Next-gen ghrelin receptor agonist designed for clean, strong performance support.

Meet MK-777 (Acetamoren)—a fourth-generation, non-peptide small molecule crafted to target the GHS-R1a receptor with high affinity (Ki ≈ 0.8 nM) and optimized pharmacokinetics. Built as a close structural analog to MK-677 (Ibutamoren), MK-777 is engineered for tighter receptor selectivity and a smoother profile, supporting performance goals without the extra noise.

Why athletes choose MK-777

• High-affinity GHS-R1a targeting → engineered for potent, efficient receptor engagement

• Clean, modern profile → designed to support outcomes with fewer unwanted effects vs typical legacy options

• All-day support → elimination half-life ~8–10 hours, with effects that may extend 18–22 hours

• Built for consistency → fluorinated thioether backbone to resist first-pass metabolism

What it may support

• Lean mass & strength: supports muscle protein synthesis pathways

• Bone & recovery: supports healthy bone metabolism and recovery environments

• Sleep architecture: may promote deeper sleep quality and REM balance in exploratory settings

• Body composition: IGF-1 pathway support that favors muscle tissue over visceral fat in research contexts

• Appetite control: designed for a calmer hunger profile vs MK-677–style approaches

Note: Mechanistic points are grounded in ghrelin/GHS-R biology and exploratory research; individual responses vary.

How it works (in short)

MK-777 engages GHS-R1a (ghrelin receptor) with high affinity, mimicking key aspects of GH-axis signaling. It also displays allosteric modulation at somatostatin receptors (SSTR2/SSTR5), which may contribute to its balanced profile. The result: a next-gen take on the classic pathway—targeted, steady, and designed to feel cleaner.

Technical profile

• Compound: MK-777 (Acetamoren)

• Class: Non-peptide ghrelin receptor agonist

• Affinity: Ki ≈ 0.8 nM (high-affinity GHS-R1a targeting)

• Half-life: 8–10 hours (with extended IGF-1 support ~18–22 hrs reported)

• Formula / Mass: C₂₈H₃₅FN₄O₅S / 558.68 g/mol

Suggested use & stack

We don’t provide medical advice or dosing guidance. Combine any supplement plan with training, nutrition, sleep, and hydration. If you’re on medication or have a condition, talk to a healthcare professional first.

Transparency & quality

• Clear labeling & batch testing priorities

• Consistent manufacturing standards