{"title":"5-Amino-1MQ","description":"\u003cp\u003e5-Amino-1MQ, in full 5-amino-1-methylquinolinium and sometimes written 5-amino-1MQ or 5A-1MQ, is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is a positively charged quinolinium salt developed as a research tool for studying fat cell metabolism, and all published data comes from cells, mice and rats. This page lists every brand of 5-Amino-1MQ stocked at Free Muscle, compared on strength per capsule where stated, capsules per pack and whether a batch certificate is available. Sold for laboratory research to adults only.\u003c\/p\u003e\n\n\u003ch2\u003eWhat is 5-Amino-1MQ?\u003c\/h2\u003e\n\u003cp\u003eNNMT is an enzyme found at high levels in the liver and in white fat. It transfers a methyl group from S-adenosylmethionine onto nicotinamide, producing 1-methylnicotinamide. In doing so it consumes both a methyl donor and a precursor of NAD+, the coenzyme at the centre of cellular energy metabolism. In 2014 a group at Harvard reported that NNMT expression is raised in the fat of obese mice and that knocking the enzyme down protected the animals against diet-induced obesity, which made NNMT a target for drug discovery.\u003c\/p\u003e\n\u003cp\u003e5-Amino-1MQ came out of a medicinal chemistry programme at the University of Texas Medical Branch that screened quinolinium compounds for NNMT inhibition and published its structure-activity results in 2017. It was chosen because it inhibits the enzyme selectively, enters cells despite its permanent positive charge, and does not inhibit related methyltransferases. In cultured fat cells it reduced the accumulation of lipid, and in mice fed a high-fat diet it reduced body weight and fat mass. It has never been in a clinical trial. There is no human pharmacokinetic, safety or efficacy data, it is not approved as a medicine anywhere, and the claims that accompany it online go well beyond anything published.\u003c\/p\u003e\n\n\u003ch2\u003eWhat the published research reports\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNNMT knockdown and diet-induced obesity in mice (2014).\u003c\/strong\u003e Using antisense oligonucleotides rather than a drug, researchers reduced NNMT in the liver and fat of mice on a high-fat diet. Treated animals gained less fat, showed higher energy expenditure, higher NAD+ levels and changes in polyamine metabolism. This established the target but did not test any small-molecule inhibitor. Kraus D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258-262. PMID: 24717514.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiscovery of the quinolinium inhibitors (2017).\u003c\/strong\u003e Enzyme assays and computer docking, without animals, identified quinolinium compounds as NNMT inhibitors active at around 1 micromolar, binding where nicotinamide normally sits. Neelakantan H, et al. Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J Med Chem. 2017;60(12):5015-5028. PMID: 28548833.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSmall-molecule NNMT inhibitors reverse diet-induced obesity in mice (2018).\u003c\/strong\u003e Membrane-permeable quinolinium inhibitors including 5-amino-1MQ were tested in cultured adipocytes and in obese mice. Treated mice lost body weight and white fat mass and had lower plasma cholesterol than controls, without a change in food intake. Treatment lasted 11 days, by subcutaneous injection, and no observable adverse effects were recorded in that short period; longer-term effects were not studied. Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152. PMID: 29155147.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMuscle regeneration in aged mice (2019).\u003c\/strong\u003e Twenty-four-month-old mice with a chemically induced muscle injury received subcutaneous injections of an NNMT inhibitor for two or four weeks. Muscle stem cell proliferation, myofibre cross-sectional area and peak contractile torque were higher than in untreated aged controls, with torque roughly 70 per cent higher. A plasma chemistry panel showed no signs of systemic toxicity. The work was limited to aged mice with an induced injury and to cultured cells. Neelakantan H, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-492. PMID: 30753815.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOral bioavailability in rats (2021).\u003c\/strong\u003e Rats were given it intravenously and by mouth, and plasma levels were tracked with a validated LC-MS\/MS assay: about 38 per cent of the oral amount reached the circulation, which the authors called good oral bioavailability. These are the only published pharmacokinetic data we know of; absorption in people has never been measured. Awosemo O, et al. Development \u0026amp; validation of LC-MS\/MS assay for 5-amino-1-methyl quinolinium in rat plasma: application to pharmacokinetic and oral bioavailability studies. J Pharm Biomed Anal. 2021;204:114255. PMID: 34304009.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInhibitor plus a reduced-calorie diet in obese mice (2021).