{"title":"Enclomiphene","description":"\u003cp\u003eEnclomiphene, also written enclomifene and known in development as Androxal or trans-clomiphene, is the (E)-isomer of clomifene citrate. It is a non-steroidal selective oestrogen receptor modulator (SERM) that acts on oestrogen receptors in the hypothalamus and pituitary. This page lists every brand of enclomiphene stocked at Free Muscle, compared on strength per capsule, capsules per pack and whether the batch has been assayed by an independent laboratory. It is sold for laboratory research to adults only.\u003c\/p\u003e\n\n\u003ch2\u003eWhat is enclomiphene?\u003c\/h2\u003e\n\u003cp\u003eClomifene, the parent compound, is a roughly 60:40 mixture of two geometric isomers. Enclomiphene is the trans (E) isomer. The other, zuclomiphene, has a much longer half-life and is generally described as the more oestrogenic of the two.\u003c\/p\u003e\n\u003cp\u003eThe mechanism is antagonism of oestrogen receptors in the hypothalamus. Oestradiol normally feeds back to reduce the release of gonadotropin-releasing hormone, so blocking that signal allows luteinising hormone (LH) and follicle-stimulating hormone (FSH) to rise, which in turn drives testicular testosterone production. This is why enclomiphene was developed as a treatment for secondary hypogonadism in men, rather than as a replacement testosterone.\u003c\/p\u003e\n\u003cp\u003eEnclomiphene citrate went through phase II and phase III clinical trials in the United States under Repros Therapeutics. A new drug application was filed in the United States and withdrawn in 2015 after the FDA raised concerns about the trial endpoints. In the European Union, the EnCyzix application was refused in 2018; the regulator's reasons are given in the research section below. Enclomiphene is available as a prescription medicine in some countries, but it is not licensed by the MHRA in the UK, and it is not an authorised food supplement. Clomifene itself is a prescription-only medicine in the UK.\u003c\/p\u003e\n\n\u003cp\u003eLabels and certificates may state the citrate salt, the form named in the trials, or the free base, and the figures differ for the same amount of active molecule. Identifiers from PubChem, checked October 2026:\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003cth\u003eCAS number\u003c\/th\u003e\n\u003cth\u003eFormula\u003c\/th\u003e\n\u003cth\u003eMolar mass (g\/mol)\u003c\/th\u003e\n\u003cth\u003ePubChem CID\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eEnclomiphene (free base)\u003c\/td\u003e\n\u003ctd\u003e15690-57-0\u003c\/td\u003e\n\u003ctd\u003eC26H28ClNO\u003c\/td\u003e\n\u003ctd\u003e406.0\u003c\/td\u003e\n\u003ctd\u003e1548953\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEnclomiphene citrate\u003c\/td\u003e\n\u003ctd\u003e7599-79-3\u003c\/td\u003e\n\u003ctd\u003eC32H36ClNO8\u003c\/td\u003e\n\u003ctd\u003e598.1\u003c\/td\u003e\n\u003ctd\u003e6420009\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThe free base is about 68 per cent of the mass of the citrate (406.0 divided by 598.1).\u003c\/p\u003e\n\n\u003ch2\u003eWhat the published research reports\u003c\/h2\u003e\n\u003cp\u003eUnlike most compounds sold in this category, enclomiphene has controlled human trial data. The findings below are reported neutrally, with their limitations.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePharmacokinetic and pharmacodynamic study (2013).\u003c\/strong\u003e A phase II randomised study in 44 men with secondary hypogonadism compared three enclomiphene doses with transdermal testosterone over six weeks. Mean morning testosterone in the highest enclomiphene group reached about 604 ng\/dL against about 500 ng\/dL with the gel, and only enclomiphene raised LH and FSH, both to above the normal range. Effects persisted for at least a week after stopping. Thyroid, cortisol and lipid values were not significantly changed, but IGF-1 fell in both groups, more so with enclomiphene. The sample was small and the study was short. Wiehle R, et al. Testosterone restoration by enclomiphene citrate in men with secondary hypogonadism: pharmacodynamics and pharmacokinetics. BJU Int. 2013;112(8):1188-1200. PMID: 23875626.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase II trial against topical testosterone (2014).\u003c\/strong\u003e Oral enclomiphene citrate was compared with 1 per cent testosterone gel in men with secondary hypogonadism. Both raised morning serum testosterone to a similar degree. With enclomiphene, oestradiol and LH rose along with testosterone, FSH also rose, and sperm counts were conserved. Wiehle RD, et al. Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. Fertil Steril. 2014;102(3):720-727. PMID: 25044085.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase III trials in overweight men (2016).\u003c\/strong\u003e Two 16-week phase III studies in overweight men aged 18 to 60 with secondary hypogonadism again found that enclomiphene raised testosterone, LH and FSH while sperm concentration was maintained, and that testosterone gel lowered LH, FSH and sperm concentration. Despite these results the US application was withdrawn after the FDA questioned whether the chosen endpoints showed a clinical benefit to patients. Kim ED, et al. Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement. BJU Int. 2016;117(4):677-685. PMID: 26496621.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn January 2018 the European Medicines Agency's committee, reviewing four main studies in 588 patients, found that testosterone rose but that effects on symptoms, among them libido, impotence, weight gain and bone strength, had not been studied, and it noted a risk of venous thromboembolism, that is, clots forming in the veins. It judged that the benefits did not outweigh the risks.\u003c\/p\u003e\n\u003cp\u003eAcross these trials the reported adverse events were generally mild, but the studies were of short duration, in clinically diagnosed patients under medical monitoring, and none of them examined long-term effects, effects in men with normal hormone levels, or effects in women. A SERM acts directly on the endocrine axis, and the trials themselves relied on repeated blood tests. None of the above is a claim about any product on this page.\u003c\/p\u003e\n\n\u003ch2\u003eBrands of enclomiphene we stock\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree Muscle Enclomiphene 25 mg, 60 capsules.\u003c\/strong\u003e Our own brand, 25 mg per capsule, 60 capsules per pack, giving 1,500 mg of enclomiphene per pack. Every Free Muscle batch is assayed by Janoshik Analytical for identity and purity, and the certificate for the batch you receive is available by email on request. \u003ca href=\"\/en-ro\/products\/enclomiphene-25mg-60-capsules-free-muscle\"\u003eView Free Muscle Enclomiphene 25 mg\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eYakka Strength Enclomiphene, 60 capsules.\u003c\/strong\u003e A third-party brand in capsule form. The label shown on the listing states 12.5 mg of enclomiphene citrate per capsule and 60 capsules per container, which is 750 mg of the citrate per pack. A batch certificate is shown only where Yakka Strength supplies one for the batch we hold. \u003ca href=\"\/en-ro\/products\/yakka-strength-yakka-strength-enclomiphene\"\u003eView Yakka Strength Enclomiphene\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow to compare them\u003c\/h3\u003e\n\u003cp\u003eMultiply the strength per capsule by the number of capsules to get total milligrams per pack, then divide the price by that figure for a cost per milligram. Two packs of 60 capsules are not equivalent if one is 12.5 mg and the other 25 mg per capsule, and two equal figures are not equivalent if one refers to the citrate salt and the other to the free base. Where a strength is not printed on the listing, treat the pack as unquantified until you have seen the certificate. Finally, check who tested the batch, what method they used and whether the batch number on the certificate matches the pack.\u003c\/p\u003e\n\n\u003ch2\u003eBatch testing and certificates of analysis\u003c\/h2\u003e\n\u003cp\u003eA certificate of analysis (COA) states identity, meaning that the material is enclomiphene and not clomifene or something else, and purity, meaning the proportion of the sample that is enclomiphene, usually by HPLC, along with the laboratory, the method, the batch number, the date and the result. For enclomiphene, identity is an isomer question: enclomiphene and zuclomiphene share one formula and one mass, so the method should separate them, typically by comparing the HPLC retention time with that of an (E)-isomer reference standard. The \u003ca href=\"\/en-ro\/products\/enclomiphene-25mg-60-capsules-free-muscle\"\u003eFree Muscle enclomiphene page\u003c\/a\u003e goes through each field.\u003c\/p\u003e\n\u003cp\u003eEvery Free Muscle batch is tested by Janoshik Analytical, an independent laboratory that we neither own nor control. To request the certificate for your batch, email us with the batch number printed on the pack and we will send it.\u003c\/p\u003e\n\u003cp\u003eA generic PDF with no batch number, no date or no named laboratory is not a batch certificate. It describes one sample at one point in time, not necessarily the material in your hands. For other brands we show a certificate only when the manufacturer has supplied one for the batch we hold. We explain what to look for on \u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003eour lab testing page\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eWhere to buy enclomiphene in the UK: how to check a supplier\u003c\/h2\u003e\n\u003cp\u003eWhichever shop you buy enclomiphene from, check these five points before you order:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eA batch number and a certificate for that batch.\u003c\/strong\u003e The pack should carry a batch number, and the seller should be able to show a certificate of analysis for that same batch from a named laboratory, with the test date. Every Free Muscle-brand batch is assayed by Janoshik Analytical, and we send the certificate for your batch on request. For Yakka Strength, a certificate is shown where the brand supplies one for the batch we hold.