{"title":"LGD-4033 (Ligandrol)","description":"\u003cp\u003eLGD-4033, also known as ligandrol, anabolicum, VK5211 and LGD4033, is a non-steroidal selective androgen receptor modulator (SARM) developed by Ligand Pharmaceuticals and later licensed to Viking Therapeutics. It is one of the few SARMs with a published placebo-controlled study in healthy men, which makes its evidence base unusually easy to describe. This page lists every brand of LGD-4033 stocked at Free Muscle, compared on strength per capsule, capsules per pack and batch testing, and summarises the research and its limits.\u003c\/p\u003e\n\u003ch2\u003eWhat is LGD-4033?\u003c\/h2\u003e\n\u003cp\u003eLGD-4033 is a pyrrolidinyl-benzonitrile compound that binds the androgen receptor (AR) with high affinity and selectivity. Like other SARMs it is not a steroid: it does not share the four-ring skeleton of testosterone and is not a substrate for aromatase or 5-alpha-reductase, so it is not converted to oestrogen or dihydrotestosterone. The design goal was to produce anabolic signalling in skeletal muscle and bone with much weaker activity in the prostate, which is the reason SARMs were pursued as candidates for age-related muscle loss and hip-fracture recovery.\u003c\/p\u003e\n\u003cp\u003eLigand Pharmaceuticals took LGD-4033 through phase 1 work in healthy volunteers around 2010. Viking Therapeutics later licensed it as VK5211 and ran a randomised, double-blind, placebo-controlled phase 2 trial in 108 patients aged 65 or over recovering from acute hip fracture, completed in December 2017 (NCT02578095). Summary results are posted on the trial registry, but no peer-reviewed report of the trial was indexed in PubMed when we searched on 2 October 2026. Development has not progressed to a licensing application. LGD-4033 has never been approved as a medicine by the MHRA, EMA, FDA or any other regulator, and it is not available on prescription anywhere.\u003c\/p\u003e\n\u003cp\u003eIdentity, as recorded in PubChem:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number\u003c\/strong\u003e: 1165910-22-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula\u003c\/strong\u003e: C14H12F6N2O\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight\u003c\/strong\u003e: 338.25\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID\u003c\/strong\u003e: 44137686\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDevelopment code\u003c\/strong\u003e: VK5211\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat the published research reports\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePlacebo-controlled study in healthy young men (2013).\u003c\/strong\u003e Basaria and colleagues randomised 76 healthy men aged 21 to 50 to placebo or one of three ascending dose levels of LGD-4033 for three weeks, with follow-up for five weeks afterwards. Lean body mass increased dose-dependently, while fat mass did not change significantly. The compound was associated with dose-dependent suppression of total testosterone, sex hormone-binding globulin, HDL cholesterol and triglycerides, with follicle-stimulating hormone and free testosterone significantly suppressed at the highest dose. Haemoglobin, prostate-specific antigen, liver enzymes and QT intervals did not change significantly. Elimination was slow, with a long half-life, and with repeated administration the compound accumulated in proportion to the dose. Hormone and lipid values returned to baseline after the compound was stopped. The authors called for longer trials before any conclusion about efficacy or health outcomes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLiver injury case reports (2020 to 2024).\u003c\/strong\u003e Barbara and colleagues described a 32-year-old man who developed severe drug-induced liver injury after using a product sold as Ligandrol; liver biopsy confirmed cholestatic hepatitis with mild portal, periportal and perisinusoidal fibrosis, and the authors noted that the compound is sold over the counter and online. Koller and colleagues reported two young men who had used ligandrol, ostarine or both and then other substances. Both developed jaundice with a mainly cholestatic injury after stopping the SARMs and both had recovered roughly three months later; the authors suggested that the other substances may have contributed. Labban and colleagues described a 52-year-old man with itching, jaundice, weight loss and raised liver enzymes after LGD-4033 use, with other causes excluded. LiverTox, the drug-induced liver injury reference on the NCBI Bookshelf, has an entry on selective androgen receptor modulators.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBone in a rat model of osteoporosis (2023).\u003c\/strong\u003e Hoffmann and colleagues gave ligandrol for five weeks, at three dose levels, to ovariectomised rats, a model of postmenopausal bone loss. Only the highest dose subtly improved some structural bone measures, with no change in biomechanical properties, and it also increased uterus and heart weights; the lower doses had no effect on bone. The authors concluded that, given these side effects, further study of ligandrol for postmenopausal osteoporosis should be reconsidered.