\u003c\/strong\u003e Obese mice switched to a lean diet lost more weight, fat and liver fat when 5-amino-1-methylquinolinium was added than with the diet alone, with no adverse effects reported over seven weeks of treatment. The lead investigator founded Ridgeline Therapeutics, and a co-author was its paid employee. Sampson CM, et al. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. Sci Rep. 2021;11(1):5637. PMID: 33707534.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAll of this is preclinical, largely from one research group, and involves doses set per kilogram of animal body weight that do not translate to a capsule. NNMT also acts in the liver and in cancer biology, and the consequences of inhibiting it in humans over time have not been studied. None of the above is a claim about any product on this page.\u003c\/p\u003e\n\n\u003ch2\u003eBrands of 5-Amino-1MQ we stock\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eThoroughbred Labs 5-Amino-1MQ, 60 capsules.\u003c\/strong\u003e A third-party brand in capsule form, 60 capsules per pack. Thoroughbred Labs states 50 mg per capsule, which is 3,000 mg per pack. A batch certificate of analysis is shown only where Thoroughbred Labs supplies one for the batch we hold, and is not shown otherwise. \u003ca href=\"\/en-ro\/products\/thoroughbred-labs-5-amino-1mq\"\u003eView Thoroughbred Labs 5-Amino-1MQ\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAt present this is the only single-compound 5-Amino-1MQ product we stock. Free Muscle does not make its own version. Other brands will be added to this page when held in stock, on the same terms.\u003c\/p\u003e\n\u003ch3\u003eHow to compare them\u003c\/h3\u003e\n\u003cp\u003eMultiply the strength per capsule by the number of capsules to get total milligrams per pack, then divide the price by that figure for a cost per milligram. Where a listing does not state a strength, treat the pack as unquantified until you have seen the certificate, because a pack of 60 capsules can contain very different amounts of compound. Check who tested the batch, what method was used, whether the certificate covers identity as well as purity, and whether the batch number on the certificate matches the pack. Note also that 5-Amino-1MQ is a salt, so the certificate should say whether the stated weight refers to the salt or to the active cation.\u003c\/p\u003e\n\n\u003cp\u003eThe difference between forms is large. Molar masses from PubChem, checked in October 2026:\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003cth\u003eFormula\u003c\/th\u003e\n\u003cth\u003eMolar mass (g\/mol)\u003c\/th\u003e\n\u003cth\u003eShare that is the active cation\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e5-amino-1-methylquinolinium cation (CID 950107)\u003c\/td\u003e\n\u003ctd\u003eC10H11N2+\u003c\/td\u003e\n\u003ctd\u003e159.21\u003c\/td\u003e\n\u003ctd\u003e100 per cent\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIodide salt (CAS 42464-96-0, CID 66522933)\u003c\/td\u003e\n\u003ctd\u003eC10H11IN2\u003c\/td\u003e\n\u003ctd\u003e286.11\u003c\/td\u003e\n\u003ctd\u003eAbout 56 per cent\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChloride salt (CID 176507677)\u003c\/td\u003e\n\u003ctd\u003eC10H11ClN2\u003c\/td\u003e\n\u003ctd\u003e194.66\u003c\/td\u003e\n\u003ctd\u003eAbout 82 per cent\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eA gram of the iodide therefore holds about 0.56 g of the cation, and a gram of the chloride about 0.82 g, so compare listings on the same basis and ask which form a certificate's quantity refers to.\u003c\/p\u003e\n\n\u003ch2\u003eBatch testing and certificates of analysis\u003c\/h2\u003e\n\u003cp\u003eA certificate of analysis (COA) for a research compound reports identity, confirming that the material is 5-amino-1-methylquinolinium, and purity, the proportion of the sample that is the compound, typically by HPLC with mass spectrometry to confirm identity. A good certificate names the laboratory, method, batch number and date. Because this compound is a simple quinolinium salt, identity testing matters: related quinolinium compounds exist and would not be distinguished by appearance. Whichever salt was weighed, mass spectrometry sees the cation, at a mass-to-charge ratio of about 159 (the validated rat-plasma method monitored the 159.1 ion); a peptide-content figure is irrelevant to a small molecule like this.\u003c\/p\u003e\n\u003cp\u003eFor Thoroughbred Labs we show a certificate only where the manufacturer supplies one for the batch we hold. A generic PDF with no batch number, no date or no named laboratory is not a batch certificate. Free Muscle brand products are assayed by Janoshik Analytical for every batch, with certificates available by email on request. See \u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003eour lab testing page\u003c\/a\u003e for how to read one.