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe strength per capsule and the capsule count.\u003c\/strong\u003e With both figures you can work out the total milligrams in the pack and the price per milligram; the comparison table above does this for every listing here that states both. If a listing does not state one of them, ask the seller before you order.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use labelling and an age check.\u003c\/strong\u003e A research compound should be sold for laboratory research use only, not for human consumption, to adults aged 18 or over, with no dosing or usage advice. That is how every listing here is sold.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrices in pounds sterling and tracked UK dispatch.\u003c\/strong\u003e UK delivery from us is free and tracked on every order, with no minimum spend, and usually arrives 2-3 working days after dispatch; orders placed before 2pm Monday to Friday are processed the same working day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA clear returns policy.\u003c\/strong\u003e Unopened items can be returned to us within 30 days.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eBrands on this page: \u003ca href=\"\/en-ro\/collections\/brand-free-muscle\"\u003eFree Muscle\u003c\/a\u003e and \u003ca href=\"\/en-ro\/collections\/brand-yakka-strength\"\u003eYakka Strength\u003c\/a\u003e. The \u003ca href=\"\/en-ro\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003ehow we test\u003c\/a\u003e go into more detail.\u003c\/p\u003e\n\n\u003ch2\u003eLegal status in the UK\u003c\/h2\u003e\n\u003cp\u003eEnclomiphene is not a licensed medicine in the UK. The MHRA has not granted it a marketing authorisation, and it has never been assessed as a food supplement, so it cannot be sold for consumption. It is supplied by Free Muscle for laboratory research to adults aged 18 or over. Its parent compound clomifene is a prescription-only medicine, and some overseas markets treat enclomiphene the same way.\u003c\/p\u003e\n\u003cp\u003eUK clinical opinion is cautious. A 2026 British Society for Sexual Medicine position statement noted that enclomiphene is unlicensed in the UK and stated that its routine use outside specialist settings is not recommended; where it is prescribed, it advised management by experienced clinicians, ideally within research frameworks (Foster J, et al. World J Mens Health. 2026;44(3):480-483. PMID: 41714894).\u003c\/p\u003e\n\u003cp\u003eFor sport, section S4.2 of the 2026 WADA Prohibited List (anti-oestrogenic substances, including SERMs) names clomifene, of which enclomiphene is an isomer, and the class is prohibited at all times, in and out of competition. It is detectable in anti-doping testing. Anyone subject to testing should treat it as prohibited. Our article on \u003ca href=\"\/en-ro\/blogs\/news\/why-post-cycle-therapy-pct-matters\"\u003ewhy post-cycle therapy is discussed\u003c\/a\u003e covers the wider background to this class of compound.\u003c\/p\u003e\n\n\u003ch2\u003eStorage and handling\u003c\/h2\u003e\n\u003cp\u003eKeep the container tightly sealed in a cool, dry place away from direct light and heat. Do not decant into unlabelled containers, keep the batch number with the material, and handle it in line with good laboratory practice. Keep out of the reach of children and animals.\u003c\/p\u003e\n\n\u003ch2\u003eDelivery and returns\u003c\/h2\u003e\n\u003cp\u003eFree Muscle is the trading name of FreeMuscle, a business registered in Andorra, with UK operations and dispatch in Scunthorpe. Every UK order goes out free of charge with tracking, in plain packaging; any order that reaches us by 2pm on a working day is processed on that day, and parcels to the EU take 3 to 7 working days. Returns of unopened items are accepted within 30 days, and every buyer must be 18 or over. Terms: \u003ca href=\"\/en-ro\/pages\/shipping\"\u003eshipping\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eRelated reading\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/enclomiphene-vs-clomifene-research-guide\"\u003eEnclomiphene vs clomiphene (clomifene): what the trials report\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/what-is-in-a-pct-blend\"\u003eWhat is in a PCT blend? Ingredients, evidence and UK status\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eHow to Read a Certificate of Analysis (COA)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/what-is-janoshik-analytical\"\u003eWhat Is Janoshik Analytical? Third-Party Testing Explained\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003ePrice per milligram: the only honest way to compare\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRelated collections: \u003ca href=\"\/en-ro\/collections\/pct-blends\"\u003ePCT blends\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/sarms\"\u003eSARMs\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/brand-free-muscle\"\u003eFree Muscle\u003c\/a\u003e and \u003ca href=\"\/en-ro\/collections\/brand-yakka-strength\"\u003eYakka Strength\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eResearch compounds sold by Free Muscle are supplied for laboratory research use only and are not for human consumption. They are not authorised as medicines by the MHRA, EMA or FDA, are not food supplements, and are sold only to adults aged 18 or over. Nothing on this page is medical or dosing advice.