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalysis of products sold online as SARMs (2017).\u003c\/strong\u003e Van Wagoner and colleagues purchased 44 products marketed online as SARMs and analysed them using anti-doping laboratory methods. Only 23 (52 per cent) contained a SARM at all (ostarine, LGD-4033 or andarine); 17 contained a different unapproved drug; 4 contained no active compound; and in only 18 of 44 did the measured amount match the label. Products bought from unverified sources therefore cannot be assumed to be LGD-4033, or to contain the stated quantity.\u003c\/p\u003e\n\u003cp\u003eThese findings describe study participants, individual patients, laboratory animals and products bought from other suppliers. None of them is a claim about the products listed on this page.\u003c\/p\u003e\n\u003ch2\u003eBrands of LGD-4033 we stock\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eiMuscle Ligandrol LGD-4033, 8mg, 60 capsules.\u003c\/strong\u003e Capsule form, 480mg of compound per pack. A certificate of analysis is shown on the listing only where iMuscle has supplied one for the batch we hold; if none is shown, none is available for that batch. \u003ca href=\"\/en-ro\/products\/imuscle-ligandrol-lgd4033-60-8mg\"\u003eView the iMuscle LGD-4033 listing\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFree Muscle does not currently produce its own LGD-4033, so there is no Janoshik-assayed batch on this page at present.\u003c\/p\u003e\n\u003ch3\u003eHow to compare them\u003c\/h3\u003e\n\u003cp\u003eThe method is the same whether there is one listing or five. Multiply strength per capsule by capsules per pack to get total milligrams (8mg by 60 gives 480mg). Divide the pack price by total milligrams for cost per milligram, which lets an 8mg product be compared fairly against a 5mg or 10mg one from another supplier. Then weigh the certificate. A batch-specific COA from an independent laboratory turns a label claim into a measurement; without one, the 2017 market analysis above shows how often the label is wrong. Our guide to \u003ca href=\"\/en-ro\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e covers the arithmetic.\u003c\/p\u003e\n\u003ch2\u003eBatch testing and certificates of analysis\u003c\/h2\u003e\n\u003cp\u003eThe only LGD-4033 on this page is made by iMuscle, so any certificate shown is the manufacturer's, displayed only where iMuscle has supplied one for the batch we hold. When reading a certificate, check that the identity result is consistent with ligandrol's formula, C14H12F6N2O, and molecular weight, 338.25, and that the content is reported per capsule against the 8mg on the label. Both checks matter here: a 2017 analysis of 44 internet products marketed as SARMs found that just 23 contained a SARM of any kind and just 18 held the labelled amount.\u003c\/p\u003e\n\u003cp\u003eA certificate that gives no batch number, laboratory name or test date cannot be tied to the capsules in a particular pack. Our \u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e explains how to read a certificate and match it to a batch.\u003c\/p\u003e\n\u003ch2\u003eWhere to buy LGD-4033 in the UK: how to check a supplier\u003c\/h2\u003e\n\u003cp\u003eWhichever shop you buy LGD-4033 from, check these five points before you order:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eA batch number and a certificate for that batch.\u003c\/strong\u003e The pack should carry a batch number, and the seller should be able to show a certificate of analysis for that same batch from a named laboratory, with the test date. For iMuscle, a certificate is shown where the brand supplies one for the batch we hold.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe strength per capsule and the capsule count.\u003c\/strong\u003e With both figures you can work out the total milligrams in the pack and the price per milligram. If a listing does not state one of them, ask the seller before you order.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use labelling and an age check.\u003c\/strong\u003e A research compound should be sold for laboratory research use only, not for human consumption, to adults aged 18 or over, with no dosing or usage advice. That is how every listing here is sold.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrices in pounds sterling and tracked UK dispatch.\u003c\/strong\u003e UK delivery from us is free and tracked on every order, with no minimum spend, and usually arrives 2-3 working days after dispatch; orders placed before 2pm Monday to Friday are processed the same working day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA clear returns policy.\u003c\/strong\u003e Unopened items can be returned to us within 30 days.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eBrand on this page: \u003ca href=\"\/en-ro\/collections\/brand-imuscle\"\u003eiMuscle\u003c\/a\u003e. The \u003ca href=\"\/en-ro\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eUK supplier checklist\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003ehow we test\u003c\/a\u003e go into more detail.