display a certificate of analysis only where the manufacturer supplies one for the exact batch we hold; if none is shown, none has been supplied and we do not substitute a generic document. Free Muscle-brand products, by contrast, are assayed batch by batch at Janoshik Analytical, with the certificate sent on request by email. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab testing page\u003c\/a\u003e explains what a certificate shows.\u003c\/p\u003e\u003cp\u003eEach compound is its own batch, so a bundle needs two certificates. On either, look for:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity, RAD-140.\u003c\/strong\u003e HPLC matches the main peak to a reference standard; LC-MS is firmer, reporting the mass itself, with the protonated ion near m\/z 394.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity, enclomiphene.\u003c\/strong\u003e The right isomer matters as much as the right molecule. Enclomiphene and zuclomiphene share a mass, so an HPLC comparison with an (E)-isomer reference standard is what separates them. A certificate naming only \"clomiphene\" does not confirm enclomiphene.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Usually an HPLC peak area percentage. For enclomiphene, zuclomiphene is the impurity of most interest. It describes the material, not the amount per capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The line that matters most for this listing, because the label gives no strength. For enclomiphene it should say citrate or free base.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLot, date and issuing laboratory.\u003c\/strong\u003e A different lot from your pack makes the report irrelevant; a named laboratory can confirm it.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eFor this brand, a missing field means something specific. With no identity line the compound is unconfirmed; with purity but no content the strength remains unknown; with no batch number the document does not describe the pack you hold. If either compound lacks a certificate, \u003ca href=\"\/pages\/contact\"\u003econtact us\u003c\/a\u003e to ask what exists for the stock we hold. Field-by-field guidance is in \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eBoth compounds are banned in sport at all times, in and out of competition. RAD-140 is named as a SARM in section S1.2 of the WADA Prohibited List (other anabolic agents). Enclomiphene falls in section S4 (hormone and metabolic modulators), which covers anti-oestrogenic substances including SERMs and names clomifene. Strict liability applies: an athlete answers for any prohibited substance in their sample, whatever its source.\u003c\/p\u003e\u003cp\u003eThe controlled detection data concern clomifene, not isolated enclomiphene. In a 2019 open-label study at an anti-doping laboratory, 12 healthy men aged 25 to 38 took clomifene citrate for 30 days. Serum testosterone, LH and FSH rose during treatment, and zuclomiphene remained detectable in urine for between 121 and more than 261 days. Isolated enclomiphene should contain little of that long-lasting isomer, and no verified study gives its own window. For RAD-140, urine methods exist but no study cited here measures a window. For both compounds in this bundle the accurate statement is therefore: detectable, window not established.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eStore both packs unopened until needed, each in its original container with the lid closed, somewhere cool, dry and dark, away from radiators, windowsills and steamy rooms. Humidity is the main enemy of capsules: shells take up water, soften and stick, and powder that has absorbed moisture breaks down faster. Heat speeds both up, and repeated opening lets humid air in each time. Never combine the two in one pot: mixed capsules cannot be traced to a batch.\u003c\/p\u003e\u003cp\u003eWe know of no published stability study for either compound in capsule form, so any expiry or best-before date printed on the pack is the working limit. Note the opening date beside each batch number. Normal laboratory practice applies: gloves for opened capsules or loose powder, no food or drink nearby, labels on any portion removed, storage out of reach of children and pets, and disposal as chemical waste, not via bins or drains.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: selective androgen receptor modulator; a non-steroidal class, including RAD-140, that binds testosterone's receptor.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSERM\u003c\/strong\u003e: selective oestrogen receptor modulator, a compound that blocks oestrogen receptors in some tissues and activates them in others.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIsomer\u003c\/strong\u003e: one of two or more molecules with the same formula but a different arrangement of atoms; enclomiphene and zuclomiphene are geometric isomers.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCitrate salt\u003c\/strong\u003e: a compound paired with citric acid; it weighs more than the free base, which changes what a milligram figure means.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSecondary hypogonadism\u003c\/strong\u003e: low testosterone caused by weak pituitary or hypothalamic signalling, not by the testes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLH and FSH\u003c\/strong\u003e: luteinising hormone and follicle-stimulating hormone, the pituitary signals that drive testosterone and sperm production.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC\u003c\/strong\u003e: a chromatography method that splits a sample into peaks; the size of the main peak gives the purity percentage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCertificate of analysis (COA)\u003c\/strong\u003e: the test report for a single production lot; a document with no lot number is a sales sheet, not a COA.