{"title":"Ostarine (MK-2866)","description":"\u003cp\u003eOstarine, also known as MK-2866, enobosarm, GTx-024, S-22 and MK2866, is a non-steroidal selective androgen receptor modulator (SARM) of the aryl-propionamide family, developed by GTx Inc. It is the most extensively studied SARM in humans, having reached phase 3 trials for cancer-related muscle wasting. This page lists every brand of ostarine stocked at Free Muscle, compared on strength per capsule, capsules per pack and batch testing, and summarises what the clinical research reported, including where it fell short.\u003c\/p\u003e\n\u003ch2\u003eWhat is ostarine?\u003c\/h2\u003e\n\u003cp\u003eOstarine binds the androgen receptor (AR) and acts as an agonist with tissue-selective effects: in preclinical and clinical work it produced anabolic signalling in skeletal muscle and bone while having a much weaker effect on the prostate in men and on hair growth in women. It is not a steroid, is not aromatised to oestrogen and is not a substrate for 5-alpha-reductase. The aryl-propionamide scaffold from which it was derived was developed at the University of Tennessee and Ohio State University in the early 2000s, and the same chemical family gave rise to andarine (S-4) and S-23.\u003c\/p\u003e\n\u003cp\u003eGTx licensed the compound and developed it as enobosarm through phase 1, phase 2 and two phase 3 trials (the POWER programme) for muscle wasting in patients with non-small cell lung cancer, later pursuing it for stress urinary incontinence and AR-positive breast cancer. The phase 3 cachexia trials did not meet the regulatory bar on their co-primary functional endpoint, and the FDA did not approve the drug. Ostarine therefore holds no marketing authorisation from the MHRA, EMA, FDA or any other regulator and is not a prescription medicine anywhere.\u003c\/p\u003e\n\u003ch2\u003eWhat the published research reports\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePhase 2 trial in healthy elderly men and postmenopausal women (2011).\u003c\/strong\u003e Dalton and colleagues ran a 12-week double-blind, placebo-controlled trial of GTx-024 in 120 healthy elderly men over 60 and postmenopausal women. Total lean body mass measured by DXA increased dose-dependently and significantly versus placebo, and physical function also improved significantly. The incidence of adverse events was similar across groups. The participants were healthy older adults, and the trial was funded and run by the developer.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhase 2 trial in cancer cachexia (2013).\u003c\/strong\u003e Dobs and colleagues randomised 159 patients with cancer and recent weight loss to placebo or one of two enobosarm doses for up to 113 days. In the 100 evaluable participants, median total lean body mass rose by 1.5 kg and 1.0 kg in the two active groups, while the placebo change was not significant. Serious adverse events, principally malignant progression, pneumonia and febrile neutropenia, occurred at similar rates across all groups and were not attributed to the study drug. The trial was funded by GTx.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalysis of products sold online as SARMs (2017).\u003c\/strong\u003e Van Wagoner and colleagues bought 44 products marketed as SARMs online. Only 52 per cent contained a SARM (ostarine, LGD-4033 or andarine), 39 per cent contained a different unapproved drug, 9 per cent contained no active compound and 25 per cent contained substances not on the label. The stated amount matched the measured amount in only 41 per cent of products.\u003c\/p\u003e\n\u003cp\u003eThese findings describe trial participants and products purchased from other suppliers. None of them is a claim about the products listed on this page.\u003c\/p\u003e\n\u003ch2\u003eBrands of ostarine we stock\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eiMuscle Ostarine MK-2866, 15mg, 60 capsules.\u003c\/strong\u003e Capsule form, 900mg of compound per pack. A certificate of analysis is shown on the listing only where iMuscle has supplied one for the batch we hold; if none is displayed, none is available for that batch. \u003ca href=\"\/products\/imuscle-ostarine-k2866-60-15mg\"\u003eView the iMuscle Ostarine listing\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFree Muscle does not currently produce its own ostarine, so there is no Janoshik-assayed Free Muscle batch on this page at present. Any Free Muscle-brand line added later will carry batch-level Janoshik testing like the rest of our range.\u003c\/p\u003e\n\u003ch3\u003eHow to compare them\u003c\/h3\u003e\n\u003cp\u003eMultiply strength per capsule by capsules per pack to get total milligrams (15mg by 60 gives 900mg). Divide the pack price by that figure for cost per milligram, which is how a 15mg pack is compared fairly against a 10mg or 25mg one elsewhere. Then look at the certificate. Because ostarine is the SARM most often found in mislabelled or substituted products in the market analyses above, a batch-specific COA from an independent laboratory carries more weight here than for almost any other compound. Our guide to \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e covers the arithmetic.