\u003c\/p\u003e\n\n\u003ch2\u003eWhere to buy 5-Amino-1MQ in the UK: how to check a supplier\u003c\/h2\u003e\n\u003cp\u003eWhichever shop you buy 5-Amino-1MQ from, check these five points before you order:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eA batch number and a certificate for that batch.\u003c\/strong\u003e The pack should carry a batch number, and the seller should be able to show a certificate of analysis for that same batch from a named laboratory, with the test date. For Thoroughbred Labs, a certificate is shown where the brand supplies one for the batch we hold.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe strength per capsule and the capsule count.\u003c\/strong\u003e With both figures you can work out the total milligrams in the pack and the price per milligram. If a listing does not state one of them, ask the seller before you order.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use labelling and an age check.\u003c\/strong\u003e A research compound should be sold for laboratory research use only, not for human consumption, to adults aged 18 or over, with no dosing or usage advice. That is how every listing here is sold.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrices in pounds sterling and tracked UK dispatch.\u003c\/strong\u003e UK delivery from us is free and tracked on every order, with no minimum spend, and usually arrives 2-3 working days after dispatch; orders placed before 2pm Monday to Friday are processed the same working day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA clear returns policy.\u003c\/strong\u003e Unopened items can be returned to us within 30 days.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eBrand on this page: \u003ca href=\"\/en-ro\/collections\/brand-thoroughbred-labs\"\u003eThoroughbred Labs\u003c\/a\u003e. The \u003ca href=\"\/en-ro\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003ehow we test\u003c\/a\u003e go into more detail.\u003c\/p\u003e\n\n\u003ch2\u003eLegal status in the UK\u003c\/h2\u003e\n\u003cp\u003eStatus of 5-Amino-1MQ in the UK as of October 2026:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMedicines:\u003c\/strong\u003e unlicensed in the UK, with no approval as a medicine in any country and no assessment by the MHRA.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eControlled drugs:\u003c\/strong\u003e not listed under the Misuse of Drugs Act 1971.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFood:\u003c\/strong\u003e neither an authorised food supplement nor a permitted novel food.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinical trials:\u003c\/strong\u003e no trial published, and none listed on ClinicalTrials.gov.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSport:\u003c\/strong\u003e prohibited at all times as an unapproved substance under section S0 of the WADA Prohibited List (details below).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupply:\u003c\/strong\u003e available from Free Muscle for laboratory research, not for human consumption, and never to anyone under 18.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor sport, 5-Amino-1MQ does not appear by name on the 2026 WADA Prohibited List, which does not make it permitted: section S0 bans, at all times, pharmacological substances that are not addressed elsewhere on the List and lack current approval by any health authority for human therapeutic use, and no authority has approved 5-Amino-1MQ. We know of no published anti-doping detection study for it, although a validated LC-MS\/MS assay for rat plasma and urine already exists. The List is revised every year, so anyone subject to anti-doping rules should also check with their governing body. Both compounds are compared at greater length in our \u003ca href=\"\/en-ro\/blogs\/news\/slu-pp-332-and-5-amino-1mq-research-guide\"\u003eSLU-PP-332 and 5-Amino-1MQ research guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eStorage and handling\u003c\/h2\u003e\n\u003cp\u003eKeep the sealed container in a cool, dry spot shielded from light and heat, and close it again straight after opening. Leave the capsules in the labelled container so the batch number stays with them, follow good laboratory practice when handling them, and store them where children and animals cannot reach them.\u003c\/p\u003e\n\n\u003ch2\u003eDelivery and returns\u003c\/h2\u003e\n\u003cp\u003eFree Muscle is the trading name of FreeMuscle, a business registered in Andorra, with UK operations and dispatch in Scunthorpe. Every order ships with free tracked UK delivery in plain packaging. Orders placed before 2pm Monday to Friday are processed the same working day. EU delivery takes 3 to 7 working days. Unopened items can be returned within 30 days. Customers must be 18 or over. See \u003ca href=\"\/en-ro\/pages\/shipping\"\u003eshipping\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/guarantee\"\u003eour guarantee\u003c\/a\u003e for the full terms.