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/rad-140\"\u003eRAD-140 (Testolone) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/enclomiphene\"\u003eEnclomiphene collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eYakka Strength brand page\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eBundles collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/yakka-strength-yakka-strength-rad140\"\u003eYakka Strength RAD-140\u003c\/a\u003e and \u003ca href=\"\/products\/yakka-strength-yakka-strength-enclomiphene\"\u003eYakka Strength enclomiphene\u003c\/a\u003e, sold separately\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eSupplied for laboratory research use only. Not a medicine, not evaluated by the MHRA, EMA or FDA, and not for human consumption. Buyers must be 18 or over. Nothing on this page is medical or dosing advice or a recommendation to use, stack or cycle any compound; research summaries describe findings in study participants or animals, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eMiller CP, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-9. PMID: 24900290.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003cli\u003eWiehle RD, et al. Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. Fertil Steril. 2014;102(3):720-7. PMID: 25044085.\u003c\/li\u003e\n\u003cli\u003eMiller GD, et al. Hypothalamic-Pituitary-Testicular Axis Effects and Urinary Detection Following Clomiphene Administration in Males. J Clin Endocrinol Metab. 2019;104(3):906-914. PMID: 30295816.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982857954,"sku":null,"price":133.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-capsule-bundle-front-z_600x_778ef193-addb-4129-9d76-ebc6de7d4618.png?v=1789931450"},{"product_id":"yakka-strength-yakka-strength-tb500-peptide-capsules","title":"Yakka Strength TB-500 Peptide Capsules","description":"\u003cp\u003e\u003cstrong\u003eYakka Strength TB-500 Peptide Capsules\u003c\/strong\u003e is a Yakka Strength listing of TB-500, supplied as 60 capsules per pack and stocked through the \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range; the manufacturer does not state a strength per capsule on the label. It is sold for laboratory research only, is not for human consumption, and is sold to adults aged 18 and over. This page covers what the published research on TB-500 and thymosin beta-4 reports, what the label documents, the UK and anti-doping position, and how batch certificates are handled for Yakka Strength products.\u003c\/p\u003e\n\u003ch2\u003eAbout TB-500\u003c\/h2\u003e\n\u003cp\u003eTB-500 is the name used in the research-compound market for synthetic peptides based on thymosin beta-4, a 43-amino-acid protein present in most human cells. Products sold as TB-500 may contain the full sequence or a shorter fragment around the actin-binding region; the label on this listing does not say which. Thymosin beta-4 binds monomeric actin and has been studied in cell migration, angiogenesis and wound repair models. It is a peptide, so it is neither a steroid nor a SARM, even though the three are often sold side by side.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIdentifier\u003c\/th\u003e\n\u003cth\u003eFull thymosin beta-4\u003c\/th\u003e\n\u003cth\u003eFragment found in TB-500 products\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eLength\u003c\/td\u003e\n\u003ctd\u003e43 amino acids\u003c\/td\u003e\n\u003ctd\u003e7 amino acids (positions 17 to 23), acetylated at the N-terminus\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSequence\u003c\/td\u003e\n\u003ctd\u003eFull protein sequence\u003c\/td\u003e\n\u003ctd\u003eAc-LKKTETQ\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC212H350N56O78S\u003c\/td\u003e\n\u003ctd\u003eC38H68N10O14\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003eabout 4,963 g\/mol\u003c\/td\u003e\n\u003ctd\u003eabout 889 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePubChem CID\u003c\/td\u003e\n\u003ctd\u003e45382195\u003c\/td\u003e\n\u003ctd\u003enot listed here\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInChIKey\u003c\/td\u003e\n\u003ctd\u003eUGPMCIBIHRSCBV-UHFFFAOYSA-N\u003c\/td\u003e\n\u003ctd\u003enot listed here\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003eWhat the published research reports\u003c\/h3\u003e\n\u003cp\u003eA 2012 review by Goldstein and colleagues summarised the peptide's properties and the clinical programmes then under way in wounds, the cornea and cardiac repair. A 2010 randomised, placebo-controlled study gave intravenous pharmaceutical-grade thymosin beta-4 to healthy volunteers as single and repeated doses. Adverse events were infrequent and mild or moderate, and none was serious. It was a safety study, not an efficacy study, and it used injection rather than a capsule. None of those programmes has produced an approved medicine, and no published human work shows that a peptide of this size survives oral administration.\u003c\/p\u003e\n\u003cp\u003eThe chemistry of what is actually sold as TB-500 comes mostly from anti-doping laboratories. In 2012 the Ghent doping control laboratory analysed a TB-500 product by high-resolution mass spectrometry and identified the acetylated 17-23 fragment of thymosin beta-4, Ac-LKKTETQ, rather than the whole protein. The same year the Hong Kong Jockey Club's racing laboratory described TB-500 as a veterinary preparation built around that acetylated fragment and published a method that found it, and its breakdown products, in urine and plasma from horses given a single administration. Neither study measured any effect in people. Nothing above is a claim about this product.\u003c\/p\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eManufacturer: Yakka Strength\u003c\/li\u003e\n\u003cli\u003eCompound: TB-500 (Thymosin Beta-4)\u003c\/li\u003e\n\u003cli\u003eForm: Capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStrength: the manufacturer does not state the amount per capsule on the label, so we do not list one\u003c\/li\u003e\n\u003cli\u003eWhich peptide: the label does not say whether the capsules hold full thymosin beta-4 or the Ac-LKKTETQ fragment\u003c\/li\u003e\n\u003cli\u003eBatch certificate of analysis: shown where Yakka Strength supplies one for the batch we hold\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWith no stated strength, total milligrams per pack cannot be worked out, and the pack cannot be set against brands that print a figure. Our \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram guide\u003c\/a\u003e explains why that matters.