{"title":"RAD-150 (TLB-150)","description":"\u003cp\u003eRAD-150, also called TLB-150 and sometimes written RAD150 or TLB150, is sold as the benzoate ester of the selective androgen receptor modulator RAD-140 (testolone), and UK Anti-Doping lists it by name among SARMs prohibited in sport. Sellers say the ester slows release of the parent molecule; no peer-reviewed study has examined this. This page lists every brand of RAD-150 stocked at Free Muscle, compared on strength per capsule, capsules per pack and batch testing, and sets out honestly how thin the published evidence for this compound is.\u003c\/p\u003e\n\u003ch2\u003eWhat is RAD-150?\u003c\/h2\u003e\n\u003cp\u003eRAD-150 is described by its manufacturers as a benzoate ester of RAD-140, a non-steroidal SARM first reported by Radius Health in 2011. In pharmacology, esterification is a familiar technique: attaching an ester group to a molecule that carries a free hydroxyl often makes it more fat-soluble, so that it is released more slowly and acts for longer once the ester is cleaved by esterase enzymes. Whether RAD-150 actually behaves this way in any biological system has not been tested in the published literature. The structure is not a market invention, however: a Radius Health patent with a 2008 priority date, granted in the US in 2012 (US 8,268,872), describes it as Example 87, one of several RAD-140 esters whose synthesis the patent sets out. No published study of the ester followed.\u003c\/p\u003e\n\u003cp\u003eEverything that can be said with any confidence about its mechanism is inherited from the parent molecule. RAD-140 binds the androgen receptor with high affinity and was designed for tissue selectivity, favouring muscle and bone over prostate. If RAD-150 is hydrolysed to RAD-140 in vivo, its receptor pharmacology would be expected to follow, but the rate and extent of that conversion, and the fate of the benzoate fragment, are unknown.\u003c\/p\u003e\n\u003cp\u003eRAD-150 has no human trial data, no published animal data, and has never been submitted for approval anywhere. It holds no marketing authorisation from the MHRA, EMA or FDA and is not a medicine in any jurisdiction.\u003c\/p\u003e\n\u003cp\u003eIdentity, as recorded in PubChem under the title TLB 150 Benzoate:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID\u003c\/strong\u003e: 68547459\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula\u003c\/strong\u003e: C27H20ClN5O3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight\u003c\/strong\u003e: 497.9\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number\u003c\/strong\u003e: suppliers quote 1208070-53-4, which PubChem lists only among depositor synonyms; it shows no validated CAS entry\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystematic name\u003c\/strong\u003e: [(1R,2S)-1-(3-chloro-4-cyano-2-methylanilino)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]propan-2-yl] benzoate\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat the published research reports\u003c\/h2\u003e\n\u003cp\u003ePubMed searches run on 2 October 2026 found no records for RAD150, TLB150, TLB-150 or RAD140 benzoate, and the three records matching \"RAD-150\" concern unrelated subjects. There are no controlled studies, no pharmacokinetic work and no case reports. Because of this, the only relevant evidence is the literature on RAD-140, and even that must be read with the caveat that an ester is a different chemical entity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRAD-140 discovery paper (2011).\u003c\/strong\u003e Miller and colleagues described the design, synthesis and preclinical characterisation of RAD140 as a potent, orally bioavailable, non-steroidal SARM, tested in several animal models of anabolic androgen action. No human data are included.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRAD-140 first-in-human study (2022).\u003c\/strong\u003e LoRusso and colleagues reported a phase 1 dose-escalation study of RAD140 in 22 postmenopausal women with ER-positive, HER2-negative metastatic breast cancer. Elevated AST (59.1 per cent), elevated ALT (45.5 per cent) and raised bilirubin (27.3 per cent) were the most common treatment-emergent adverse events, and grade 3 or 4 events occurred in 72.7 per cent of patients. Clinical benefit rate at 24 weeks was 18.2 per cent. It is the only published clinical trial of the parent compound.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUK market analysis of SARM products (2021).\u003c\/strong\u003e Leaney and colleagues, working in a UK laboratory, purchased supplement products marketed as SARMs to UK consumers and analysed them by high-resolution mass spectrometry. They found discrepancies ranging from products with no active ingredient at all to products containing undeclared prohibited substances, and where a SARM was present its measured concentration often differed from the label. The authors noted that no SARM has yet gained clinical approval from the EMA or FDA and that toxicity data, especially for combinations, are incomplete.