\u003c\/p\u003e\n\n\u003ch2\u003eLegal status in the UK\u003c\/h2\u003e\n\u003cp\u003eLGD-4033 is not listed in the Misuse of Drugs Act 1971. Without an MHRA marketing authorisation it cannot lawfully be marketed as a medicine for people, and the Food Standards Agency, as UK Anti-Doping records, classes SARMs as unauthorised novel foods, which excludes them from food and dietary supplements. Free Muscle offers it for laboratory research only, and only to buyers who are at least 18.\u003c\/p\u003e\n\u003cp\u003eThe 2026 WADA Prohibited List names LGD-4033 (ligandrol) in S1.2, other anabolic agents, prohibited in and out of competition; SARMs as a class have been banned since 2008, and ligandrol was first named on the list in 2018. UK Anti-Doping lists it as ligandrol (Anabolicum, LGD-4033, VK-5211). Anti-doping laboratories screen for it: a Polish laboratory has described ligandrol metabolites in routine athlete urine samples and noted that dietary supplements may contain the compound as a listed ingredient or as a contaminant (Kwiatkowska 2023). More on the class is in our \u003ca href=\"\/en-ro\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eresearch guide to SARMs\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eStorage and handling\u003c\/h2\u003e\n\u003cp\u003eKeep the iMuscle pack sealed in its original container, so the batch number stays with the capsules, in a cool, dry place away from light. Store it out of reach of children and pets, follow ordinary laboratory good practice, wearing gloves and keeping food and drink away from the bench, and dispose of unused material in line with local rules for research chemicals.\u003c\/p\u003e\n\u003ch2\u003eDelivery and returns\u003c\/h2\u003e\n\u003cp\u003eFree Muscle, whose UK operations are in Scunthorpe, posts every order with free tracked UK delivery in plain packaging. Weekday orders received before 2pm are processed that working day. Delivery to EU addresses takes 3 to 7 working days. Unopened items can be returned within 30 days, and all customers must be 18 or over. Full terms are on our \u003ca href=\"\/en-ro\/pages\/shipping\"\u003eshipping page\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/guarantee\"\u003eguarantee page\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eRelated reading\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eHow to choose a SARMs supplier in the UK: a checklist\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eHow to read a certificate of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003ePrice per milligram: the only honest way to compare SARMs and peptides\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/ostarine-mk-2866-research-guide\"\u003eOstarine (MK-2866): what the clinical trials found\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRelated collections: \u003ca href=\"\/en-ro\/collections\/rad-140\"\u003eRAD-140 (Testolone)\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/ostarine\"\u003eOstarine (MK-2866)\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/brand-imuscle\"\u003eiMuscle\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eBasaria S, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95. PMID: 22459616.\u003c\/li\u003e\n\u003cli\u003eBarbara M, et al. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J. 2020;7(6):e00370. PMID: 32637435.\u003c\/li\u003e\n\u003cli\u003eKoller T, et al. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review. World J Clin Cases. 2021;9(16):4062-4071. PMID: 34141767.\u003c\/li\u003e\n\u003cli\u003eLabban H, et al. LGD-4033 and a Case of Drug-Induced Liver Injury: Exploring the Clinical Implications of Off-Label Selective Androgen Receptor Modulator Use in Healthy Adults. Cureus. 2024;16(9):e69601. PMID: 39421081.\u003c\/li\u003e\n\u003cli\u003eHoffmann DB, et al. Effects of ligandrol as a selective androgen receptor modulator in a rat model for osteoporosis. J Bone Miner Metab. 2023;41(6):741-751. PMID: 37407738.\u003c\/li\u003e\n\u003cli\u003eVan Wagoner RM, et al. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017;318(20):2004-2010. PMID: 29183075.\u003c\/li\u003e\n\u003cli\u003eKwiatkowska D, et al. Variation of Sequential Ligandrol (LGD-4033) Metabolite Levels in Routine Anti-Doping Urine Samples Detected with or without Other Xenobiotics. Molecules. 2023;28(18):6486. PMID: 37764261.\u003c\/li\u003e\n\u003cli\u003eKintz P, Gheddar L. Drug transfer during intimate moments can produce an adverse analytical finding during a doping control: A case report with ligandrol. J Anal Toxicol. 2025;49(8):615-619. PMID: 40338642.\u003c\/li\u003e\n\u003cli\u003eClinicalTrials.gov. NCT02578095: Acute Hip Fracture Study in Patients 65 Years or Greater. Completed 17 December 2017.\u003c\/li\u003e\n\u003cli\u003eLiverTox (NCBI Bookshelf). Selective Androgen Receptor Modulators. NBK619971.\u003c\/li\u003e\n\u003cli\u003eUK Anti-Doping. SARMs (supplement ingredient warning). Last updated 29 April 2026.