\u003c\/p\u003e\n\n\u003ch2\u003eRelated reading\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/slu-pp-332-and-5-amino-1mq-research-guide\"\u003eSLU-PP-332 and 5-Amino-1MQ: what the mouse data show\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eHow to Read a Certificate of Analysis (COA)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003ePrice per milligram: the only honest way to compare\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eHow to choose a SARMs or peptide supplier in the UK: a checklist\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRelated collections: \u003ca href=\"\/en-ro\/collections\/slu-pp-332\"\u003eSLU-PP-332\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/weight-loss\"\u003eMetabolic support\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/cardarine\"\u003eCardarine (GW-501516)\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/brand-thoroughbred-labs\"\u003eThoroughbred Labs\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eResearch compounds sold by Free Muscle are supplied for laboratory research use only and are not for human consumption. They are not authorised as medicines by the MHRA, EMA or FDA, are not food supplements, and are sold only to adults aged 18 or over. Nothing on this page is medical or dosing advice.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"thoroughbred-labs-5-amino-1mq","title":"Thoroughbred Labs 5-Amino-1MQ","description":"\u003cp\u003e\u003cstrong\u003eThoroughbred Labs 5-Amino-1MQ\u003c\/strong\u003e is supplied as a 60-capsule tub, and Thoroughbred Labs prints 50 mg per capsule in the side FACTS panel and repeats it in its own product title. It is supplied through the \u003ca href=\"\/en-ro\/pages\/muscle-market\"\u003eMuscle Market\u003c\/a\u003e range for laboratory research only, is not for human consumption, and is sold to adults aged 18 and over. Below: what the published research on 5-Amino-1MQ reports, what the label documents, how batch certificates are handled for Thoroughbred Labs products, and the questions most often asked about buying 5-Amino-1MQ in the UK.\u003c\/p\u003e\n\u003ch2\u003eAbout 5-Amino-1MQ\u003c\/h2\u003e\n\u003cp\u003e5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed in fat tissue and liver that methylates nicotinamide and in doing so influences the cellular availability of NAD+ precursors and S-adenosylmethionine. It was developed by a group at the University of Texas Medical Branch as a membrane-permeable, selective NNMT inhibitor. It is not a SARM and not a peptide.\u003c\/p\u003e\n\u003cp\u003eInterest in the enzyme came first. A 2014 Nature paper found that NNMT expression was raised in the white fat and liver of obese and diabetic mice, and that lowering NNMT in those tissues with an antisense oligonucleotide protected mice against diet-induced obesity, with higher energy expenditure and higher fat-tissue levels of S-adenosylmethionine and NAD+ (Kraus et al., 2014). That work used a genetic tool, not a drug, but it made NNMT a target, and small-molecule inhibitors such as 5-Amino-1MQ followed.\u003c\/p\u003e\n\u003cp\u003eIn a 2018 study, diet-induced obese mice given an NNMT inhibitor from this series showed lower body weight and white fat mass and lower plasma cholesterol than vehicle-treated animals over the treatment period (Neelakantan et al., 2018). A 2019 study in aged mice reported that the inhibitor increased muscle stem cell activity and larger muscle fibres after an experimental injury (Neelakantan et al., 2019). Both studies used subcutaneous injection in mice over a few weeks, the same laboratory produced both, and neither was designed to assess long-term toxicity. A 2021 study from a collaborating team developed an assay for the compound in rat plasma and urine and measured its behaviour in rats after intravenous and oral administration (Awosemo et al., 2021). There are no human trials, no human pharmacokinetic data and no safety data in people, and the compound has never been approved as a medicine. It is frequently sold alongside claims that nothing published supports. Nothing above is a claim about this product.\u003c\/p\u003e\n\u003cp\u003eIn chemical terms, PubChem (CID 950107) records 5-amino-1-methylquinolinium under CAS number 685079-15-6, with the formula C10H11N2+ and a mass of 159.21 for the ion. The plus sign matters: the ring nitrogen carries a permanent positive charge, so the substance cannot exist on its own as a neutral powder and is always supplied as a salt paired with a negative counter-ion. Its systematic name is 1-methylquinolin-1-ium-5-amine.\u003c\/p\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eManufacturer: Thoroughbred Labs\u003c\/li\u003e\n\u003cli\u003eCompound: 5-Amino-1MQ\u003c\/li\u003e\n\u003cli\u003eForm: Capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStrength: 50 mg per capsule, per the Thoroughbred Labs FACTS panel; 3,000 mg per tub as labelled\u003c\/li\u003e\n\u003cli\u003eBatch certificate of analysis: shown where Thoroughbred Labs supplies one for the batch we hold\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e5-Amino-1MQ in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eSearches such as \"5-Amino-1MQ UK\" and \"5 amino 1mq UK buy\" ask whether a UK shop may sell it and how to judge a listing. 