\u003c\/p\u003e\n\u003ch2\u003eBatch testing and certificates of analysis\u003c\/h2\u003e\n\u003cp\u003eA certificate of analysis (COA) answers the two questions that matter about an ostarine capsule: is the compound what the label says, and how much is present. A genuine batch certificate is issued by an independent laboratory, names the lot number, and reports identity (by HPLC or mass spectrometry against a reference standard) and assayed purity or content.\u003c\/p\u003e\n\u003cp\u003eEvery Free Muscle-brand batch is assayed by Janoshik Analytical, an independent laboratory, and the certificate for the batch you receive is sent on request by email. For other brands we show a COA only where the manufacturer has supplied one for the batch we hold. A generic PDF with no batch number, or one dated long before the product was made, is not a batch certificate and tells you nothing about the capsules in your hand. Our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e explains how to read a Janoshik certificate and match it to your batch.\u003c\/p\u003e\n\u003ch2\u003eLegal status in the UK\u003c\/h2\u003e\n\u003cp\u003eOstarine is not a licensed medicine in the United Kingdom. It has never been granted a marketing authorisation by the MHRA, and it is not an authorised food supplement or a permitted novel food ingredient. It cannot legally be sold or labelled for human consumption. Free Muscle sells ostarine to adults aged 18 or over for laboratory and research purposes only, and every listing states this. Ostarine (enobosarm) is named on the World Anti-Doping Agency Prohibited List under S1.2, Other Anabolic Agents, and is prohibited at all times; it is one of the most frequently reported SARMs in anti-doping findings worldwide. Anyone subject to anti-doping rules should treat any product in this class as prohibited at all times, in and out of competition. For a fuller overview of the class, see our \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eresearch guide to SARMs\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eStorage and handling\u003c\/h2\u003e\n\u003cp\u003eKeep ostarine capsules in the original sealed container in a cool, dry place away from light and heat. Do not decant into unlabelled containers, and record the batch number so that a COA request can be matched to the exact material. Keep out of reach of children and pets, and follow standard laboratory good practice: gloves when handling, no eating or drinking in the work area, and disposal in line with local rules for research chemicals.\u003c\/p\u003e\n\u003ch2\u003eDelivery and returns\u003c\/h2\u003e\n\u003cp\u003eUK delivery is free and tracked on every order, and parcels are sent in plain packaging by FreeMuscle LTD, a UK company based in Scunthorpe. Orders placed before 2pm Monday to Friday are processed the same working day; EU customers should allow 3 to 7 working days. Our 30-day return window applies to unopened items. Buyers must be 18 or over. The \u003ca href=\"\/pages\/shipping\"\u003eshipping page\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee page\u003c\/a\u003e set out the details.\u003c\/p\u003e\n\u003ch2\u003eRelated reading\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/sarms-explained-how-selective-androgen-receptor-modulators-work-1135-86\"\u003eSARMs explained: how selective androgen receptor modulators work\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eHow to read a certificate of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/sarms-vs-peptides-choosing-by-goal\"\u003eSARMs vs peptides: choosing by research goal\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/muscle-market-launch\"\u003eMuscle Market: five brands, one basket, one parcel\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRelated collections: \u003ca href=\"\/collections\/andarine\"\u003eAndarine (S-4)\u003c\/a\u003e, \u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033 (Ligandrol)\u003c\/a\u003e, \u003ca href=\"\/collections\/brand-imuscle\"\u003eiMuscle\u003c\/a\u003e, \u003ca href=\"\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eOstarine is sold strictly for laboratory research use only. It is not a licensed medicine, has not been evaluated or approved by the MHRA, EMA or FDA, is not a food supplement and is not for human consumption. Buyers must be 18 or over. Nothing on this page is medical advice, dosing advice or a recommendation to use this compound in any way; the published findings summarised above describe study participants and laboratory models, not the products listed.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"imuscle-ostarine-k2866-60-15mg","title":"iMuscle Ostarine MK-2866 — 60 caps, 15mg","description":"\u003cp\u003eiMuscle Ostarine MK-2866 is a pack of 60 capsules stated at 15 mg each, 900 mg of ostarine in total. Ostarine, also known as enobosarm, MK-2866 or GTx-024, is the most clinically studied compound in the SARM class, having reached Phase 3 trials without approval. iMuscle manufactures it and Free Muscle stocks it in the Muscle Market range for research use by adults aged 18 and over.