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"enclomiphene-25mg-60-capsules-free-muscle","title":"Enclomiphene — 25mg · 60 Capsules","description":"\u003cp\u003e\u003cstrong\u003eEnclomiphene, 25mg × 60 capsules.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eEnclomiphene is a selective oestrogen receptor modulator, an isomer of clomifene that acts at oestrogen receptors in the hypothalamus. It has been studied in clinical trials but is \u003cstrong\u003enot authorised as a medicine or a food supplement\u003c\/strong\u003e in the UK or EU.\u003c\/p\u003e\u003cp\u003eIt acts directly on the endocrine axis. Use without blood work and clinical monitoring is not something we will guide you through, and we will not supply a protocol. Selective oestrogen receptor modulators are on the WADA Prohibited List.\u003c\/p\u003e\u003cp\u003eIdentity and purity are verified per batch by Janoshik Analytical, an independent laboratory. Certificate of Analysis available on request.\u003c\/p\u003e\u003cp\u003e\u003csmall\u003eResearch compounds sold by Free Muscle are supplied for laboratory research use only and are not for human consumption. They are not authorised as medicines by the MHRA, EMA or FDA, are not food supplements, and are sold only to adults aged 18 or over. Nothing on this page is medical or dosing advice.\u003c\/small\u003e\u003c\/p\u003e","brand":"FreeMuscle","offers":[{"title":"Default Title","offer_id":46945548206306,"sku":"10000006","price":59.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/openart-image_wf-gvHJY_1760827666535_raw_1.jpg?v=1766262540"},{"product_id":"yakka-strength-yakka-strength-enclomiphene","title":"Yakka Strength Enclomiphene","description":"\u003cp\u003e\u003cstrong\u003eYakka Strength Enclomiphene\u003c\/strong\u003e is a Yakka Strength listing of enclomiphene citrate, supplied as 60 capsules per pot; the label facts panel states 12.5 mg of enclomiphene citrate per capsule, 750 mg per pot as labelled, with Yakka Strength Ltd named as distributor. It is supplied through the Muscle Market range for laboratory research only, is not for human consumption, and is sold to adults aged 18 and over. This page sets out what the published research on enclomiphene reports, what the label documents, how it differs from clomifene, how to read a batch certificate for a Yakka Strength product, and where it stands in UK law and in sport.\u003c\/p\u003e\n\u003ch2\u003eAbout Enclomiphene\u003c\/h2\u003e\n\u003cp\u003eEnclomiphene is the trans-isomer of clomifene, a selective oestrogen receptor modulator (SERM). Clomifene as prescribed is a mixture of two isomers; enclomiphene is the one that blocks oestrogen receptors in the hypothalamus and pituitary, which reduces negative feedback and raises secretion of LH and FSH. It was developed by Repros Therapeutics under the name Androxal for secondary hypogonadism in men. Chemically it is a small synthetic molecule, formula C26H28ClNO, molecular weight 406.0 as the free base, CAS 15690-57-0, PubChem CID 1548953, also indexed as enclomifene, trans-clomifene and RMI 16,289.\u003c\/p\u003e\n\u003ch3\u003eWhat the trials measured\u003c\/h3\u003e\n\u003cp\u003eA 2013 phase IIB study enrolled 12 men with secondary hypogonadism who had previously used topical testosterone, randomising them to oral enclomiphene citrate or testosterone gel. Both groups reached similar morning testosterone values at six months, but only the enclomiphene group showed higher LH and FSH, and sperm concentrations rose in every man in that group who was measured. Testosterone fell back to pre-treatment values one month after the study ended.\u003c\/p\u003e\n\u003cp\u003eA 2014 randomised phase II trial in men with secondary hypogonadism reported that oral enclomiphene citrate raised serum testosterone into the normal range while sperm concentration was maintained, whereas topical testosterone lowered sperm counts. Two phase III trials published in 2016 reported the same pattern in obese hypogonadal men, with adverse events recorded in both arms.\u003c\/p\u003e\n\u003ch3\u003eLimits of the evidence and regulatory outcome\u003c\/h3\u003e\n\u003cp\u003eThese studies were small or short, sponsored by the developer, and measured blood hormones and semen counts in men with a diagnosed condition rather than symptoms or long-term outcomes. Despite those data, the US application did not succeed: the FDA raised concerns about the trials and did not approve it. A European application did not lead to an authorisation either, so enclomiphene is not an authorised medicine in the UK, the EU or the US. Clomifene, its parent, is prescription-only in the UK. Nothing above is a claim about this product.