\u003c\/p\u003e\n\u003ch2\u003eTB-500 in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eUK searches for this peptide cluster around three questions: whether it is legal (\"TB 500 legal UK\"), where it can be bought (\"buy TB 500 UK\", \"TB 500 UK for sale\", \"TB 500 capsules UK\"), and how to judge the seller.\u003c\/p\u003e\n\u003ch3\u003eThe legal position\u003c\/h3\u003e\n\u003cp\u003eTB-500 is not a licensed medicine in the UK, has not been assessed by the MHRA, and is not an authorised food supplement. It is not a controlled drug either, which is why it can be supplied at all, but only as a laboratory research material to adults aged 18 and over and never for human consumption. Thymosin beta-4 and its derivatives, with TB-500 named as an example, are listed under section S2 (peptide hormones, growth factors and related substances) of the WADA Prohibited List and are prohibited at all times in sport. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eresearch guide\u003c\/a\u003e covers the wider legal picture for research compounds, and the \u003ca href=\"\/blogs\/news\/tb-500-thymosin-beta-4-research-guide\"\u003eTB-500 and thymosin beta-4 research guide\u003c\/a\u003e covers this peptide in depth.\u003c\/p\u003e\n\u003ch3\u003eWhat a trustworthy UK listing shows\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe peptide identified\u003c\/strong\u003e: whether the product is full thymosin beta-4 or the acetylated fragment, since the two differ roughly fivefold in molecular weight.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated amount per capsule or vial\u003c\/strong\u003e, so a buyer can see what the pack is supposed to contain.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTraceability\u003c\/strong\u003e: a lot code printed on every tub, matched by the lot code on its certificate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA named maker and a UK company behind the sale\u003c\/strong\u003e, reachable by email.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-only terms\u003c\/strong\u003e: an 18+ restriction, no instructions for use and no promised results.\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003ePlain packaging, tracked delivery and a written returns policy.\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow this listing measures up\u003c\/h3\u003e\n\u003cp\u003eFree Muscle is FreeMuscle LTD, a UK company in Scunthorpe. Orders ship by free tracked UK delivery in plain packaging, orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes three to seven working days, and unopened items can be returned within 30 days. Two points depend on the manufacturer and are not met on the label: the strength per capsule and the identity of the peptide. A batch certificate is the only document that could fill those gaps, and we show one only where Yakka Strength supplies it for the batch we hold. More in our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eMost TB-500 on the market is freeze-dried powder in glass vials, often labelled \"10mg\", which is why \"TB 500 10mg UK\" is a common search. Capsules and tablets, as in this listing, are a newer format. The literature shows how each route was studied and where the obstacles lie.\u003c\/p\u003e\n\u003cp\u003eThe human programmes summarised in the 2012 review used intravenous infusion or preparations applied directly to skin or eye. The anti-doping work on the Ac-LKKTETQ fragment used horses given the veterinary preparation, not an oral form. No published study has measured whether either peptide reaches the blood intact after being swallowed. The general obstacle is digestion: stomach and intestinal proteases cleave peptide chains, and a 43-residue protein offers them many sites. Even the 7-residue fragment is a target, and the Hong Kong group's method looked for its metabolites as well as the parent peptide. Our article on \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003ewhether oral peptides work\u003c\/a\u003e covers the digestion problem across the class.\u003c\/p\u003e\n\u003cp\u003eAs materials the formats differ in handling rather than in molecule. A sealed vial of freeze-dried powder is dry and relatively stable, but once dissolved it becomes vulnerable to hydrolysis and contamination, and any measured volume depends on the mixing. A capsule holds a fixed fill of dry powder, usually with a filler, and its consistency from capsule to capsule depends on how evenly the batch was blended, which only a per-capsule content test can show. None of this implies that any format produces an effect.\u003c\/p\u003e\n\u003ch2\u003eTB-500 compared with BPC-157\u003c\/h2\u003e\n\u003cp\u003eBPC-157 is the peptide most often searched with this one (\"TB 500 vs BPC 157\", \"TB 500 and BPC 157\"). They are sold side by side and sometimes in the same bundle, but they come from unrelated proteins and sit in different parts of the WADA list.