\u003c\/p\u003e\n\u003cp\u003eThese findings describe study participants, laboratory animals and purchased products from other suppliers. None of them is a claim about the RAD-150 listed on this page, and none of the RAD-140 findings can be assumed to transfer to the ester.\u003c\/p\u003e\n\u003ch2\u003eBrands of RAD-150 we stock\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree Muscle RAD-150 (TLB-150), Bioreactive Series, 25mg, 60 capsules.\u003c\/strong\u003e Our own brand, capsule form, 1,500mg of compound per pack. Every batch is assayed by Janoshik Analytical and the certificate for your batch is available by email on request. \u003ca href=\"\/en-ro\/products\/rad-150-tlb-150-bioreactive-series\"\u003eView the Free Muscle RAD-150 listing\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRAD-150 is currently a single-brand line at Free Muscle. Third-party brands in the Muscle Market range (iMuscle, Yakka Strength, Thoroughbred Labs and BioLab) do not supply it at present.\u003c\/p\u003e\n\u003ch3\u003eHow to compare them\u003c\/h3\u003e\n\u003cp\u003eWith one brand on the page the comparison is against the RAD-140 collection rather than between RAD-150 products. Compute total milligrams per pack (strength per capsule multiplied by capsules per pack), divide the price by that figure for cost per milligram, and remember that a milligram of the ester contains less of the parent molecule because the benzoate group adds mass: by formula weight, 393.8 of the ester's 497.9 comes from RAD-140, roughly 79 per cent. That figure is worked out from the formulas; it is not a measurement of how much RAD-140 is released. Above all, check the batch certificate: with a compound this poorly characterised, an independent identity and purity assay is the only objective information available. Our guide to \u003ca href=\"\/en-ro\/blogs\/news\/price-per-mg-compare-sarms-peptides\"\u003eprice per milligram\u003c\/a\u003e covers the arithmetic.\u003c\/p\u003e\n\u003ch2\u003eBatch testing and certificates of analysis\u003c\/h2\u003e\n\u003cp\u003eRAD-150 has no published analytical literature, so the batch certificate is the main evidence of what a capsule holds, and for an ester it has to answer a sharper question than usual: is the material the ester, or RAD-140 sold under another name? In liquid chromatography with mass spectrometry, the ester's protonated molecule is expected near m\/z 498, calculated from its formula, while RAD-140 gives about m\/z 394. A distinct RAD-140 peak alongside the ester suggests leftover starting material or partial hydrolysis. Nuclear magnetic resonance (NMR), which some certificates include, is a separate identity technique that shows how the atoms are connected and can tell an ester from its parent without relying on mass.\u003c\/p\u003e\n\u003cp\u003eJanoshik Analytical, an independent laboratory, tests every Free Muscle batch of RAD-150, and we email the certificate for any batch on request when given the batch number printed on the bottle. A certificate with no batch number or test date, or one whose identity result names RAD-140, does not describe these capsules. The \u003ca href=\"\/en-ro\/pages\/lab-tests\"\u003elab tests page\u003c\/a\u003e sets out how a certificate is matched to its batch.\u003c\/p\u003e\n\u003ch2\u003eLegal status in the UK\u003c\/h2\u003e\n\u003cp\u003eNo SARM appears in the Misuse of Drugs Act 1971, RAD-150 included. The ester has never been granted an MHRA marketing authorisation, which rules out its sale or presentation as a medicine, and, as UK Anti-Doping points out, the Food Standards Agency considers SARMs unauthorised novel foods, making their sale or advertising as food, or inside dietary supplements, unlawful in the UK. Free Muscle supplies RAD-150 for laboratory research only, to buyers aged 18 or over.\u003c\/p\u003e\n\u003cp\u003eThe 2026 WADA Prohibited List does not name the ester, but the S1.2 heading reads \"including, but not limited to\", and its SARM entry gives examples rather than a closed list. For athletes tested in the UK, UK Anti-Doping lists RAD-150 (TLB-150) by name among commonly available SARMs, prohibited at all times under S1. The wider SARM class is covered in our \u003ca href=\"\/en-ro\/blogs\/news\/what-are-sarms-the-2026-research-guide\"\u003eresearch guide to SARMs\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eStorage and handling\u003c\/h2\u003e\n\u003cp\u003eMoisture is the particular risk for an ester, because water can split RAD-150 back into RAD-140 and benzoic acid, so keep the capsules sealed in their original, batch-numbered bottle in a cool, dry, dark place, away from children and pets, and handle them with ordinary laboratory good practice. Condensation, record keeping and disposal are covered in more detail on the \u003ca href=\"\/en-ro\/products\/rad-150-tlb-150-bioreactive-series\"\u003eFree Muscle RAD-150 page\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eDelivery and returns\u003c\/h2\u003e\n\u003cp\u003eEvery RAD-150 order is sent from our UK operations in Scunthorpe with free tracked delivery to any UK address, in plain packaging. Orders placed before 2pm Monday to Friday are processed the same working day, and EU orders normally arrive within 3 to 7 working days. Unopened items may be returned within 30 days. Customers must be 18 or over. See the \u003ca href=\"\/en-ro\/pages\/shipping\"\u003eshipping page\u003c\/a\u003e and \u003ca href=\"\/en-ro\/pages\/guarantee\"\u003eguarantee page\u003c\/a\u003e for the full terms.