\u003c\/p\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eBrand and distributor: Yakka Strength (back panel: Distributed by Yakka Strength Ltd; side panel: Made in the UK; no manufacturer named)\u003c\/li\u003e\n\u003cli\u003eCompound: Enclomiphene citrate, as the label names it\u003c\/li\u003e\n\u003cli\u003eForm: Capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStrength: 12.5 mg enclomiphene citrate per capsule, as printed in the label facts panel; the brand gives no free-base equivalent\u003c\/li\u003e\n\u003cli\u003eTotal per pot: 750 mg of the citrate salt, as labelled (12.5 mg x 60)\u003c\/li\u003e\n\u003cli\u003eBatch certificate of analysis: shown where Yakka Strength supplies one for the batch we hold\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAt a labelled 750 mg of enclomiphene citrate per pot, the cost of each milligram can be set against other listings, with one caution: the figure is for the citrate salt, and a listing that states free-base enclomiphene is not directly comparable without conversion. Our guide to \u003ca href=\"\/en-ro\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e explains the comparison.\u003c\/p\u003e\n\u003ch2\u003eEnclomiphene in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eSearches such as \"enclomiphene uk buy\" and \"enclomiphene uk legal\" come down to two questions. Can an adult in the UK obtain enclomiphene lawfully, and how can a buyer tell a documented listing from an undocumented one.\u003c\/p\u003e\n\u003ch3\u003eWhere enclomiphene sits in UK law\u003c\/h3\u003e\n\u003cp\u003eEnclomiphene is not a licensed medicine in the UK, holds no MHRA marketing authorisation, and is not an authorised food supplement. It is not a controlled drug. It is sold for laboratory research to adults aged 18 and over and is not for human consumption. Its position differs from its parent: clomifene is a prescription-only medicine, supplied only against a prescription for licensed uses, whereas enclomiphene on its own has no licence to be prescribed against. It is not a SARM either, although some sellers file it under that heading; it acts on oestrogen receptors, not androgen receptors. SERMs including clomifene are named under section S4 (hormone and metabolic modulators) of the WADA Prohibited List. Our \u003ca href=\"\/en-ro\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eresearch guide\u003c\/a\u003e covers the wider legal picture.\u003c\/p\u003e\n\u003ch3\u003eWhat a documented UK listing shows\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA named manufacturer\u003c\/strong\u003e and a seller that can be identified and contacted in the UK.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA milligram figure on the label\u003c\/strong\u003e, with enclomiphene specified as citrate or free base.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA batch or lot number on the pack\u003c\/strong\u003e that can be matched to paperwork.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate of analysis for that batch\u003c\/strong\u003e, from a named laboratory, with a date.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use terms\u003c\/strong\u003e: sales restricted to adults, with no usage directions or outcome promises.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClear delivery and returns terms\u003c\/strong\u003e, published before purchase.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow this listing compares with that list\u003c\/h3\u003e\n\u003cp\u003eThe distributor is named on the pack and the seller is FreeMuscle, a business registered in Andorra with UK operations and dispatch in Scunthorpe. UK orders go by free tracked delivery in plain packaging, orders placed before 2pm Monday to Friday are processed the same working day, EU delivery takes 3-7 working days, and unopened items can be returned within 30 days under our \u003ca href=\"\/en-ro\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e. Details are on the \u003ca href=\"\/en-ro\/pages\/shipping\"\u003eshipping page\u003c\/a\u003e. The strength point is met: Yakka Strength prints 12.5 mg of enclomiphene citrate per capsule. The open point is the certificate, which appears only where the brand supplies one for the batch we hold. A buyer who needs a certificate for every batch can compare \u003ca href=\"\/en-ro\/products\/enclomiphene-25mg-60-capsules-free-muscle\"\u003eFree Muscle enclomiphene\u003c\/a\u003e, whose batches are assayed by Janoshik Analytical. A longer checklist is in \u003ca href=\"\/en-ro\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eSearches for \"enclomiphene tablets\" arise because clomifene is dispensed as tablets, while research enclomiphene appears as capsules, tablets and occasionally liquids. The active molecule is identical across these formats; what varies is how precisely each unit is filled and how well the material is protected from moisture, air and light.