{"title":"Ipamorelin","description":"\u003cp\u003eIpamorelin (also written NNC 26-0161) is a synthetic pentapeptide growth hormone secretagogue, a five-amino-acid chain that acts as a selective agonist at the ghrelin receptor, GHS-R1a. It belongs to the growth hormone releasing peptide family alongside GHRP-6 and GHRP-2, and shares its receptor with the non-peptide compound MK-677. This page lists every brand of ipamorelin stocked at Free Muscle, compared on pack size, form and batch testing, and explains what the published research does and does not cover. Research use only, 18+.\u003c\/p\u003e\n\n\u003ch2\u003eWhat is ipamorelin?\u003c\/h2\u003e\n\u003cp\u003eIpamorelin has the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2. It was identified in the 1990s from a chemistry programme that stripped the central Ala-Trp dipeptide out of the earlier growth hormone releasing peptide GHRP-1, and was first described in full in 1998. Like the other members of its family it binds the growth hormone secretagogue receptor on pituitary somatotrophs and triggers a pulse of growth hormone release. What set it apart in the original animal work was selectivity: unlike GHRP-6 and GHRP-2, it did not raise ACTH or cortisol, and it left FSH, LH, prolactin and TSH unchanged.\u003c\/p\u003e\n\u003cp\u003eIpamorelin went into human pharmacokinetic studies and later into a phase 2 clinical trial for postoperative ileus, a slowing of the gut after bowel surgery. That trial did not meet its efficacy endpoints and development was discontinued. Ipamorelin has never been approved as a medicine anywhere. In the UK it is not a licensed medicine and not an authorised food supplement. It is also a peptide, which matters for a capsule product: peptides taken by mouth are largely broken down by digestive enzymes, which is why every human study of ipamorelin used intravenous infusion. Our article \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003eDo oral peptides actually work?\u003c\/a\u003e covers that problem honestly.\u003c\/p\u003e\n\n\u003ch2\u003eWhat the published research reports\u003c\/h2\u003e\n\u003cp\u003eRaun and colleagues (1998) characterised ipamorelin in rat pituitary cells, anaesthetised rats and conscious pigs. It released growth hormone with a potency and efficacy similar to GHRP-6, and in pigs it did not raise ACTH or cortisol even at doses more than 200-fold above the level needed for half-maximal growth hormone release. This is the source of the compound's reputation for selectivity, and it is an animal study.\u003c\/p\u003e\n\u003cp\u003eGobburu and colleagues (1999) gave intravenous infusions of ipamorelin to healthy male volunteers, eight at each of five infusion rates. Pharmacokinetics were dose-proportional, with a terminal half-life of about two hours. Each infusion produced a single episode of growth hormone release, peaking at about 40 minutes and falling back to negligible levels; the variability of the growth hormone response between individuals was larger than the variability in pharmacokinetics.\u003c\/p\u003e\n\u003cp\u003eBeck and colleagues (2014) ran a multicentre, double-blind, placebo-controlled phase 2 trial in 117 adults recovering from bowel resection. Intravenous ipamorelin given for up to seven days after surgery was described as well tolerated, but the median time to tolerating a first solid meal was 25.3 hours against 32.6 hours on placebo, a difference that was not statistically significant, and no secondary endpoint differed from placebo either.\u003c\/p\u003e\n\u003cp\u003eJohansen and colleagues (1999) reported that ipamorelin increased longitudinal bone growth in growing rats, which is again an animal finding. None of these results is a claim about the capsules listed on this page. They describe injected peptide in animals and in supervised human studies, and the compound did not succeed in its one clinical trial.\u003c\/p\u003e\n\n\u003ch2\u003eBrands of ipamorelin we stock\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003ca href=\"\/products\/ipamorelin\"\u003eFree Muscle Ipamorelin, Research Peptide\u003c\/a\u003e\u003c\/strong\u003e: Free Muscle brand, capsule form, 60 capsules per bottle. Every batch is assayed for identity and purity by Janoshik Analytical, with the certificate sent on request. The listing states the declared peptide quantity per capsule where one is given; where it is not, we do not state a figure here.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis collection currently holds one listing. Any other brand of ipamorelin stocked in future would be listed here with its capsule count, declared quantity and batch-certificate status. Related peptides we stock are listed in the \u003ca href=\"\/collections\/peptides\"\u003epeptides collection\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eHow to compare them\u003c\/h3\u003e\n\u003cp\u003eMultiply the declared quantity per capsule by the number of capsules to get total peptide per bottle, then divide the listed price by that figure. Where a manufacturer does not declare a quantity per capsule, that calculation cannot be done and no honest cost per milligram exists; treat that as information in itself. Peptides also degrade more readily than small molecules, so the date and batch on the certificate matter more than they do for a compound like MK-677. See \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e for the method.