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eResearch compounds sold by Free Muscle are supplied for laboratory research use only and are not for human consumption. They are not authorised as medicines by the MHRA, EMA or FDA, are not food supplements, and are sold only to adults aged 18 or over. Nothing on this page is medical or dosing advice. Summaries of published research describe study findings and are not claims about any product.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"imuscle-ligandrol-lgd4033-60-8mg","title":"iMuscle Ligandrol LGD-4033 — 60 caps, 8mg","description":"\u003cp\u003eiMuscle Ligandrol LGD-4033 is supplied as 60 capsules stated at 8 mg each, a total of 480 mg of LGD-4033 per pack. LGD-4033, also called ligandrol, is a non-steroidal selective androgen receptor modulator with a placebo-controlled human trial behind it. This iMuscle product is stocked by Free Muscle through Muscle Market for laboratory research by adults only.\u003c\/p\u003e\n\u003ch2\u003eAbout LGD-4033\u003c\/h2\u003e\n\u003cp\u003eLGD-4033, known as ligandrol and, in later development, as VK5211, is a non-steroidal selective androgen receptor modulator developed by Ligand Pharmaceuticals. It binds the androgen receptor with high affinity and was designed to act on muscle and bone while producing less effect on the prostate and skin than testosterone.\u003c\/p\u003e\n\u003cp\u003eIn a placebo-controlled study published in 2013, 76 healthy men aged 21 to 50 received placebo or one of three amounts of LGD-4033 for 21 days (Basaria et al., 2013). Lean body mass rose in a dose-dependent manner, while fat mass did not change significantly. The same study recorded dose-dependent falls in total testosterone, sex hormone-binding globulin, HDL cholesterol and triglycerides; free testosterone and follicle-stimulating hormone fell significantly at the highest amount only. Hormones and lipids returned to baseline after the study ended. Muscle strength and stair-climbing power were also measured, but the abstract reports no functional result, and the authors called for longer trials. Later development did not lead to approval.\u003c\/p\u003e\n\u003cp\u003eOutside clinical trials, the main evidence of harm comes from case reports. In 2020 physicians at Baylor College of Medicine described a 32-year-old man admitted with jaundice, itching and raised liver enzymes after taking a product sold over the counter as Ligandrol for about two weeks (Barbara et al., 2020). A liver biopsy showed cholestatic hepatitis with mild fibrosis, and his blood tests improved once he stopped. The product was never analysed, and the authors noted it may have contained other unapproved drugs. One case cannot show how often such injury occurs, and no long-term human data have been published. Nothing summarised here is a claim about this product.\u003c\/p\u003e\n\u003ch3\u003eChemical identity\u003c\/h3\u003e\n\u003cp\u003ePubChem records LGD-4033 under the identifiers below, which describe the molecule a certificate for this pack should report finding.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystematic name\u003c\/strong\u003e: 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number\u003c\/strong\u003e: 1165910-22-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula and molecular weight\u003c\/strong\u003e: C14H12F6N2O, 338.25 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInChIKey\u003c\/strong\u003e: OPSIVAKKLQRWKC-VXGBXAGGSA-N\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID\u003c\/strong\u003e: 44137686\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eThis listing\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCompound: LGD-4033 (Ligandrol)\u003c\/li\u003e\n\u003cli\u003eBrand: iMuscle\u003c\/li\u003e\n\u003cli\u003eForm: capsules\u003c\/li\u003e\n\u003cli\u003ePack size: 60 capsules\u003c\/li\u003e\n\u003cli\u003eStated strength: 8 mg per capsule (manufacturer's label claim)\u003c\/li\u003e\n\u003cli\u003eStated total per pack: 480 mg\u003c\/li\u003e\n\u003cli\u003eIntended use: laboratory research only, not for human consumption\u003c\/li\u003e\n\u003cli\u003eSold to adults aged 18 and over\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe strength is the manufacturer's label claim; only a batch certificate confirms it. To compare brands of LGD-4033, use total milligrams per pack, as explained in \u003ca href=\"\/en-ro\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eLGD-4033 in the UK: buying, legal status and what to check\u003c\/h2\u003e\n\u003cp\u003eSearches such as \"LGD 4033 UK buy\" and \"ligandrol UK\" ask two things: whether it can be bought lawfully here, and how to tell one listing from another.