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eQuestion\u003c\/th\u003e\n\u003cth\u003eTB-500\u003c\/th\u003e\n\u003cth\u003eBPC-157\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eParent molecule\u003c\/td\u003e\n\u003ctd\u003eThymosin beta-4, an intracellular actin-sequestering protein\u003c\/td\u003e\n\u003ctd\u003eA protein isolated from gastric juice\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWhat is sold\u003c\/td\u003e\n\u003ctd\u003eFull 43-residue protein or the 7-residue Ac-LKKTETQ fragment; labels rarely say which\u003c\/td\u003e\n\u003ctd\u003eA single defined 15-residue sequence, GEPPPGKPADDAGLV\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSize\u003c\/td\u003e\n\u003ctd\u003eAbout 4,963 g\/mol (full) or about 889 g\/mol (fragment)\u003c\/td\u003e\n\u003ctd\u003eAbout 1,419 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman research\u003c\/td\u003e\n\u003ctd\u003eFull protein: a volunteer infusion study and early wound and eye programmes. Fragment: none\u003c\/td\u003e\n\u003ctd\u003eNo published randomised controlled trial\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eUnlicensed; research material only\u003c\/td\u003e\n\u003ctd\u003eUnlicensed; research material only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA section\u003c\/td\u003e\n\u003ctd\u003eS2, named under thymosin beta-4 and its derivatives\u003c\/td\u003e\n\u003ctd\u003eS0, non-approved substances\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThe difference that matters most for a buyer is definition. BPC-157 has one sequence, so a certificate either finds it or does not. TB-500 is a trade name that has been applied to two different molecules, so a certificate must say which one it found before its purity figure means anything. The proposed biology also differs: thymosin beta-4's established role is holding actin in its unpolymerised form, which governs cell movement, while most BPC-157 work comes from rodent gut and tendon models. No human study has compared them, neither can be ranked above the other, and we publish no guidance on using them together. The \u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157 collection\u003c\/a\u003e lists every brand we hold, and \u003ca href=\"\/blogs\/news\/bpc-157-what-research-shows\"\u003eBPC-157: what the research shows\u003c\/a\u003e reviews its evidence.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eYakka Strength is a third-party brand in the Muscle Market range, so the testing position differs from our own label. Every Free Muscle-brand batch is assayed by Janoshik Analytical, an independent laboratory, with the certificate sent on request by email. For Yakka Strength products we show a certificate of analysis only where the manufacturer supplies one for the specific batch we hold. A generic PDF with no batch number is not a batch certificate, and we do not present one as such. Email us with the product name and we will send what we hold, or say plainly that there is none. On a certificate for this pack, check these lines.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity and method.\u003c\/strong\u003e LC-MS weighs the molecule and is the stronger test. The Ac-LKKTETQ fragment has a monoisotopic mass of about 888.5, usually seen as an ion near m\/z 889.5 or, doubly charged, near m\/z 445.3. Full thymosin beta-4 is far heavier and appears as a spread of multiply charged ions. HPLC alone only matches a retention time to a reference standard.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity (%).\u003c\/strong\u003e The share of the chromatogram taken by the main peak. It grades cleanliness, not quantity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The measured amount of peptide in a capsule, the figure the label omits. For peptides, check whether it is net peptide or total powder, since water and acetate counter-ions add weight.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number.\u003c\/strong\u003e It must match the lot printed on the tub you hold.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWho tested it, and when.\u003c\/strong\u003e A named laboratory can be asked to confirm the report; the date shows whether it predates the stock.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor this brand, each missing field has a specific cost. No identity line means the certificate cannot settle whether the product is the fragment or the full protein. No content line means the strength remains unknown. A different or absent batch number means the report describes other material. \u003ca href=\"\/pages\/contact\"\u003eContact us\u003c\/a\u003e with the lot number for what exists on current stock; our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e and \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eguide to reading a COA\u003c\/a\u003e go further.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eWADA names thymosin beta-4 and its derivatives, with TB-500 as the example, in section S2 of the Prohibited List. That section applies in and out of competition, across every sport that has adopted the World Anti-Doping Code, including testing by UK Anti-Doping. Under strict liability an athlete is responsible for any prohibited substance in their sample, whatever the label said.\u003c\/p\u003e\n\u003cp\u003eDetection methods have been published for more than a decade. The Ghent laboratory proposed an LC-MS\/MS strategy for the Ac-LKKTETQ fragment in plasma and urine in 2012, and the Hong Kong racing laboratory reported confirmation of the fragment at 0.01 ng\/mL in equine urine and 0.02 ng\/mL in equine plasma, together with its metabolites, after a single administration to horses. Those limits come from horse samples. No published study has set out how long TB-500 remains detectable in human urine, so the accurate statement is that it is detectable and the window is not established.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eNo stability study of TB-500 capsules has been published, so the expiry or best-before date printed by the manufacturer, if present, is the limit to work to. General peptide chemistry still identifies the risks. Moisture allows peptide bonds to hydrolyse and makes powder clump and capsule shells soften. Heat accelerates every degradation reaction, and light adds to it. Full thymosin beta-4 also contains a methionine residue, which oxidises readily, whereas the Ac-LKKTETQ fragment has none.\u003c\/p\u003e\n\u003cp\u003eKeep the tub closed, in a cool, dry place away from direct light, radiators and damp rooms. If it is refrigerated, let it reach room temperature before opening so condensation does not form inside, and leave any desiccant sachet in the tub. Write the opening date next to the batch number. Handle the capsules as a laboratory reagent: gloves for opened capsules or loose powder, well away from food and drink, and out of reach of children and animals. Dispose of waste as chemical waste, not in household bins or drains. Keep capsules in their original container so they stay linked to the lot number and any certificate.