\u003c\/p\u003e\u003ch2\u003eAbout Ostarine (MK-2866)\u003c\/h2\u003e\u003cp\u003eOstarine is a non-steroidal selective androgen receptor modulator developed by GTx Inc. for muscle wasting and, later, for breast cancer.\u003c\/p\u003e\u003cp\u003eA 2011 Phase 2 trial in 120 healthy elderly men and postmenopausal women reported a placebo-adjusted increase in lean body mass of about 1.3 kg at the 3 mg dose over 12 weeks, alongside improved stair-climb performance, and also recorded falls in HDL cholesterol and modest suppression of testosterone (Dalton et al., 2011). A 2013 randomised Phase 2 trial in patients with cancer-related muscle wasting again found increases in lean body mass (Dobs et al., 2013), but the subsequent Phase 3 POWER trials did not meet their co-primary endpoints and enobosarm was not approved. It remains unlicensed as a medicine in every country.\u003c\/p\u003e\u003cp\u003eThe adverse findings carry as much weight as the lean mass figure. In the full 2011 report, HDL cholesterol fell with dose, by 27 per cent at the highest dose; in men, SHBG and total testosterone fell, though free testosterone did not change significantly; and eight participants had transient rises in the liver enzyme ALT, one of whom was withdrawn. Outside trials, physicians at the University of British Columbia described a previously healthy man in his early forties admitted with jaundice after two months of taking ostarine bought online, without medical supervision (Bedi et al., 2021). A liver biopsy showed moderate to severe cholestasis consistent with drug-induced liver injury, and his blood tests improved gradually over the following months. He had also been taking two prescribed medicines, and the report describes no analysis of the product. One case cannot show how often such injury occurs, and no long-term human data exist.\u003c\/p\u003e\u003cp\u003eThe findings above describe the compound in clinical research and case reports and are not claims about this listing. The later breast cancer trial and the wider literature are covered in the \u003ca href=\"\/blogs\/news\/ostarine-mk-2866-research-guide\"\u003eostarine research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eThis listing\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eCompound: Ostarine (MK-2866)\u003c\/li\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStated strength: 15 mg per capsule (manufacturer's label claim)\u003c\/li\u003e\n\u003cli\u003eStated total per pack: 900 mg\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eThe strength is the manufacturer's label claim; only a batch certificate confirms it. To compare brands of Ostarine, use total milligrams per pack, as explained in \u003ca href=\"\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eOstarine in the UK: buying, legal status and what to check\u003c\/h2\u003e\u003cp\u003eBehind \"ostarine UK\", \"MK 2866 buy UK\" and \"ostarine UK sale\" sit two questions: is buying it here lawful, and what separates one listing from another?\u003c\/p\u003e\u003ch3\u003eThe legal position\u003c\/h3\u003e\u003cp\u003eOstarine is not a licensed medicine in the UK: it has no MHRA marketing authorisation, is not an authorised food supplement, and cannot lawfully be sold for human consumption. It is not a controlled drug under the Misuse of Drugs Act 1971, and Free Muscle supplies it to adults aged 18 or over for laboratory research only. It is prohibited at all times under section S1 (anabolic agents) of the WADA Prohibited List. Buyers are responsible for the rules that apply to them, including any anti-doping code. Background on the class is in \u003ca href=\"\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\u003ch3\u003eSix things a UK listing should show\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLabel figures that can be tested.\u003c\/strong\u003e A strength per capsule and a count, as listed above; without them a listing can be neither checked nor compared.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWho makes it and who sells it.\u003c\/strong\u003e The manufacturer is iMuscle; the seller is FreeMuscle LTD, a UK company based in Scunthorpe.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA lot number that leads to a certificate.\u003c\/strong\u003e The number printed on the pot ties the capsules to an analysis; how this works for iMuscle stock is set out in the certificate section below.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSold for research, to adults.\u003c\/strong\u003e The page gives no directions for use and promises nothing about outcomes, and every buyer must be 18 or over.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDelivery that can be followed.\u003c\/strong\u003e Every UK order travels free, tracked and in plain packaging; orders placed before 2pm Monday to Friday are processed the same working day, and EU delivery takes 3-7 working days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA way back.\u003c\/strong\u003e Unopened items can be returned within 30 days, on the terms given on our \u003ca href=\"\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e pages.