\u003c\/p\u003e\n\u003cp\u003eCapsules and tablets both start as a powder blend of the compound and an inactive filler. How close each unit is to its target depends on how evenly that blend was mixed before filling, and the only way to check is to assay several units from the same batch. A liquid holds the compound in solution, so its content is a concentration: accuracy depends on complete dissolution, on the measuring device and on the solvent not evaporating over time, which would slowly concentrate what is left. Dry solids generally degrade more slowly than solutions.\u003c\/p\u003e\n\u003cp\u003eEnclomiphene is not a peptide, so the enzymatic breakdown in the gut that limits peptides given by mouth, discussed in \u003ca href=\"\/en-ro\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e, does not apply to it. The published trials all gave enclomiphene citrate by mouth, which describes their design and says nothing about the performance of this product. The citrate point also matters for labels: a milligram figure for the salt contains less enclomiphene base than the same figure for the free base, so a strength is only comparable once the form is stated.\u003c\/p\u003e\n\u003ch2\u003eEnclomiphene compared with clomifene\u003c\/h2\u003e\n\u003cp\u003e\"Enclomiphene vs clomiphene\" is the most-searched comparison for this compound. Clomiphene is the US spelling; clomifene is the UK and international name. The answer is a matter of chemistry, evidence and regulation rather than one being better than the other.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003ePoint\u003c\/th\u003e\n\u003cth\u003eEnclomiphene\u003c\/th\u003e\n\u003cth\u003eClomifene\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eWhat it is\u003c\/td\u003e\n\u003ctd\u003eA single geometric isomer, (E) or trans\u003c\/td\u003e\n\u003ctd\u003eA mixture of the (E) isomer and the (Z) isomer, zuclomiphene\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBehaviour of the isomers\u003c\/td\u003e\n\u003ctd\u003eThe shorter-lived, oestrogen-blocking component\u003c\/td\u003e\n\u003ctd\u003eAlso contains zuclomiphene, which is longer-lived and weakly oestrogenic\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman evidence\u003c\/td\u003e\n\u003ctd\u003ePhase II and phase III trials in men with secondary hypogonadism, sponsored by the developer\u003c\/td\u003e\n\u003ctd\u003eDecades of clinical use in female infertility; the 2019 detection study in healthy men\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUK status\u003c\/td\u003e\n\u003ctd\u003eNot licensed; sold for research only\u003c\/td\u003e\n\u003ctd\u003ePrescription-only medicine\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eSection S4, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eNamed in section S4, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThe two isomers share a formula and a mass but differ in shape, and that shape difference changes how they bind the oestrogen receptor and how long they stay in the body. The case for developing enclomiphene alone rested on removing the slow-clearing zuclomiphene from the mixture. The trials in men compared enclomiphene with testosterone gel, not with clomifene, so there is no head-to-head human trial of the two. Clomifene is not stocked by Free Muscle, because it is a prescription medicine; the only related collection we hold is the \u003ca href=\"\/en-ro\/collections\/enclomiphene\"\u003eenclomiphene collection\u003c\/a\u003e, which lists every brand of enclomiphene we carry. A longer treatment of the trials, with their adverse findings, is in our \u003ca href=\"\/en-ro\/blogs\/news\/enclomiphene-vs-clomifene-research-guide\"\u003eenclomiphene vs clomifene research guide\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eYakka Strength is a third-party brand in the Muscle Market range, so the testing position differs from our own label. Every Free Muscle-brand batch is assayed by Janoshik Analytical, an independent laboratory, with the certificate sent on request by email. For Yakka Strength products we show a certificate of analysis only where the manufacturer supplies one for the specific batch we hold. A generic PDF with no batch number is not a batch certificate, and we do not present one as such. If you want to know whether a certificate is held for the current batch, ask through our contact page.\u003c\/p\u003e\n\u003cp\u003eWhen a certificate is available, these are the lines to read:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e HPLC compares the retention time of the main peak with a reference standard; LC-MS adds the measured mass. For enclomiphene the isomer matters: enclomiphene and zuclomiphene have the same mass, so identity should be confirmed against an (E)-isomer reference. A report that says only \"clomiphene\" does not show which isomer is present.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Usually an HPLC peak-area percentage. It describes the material tested, not how much is in each capsule, and zuclomiphene is the impurity most worth looking for.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAssay or content.