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eThymosin beta-4\u003c\/strong\u003e: a 43-amino-acid protein found inside most human cells that binds actin; TB-500 products are based on it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAc-LKKTETQ\u003c\/strong\u003e: the seven-residue fragment of thymosin beta-4 (positions 17 to 23), with an acetyl group added, that anti-doping laboratories identified in TB-500 products.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActin\u003c\/strong\u003e: the protein that forms filaments inside cells and drives cell shape and movement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eG-actin\u003c\/strong\u003e: single, unpolymerised actin units; thymosin beta-4 holds a reserve of these.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAcetylation\u003c\/strong\u003e: capping the first amino acid of a chain with an acetyl group (the \"Ac\" in Ac-LKKTETQ), adding 42 mass units.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLC-MS\/MS\u003c\/strong\u003e: liquid chromatography linked to tandem mass spectrometry, which separates, weighs and fragments each molecule for identification.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003em\/z\u003c\/strong\u003e: mass-to-charge ratio, the value a mass spectrometer reports for each ion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: under the World Anti-Doping Code, a positive sample is a violation whether or not the athlete knew what the product contained.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/tb-500\"\u003eAll brands of TB-500 we stock, compared\u003c\/a\u003e, including \u003ca href=\"\/products\/thoroughbred-labs-tb500-peptide-capsule-ndash-thoroughbred-labs\"\u003eThoroughbred Labs TB-500 capsules\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eAll Yakka Strength products\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/peptides\"\u003eResearch peptides\u003c\/a\u003e and \u003ca href=\"\/products\/yakka-strength-yakka-strength-bpc157-peptide-capsules\"\u003eYakka Strength BPC-157 capsules\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/pages\/lab-tests\"\u003eBatch testing and certificates of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It has not been evaluated by the MHRA, EMA or FDA. It is not a medicine, not a food supplement and not for human consumption. Sold only to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice, and descriptions of published studies are not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eGoldstein AL, et al. Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. PMID: 22074294.\u003c\/li\u003e\n\u003cli\u003eRuff D, et al. A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. Ann N Y Acad Sci. 2010;1194:223-9. PMID: 20536472.\u003c\/li\u003e\n\u003cli\u003eEsposito S, et al. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012;4(9):733-8. PMID: 22962027.\u003c\/li\u003e\n\u003cli\u003eHo EN, et al. Doping control analysis of TB-500, a synthetic version of an active region of thymosin beta4, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012;1265:57-69. PMID: 23084823.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982956258,"sku":null,"price":54.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-capsules-front-c_600x_a083145b-50be-44de-8bc6-a1a69670c1d7.png?v=1789931451"},{"product_id":"yakka-strength-yakka-strength-wolverine-stack-bpc157-tb500-capsule-peptide-bundle","title":"Yakka Strength Wolverine Stack — BPC-157 \u0026 TB-500","description":"\u003cp\u003eThe Yakka Strength Wolverine Stack is the manufacturer's name for a capsule bundle of two research peptides, BPC-157 (Body Protection Compound 157, also sold as BPC157) and TB-500 (TB500, a synthetic fragment of thymosin beta-4). The name is a marketing label and is not a claim about what the peptides do. Yakka Strength lists the pack as 60 capsules and does not state a peptide content per capsule, so we do not quote one. Supplied to adults for laboratory research only and not for human consumption.\u003c\/p\u003e\u003cp\u003eA bundle is a listing convenience only: it lets products from one manufacturer be ordered in a single purchase. Nothing on this page claims that they act together or should be studied together, and Free Muscle publishes no stack or cycle guidance for any product. Each peptide is therefore described on its own below.\u003c\/p\u003e\u003ch2\u003eAbout the compounds in this bundle\u003c\/h2\u003e\u003ch3\u003eBPC-157\u003c\/h3\u003e\u003cp\u003eBPC-157 is a synthetic fifteen-amino-acid peptide based on a sequence from a human gastric protein. Almost all published work is rodent and cell research, largely from one Croatian group, covering animal models of gut, tendon, muscle and vascular injury. Its developers mention early trials in inflammatory bowel disease, but no controlled human trial has been published in full, and oral absorption is unproven. WADA lists it under S0 (non-approved substances). Compare brands on the \u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157 collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eTB-500 (Thymosin Beta-4 fragment)\u003c\/h3\u003e\u003cp\u003eTB-500 is the trade name for a synthetic fragment of thymosin beta-4, a 43-amino-acid actin-binding peptide found in most human and animal cells. Reviews of thymosin beta-4 cover preclinical wound, corneal and cardiac repair models and early clinical trials of the full peptide. TB-500 itself has no published human data. When anti-doping chemists at Ghent University analysed a TB-500 product in 2012, the peptide they identified was the N-terminally acetylated 17-23 segment of thymosin beta-4, written Ac-LKKTETQ, not the whole protein. WADA names thymosin beta-4 and its derivatives, including TB-500, under S2. Compare brands on the \u003ca href=\"\/collections\/tb-500\"\u003eTB-500 (Thymosin Beta-4 fragment) collection