\u003c\/p\u003e\n\u003ch3\u003eThe legal position\u003c\/h3\u003e\n\u003cp\u003eLGD-4033 is not a licensed medicine in the UK: it has no MHRA marketing authorisation, is not an authorised food supplement, and cannot lawfully be sold for human consumption. It is not scheduled under the Misuse of Drugs Act, and Free Muscle supplies it only as a research compound, to adults aged 18 or over, for laboratory research. It is prohibited at all times under section S1 (anabolic agents) of the WADA Prohibited List. Buyers are responsible for the rules that apply to them, including any anti-doping code. Background on the class is in \u003ca href=\"\/en-ro\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eWhat are SARMs? The 2026 research guide\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eWhat a trustworthy listing shows, and where to find it here\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eA strength and a count that multiply.\u003c\/strong\u003e Here, 8 mg by 60 capsules gives the 480 mg stated for the pack; a listing with no strength can be neither compared nor checked.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA named maker and seller.\u003c\/strong\u003e iMuscle manufactures this product; FreeMuscle, a business registered in Andorra, sells it and dispatches it from Scunthorpe.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eA certificate for the batch, not the brand.\u003c\/strong\u003e How this works for iMuscle stock is set out in the certificate section below.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-use terms and an age limit.\u003c\/strong\u003e No instructions for use, no outcome claims, adults aged 18 or over only.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTracked, discreet delivery.\u003c\/strong\u003e Free tracked UK delivery in plain packaging; orders before 2pm Monday to Friday processed the same working day; EU delivery in 3-7 working days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReturns.\u003c\/strong\u003e Unopened items within 30 days, under our \u003ca href=\"\/en-ro\/pages\/shipping\"\u003edelivery\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/guarantee\"\u003eguarantee\u003c\/a\u003e terms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eA label proves little by itself: the doctors behind the 2020 liver injury report could not say what their patient's \"Ligandrol\" contained, and nor can anyone holding a pot without a batch certificate. Threads under \"ligandrol reddit\" record experiences, not contents. More checks are in \u003ca href=\"\/en-ro\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003ehow to choose a SARMs supplier in the UK\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eCapsules compared with other forms\u003c\/h2\u003e\n\u003cp\u003eProducts labelled LGD-4033 appear as capsules, tablets, liquids and loose powder. The molecule is the same in each; what differs is how the amount per unit is fixed and how it can be checked. No published study has compared the formats.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCapsules (this product).\u003c\/strong\u003e A blended powder is portioned into shells at manufacture, so the amount per capsule is fixed then and a certificate can report it directly against the 8 mg claim. Accuracy depends on even mixing, and one assay gives the average of the capsules tested, not the spread between them.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTablets.\u003c\/strong\u003e A similar blend compressed with binders, with the same dependence on mixing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiquids.\u003c\/strong\u003e Labelled in milligrams per millilitre. A certificate describes the solution on the day of testing; later accuracy depends on drawing exact volumes and on the compound staying dissolved, and solvent lost from a bottle opened often concentrates what remains.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLoose powder.\u003c\/strong\u003e Sold for weighing, which moves the whole question of accuracy onto the balance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSolutions suit very small quantities: the Cologne excretion study described below prepared its microgram amounts from an ethanol solution (Wagener et al., 2022). Because LGD-4033 is a small synthetic molecule rather than a peptide, the usual objection to swallowed peptides, breakdown by digestive enzymes, does not arise in the same way (see \u003ca href=\"\/en-ro\/blogs\/news\/do-oral-peptides-work\"\u003edo oral peptides work\u003c\/a\u003e), and the 2013 trial gave it by mouth. We know of no published human study of LGD-4033 given by injection.\u003c\/p\u003e\n\u003ch2\u003eLGD-4033 compared with RAD-140\u003c\/h2\u003e\n\u003cp\u003e\"LGD 4033 vs RAD 140\" and \"ligandrol vs RAD 140\" are the comparisons searched most often for this compound. Both are non-steroidal SARMs that activate the androgen receptor, and both began as drug candidates that never reached approval.