\u003c\/strong\u003e The measured amount per capsule, to be read against the 12.5 mg of citrate on the label; check which form, salt or base, the laboratory reports.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number and test date.\u003c\/strong\u003e The batch must match the pack; the date shows how old the analysis is relative to the stock.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIssuing laboratory.\u003c\/strong\u003e A named laboratory can be asked to confirm that it issued the report.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor a third-party brand a missing field has a plain meaning. No identity line leaves the compound unconfirmed; purity without content leaves the strength unknown; no batch number means the document cannot be tied to the pack in hand. Our \u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e and the article on \u003ca href=\"\/en-ro\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a certificate of analysis\u003c\/a\u003e cover the general method, and our \u003ca href=\"\/en-ro\/pages\/contact\"\u003econtact page\u003c\/a\u003e is the route for requesting what we hold.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eEnclomiphene is prohibited in sport at all times, in and out of competition. SERMs including clomifene are named under section S4 (hormone and metabolic modulators) of the WADA Prohibited List. Enclomiphene, as an isomer of clomifene, falls within that class. Strict liability applies, including to a mislabelled product.\u003c\/p\u003e\n\u003cp\u003eThe controlled detection study cited here concerns clomifene rather than isolated enclomiphene. In 2019 an anti-doping laboratory gave clomifene citrate to 12 healthy men aged 25 to 38 for a month. Serum testosterone, LH and FSH rose during treatment, drug concentrations varied widely between individuals, and zuclomiphene stayed detectable in urine from 121 to more than 261 days. That long window belongs to the zuclomiphene component. No verified study reports a urinary window for enclomiphene given alone, so for this product the accurate statement is: detectable, window not established.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eKeep the pack sealed in its original container until it is needed, with the lid closed, in a cool, dry and dark place away from heaters, sunny windows, kitchens and bathrooms. Moisture is the main threat to capsules: gelatine and plant shells absorb water, soften and can stick together, and damp powder degrades faster. Warmth accelerates both processes, and each opening of the container lets in humid air.\u003c\/p\u003e\n\u003cp\u003eNo published stability study covers enclomiphene in capsule form that we are aware of, so the expiry or best-before date on the pack is the working limit, and the batch number should be recorded alongside the date the pack was opened. Do not decant capsules into unlabelled containers or mix them with another batch, because that breaks the link between the material and its certificate. Standard laboratory practice applies: gloves when handling opened capsules or loose powder, no food or drink in the working area, clear labelling, storage out of reach of children and pets, and disposal as chemical waste rather than in household bins or drains.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSERM\u003c\/strong\u003e: a compound whose effect at the oestrogen receptor depends on the tissue, acting as a blocker in some and an activator in others.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGeometric isomers\u003c\/strong\u003e: molecules with the same atoms and formula but a different fixed arrangement around a double bond, labelled (E) and (Z).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eZuclomiphene\u003c\/strong\u003e: the (Z) or cis isomer of clomifene, cleared from the body much more slowly than enclomiphene.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree base and citrate salt\u003c\/strong\u003e: the molecule alone, and the molecule paired with citric acid; the salt weighs more per unit of active compound.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSecondary hypogonadism\u003c\/strong\u003e: a testosterone shortfall that originates in the brain's hormone signals, with the testes themselves intact.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGonadotrophins\u003c\/strong\u003e: LH (luteinising hormone) and FSH (follicle-stimulating hormone), released by the pituitary gland to regulate the testes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHPLC and LC-MS\u003c\/strong\u003e: liquid chromatography methods; HPLC separates a sample into peaks, and LC-MS adds a measurement of each molecule's mass.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCertificate of analysis (COA)\u003c\/strong\u003e: a dated test report tied by number to a single manufactured batch.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrict liability\u003c\/strong\u003e: the anti-doping rule that an athlete is responsible for any prohibited substance in their sample, regardless of intent.