{"title":"MK-677 Ibutamoren","description":"\u003cp\u003eFree Muscle MK-677 Ibutamoren is our own-brand ibutamoren (MK-677, MK-0677, L-163,191, Nutrobal), a non-peptide growth hormone secretagogue and ghrelin receptor agonist, supplied as capsules in three strengths: 10mg, 12.5mg and 25mg, 60 capsules per bottle. This page is about those three listings, made to one specification and assayed batch by batch at Janoshik Analytical. If you want to see Free Muscle set against iMuscle, Yakka Strength and Thoroughbred Labs, the comparison page is \u003ca href=\"\/collections\/mk-677\"\u003eMK-677, all brands\u003c\/a\u003e. Research use only, 18+.\u003c\/p\u003e\n\n\u003ch2\u003eWhat is MK-677?\u003c\/h2\u003e\n\u003cp\u003eIbutamoren is a spiroindoline small molecule designed at Merck in the mid-1990s to reproduce, in an orally active form, the growth hormone release triggered by the injected growth hormone releasing peptides. Its target is the growth hormone secretagogue receptor GHS-R1a, a G protein-coupled receptor expressed in the pituitary and hypothalamus and later identified as the receptor for the stomach hormone ghrelin. Activation of that receptor in trial participants increased the amplitude of growth hormone pulses and, over days to weeks, raised circulating IGF-1 and IGF-binding protein 3.\u003c\/p\u003e\n\u003cp\u003eIbutamoren is chemically unrelated to SARMs and to anabolic steroids, is not a peptide, and contains no growth hormone. It has been studied in humans in more than a dozen published trials, spanning healthy older adults, dieting volunteers, obese men, hip fracture patients and people with Alzheimer disease. It was never granted a marketing authorisation in any country and its clinical programme was discontinued. In the UK it is neither a licensed medicine nor an authorised food supplement.\u003c\/p\u003e\n\n\u003ch2\u003eWhat the published research reports\u003c\/h2\u003e\n\u003cp\u003eIn a randomised, double-blind, placebo-controlled study of 32 healthy adults aged 64 to 81 (Chapman et al., 1996), two weeks of oral MK-677 increased 24-hour mean growth hormone concentration in a dose-dependent way, roughly doubling it at the highest level studied, by enhancing existing pulsatile secretion rather than adding pulses. Serum IGF-1 rose into the young-adult range by four weeks. The same participants showed a significant rise in fasting glucose, from about 5.4 to 6.8 mmol\/L, and a 23 per cent rise in prolactin that stayed within the reference range.\u003c\/p\u003e\n\u003cp\u003eIn a cross-over study of eight healthy young men placed on a calorie-restricted diet (Murphy et al., 1998), a week of MK-677 during the second week of dieting reversed the negative nitrogen balance seen on placebo, and IGF-1 and IGF-binding protein 3 rose. The study lasted 14 days per period, involved eight people, and measured nitrogen balance rather than body composition or performance.\u003c\/p\u003e\n\u003cp\u003eThe largest trial, in 563 patients with mild to moderate Alzheimer disease (Sevigny et al., 2008), gave MK-677 or placebo for 12 months. Serum IGF-1 increased by around 60 per cent at six weeks and 73 per cent at 12 months, confirming that the compound engaged its target, but there was no difference from placebo on any of the four clinical outcome scales. Target engagement, in other words, did not produce a clinical effect.\u003c\/p\u003e\n\u003cp\u003eThese findings describe trial participants under medical supervision. They are not claims about the capsules on this page, and the elevated glucose and unchanged clinical outcomes are as much part of the record as the IGF-1 numbers.\u003c\/p\u003e\n\n\u003ch2\u003eFree Muscle MK-677 Ibutamoren: the three strengths\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/mk-677-ibutamoren-10mg\"\u003eMK-677 Ibutamoren 10mg\u003c\/a\u003e: 60 capsules, 600mg of ibutamoren per bottle.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/mk-677-ibutamoren-12-5mg\"\u003eMK-677 Ibutamoren 12.5mg\u003c\/a\u003e: 60 capsules, 750mg per bottle.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/mk-677-ibutamoren-25mg\"\u003eMK-677 Ibutamoren 25mg\u003c\/a\u003e: 60 capsules, 1,500mg per bottle.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAll three are Free Muscle brand, capsule form, and every batch of each strength is tested for identity and purity by Janoshik Analytical. The only variable between them is the quantity of ibutamoren per capsule and therefore per bottle. We do not recommend one strength over another, because a recommendation would be dosing guidance for a compound sold for laboratory research, and we do not give that. Which listing suits a given piece of laboratory work is a matter for the researcher's own protocol.