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eReviews and \"ostarine UK reddit\" threads can say how fast a parcel arrived, not what the capsules contained; only a laboratory can say that. A longer checklist is in \u003ca href=\"\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\u003cp\u003e\"Ostarine tablets UK\", \"ostarine capsules UK\" and \"ostarine liquid UK\" are all searched. Ostarine is a small synthetic molecule with a molecular weight of 389.3, not a peptide, so the usual objection to swallowed peptides, breakdown by digestive enzymes, does not apply in the same way (see \u003ca href=\"\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e); the Cologne excretion study described below gave it by mouth. The forms differ in how the amount per unit is fixed and how far a certificate can confirm it; no published study has compared them.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003cth\u003eHow the amount is set\u003c\/th\u003e\n\u003cth\u003eWhat a certificate can confirm\u003c\/th\u003e\n\u003cth\u003eMain weakness\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCapsules (this product)\u003c\/td\u003e\n\u003ctd\u003eA powder blend is filled into shells at manufacture\u003c\/td\u003e\n\u003ctd\u003eMeasured content per capsule against the 15 mg label figure\u003c\/td\u003e\n\u003ctd\u003eUniformity between capsules depends on how well the blend was mixed, which an assay of pooled capsules does not reveal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTablets\u003c\/td\u003e\n\u003ctd\u003eA blend is compressed with binders and fillers\u003c\/td\u003e\n\u003ctd\u003eContent per tablet\u003c\/td\u003e\n\u003ctd\u003eThe same reliance on mixing, plus uneven content if tablets are split\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLiquids\u003c\/td\u003e\n\u003ctd\u003eDissolved to a stated concentration in milligrams per millilitre\u003c\/td\u003e\n\u003ctd\u003eConcentration of the solution on the day it was tested\u003c\/td\u003e\n\u003ctd\u003eThe quantity per millilitre can drift after testing, through inaccurate measuring, the compound coming out of solution, or evaporation from a bottle opened repeatedly\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLoose powder\u003c\/td\u003e\n\u003ctd\u003eNot portioned at all\u003c\/td\u003e\n\u003ctd\u003eIdentity and purity of the powder\u003c\/td\u003e\n\u003ctd\u003eEvery quantity must be weighed, so accuracy rests on the balance\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eNone of this is a claim that one form works better than another; it concerns only how a stated quantity can be verified.\u003c\/p\u003e\u003ch2\u003eOstarine compared with LGD-4033\u003c\/h2\u003e\u003cp\u003e\"Ligandrol vs ostarine\" sets ostarine against another member of its class; \"MK 2866 vs MK 677\", a pairing with an unrelated growth hormone secretagogue, is answered in the questions below. Ostarine and LGD-4033 are both non-steroidal SARMs that activate the androgen receptor, and both began as drug candidates that were never approved.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFeature\u003c\/th\u003e\n\u003cth\u003eOstarine (this product)\u003c\/th\u003e\n\u003cth\u003eLGD-4033\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eEnobosarm, MK-2866, GTx-024\u003c\/td\u003e\n\u003ctd\u003eLigandrol, VK5211\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOriginator\u003c\/td\u003e\n\u003ctd\u003eGTx Inc.\u003c\/td\u003e\n\u003ctd\u003eLigand Pharmaceuticals\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical family\u003c\/td\u003e\n\u003ctd\u003eAryl-propionamide with one stereocentre, the (2S) form\u003c\/td\u003e\n\u003ctd\u003ePyrrolidinyl-benzonitrile with two stereocentres\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula and molecular weight\u003c\/td\u003e\n\u003ctd\u003eC19H14F3N3O3, 389.3\u003c\/td\u003e\n\u003ctd\u003eC14H12F6N2O, 338.25\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e841205-47-8\u003c\/td\u003e\n\u003ctd\u003e1165910-22-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFurthest clinical stage\u003c\/td\u003e\n\u003ctd\u003ePhase 3 (the POWER trials in cancer-related muscle wasting)\u003c\/td\u003e\n\u003ctd\u003ePhase 1: one placebo-controlled trial in 76 healthy men aged 21 to 50, lasting 21 days (2013)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAdverse findings reported in people\u003c\/td\u003e\n\u003ctd\u003eFalls in HDL cholesterol, SHBG and total testosterone; transient ALT rises; a biopsy-proven case of cholestatic liver injury\u003c\/td\u003e\n\u003ctd\u003eTotal testosterone, SHBG, HDL cholesterol and triglycerides fell as the dose rose; one biopsy-confirmed report of cholestatic liver injury\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLicensed as a medicine\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eS1.2, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eS1.2, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eThe table invites a head-to-head reading the evidence cannot support. Ostarine's Phase 2 trials enrolled older adults and people with cancer over roughly twelve to sixteen weeks; the only LGD-4033 trial enrolled young, healthy men for three weeks. No study has given both compounds to comparable participants, so any ranking by strength or tolerability has no trial behind it, and a milligram of one molecule is not equivalent to a milligram of the other.