5-Amino-1MQ is not a licensed medicine in the UK, has not been assessed by the MHRA, and is not an authorised food supplement. It is not a controlled drug. It is sold for laboratory research to adults aged 18 and over and is not for human consumption. Whether or not it is named on the WADA Prohibited List, a substance with no current approval for human therapeutic use falls under section S0 (non-approved substances) and is prohibited at all times in sport. Anyone subject to anti-doping rules should consult the current list.\u003c\/p\u003e\n\u003cp\u003eA research listing that publishes instructions for use or promised results contradicts the terms it sells under. What it should publish is information a researcher can check against the pack and a laboratory report. The table sets out those checks for 5-Amino-1MQ and how this listing answers each.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eWhat to look for\u003c\/th\u003e\n\u003cth\u003eWhy it matters for 5-Amino-1MQ\u003c\/th\u003e\n\u003cth\u003eThis listing\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStrength per capsule\u003c\/td\u003e\n\u003ctd\u003eWithout it, total content per pack cannot be calculated\u003c\/td\u003e\n\u003ctd\u003e50 mg per capsule, from the FACTS panel; 3,000 mg per tub as labelled\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSalt form\u003c\/td\u003e\n\u003ctd\u003eThe compound is a charged ion, so the counter-ion changes the weight of each milligram of powder\u003c\/td\u003e\n\u003ctd\u003eNot stated on the label; check any certificate supplied\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBatch number and matching certificate\u003c\/td\u003e\n\u003ctd\u003eConnects an analysis to the stock actually shipped\u003c\/td\u003e\n\u003ctd\u003eCertificate shown only where the manufacturer supplies one for the batch we hold\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIdentifiable UK seller\u003c\/td\u003e\n\u003ctd\u003eGives an age check, a contact and a returns route\u003c\/td\u003e\n\u003ctd\u003eFreeMuscle, registered in Andorra, dispatching from Scunthorpe; 18+ only; 30-day returns on unopened items\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDelivery\u003c\/td\u003e\n\u003ctd\u003eTraceable, discreet transit\u003c\/td\u003e\n\u003ctd\u003eFree tracked UK delivery in plain packaging; EU delivery 3-7 working days\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eOrders placed before 2pm Monday to Friday are processed the same working day. The full terms are on our \u003ca href=\"\/en-ro\/pages\/shipping\"\u003eshipping\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e pages, and the \u003ca href=\"\/en-ro\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e sets out the same tests for any shop. Our \u003ca href=\"\/en-ro\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eresearch guide\u003c\/a\u003e covers the wider legal picture for compounds sold on this basis.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eTesting works differently here than on our own label. Free Muscle-brand batches are each assayed by Janoshik Analytical, an independent laboratory, and the certificate is emailed on request. Thoroughbred Labs is a third-party Muscle Market brand, so for this 5-Amino-1MQ we can show a certificate only if Thoroughbred Labs supplies one for the exact batch in stock. We do not pass off an undated or batchless PDF as a batch certificate. You can \u003ca href=\"\/en-ro\/pages\/contact\"\u003econtact us\u003c\/a\u003e to ask whether a certificate is held for the current batch. Where a certificate exists, the charged structure of 5-Amino-1MQ makes some fields more telling than usual.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity\u003c\/strong\u003e: HPLC compares the sample with a reference standard by retention time; LC-MS adds a mass. Because the molecule is already charged, it appears in positive-mode mass spectrometry at about m\/z 159 without needing to pick up a proton, and the published rat assay monitored a transition from m\/z 159.1 to a fragment at m\/z 90 (Awosemo et al., 2021). A reported mass far from 159 points to a different substance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity\u003c\/strong\u003e: the percentage of detected material that is 5-Amino-1MQ, usually from HPLC peak areas. It describes the powder, not the quantity in each capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSalt form and content\u003c\/strong\u003e: a content figure should say whether it is expressed as the salt or as the ion alone. The same weighed powder gives a smaller number when only the 159.21 ion is counted, so two honest certificates can report different milligrams for identical capsules.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number\u003c\/strong\u003e: must match the number printed on the pack you hold.