page\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eIdentifiers\u003c\/h3\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIdentifier\u003c\/th\u003e\n\u003cth\u003eBPC-157\u003c\/th\u003e\n\u003cth\u003eThymosin beta-4 (parent of TB-500)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eLength\u003c\/td\u003e\n\u003ctd\u003e15 amino acids\u003c\/td\u003e\n\u003ctd\u003e43 amino acids; TB-500 is a 7-residue acetylated fragment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC62H98N16O22\u003c\/td\u003e\n\u003ctd\u003eC212H350N56O78S\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e1419.5 g\/mol\u003c\/td\u003e\n\u003ctd\u003eabout 4,963 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e137525-51-0\u003c\/td\u003e\n\u003ctd\u003enot listed in our PubChem record\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePubChem CID\u003c\/td\u003e\n\u003ctd\u003e9941957\u003c\/td\u003e\n\u003ctd\u003e45382195\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003ch3\u003eWhat the published research reports\u003c\/h3\u003e\u003cp\u003eFor BPC-157, the most cited overview is a 2016 review by the originating Zagreb group, which gathers its own rodent findings on the gut, brain and blood vessels and proposes a brain-gut axis role. Its main limitation is that it reviews largely single-laboratory work. For thymosin beta-4, a 2012 review by Goldstein and colleagues describes actin binding, cell migration and repair findings in animal models and early human studies of the full-length protein applied to skin and eye. Neither review concerns this product or TB-500 as sold, and none of it is a claim about the bundle. The \u003ca href=\"\/blogs\/news\/bpc-157-what-research-shows\"\u003eBPC-157 research article\u003c\/a\u003e and the \u003ca href=\"\/blogs\/news\/tb-500-thymosin-beta-4-research-guide\"\u003eTB-500 and thymosin beta-4 research guide\u003c\/a\u003e go further.\u003c\/p\u003e\u003cp\u003eBoth peptides are supplied here in capsule form. Whether peptides survive the digestive tract in any meaningful quantity is an open question, discussed in our article \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003eDo oral peptides actually work?\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eBrand: Yakka Strength (third-party brand, \u003ca href=\"\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e)\u003c\/li\u003e\n\u003cli\u003eCompounds: BPC-157 and TB-500 (thymosin beta-4 fragment)\u003c\/li\u003e\n\u003cli\u003eForm and pack size: 60 capsules, as listed by the manufacturer\u003c\/li\u003e\n\u003cli\u003ePeptide content per capsule: not stated by the manufacturer\u003c\/li\u003e\n\u003cli\u003eTotal milligrams per pack: cannot be worked out without a stated strength\u003c\/li\u003e\n\u003cli\u003eCOA: only where Yakka Strength supplies one for the batch held\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over, for laboratory research only\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eThe two peptides are also listed singly as \u003ca href=\"\/products\/yakka-strength-yakka-strength-bpc157-peptide-capsules\"\u003eYakka Strength BPC-157 capsules\u003c\/a\u003e and \u003ca href=\"\/products\/yakka-strength-yakka-strength-tb500-peptide-capsules\"\u003eYakka Strength TB-500 capsules\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eBPC-157 and TB-500 in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eSearches such as \"BPC157 TB500 UK\", \"buy TB 500 UK\" and \"TB 500 legal UK\" come down to three questions: is it lawful to sell, who is a credible supplier, and what the listing should prove.\u003c\/p\u003e\u003ch3\u003eLegal position\u003c\/h3\u003e\u003cp\u003eNone of the compounds on this page is a licensed medicine in the United Kingdom, none has been assessed by the MHRA and none is an authorised food supplement. Neither peptide is a controlled drug. They are supplied only as research materials, never for human consumption. Free Muscle supplies them to adults aged 18 and over for laboratory research only. There is no licensed product containing either peptide, so neither is available on prescription. BPC-157 is listed by WADA under S0 and TB-500 under S2, and both are prohibited at all times in tested sport. Buyers are responsible for the rules that apply to them. Our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eSARMs research guide\u003c\/a\u003e has more background.\u003c\/p\u003e\u003ch3\u003eWhat a trustworthy UK listing shows\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBoth compounds named separately\u003c\/strong\u003e, with the manufacturer identified, rather than a blend described only by a nickname.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA lot or batch number\u003c\/strong\u003e on each container, because test results attach to batches, not to product names.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for that batch\u003c\/strong\u003e, covering each peptide in the bundle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA stated strength\u003c\/strong\u003e per capsule for each peptide, or an honest note that none is given.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSale terms that match the law\u003c\/strong\u003e: adults only, laboratory use stated, and no usage instructions or promised effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA traceable UK seller\u003c\/strong\u003e with tracked delivery, plain packaging and a written returns policy.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eHow this listing measures up\u003c\/h3\u003e\u003cp\u003eFreeMuscle LTD is a UK company based in Scunthorpe. The manufacturer is named, sales are restricted to adults and this page gives no directions for use. Every order ships by free tracked UK delivery in plain packaging, orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3 to 7 working days, and unopened items can be returned within 30 days. Two points depend on Yakka Strength: the label gives no per-capsule strength, so that check is not met, and a certificate appears only where one has been supplied for the batch we hold. Our \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e sets out these checks in full, and delivery terms are on the \u003ca href=\"\/pages\/shipping\"\u003eshipping page\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003eBPC-157 and TB-500 are both offered as capsules or tablets, as freeze-dried powder in sealed vials, and occasionally as pre-mixed liquids. The research literature on both peptides relies overwhelmingly on injection: into the abdominal cavity or muscle in rodent studies of BPC-157, and by injection or topical application in thymosin beta-4 work. Some Zagreb experiments gave BPC-157 in drinking water, but no study has measured blood levels in people after an oral dose of either peptide.