\u003c\/p\u003e\u003cp\u003eWhat they share is status: unlicensed everywhere, sold here for laboratory research only, and prohibited under the same WADA section. Brands of LGD-4033 are compared in the \u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033 (Ligandrol) collection\u003c\/a\u003e, and its trial is summarised in \u003ca href=\"\/blogs\/news\/lgd-4033-ligandrol-research-guide\"\u003eLGD-4033 (ligandrol): trials, findings and UK status\u003c\/a\u003e.\u003c\/p\u003e\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\u003cp\u003eiMuscle is a third-party brand, so any certificate of analysis (COA) for this pack is the manufacturer's, not ours. Where iMuscle supplies a COA for the batch we hold, we show it; where none exists for the batch in stock, we say so rather than show a generic document. Free Muscle-brand compounds are assayed batch by batch at Janoshik Analytical; that programme does not cover iMuscle. When a certificate is available, check each field against the table.\u003c\/p\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eField\u003c\/th\u003e\n\u003cth\u003eWhat it should show for this product\u003c\/th\u003e\n\u003cth\u003eWhat a gap means\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCompound\u003c\/td\u003e\n\u003ctd\u003eOstarine, enobosarm or MK-2866, ideally with CAS 841205-47-8\u003c\/td\u003e\n\u003ctd\u003eIt does not describe this pot\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIdentity\u003c\/td\u003e\n\u003ctd\u003eHPLC against a reference standard, or LC-MS showing a mass consistent with C19H14F3N3O3 (molecular weight 389.3)\u003c\/td\u003e\n\u003ctd\u003eWithout identity, a purity figure could belong to a different substance\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStereochemistry\u003c\/td\u003e\n\u003ctd\u003eThe (2S) form that PubChem records under InChIKey JNGVJMBLXIUVRD-SFHVURJKSA-N\u003c\/td\u003e\n\u003ctd\u003eIts mirror image has the same mass and is resolved only by a chiral method, so a certificate naming none has not addressed it\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003eA percentage, usually from HPLC peak area\u003c\/td\u003e\n\u003ctd\u003eNothing is known about impurities or breakdown products\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eContent per capsule\u003c\/td\u003e\n\u003ctd\u003eA measured figure in milligrams to set against the 15 mg label claim\u003c\/td\u003e\n\u003ctd\u003eThe 900 mg per pack stays an untested label claim\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBatch number\u003c\/td\u003e\n\u003ctd\u003eThe same lot as printed on your pot\u003c\/td\u003e\n\u003ctd\u003eThe certificate describes other stock\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTest date and laboratory\u003c\/td\u003e\n\u003ctd\u003eA date and a named laboratory that can confirm the report\u003c\/td\u003e\n\u003ctd\u003eThe result cannot be traced\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003eWhere a field is blank on the certificate for our current batch, ask us through the \u003ca href=\"\/pages\/contact\"\u003econtact page\u003c\/a\u003e what is known before relying on that batch. Further detail is in \u003ca href=\"\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and on our \u003ca href=\"\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\u003cp\u003eOstarine is named in section S1.2 (other anabolic agents) of the WADA Prohibited List, banned in and out of competition, and is the SARM most frequently detected in anti-doping analyses. Under strict liability an athlete answers for any prohibited substance in their sample, whatever its source, and supplements contaminated with minute amounts of ostarine have become a major concern for athletes and the authorities that manage results.\u003c\/p\u003e\u003cp\u003eThat concern prompted a controlled study at the German Sport University Cologne, where single and repeated oral amounts of 1, 10 and 50 micrograms of ostarine were given and urine was analysed by LC-MS\/MS (Walpurgis et al., 2020). A single 1 microgram amount could be detected for up to nine days, depending on whether ostarine itself or its glucuronide was the target, while hydroxylated metabolites gave considerably shorter windows. Peak urine levels and detection times rose with the amount given and varied widely between individuals.\u003c\/p\u003e\u003cp\u003eNo verified study we can cite gives a detection window after milligram quantities such as the 15 mg stated per capsule here, so the accurate statement for this product is: detectable, window not established. Because detection time increased with the amount, the microgram figures are not an upper limit. Anyone subject to an anti-doping code should treat any contact with ostarine as a risk of an adverse finding.