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTest date and laboratory\u003c\/strong\u003e: identify when and by whom the analysis was done.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMissing fields should be read at face value. A certificate with purity but no content figure confirms what the molecule is while leaving the 50 mg on the label unmeasured. A certificate without a batch number cannot be tied to this stock. If Thoroughbred Labs has supplied nothing for the current batch, this listing makes no analytical claim. Our \u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e and the guide on \u003ca href=\"\/en-ro\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e go further.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eSearch terms such as \"5 amino 1mq capsules UK\", \"5 amino 1mq tablets UK\", \"5 amino 1mq oral\" and \"5-amino-1mq subcutaneous\" show that the compound circulates as capsules, tablets, loose powder and injectable solutions. The published record for each route is thin and should be read carefully.\u003c\/p\u003e\n\u003cp\u003eThe two mouse efficacy papers gave the compound by subcutaneous injection, so they say nothing direct about capsules. The only published oral data come from the 2021 rat study, which found the compound in plasma after oral administration and reported an oral bioavailability of about 38 per cent in rats, meaning a sizeable fraction of the orally administered amount reached the circulation in those animals (Awosemo et al., 2021). Rat figures cannot be converted into human figures, and no study has measured oral absorption in people.\u003c\/p\u003e\n\u003cp\u003eBecause 5-Amino-1MQ is a small molecule rather than a chain of amino acids, it is not broken down by stomach and gut proteases in the way oral peptides are, which is why the \"peptide\" label sometimes attached to it in search results is misleading. Its permanent charge is a different consideration, since charged molecules often cross gut membranes less readily than neutral ones.\u003c\/p\u003e\n\u003cp\u003eOtherwise the formats differ in measurement. A capsule holds a weighed blend of active powder and filler, so consistency depends on even mixing; a solution depends on the compound staying dissolved and intact. Only a content assay could show whether each capsule holds the 50 mg the label states. None of this is a claim about effect.\u003c\/p\u003e\n\u003ch2\u003e5-Amino-1MQ compared with SLU-PP-332\u003c\/h2\u003e\n\u003cp\u003eThe compound most often searched alongside 5-Amino-1MQ is \u003ca href=\"\/en-ro\/collections\/slu-pp-332\"\u003eSLU-PP-332\u003c\/a\u003e, and Thoroughbred Labs also lists the two in a single research pack. They are grouped together because both are recent small molecules discussed in metabolic research, but they act at different points in the cell and have different histories.\u003c\/p\u003e\n\u003cp\u003e5-Amino-1MQ blocks an enzyme. By inhibiting NNMT it reduces the methylation of nicotinamide, which in animal and cell work was linked to changes in NAD+ and S-adenosylmethionine levels. SLU-PP-332 activates receptors: it is a pan-agonist of the oestrogen-related receptors ERR alpha, beta and gamma, nuclear receptors that switch on genes for mitochondrial energy production. One works by taking an enzyme out of play, the other by turning on a transcription programme. Neither acts at the androgen receptor, and neither is a peptide or a hormone.\u003c\/p\u003e\n\u003cp\u003eThe evidence bases are alike in shape. The published mouse studies of SLU-PP-332, looking at endurance and metabolic measures, are recent and come mainly from the group that developed it as an ERR agonist, just as the 5-Amino-1MQ work comes mainly from the group that developed that compound. Neither compound has been given to people in a published study.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint of comparison\u003c\/th\u003e\n\u003cth\u003e5-Amino-1MQ\u003c\/th\u003e\n\u003cth\u003eSLU-PP-332\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eType of action\u003c\/td\u003e\n\u003ctd\u003eEnzyme inhibitor (NNMT)\u003c\/td\u003e\n\u003ctd\u003eReceptor agonist (ERR alpha, beta, gamma)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemistry\u003c\/td\u003e\n\u003ctd\u003eQuinolinium cation, supplied as a salt\u003c\/td\u003e\n\u003ctd\u003eNeutral acylhydrazone, C18H14N2O2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAnimal evidence\u003c\/td\u003e\n\u003ctd\u003eMouse studies from one laboratory\u003c\/td\u003e\n\u003ctd\u003eRecent mouse studies, mainly from one laboratory\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOral data\u003c\/td\u003e\n\u003ctd\u003eRat pharmacokinetics only\u003c\/td\u003e\n\u003ctd\u003eNone published\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman data\u003c\/td\u003e\n\u003ctd\u003eNone\u003c\/td\u003e\n\u003ctd\u003eNone\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA position\u003c\/td\u003e\n\u003ctd\u003eProhibited at all times under S0 (non-approved substances)\u003c\/td\u003e\n\u003ctd\u003eProhibited at all times under S0 (non-approved substances)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eUnlicensed; research use only\u003c\/td\u003e\n\u003ctd\u003eUnlicensed; research use only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThis comparison is pharmacological and regulatory only. Nothing here suggests that the two compounds act together or should be used together, and the \u003ca href=\"\/en-ro\/blogs\/news\/slu-pp-332-and-5-amino-1mq-research-guide\"\u003eSLU-PP-332 and 5-Amino-1MQ research guide\u003c\/a\u003e covers each in more depth.