\u003c\/p\u003e\u003cp\u003eThe obstacle for any swallowed peptide is enzymatic. Pepsin in the stomach and trypsin, chymotrypsin and brush-border peptidases in the small intestine cleave peptide bonds, and short linear chains such as a 15-residue or 7-residue peptide are ordinary substrates. The originating group reports that BPC-157 resists human gastric juice in its own tests; no equivalent claim has been published for the TB-500 fragment. Whether either survives in meaningful amounts is unresolved, which is the subject of \u003ca href=\"\/blogs\/news\/bpc-157-capsules-vs-injection-what-studies-used\"\u003eBPC-157 capsules vs injection: what the studies used\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eAs materials, the formats behave differently. Dry powder, in a capsule or sealed vial, is more stable than peptide in solution. Fill accuracy is another difference: a capsule's content depends on how evenly the powder was blended with filler before encapsulation, while a liquid's depends on how accurately it was made up and measured. None of this implies that any format produces an effect.\u003c\/p\u003e\u003ch2\u003eBPC-157 compared with TB-500\u003c\/h2\u003e\u003cp\u003e\"TB 500 vs BPC 157\" is the comparison searched most often for this pair. Though often sold side by side, they are unrelated, with different parent proteins, different research traditions and different anti-doping classifications.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrigin.\u003c\/strong\u003e BPC-157 is a 15-residue sequence (GEPPPGKPADDAGLV) derived from a protein in gastric juice. TB-500 is built around residues 17 to 23 of thymosin beta-4, the segment linked to actin binding.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProposed mechanism.\u003c\/strong\u003e Work on BPC-157 points to growth factor, nitric oxide and cell-signalling pathways in rodent tissue. Thymosin beta-4 is best known for holding a pool of unpolymerised actin, which influences how cells migrate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvidence base.\u003c\/strong\u003e BPC-157 has rodent and cell studies, mostly from one research network, and no published randomised human trial. Thymosin beta-4 has animal studies from many laboratories and small early human trials of the full protein; the TB-500 fragment itself has none.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegulatory status.\u003c\/strong\u003e Both are unlicensed research compounds in the UK, with no approval from the MHRA, EMA or FDA.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWADA class.\u003c\/strong\u003e S0 for BPC-157, as a substance with no therapeutic approval; S2 for TB-500, because the list names thymosin beta-4 and its derivatives.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eIs TB-500 the same as thymosin beta-4?\u003c\/h3\u003e\u003cp\u003eNo, although the names are often used interchangeably. Thymosin beta-4 is the whole 43-residue protein, about 4,963 g\/mol. The product sold as TB-500 was shown by laboratory analysis to contain the acetylated seven-residue fragment Ac-LKKTETQ, a far smaller molecule. No human study has compared BPC-157 with TB-500, so neither can be ranked above the other, and we give no guidance on studying them together. Single-compound listings are on the \u003ca href=\"\/collections\/tb-500\"\u003eTB-500 collection\u003c\/a\u003e and \u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157 collection\u003c\/a\u003e pages, and the wider class is covered in \u003ca href=\"\/blogs\/news\/sarms-vs-peptides-choosing-by-goal\"\u003eSARMs vs peptides\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eYakka Strength is a third-party brand sold through Muscle Market. For third-party brands we display a certificate of analysis only where the manufacturer supplies one for the exact batch we hold; if none is shown, none has been supplied and we do not substitute a generic document. Free Muscle-brand products, by contrast, are assayed batch by batch at Janoshik Analytical, with the certificate sent on request by email, as with our own \u003ca href=\"\/collections\/bpc-150\"\u003eBPC-150 capsules\u003c\/a\u003e. That testing does not extend to Yakka Strength.\u003c\/p\u003e\u003cp\u003eA certificate covering one peptide says nothing about the other, so read each line against the pack:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompound named.\u003c\/strong\u003e The report should say whether it covers BPC-157, TB-500 or both, and which container it belongs to.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity method.\u003c\/strong\u003e HPLC compares retention time with a reference standard; LC-MS also measures molecular mass. For TB-500, the mass found should match the small acetylated fragment, not the full thymosin beta-4 protein, which is one of the clearest identity checks available.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity percentage.\u003c\/strong\u003e How much of the detected material is the named peptide rather than synthesis by-products; a high figure says nothing about the quantity in a capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The only figure that could supply the strength missing from this label. It should say whether it reports net peptide or total powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number and test date.\u003c\/strong\u003e These must match the lot printed on the container and show how recent the analysis is.