\u003c\/p\u003e\n\u003ch3\u003eHow to compare them\u003c\/h3\u003e\n\u003cp\u003eMultiply strength by capsule count to get total compound per bottle, then divide the listed price by that figure for a cost per milligram. Within the Free Muscle range the arithmetic is straightforward because the capsule count is fixed at 60. When you compare against another brand, add a third check: does a batch-specific certificate exist for the bottle you would receive? Our article on \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e covers the method, and the \u003ca href=\"\/collections\/mk-677\"\u003eall-brands MK-677 page\u003c\/a\u003e sets out every MK-677 product we stock side by side.\u003c\/p\u003e\n\n\u003ch2\u003eBatch testing and certificates of analysis\u003c\/h2\u003e\n\u003cp\u003eEach production batch of Free Muscle MK-677, at every strength, is sent to Janoshik Analytical, an independent laboratory, for assay. The certificate for a batch reports the identity of the compound against a reference standard and its measured purity, with the batch number, test date and laboratory details. The batch number is printed on your label: email it to us with the product name and strength and we send the Certificate of Analysis for that exact batch. We do not publish one representative certificate and apply it to every bottle, because a certificate that does not carry your batch number is not evidence about your bottle. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e explains what each line means, and \u003ca href=\"\/blogs\/news\/what-is-janoshik-analytical\"\u003ethis article\u003c\/a\u003e covers who Janoshik are and how their testing works.\u003c\/p\u003e\n\n\u003ch2\u003eLegal status in the UK\u003c\/h2\u003e\n\u003cp\u003eMK-677 has no MHRA marketing authorisation and is not a licensed medicine in the UK. It is not an authorised food supplement or novel food and cannot be sold for human consumption. Free Muscle supplies it strictly for laboratory research to adults aged 18 or over. Under the WADA Prohibited List, growth hormone secretagogues including ibutamoren are prohibited at all times, so the compound is incompatible with tested sport. Our \u003ca href=\"\/pages\/mk-677-legal-status-uk\"\u003eMK-677 legal status in the UK\u003c\/a\u003e page sets out the position in full.\u003c\/p\u003e\n\n\u003ch2\u003eStorage and handling\u003c\/h2\u003e\n\u003cp\u003eStore the sealed bottle in a cool, dry place away from light and heat, and reseal it after each opening. Do not transfer capsules to unlabelled containers. Note the batch number in your records at receipt so any certificate request or query can be matched to the material. Keep out of reach of children and pets and follow normal laboratory good practice when handling.\u003c\/p\u003e\n\n\u003ch2\u003eDelivery and returns\u003c\/h2\u003e\n\u003cp\u003eFreeMuscle LTD is registered in Scunthorpe, and all three strengths are dispatched from the UK. Delivery is free and tracked on every order, the packaging is plain, and an order received before 2pm on a working day (Monday to Friday) is processed that same day. Customers in the EU should allow 3 to 7 working days. If an item arrives and stays unopened, it can be returned within 30 days under our guarantee. See \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eRelated reading\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/mk-677-ibutamoren-what-the-research-says\"\u003eMK-677 (Ibutamoren): What the Research Says\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/what-is-janoshik-analytical\"\u003eWhat Is Janoshik Analytical? Third-Party Testing Explained\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eHow to Read a Certificate of Analysis (COA)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/mk-677-brands-compared\"\u003eMK-677 by brand: what actually differs when the molecule is the same\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/mk-677\"\u003eMK-677 (Ibutamoren), all brands\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/brand-free-muscle\"\u003eFree Muscle brand\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/mk-777\"\u003eMK-777 (Acetamoren)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/collections\/bulk\"\u003eBulk collection\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cem\u003eThe three Free Muscle MK-677 Ibutamoren listings on this page are supplied strictly for laboratory research. No medicines regulator (MHRA, EMA or FDA) has evaluated them, they are neither a medicine nor a food supplement, and they must not be consumed. Sales are to adults aged 18 or over only. This page gives no medical or dosing advice, and the trial results summarised above relate to study participants, not to these capsules.