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFeature\u003c\/th\u003e\n\u003cth\u003eLGD-4033 (this product)\u003c\/th\u003e\n\u003cth\u003eRAD-140\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eOther names\u003c\/td\u003e\n\u003ctd\u003eLigandrol, VK5211\u003c\/td\u003e\n\u003ctd\u003eTestolone, vosilasarm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDeveloper\u003c\/td\u003e\n\u003ctd\u003eLigand Pharmaceuticals, later licensed to Viking Therapeutics\u003c\/td\u003e\n\u003ctd\u003eRadius Health\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical family\u003c\/td\u003e\n\u003ctd\u003ePyrrolidinyl-benzonitrile with six fluorine atoms\u003c\/td\u003e\n\u003ctd\u003eChlorinated benzonitrile with an oxadiazole ring\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormula, molecular weight, CAS\u003c\/td\u003e\n\u003ctd\u003eC14H12F6N2O, 338.25, 1165910-22-4\u003c\/td\u003e\n\u003ctd\u003eC20H16ClN5O2, 393.8, 1182367-47-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublished clinical trial\u003c\/td\u003e\n\u003ctd\u003ePlacebo-controlled study in 76 healthy men over 21 days (2013)\u003c\/td\u003e\n\u003ctd\u003ePhase 1 in women with advanced ER-positive, HER2-negative breast cancer (2022)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMain adverse findings in people\u003c\/td\u003e\n\u003ctd\u003eDose-related falls in testosterone, SHBG, HDL cholesterol and triglycerides; a biopsy-confirmed liver injury case\u003c\/td\u003e\n\u003ctd\u003eRaised liver enzymes and bilirubin common in the trial; liver injury case reports\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLicensed as a medicine\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003ctd\u003eNowhere\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWADA\u003c\/td\u003e\n\u003ctd\u003eNamed in S1.2, prohibited at all times\u003c\/td\u003e\n\u003ctd\u003eNamed in S1.2, prohibited at all times\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eThe two trials cannot be set side by side. LGD-4033 went to young, screened, healthy men for three weeks, with body composition and hormones among the outcomes; RAD-140 went to women with advanced cancer to find a tolerable amount for oncology, and muscle was not its question. No study has given the two compounds to comparable groups, so claims that one is \"stronger\" or \"milder\" rest on anecdote, and milligrams of two different molecules are no common currency either.\u003c\/p\u003e\n\u003cp\u003eIn law and in sport they stand together, as the last two rows show, and both are sold here for laboratory research only. RAD-140 brands are compared in the \u003ca href=\"\/en-ro\/collections\/rad-140\"\u003eRAD-140 (Testolone) collection\u003c\/a\u003e, and its trial and case reports are covered in \u003ca href=\"\/en-ro\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReading the certificate of analysis for this product\u003c\/h2\u003e\n\u003cp\u003eBecause iMuscle is a third-party brand, a certificate of analysis (COA) for this pack is the manufacturer's document, not ours. A certificate is shown only where iMuscle has supplied one for the batch we hold; a generic document that names no batch is not a substitute. Free Muscle-brand compounds are assayed batch by batch at Janoshik Analytical, but that programme does not cover iMuscle. A real batch certificate is specific to one lot. Each part answers a different question, and each gap leaves that question open:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompound.\u003c\/strong\u003e It should name LGD-4033 or ligandrol, ideally with the CAS number. A certificate naming only \"SARM\" or another compound does not relate to this pack.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity.\u003c\/strong\u003e HPLC matches the sample's peak to a reference standard; LC-MS adds a molecular mass that should fit C14H12F6N2O. Without identity, a purity figure could describe the wrong substance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIsomer.\u003c\/strong\u003e The (2R) and (1R) in the systematic name mark two stereocentres, so other isomers share the formula and mass. One, the epimer labelled M1, forms in the body and separates from LGD-4033 on chromatography (Wagener et al., 2022); mirror-image forms separate only by chiral methods, so a certificate naming none has not addressed them.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity.\u003c\/strong\u003e Usually an HPLC area percentage: how much of the detected material is LGD-4033. It says nothing about milligrams per capsule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContent per capsule.\u003c\/strong\u003e The measured figure to set against 8 mg. Without it, the 480 mg on the label stays untested.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLot, date and laboratory.\u003c\/strong\u003e The lot must match your pot, the date shows the age of the result, and a named laboratory can be asked to confirm it. A different lot describes other stock.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eIf an iMuscle certificate leaves any of these gaps, \u003ca href=\"\/en-ro\/pages\/contact\"\u003econtact us\u003c\/a\u003e before relying on the batch. See also \u003ca href=\"\/en-ro\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003ehow to read a COA\u003c\/a\u003e and our \u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003elab tests\u003c\/a\u003e page.