\u003c\/p\u003e\n\n\u003ch2\u003eBatch testing and certificates of analysis\u003c\/h2\u003e\n\u003cp\u003eA Certificate of Analysis for a peptide batch should report identity, normally by HPLC and mass spectrometry confirming the expected molecular mass, and purity as a percentage, together with the batch number, test date and the laboratory that performed the work. Every Free Muscle batch is assayed by Janoshik Analytical, an independent laboratory; email us the batch number from your label with the product name and we send the certificate for that batch. For other brands we show a certificate only where the manufacturer supplies one for the batch we hold. A generic PDF without a batch number is not a batch certificate. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e and the article \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eHow to read a COA\u003c\/a\u003e explain the detail.\u003c\/p\u003e\n\n\u003ch2\u003eLegal status in the UK\u003c\/h2\u003e\n\u003cp\u003eIpamorelin is not a licensed medicine in the UK, holds no MHRA marketing authorisation and is not an authorised food supplement or novel food. It cannot be sold for human consumption, and Free Muscle supplies it for laboratory research only, to adults aged 18 or over. Under section S2 of the WADA Prohibited List, growth hormone secretagogues and growth hormone releasing peptides are prohibited at all times, so ipamorelin is incompatible with tested sport. For a wider look at how peptides differ from SARMs in UK law and in research, see \u003ca href=\"\/blogs\/news\/sarms-vs-peptides-choosing-by-goal\"\u003eSARMs vs Peptides\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eStorage and handling\u003c\/h2\u003e\n\u003cp\u003ePeptides are less stable than small-molecule compounds. Keep the sealed bottle in a cool, dry place away from light and heat, and follow any storage instruction on the label. Reseal promptly after opening and do not transfer capsules to unlabelled containers. Record the batch number and date of receipt. Keep out of reach of children and pets and apply normal laboratory good practice.\u003c\/p\u003e\n\n\u003ch2\u003eDelivery and returns\u003c\/h2\u003e\n\u003cp\u003eFree Muscle is a UK company, FreeMuscle LTD of Scunthorpe. Orders ship with free tracked UK delivery in plain packaging, and orders placed before 2pm Monday to Friday are processed the same working day. EU delivery takes 3 to 7 working days. Unopened items can be returned within 30 days. See \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eour 30-day guarantee\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eRelated reading\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003eDo Oral Peptides Actually Work? The Honest Answer\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/sarms-vs-peptides-choosing-by-goal\"\u003eSARMs vs Peptides: Choosing by Goal\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eHow to Read a Certificate of Analysis (COA)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/what-is-janoshik-analytical\"\u003eWhat Is Janoshik Analytical? Third-Party Testing Explained\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/peptides\"\u003eResearch Peptides\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/igf-1-lr3\"\u003eIGF-1 LR3\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/hgh\"\u003eHGH (Somatropin)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cem\u003eIpamorelin is sold for laboratory research use only. It is not a licensed medicine, has not been evaluated by the MHRA, EMA or FDA, is not a food supplement and is not for human consumption. Customers must be 18 or over. Nothing on this page is medical advice or dosing guidance, and the published findings summarised above describe animals and supervised study participants, not the products listed.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"ipamorelin","title":"Ipamorelin — Research Peptide","description":"\u003cp\u003e\u003cstrong\u003eIpamorelin — 60 capsules.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eIpamorelin is a selective agonist at the ghrelin (GHS-R1a) receptor. It was studied in early clinical work and development was discontinued. Effects on glucose regulation and long-term safety are not established.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eIt is a capsule, and peptides taken by mouth are largely broken down by digestive enzymes before absorption.\u003c\/strong\u003e That is why clinical work on this class uses injection. We are not going to claim a capsule matches that.\u003c\/p\u003e\u003cp\u003eIt is \u003cstrong\u003enot authorised as a medicine or a food supplement in the UK or EU\u003c\/strong\u003e, and growth hormone secretagogues are on the WADA Prohibited List.\u003c\/p\u003e\u003cp\u003eIdentity and purity are verified per batch by Janoshik Analytical, an independent laboratory. Certificate of Analysis available on request.\u003c\/p\u003e\u003cp\u003e\u003csmall\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e Not a medicine or dietary supplement, not evaluated by the MHRA, EMA or FDA, not for human consumption.\u003c\/small\u003e\u003c\/p\u003e","brand":"FreeMuscle","offers":[{"title":"Default Title","offer_id":47171533635810,"sku":"25506679","price":29.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/IMG-2904.jpg?v=1766262743"}],"url":"https:\/\/freemuscle.co.uk\/collections\/ipamorelin.oembed","provider":"Free Muscle","version":"1.0","type":"link"}