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLaboratory name.\u003c\/strong\u003e An unnamed lab cannot be asked to confirm that it issued the report.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eFor this brand, a missing field matters directly: with no content line the strength stays unknown, and a report without a batch number cannot be linked to the capsules in hand. To ask what exists for current stock, send the batch number on the pack through our \u003ca href=\"\/pages\/contact\"\u003econtact page\u003c\/a\u003e. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab testing page\u003c\/a\u003e explains what a certificate shows, and \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e works through an example.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eBoth peptides are prohibited at all times, in and out of competition, under the World Anti-Doping Code, which UK Anti-Doping applies in the UK. BPC-157 is named in S0, the class for substances with no current approval for human therapeutic use. TB-500 falls under S2 through thymosin beta-4 and its derivatives. Strict liability applies, so an athlete is responsible for whatever is found in a sample, whatever the label said.\u003c\/p\u003e\u003cp\u003eAnti-doping laboratories have published methods for each. In 2012 the Ghent doping control laboratory identified Ac-LKKTETQ in a TB-500 product by high-resolution mass spectrometry, synthesised a reference standard and proposed a strategy for finding it in plasma and urine. In 2017 the Salt Lake City laboratory validated a urine test for BPC-157 with a limit of detection of 0.1 ng\/mL, found the peptide stable in urine for at least four days, and improved specificity by measuring a stable metabolite as well. Neither study established how long either peptide stays detectable after human exposure, so the accurate position for both is detectable, window not established.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eNo published stability study covers BPC-157 or TB-500 in capsule form, so the expiry or best-before date printed by the manufacturer, if there is one, is the limit to observe. General peptide chemistry indicates the main risks. Water drives hydrolysis of peptide bonds and makes powder clump and gelatin shells soften. Heat speeds up degradation and some amino acids oxidise over time, a process that light can accelerate.\u003c\/p\u003e\u003cp\u003eKeep each container tightly closed in a cool, dry, dark cupboard, away from heaters and steamy rooms, with any desiccant left in place. If a container is refrigerated, allow it to reach room temperature before opening so moisture does not condense inside. Keep capsules in the original container that carries the batch number, so they can still be matched to a certificate. Handle the contents as laboratory reagents: gloves when working with opened capsules, separation from food and drink, storage out of reach of children and pets, and disposal as chemical waste rather than down a drain.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eActin\u003c\/strong\u003e: a structural protein inside cells; thymosin beta-4 binds its unpolymerised form.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAcetylation\u003c\/strong\u003e: addition of an acetyl group, here to the start of the TB-500 fragment, marked \"Ac-\" in its sequence.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtease\u003c\/strong\u003e: an enzyme that cuts peptide bonds, found throughout the digestive tract.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRetention time\u003c\/strong\u003e: how long a compound takes to pass through a chromatography column, used to match it to a standard.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh-resolution mass spectrometry\u003c\/strong\u003e: measurement of molecular mass precise enough to separate compounds of very similar weight.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eS0 and S2\u003c\/strong\u003e: WADA Prohibited List sections for non-approved substances and for hormones, growth factors and related substances.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: the anti-doping rule that an athlete answers for any prohibited substance in a sample.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/bpc-157\"\u003eBPC-157 collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/tb-500\"\u003eTB-500 (Thymosin Beta-4) collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-yakka-strength\"\u003eYakka Strength brand page\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/peptides\"\u003ePeptides collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/market-bundles\"\u003eBundles collection\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eSupplied for laboratory research use only. Not a medicine, not evaluated by the MHRA, EMA or FDA, and not for human consumption. Buyers must be 18 or over. Nothing on this page is medical or dosing advice or a recommendation to use, stack or cycle any compound; research summaries describe findings in study participants or animals, not claims about this product.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eSikiric P, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857-865. PMID: 27138887.\u003c\/li\u003e\n\u003cli\u003eGoldstein AL, et al. Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. PMID: 22074294.\u003c\/li\u003e\n\u003cli\u003eEsposito S, et al. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012;4(9):733-8. PMID: 22962027.\u003c\/li\u003e\n\u003cli\u003eCox HD, et al. Detection and in vitro metabolism of the confiscated peptides BPC 157 and MGF R23H. Drug Test Anal. 2017;9(10):1490-1498. PMID: 28035768.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468983021794,"sku":null,"price":101.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-research-capsules-bundle-front-d_600x_98cd7685-3b1a-48c2-983e-e465ef78b74a.png?v=1789931453"}],"url":"https:\/\/freemuscle.co.uk\/collections\/brand-yakka-strength.oembed","provider":"Free Muscle","version":"1.0","type":"link"}