\u003c\/p\u003e\n\u003ch2\u003eDetection, sport and testing\u003c\/h2\u003e\n\u003cp\u003eLGD-4033 is named in section S1.2 (other anabolic agents) of the WADA Prohibited List and is banned in and out of competition. Under strict liability an athlete answers for any prohibited substance in their sample, whether it came from a research compound, a mislabelled product or a contaminated supplement. WADA reported 62 adverse analytical findings involving LGD-4033 in 2019, a number the Cologne authors described as the highest reported so far (Wagener et al., 2022).\u003c\/p\u003e\n\u003cp\u003eThe most detailed controlled detection data come from microgram amounts. At the German Sport University Cologne, groups of five healthy men took a single 1, 10 or 50 microgram amount, or the same amount on five consecutive days, and their urine was analysed by LC-HRMS\/MS with a limit of detection of 8 picograms per millilitre. After one 50 microgram amount, the longest-lasting metabolite, M5-a, gave its first negative sample only after 11 days. After five daily 50 microgram amounts, metabolite M5-b was still present in every sample when collection ended, 1,004 to 1,128 hours (about 42 to 47 days) after the last intake, so no end point could be set. The authors proposed the ratio of M1 to LGD-4033 for estimating when intake occurred.\u003c\/p\u003e\n\u003cp\u003eNo published study that we can cite establishes a detection window after milligram amounts such as the 8 mg stated per capsule here, so for this product the accurate statement is: detectable, window not established. The microgram results set no upper limit. Anyone subject to anti-doping rules should treat any contact with LGD-4033 as a risk of an adverse finding.\u003c\/p\u003e\n\u003ch2\u003eStorage, stability and handling\u003c\/h2\u003e\n\u003cp\u003eWe are not aware of any published shelf-life study of LGD-4033 capsules. An expiry or best-before date printed by iMuscle is the limit, and a certificate describes the batch only as it stood on its test date.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eKeep the capsules in their original pot with the lid closed after every opening; the lot number on it is the only link to a certificate.\u003c\/li\u003e\n\u003cli\u003eChoose a cool, dry, dark cupboard away from ovens, radiators, sunny windows and bathrooms. Hard capsule shells soften and stick in damp air and turn brittle in hot, dry air.\u003c\/li\u003e\n\u003cli\u003eIf the pot has been somewhere cold, let it reach room temperature before opening, so condensation does not settle on the capsules.\u003c\/li\u003e\n\u003cli\u003eRecord when the seal was first broken alongside the lot number, and give any portion taken for analysis its own label showing compound, lot and date.\u003c\/li\u003e\n\u003cli\u003eWear gloves with opened capsules or loose powder, keep the material away from food and drink and out of reach of children and pets, and dispose of it as chemical waste, never in household bins or drains.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eReturns are accepted only on unopened items within 30 days, so a pack left sealed until needed keeps its return option.\u003c\/p\u003e\n\u003ch2\u003eGlossary\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAndrogen receptor\u003c\/strong\u003e: the protein inside cells that testosterone switches on; LGD-4033 binds the same receptor.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSARM\u003c\/strong\u003e: a non-steroidal ligand of the androgen receptor, developed in the hope of anabolic action in muscle and bone with less action on the prostate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSHBG\u003c\/strong\u003e: sex hormone-binding globulin, the blood protein that carries much circulating testosterone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHDL cholesterol\u003c\/strong\u003e: cholesterol carried in high-density lipoproteins, a standard blood lipid measurement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase 1 trial\u003c\/strong\u003e: an early, usually small clinical study of how a compound is tolerated and handled by the body, before any larger trial examines efficacy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCholestatic liver injury\u003c\/strong\u003e: damage that impairs the flow of bile, typically causing jaundice and itching.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStereocentre\u003c\/strong\u003e: an atom whose attached groups can be arranged in two mirror-image ways; LGD-4033 has two.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpimer\u003c\/strong\u003e: an isomer differing from another at only one of several stereocentres.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolite\u003c\/strong\u003e: a substance the body makes from another; anti-doping tests target long-lasting ones.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLimit of detection\u003c\/strong\u003e: the lowest concentration a method can reliably detect.