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eFor anyone bound by an anti-doping code, 5-Amino-1MQ is prohibited at all times. Section S0 of the WADA Prohibited List covers any pharmacological substance not approved for human therapeutic use, and this compound has never been approved anywhere, so it is caught whether or not it is named. A compound missing from the named examples is therefore not permitted.\u003c\/p\u003e\n\u003cp\u003eOn detection, the published evidence is limited but clear in one respect. The 2021 rat study validated a liquid chromatography tandem mass spectrometry method that quantified 5-Amino-1MQ in both plasma and urine, the two sample types used in sport testing (Awosemo et al., 2021). What is missing is any excretion study in people, so there is no established detection window in human urine or blood. Any figure quoted online for how long it remains detectable is unsupported. The accurate position is that it is detectable in principle and the window has not been established.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eWith no published stability data for these capsules, storage guidance rests on the compound's chemistry and laboratory practice. The amino group on the aromatic ring is the kind of structure that can slowly oxidise and discolour with air and light, and organic salts in powder form often take up moisture from humid air, which can cause clumping and soften gelatin or plant-based capsule shells. Heat speeds both processes.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eKeep the capsules sealed in the original container, closing it promptly after opening and leaving any desiccant sachet inside.\u003c\/li\u003e\n\u003cli\u003eStore at room temperature or below, away from radiators, windowsills and direct sunlight.\u003c\/li\u003e\n\u003cli\u003eAvoid damp rooms such as bathrooms and kitchens.\u003c\/li\u003e\n\u003cli\u003eKeep the pack and its label together, since the batch number is the link to any certificate of analysis.\u003c\/li\u003e\n\u003cli\u003eKeep out of reach of children and separate from food and drink.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCapsules that have stuck together, changed colour or developed an unusual smell should be set aside and not used for research. Standard laboratory rules on gloves, labelling and disposal of unwanted material apply.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNNMT (nicotinamide N-methyltransferase)\u003c\/strong\u003e: the enzyme 5-Amino-1MQ inhibits; it transfers a methyl group to nicotinamide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNicotinamide\u003c\/strong\u003e: a form of vitamin B3 and a precursor of NAD+.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNAD+\u003c\/strong\u003e: nicotinamide adenine dinucleotide, a coenzyme central to energy metabolism in cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eS-adenosylmethionine (SAM)\u003c\/strong\u003e: the methyl donor NNMT uses; it also supplies methyl groups to DNA and histones.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuinolinium\u003c\/strong\u003e: a quinoline ring with a positively charged nitrogen, the core of 5-Amino-1MQ.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCounter-ion\u003c\/strong\u003e: the negatively charged partner that turns a charged molecule into a stable salt.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOral bioavailability\u003c\/strong\u003e: the fraction of an amount given by mouth that reaches the bloodstream unchanged.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePharmacokinetics\u003c\/strong\u003e: the study of how a substance is absorbed, distributed, broken down and eliminated.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLC-MS\/MS\u003c\/strong\u003e: liquid chromatography with tandem mass spectrometry, used to identify and measure a compound by mass and fragments.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSection S0\u003c\/strong\u003e: the WADA category covering substances with no current approval for human therapeutic use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCertificate of analysis (COA)\u003c\/strong\u003e: a laboratory report of identity, purity and content for a named batch.