\u003c\/p\u003e\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\u003cp\u003eWe can cite no published stability study of ostarine capsules, so we quote no shelf life. Work to the expiry date on the iMuscle pot; a certificate reflects the batch only on its test date.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eContainer.\u003c\/strong\u003e Keep the capsules in the original pot, closed fully after each opening; the pot carries the lot number, and decanting into an unlabelled container breaks the link to any certificate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConditions.\u003c\/strong\u003e A cool, dry, dark place away from heat and direct sunlight. Kitchens and bathrooms are poor choices, as capsule shells take up moisture and can soften or stick together.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecords.\u003c\/strong\u003e Note the lot number and the date the seal was broken, and label any sample taken for analysis with compound, lot and date.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHandling.\u003c\/strong\u003e Use gloves with opened capsules or loose powder, keep the material away from food and drink and out of reach of children and pets, and dispose of it as chemical waste rather than in household bins or drains.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eBreaking the seal also ends the 30-day return option, which applies to unopened items only.\u003c\/p\u003e\u003ch2\u003eGlossary\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnobosarm\u003c\/strong\u003e: the International Nonproprietary Name for ostarine, used in clinical publications; MK-2866 and GTx-024 are development codes for the same molecule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSelective androgen receptor modulator (SARM)\u003c\/strong\u003e: a non-steroidal androgen receptor activator whose developers aimed for effects on muscle and bone with less action on the prostate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAryl-propionamide\u003c\/strong\u003e: the chemical family ostarine belongs to, which also includes andarine (S-4) and S-23.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLean body mass\u003c\/strong\u003e: body weight minus fat, measured in the ostarine trials by dual-energy X-ray absorptiometry (DXA); it includes water and organs as well as muscle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCo-primary endpoint\u003c\/strong\u003e: one of the main outcomes, set in advance, that a trial must meet to count as a success; the POWER trials fell short on theirs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSHBG\u003c\/strong\u003e: sex hormone-binding globulin, which binds testosterone in the blood, so total testosterone tends to fall when SHBG does.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eALT\u003c\/strong\u003e: alanine aminotransferase, a liver enzyme whose blood level rises when liver cells are damaged.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCholestasis\u003c\/strong\u003e: reduced flow of bile from the liver, which can cause jaundice; the pattern seen in the ostarine case report.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucuronide\u003c\/strong\u003e: a compound joined to glucuronic acid by the body so it can be excreted in urine; anti-doping methods can target it.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/ostarine\"\u003eAll brands of Ostarine (MK-2866)\u003c\/a\u003e, compared on strength, pack size and batch testing\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/blogs\/news\/ostarine-mk-2866-research-guide\"\u003eOstarine (MK-2866): the most-studied SARM, what trials found\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e stocked at Free Muscle\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/collections\/lgd-4033\"\u003eLGD-4033 (Ligandrol)\u003c\/a\u003e and \u003ca href=\"\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is supplied for laboratory research use only. It is not a medicine, has not been evaluated by the MHRA, EMA or FDA, and is not for human consumption. Sold to adults aged 18 and over. Nothing on this page is medical, dosing or usage advice.\u003c\/em\u003e\u003c\/p\u003e\u003ch2\u003eReferences\u003c\/h2\u003e\u003col\u003e\n\u003cli\u003eDalton JT, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle. 2011;2(3):153-161. PMID: 22031847.\u003c\/li\u003e\n\u003cli\u003eDobs AS, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol. 2013;14(4):335-45. PMID: 23499390.\u003c\/li\u003e\n\u003cli\u003eBedi H, et al. Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator. ACG Case Rep J. 2021;8(1):e00518. PMID: 34368386.\u003c\/li\u003e\n\u003cli\u003eWalpurgis K, et al. Elimination profiles of microdosed ostarine mimicking contaminated products ingestion. Drug Test Anal. 2020;12(11-12):1570-1580. PMID: 32959982.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468980039906,"sku":null,"price":41.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/OSTABOLON_720x_038c6b35-a391-48d6-a65a-43cf847f030f.jpg?v=1789931412"}],"url":"https:\/\/freemuscle.co.uk\/collections\/ostarine.oembed","provider":"Free Muscle","version":"1.0","type":"link"}