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdverse analytical finding\u003c\/strong\u003e: an anti-doping laboratory's report that a sample contains a prohibited substance, its metabolites or markers of its use; it starts the results-management process rather than concluding it.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eAbout iMuscle Ligandrol LGD-4033\u003c\/h2\u003e\u003cp\u003eiMuscle's ligandrol comes in a pot labelled LIGANDROL in light blue, with LGD and 4033 printed underneath and the iMUSCLE logo above. At 8 mg per capsule it carries the lowest figure in the brand's single-compound line, where every other pot is labelled 10 or 15 mg. The front box states 60 capsules; the side panel gives 8 mg of Ligandrol LGD 4033 per capsule beside a chemical name and the brand's claim of purity tested above 97%; and the brand's own shop lists it as \"60\/8mg\", 480 mg per pot.\u003c\/p\u003e\u003cp\u003eOn its About page iMuscle calls itself an international online shop for SARMs. Free Muscle stocks its products as a retailer, not as an appointed distributor: we found no iMuscle page naming UK sellers, and we make no claim to official or exclusive status. Ligandrol appears in three iMuscle stacks we list, \u003ca href=\"\/en-ro\/products\/imuscle-cardarine-gw501516-ligandrol\"\u003eCardarine and Ligandrol\u003c\/a\u003e, \u003ca href=\"\/en-ro\/products\/imuscle-ligandrol-ibutamoren-ostarine\"\u003eLigandrol, Ibutamoren and Ostarine\u003c\/a\u003e and \u003ca href=\"\/en-ro\/products\/imuscle-ligandrol-testolon-yk-11\"\u003eLigandrol, Testolon and YK-11\u003c\/a\u003e, and the whole range is on the \u003ca href=\"\/en-ro\/collections\/brand-imuscle\"\u003eiMuscle brand page\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eLGD-4033 is a non-steroidal SARM first developed by Ligand Pharmaceuticals; its main human evidence is one short placebo-controlled study in healthy young men. It is unlicensed in the UK and banned under WADA section S1. As of October 2026 no other brand of LGD-4033 is on our shelves; the \u003ca href=\"\/en-ro\/collections\/lgd-4033\"\u003eLGD-4033 collection\u003c\/a\u003e and the \u003ca href=\"\/en-ro\/blogs\/news\/lgd-4033-ligandrol-research-guide\"\u003eligandrol research guide\u003c\/a\u003e cover the compound itself.\u003c\/p\u003e\u003cp\u003eIts gallery shows protocol RN18654 from 2021, recording an HPLC assay of one sample without a lot number, and an HPLC print-out labelled LGD4033 with lot 20210911. Both record a 2021 test rather than the pots on sale now. Check the lot code printed on your pot and \u003ca href=\"\/en-ro\/pages\/contact\"\u003econtact us\u003c\/a\u003e with it; we pass on whatever iMuscle supplies for that lot, and Free Muscle's Janoshik programme does not cover this brand.\u003c\/p\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-ro\/collections\/lgd-4033\"\u003eAll brands of LGD-4033 (Ligandrol)\u003c\/a\u003e, compared on strength, pack size and batch testing\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-ro\/collections\/brand-imuscle\"\u003eAll iMuscle products\u003c\/a\u003e stocked at Free Muscle\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-ro\/blogs\/news\/lgd-4033-ligandrol-research-guide\"\u003eLGD-4033 (ligandrol): trials, findings and UK status\u003c\/a\u003e, the full research guide\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-ro\/collections\/ostarine\"\u003eOstarine (MK-2866)\u003c\/a\u003e and \u003ca href=\"\/en-ro\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-ro\/pages\/shipping\"\u003eDelivery\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/guarantee\"\u003ereturns\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eResearch compounds sold by Free Muscle are supplied for laboratory research use only and are not for human consumption. They are not authorised as medicines by the MHRA, EMA or FDA, are not food supplements, and are sold only to adults aged 18 or over. Nothing on this page is medical or dosing advice.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eBasaria S, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22459616\/\" rel=\"noopener\"\u003ePMID: 22459616\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003eBarbara M, et al. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J. 2020;7(6):e00370. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32637435\/\" rel=\"noopener\"\u003ePMID: 32637435\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003eWagener F, et al. Investigations into the elimination profiles and metabolite ratios of micro-dosed selective androgen receptor modulator LGD-4033 for doping control purposes. Anal Bioanal Chem. 2022;414(2):1151-1162. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34734312\/\" rel=\"noopener\"\u003ePMID: 34734312\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"iMuscle","offers":[{"title":"Default Title","offer_id":48468979482850,"sku":null,"price":35.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/LIGANDROL_720x_31d8619e-fb4e-4156-b614-1cc97bde668c.jpg?v=1789931406"}],"url":"https:\/\/freemuscle.co.uk\/en-ro\/collections\/lgd-4033.oembed","provider":"Free Muscle","version":"1.0","type":"link"}