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eAbout Thoroughbred Labs 5-Amino-1MQ\u003c\/h2\u003e\n\u003cp\u003eThoroughbred Labs is a UK online brand, sold at thoroughbredlabs.co.uk in pounds, with 24\/7 Billing Limited (company number 14990140) named in its footer as the business for statutory purposes; Companies House shows that company as active and London-registered, incorporated in July 2023. The brand states that it has no premises open to customers and deals with enquiries by email or in writing. It offers 5-Amino-1MQ in two forms, a 10 mg freeze-dried vial and these 50 mg capsules, and pairs the capsules with SLU-PP-332 in a Research System. We stock the capsules and the Research System, not the vial.\u003c\/p\u003e\n\u003cp\u003eThe tub carries 5-AMINO-1MQ, 60 CAPSULES and the research-only band on its yellow front label; the side FACTS panel states 5-AMINO-1MQ 50mg per capsule; the fillers are microcrystalline cellulose and magnesium stearate, in a vegetarian capsule. At that stated figure the tub holds 3 g, the largest labelled amount per capsule among the Thoroughbred Labs tubs we stock. The label does not name the counter-ion. When we checked its certificate page on 2 October 2026 it listed a report for the 5-AMINO-1MQ vial (batch TBL5A890) but none for the capsules; a vial report describes different material, so this listing shows no certificate.\u003c\/p\u003e\n\u003cp\u003eThis is the only 5-Amino-1MQ capsule we stock, so the \u003ca href=\"\/en-ro\/collections\/5-amino-1mq\"\u003e5-Amino-1MQ collection\u003c\/a\u003e has no cross-brand comparison; the nearest point of reference is the brand's own \u003ca href=\"\/en-ro\/products\/thoroughbred-labs-research-system-slu-pp-332-amp-5-amino-1mq-ndash-thoroughbred-labs\"\u003eResearch System\u003c\/a\u003e, which contains a tub with the same panel. The \u003ca href=\"\/en-ro\/collections\/brand-thoroughbred-labs\"\u003eThoroughbred Labs collection\u003c\/a\u003e sets out the brand's labelling conventions and published documents. Check the seal, read the panel against this page, keep the batch number and ask us what paperwork exists for it.\u003c\/p\u003e\n\u003cp\u003e5-Amino-1MQ is a small-molecule NNMT inhibitor with rodent data only; nothing containing it is licensed, it is neither medicine nor food under UK law, and WADA section S0 covers it as a substance without any health-authority licence, so it is prohibited at all times. Adults only, laboratory research only.\u003c\/p\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/collections\/5-amino-1mq\"\u003eAll brands of 5-Amino-1MQ we stock, compared\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/collections\/brand-thoroughbred-labs\"\u003eAll Thoroughbred Labs products\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-ro\/products\/thoroughbred-labs-slu\"\u003eThoroughbred Labs SLU-PP-332\u003c\/a\u003e and the \u003ca href=\"\/en-ro\/products\/thoroughbred-labs-research-system-slu-pp-332-amp-5-amino-1mq-ndash-thoroughbred-labs\"\u003eThoroughbred Labs research pack listing both compounds\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/collections\/weight-loss\"\u003eMetabolic research compounds\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003eBatch testing and certificates of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-ro\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eResearch compounds sold by Free Muscle are supplied for laboratory research use only and are not for human consumption. They are not authorised as medicines by the MHRA, EMA or FDA, are not food supplements, and are sold only to adults aged 18 or over. Nothing on this page is medical or dosing advice. Summaries of published research describe study findings and are not claims about any product.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eKraus D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258-262. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24717514\/\" rel=\"noopener\"\u003ePMID: 24717514\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003eNeelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29155147\/\" rel=\"noopener\"\u003ePMID: 29155147\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003eNeelakantan H, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-492. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30753815\/\" rel=\"noopener\"\u003ePMID: 30753815\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003eAwosemo O, et al. Development \u0026amp; validation of LC-MS\/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies. J Pharm Biomed Anal. 2021;204:114255. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34304009\/\" rel=\"noopener\"\u003ePMID: 34304009\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Thoroughbred Labs","offers":[{"title":"Default Title","offer_id":48468980433122,"sku":null,"price":85.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/AMINO_fe46437e-6751-4d1e-acfc-495a52c066d7.png?v=1789931423"}],"url":"https:\/\/freemuscle.co.uk\/en-ro\/collections\/5-amino-1mq.oembed","provider":"Free Muscle","version":"1.0","type":"link"}