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eAbout Yakka Strength Enclomiphene\u003c\/h2\u003e\n\u003cp\u003eYakka Strength names the salt on its enclomiphene label. The front of the pot reads \"Enclomiphene Citrate\" in white on the brand's black label, with \"60 capsules\" and the research-only line; the side panel gives enclomiphene citrate 12.5 mg a capsule, sixty to the pot, so 750 mg of the salt per pot as labelled, and \"Made in the UK\". The brand's product page gives the same figures. A citrate figure contains less enclomiphene itself than the same figure of free base; the brand states no conversion, so neither do we.\u003c\/p\u003e\n\u003cp\u003eThe pot is distributed by Yakka Strength Ltd, which the Companies House register lists under number 13284431 with an office in County Durham, and which trades mainly in gym equipment and sports nutrition; the research capsules, eleven products in all, are a sideline. Enclomiphene appears in two of them: this pot and the \u003ca href=\"\/en-ro\/products\/yakka-strength-yakka-strength-rad140-enclomiphene-bundle\"\u003eRAD-140 and Enclomiphene bundle\u003c\/a\u003e, meaning this pot boxed with the brand's RAD140 pot, each with its own label. The full range is on the \u003ca href=\"\/en-ro\/collections\/brand-yakka-strength\"\u003eYakka Strength brand page\u003c\/a\u003e. Yakka Strength's website gives no analytical results and names no laboratory or manufacturer. To check a pot, find the lot number on the container itself (the label artwork has no batch field) and ask us, quoting it, what certificate the brand has supplied for that batch; a useful certificate identifies enclomiphene, says whether it measured citrate or free base, and gives a content per capsule.\u003c\/p\u003e\n\u003cp\u003eEnclomiphene is clomifene's trans isomer, an oestrogen receptor modulator. It has no MHRA marketing authorisation, and the US application for it was withdrawn in 2015 after FDA objections. Some countries license it as a prescription medicine, and WADA section S4 prohibits it in sport. The only other enclomiphene we stock is Free Muscle's own, labelled 25 mg in 60 capsules, with every Free Muscle batch going to Janoshik Analytical; the two are set side by side in the \u003ca href=\"\/en-ro\/collections\/enclomiphene\"\u003eenclomiphene collection\u003c\/a\u003e, where the salt question matters for any like-for-like comparison.\u003c\/p\u003e\n\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/collections\/enclomiphene\"\u003eAll brands of Enclomiphene we stock, compared\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/collections\/brand-yakka-strength\"\u003eAll Yakka Strength products\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/products\/yakka-strength-yakka-strength-rad140-enclomiphene-bundle\"\u003eYakka Strength RAD-140 and Enclomiphene bundle\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/enclomiphene-vs-clomifene-research-guide\"\u003eEnclomiphene vs clomifene: what the trials report\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003eBatch testing and certificates of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-ro\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eResearch compounds sold by Free Muscle are supplied for laboratory research use only and are not for human consumption. They are not authorised as medicines by the MHRA, EMA or FDA, are not food supplements, and are sold only to adults aged 18 or over. Nothing on this page is medical or dosing advice. Summaries of published research describe study findings and are not claims about any product.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eKaminetsky J, et al. Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel. J Sex Med. 2013;10(6):1628-35. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23530575\/\" rel=\"noopener\"\u003ePMID: 23530575\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003eWiehle RD, et al. Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. Fertil Steril. 2014;102(3):720-7. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25044085\/\" rel=\"noopener\"\u003ePMID: 25044085\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003eKim ED, et al. Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement. BJU Int. 2016;117(4):677-85. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26496621\/\" rel=\"noopener\"\u003ePMID: 26496621\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003eMiller GD, et al. Hypothalamic-Pituitary-Testicular Axis Effects and Urinary Detection Following Clomiphene Administration in Males. J Clin Endocrinol Metab. 2019;104(3):906-914. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30295816\/\" rel=\"noopener\"\u003ePMID: 30295816\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Yakka Strength","offers":[{"title":"Default Title","offer_id":48468982268130,"sku":null,"price":63.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/yakka-strength-enclomiphene-pack-shot-white.jpg?v=1791052895"}],"url":"https:\/\/freemuscle.co.uk\/en-ro\/collections\/enclomiphene.oembed","provider":"Free Muscle","version":"1.0","type":"link"}