\u003c\/p\u003e\n\u003ch2\u003eRelated reading\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/rad-140-vs-rad-150-tlb-150\"\u003eRAD-140 vs RAD-150 (TLB-150): ester chemistry and the evidence gap\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/rad-140-testolone-what-the-research-says\"\u003eRAD-140 (testolone): what the research says\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/how-to-read-a-certificate-of-analysis\"\u003eHow to read a certificate of analysis\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/what-is-janoshik-analytical\"\u003eWhat is Janoshik Analytical?\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en-ro\/blogs\/news\/how-to-choose-a-sarms-supplier-uk-checklist\"\u003eHow to choose a SARMs supplier in the UK: a checklist\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRelated collections: \u003ca href=\"\/en-ro\/collections\/rad-140\"\u003eRAD-140 (Testolone)\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/bioreactive-series\"\u003eBioreactive Series\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/yk-11\"\u003eYK-11\u003c\/a\u003e, \u003ca href=\"\/en-ro\/collections\/sarms\"\u003eall SARMs\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eMiller CP, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-129. PMID: 24900290.\u003c\/li\u003e\n\u003cli\u003eLoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+\/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.\u003c\/li\u003e\n\u003cli\u003eLeaney AE, et al. Analysis of supplements available to UK consumers purporting to contain selective androgen receptor modulators. Drug Test Anal. 2021;13(1):122-127. PMID: 32748554.\u003c\/li\u003e\n\u003cli\u003eMiller CP (inventor), Radius Health Inc (original assignee). Selective androgen receptor modulators. US Patent 8,268,872 B2, granted 18 September 2012; priority date 22 February 2008.\u003c\/li\u003e\n\u003cli\u003eUK Anti-Doping. SARMs (supplement ingredient warning). Last updated 29 April 2026.\u003c\/li\u003e\n\u003cli\u003eWorld Anti-Doping Agency. Prohibited List 2026, section S1.2, other anabolic agents.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eResearch compounds sold by Free Muscle are supplied for laboratory research use only and are not for human consumption. They are not authorised as medicines by the MHRA, EMA or FDA, are not food supplements, and are sold only to adults aged 18 or over. Nothing on this page is medical or dosing advice. Summaries of published research describe study findings and are not claims about any product.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"rad-150-tlb-150-bioreactive-series","title":"RAD-150 (TLB-150) — Bioreactive Series","description":"\u003cp\u003e\u003cstrong\u003eRAD-150 (TLB-150), Bioreactive Series.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eRAD-150 is a benzoate-ester form of RAD-140 (Testolone), a selective androgen receptor modulator. A benzoate ester generally slows release of the parent compound; that is a chemistry property, not a promised outcome. Neither compound has the clinical data to support a comparison of human results, and we are not going to invent one.\u003c\/p\u003e\u003cp\u003eSARMs have been associated with liver injury and testosterone suppression in published case reports. RAD-150 is \u003cstrong\u003enot authorised for human consumption in the UK or EU\u003c\/strong\u003e and is prohibited in sport by WADA.\u003c\/p\u003e\u003cp\u003eIdentity and purity are verified per batch by Janoshik Analytical, an independent laboratory. Certificate of Analysis available on request.\u003c\/p\u003e\u003cp\u003e\u003csmall\u003eResearch compounds sold by Free Muscle are supplied for laboratory research use only and are not for human consumption. They are not authorised as medicines by the MHRA, EMA or FDA, are not food supplements, and are sold only to adults aged 18 or over. Nothing on this page is medical or dosing advice.\u003c\/small\u003e\u003c\/p\u003e","brand":"FreeMuscle","offers":[{"title":"Default Title","offer_id":47040801865954,"sku":"10000000","price":69.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/3499\/5426\/files\/IMG-2551.jpg?v=1766262716"}],"url":"https:\/\/freemuscle.co.uk\/en-ro\/collections\/rad-150.oembed","provider":"Free Muscle","version":"1.0","type":"link"}