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"mk-677-ibutamoren-25mg","title":"MK-677 Ibutamoren — 25mg · 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eMK-677 (Ibutamoren) — 25mg × 60 capsules.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eIbutamoren is a growth hormone secretagogue: an agonist at the ghrelin (GHS-R1a) receptor. It has published human trial data, which is unusual in this category, but development as a medicine was never completed and it is \u003cstrong\u003enot authorised as a medicine or a food supplement in the UK or EU\u003c\/strong\u003e. It is on the WADA Prohibited List and is detectable.\u003c\/p\u003e\u003cp\u003eKnown effects reported in trials include increased appetite, water retention and raised blood glucose. We do not publish dosing schedules, cycle lengths or post-cycle protocols for human use.\u003c\/p\u003e\u003cp\u003eWhat we do verify: identity and purity, per batch, by Janoshik Analytical — an independent laboratory we neither own nor control. The batch number is printed on the pack; email it to us and we will send that batch's Certificate of Analysis. You do not need to have bought anything to ask.\u003c\/p\u003e\u003cp\u003e\u003csmall\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e Not a medicine or dietary supplement, not evaluated by the MHRA, EMA or FDA, not for human consumption. Nothing on this page is medical advice.\u003c\/small\u003e\u003c\/p\u003e","brand":"FreeMuscle","offers":[{"title":"Default Title","offer_id":46856631550178,"sku":"10000014","price":69.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/openart-image_nIMXU6ba_1760816509377_raw.jpg?v=1766262315"},{"product_id":"mk-677-ibutamoren-10mg","title":"MK-677 Ibutamoren — 10mg · 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eMK-677 (Ibutamoren) — 10mg × 60 capsules.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eIbutamoren is a growth hormone secretagogue: an agonist at the ghrelin (GHS-R1a) receptor. It has published human trial data, but development as a medicine was never completed and it is \u003cstrong\u003enot authorised as a medicine or a food supplement in the UK or EU\u003c\/strong\u003e. It is on the WADA Prohibited List and is detectable.\u003c\/p\u003e\u003cp\u003eThe only difference between our 10mg, 12.5mg and 25mg is the amount per capsule. We do not recommend a strength, because that would be dosing advice for a compound sold for research use only.\u003c\/p\u003e\u003cp\u003eIdentity and purity are verified per batch by Janoshik Analytical, an independent laboratory. Certificate of Analysis available on request.\u003c\/p\u003e\u003cp\u003e\u003csmall\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e Not a medicine or dietary supplement, not evaluated by the MHRA, EMA or FDA, not for human consumption.\u003c\/small\u003e\u003c\/p\u003e","brand":"FreeMuscle","offers":[{"title":"Default Title","offer_id":46856695185634,"sku":"10000013","price":49.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/openart-image_Z_Qi57Md_1760817219254_raw.jpg?v=1766262333"},{"product_id":"mk-677-ibutamoren-12-5mg","title":"MK-677 Ibutamoren — 12.5mg · 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eMK-677 (Ibutamoren) — 12.5mg × 60 capsules.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eIbutamoren is a growth hormone secretagogue: an agonist at the ghrelin (GHS-R1a) receptor. It has published human trial data, but development as a medicine was never completed and it is \u003cstrong\u003enot authorised as a medicine or a food supplement in the UK or EU\u003c\/strong\u003e. It is on the WADA Prohibited List and is detectable.\u003c\/p\u003e\u003cp\u003eThe only difference between our 10mg, 12.5mg and 25mg is the amount per capsule. We do not recommend a strength, because that would be dosing advice for a compound sold for research use only.\u003c\/p\u003e\u003cp\u003eIdentity and purity are verified per batch by Janoshik Analytical, an independent laboratory. Certificate of Analysis available on request.\u003c\/p\u003e\u003cp\u003e\u003csmall\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e Not a medicine or dietary supplement, not evaluated by the MHRA, EMA or FDA, not for human consumption.\u003c\/small\u003e\u003c\/p\u003e","brand":"FreeMuscle","offers":[{"title":"Default Title","offer_id":46961071292642,"sku":"10000001","price":44.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/mk.webp?v=1766262843"}],"url":"https:\/\/freemuscle.co.uk\/collections\/mk-677-ibutamoren.oembed","provider":"Free Muscle","version":"1.0","type":"link"}