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Carefully curated scientific guides and research insights, reviewed for accuracy, clarity and evidence-based consistency.

Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

What is in a PCT blend? Ingredients, evidence and UK status

Products sold as PCT blends or PCT supplements may contain SERMs such as clomifene and tamoxifen, which are prescription only medicines, the unlicensed isomer enclomiphene, aromatase inhibitors, or herbal and nutrient ingredients such as tongkat ali, D-aspa...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

Is HGH legal in the UK? Somatropin, prescriptions and the law

Somatropin, the medicine usually meant by HGH, is a prescription-only medicine and a Class C controlled drug in the UK. This guide explains both legal layers, the Human Medicines Regulations 2012 and the Misuse of Drugs Act 1971, what Schedule 4 Part II mea...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

MK-777 (Acetamoren): what the name means and how it relates to MK-677

MK-777, listed as Acetamoren, is Free Muscle's own designation for a Bioreactive Series product, not a compound name found in the scientific literature. This guide shows how we searched PubMed and PubChem and found no records, explains what a product design...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

RAD-140 (Testolone): what the research says and its UK status

RAD-140, sold under the name testolone, is a non-steroidal selective androgen receptor modulator that has only ever been tested in humans as an experimental breast cancer drug. This guide summarises the preclinical work, the single published phase 1 trial, ...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

Ostarine (MK-2866): what the clinical trials found and UK status

Ostarine, also known as MK-2866, enobosarm, GTx-024 and S-22, is the selective androgen receptor modulator with the largest clinical programme: phase 2 trials in healthy older adults and in cancer cachexia, a phase 3 programme that did not lead to approval,...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

MK-677 vs ipamorelin vs HGH: three routes to the GH axis compared

MK-677 and ipamorelin both act at the ghrelin receptor to make the pituitary release its own growth hormone, while somatropin is the hormone itself, a prescription-only medicine and Class C controlled drug in the UK. This guide compares the three on molecul...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

IGF-1 LR3: a cell-culture reagent, not a supplement

IGF-1 LR3 is an engineered analogue of insulin-like growth factor 1, designed in 1992 as a laboratory tool and used mainly to grow cells in serum-free culture. This guide explains how its structure lets it escape IGF-binding proteins, what cell and rat stud...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

RAD-140 vs RAD-150 (TLB-150): ester chemistry and the evidence gap

RAD-150, also sold as TLB-150, is the benzoate ester of the SARM RAD-140 (testolone). This guide compares the two: their PubChem identities, what adding the ester changes chemically, the single patent assay that measured both at the androgen receptor, why c...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

SR9009 (Stenabolic): REV-ERB research and the bioavailability problem

SR9009, sold as Stenabolic, is a synthetic REV-ERB agonist developed as a research probe for the circadian clock. What is known comes from mouse studies that gave it by injection and from cell work showing effects that do not depend on REV-ERB. There are no...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

Enclomiphene vs clomiphene (clomifene): what the trials report

Enclomiphene is one of the two isomers that make up clomifene (clomiphene), isolated on its own. This guide compares them: chemistry and mechanism, what the phase III trials and clinic studies reported, the adverse findings including the venous thromboembol...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

Ipamorelin research guide: trials, side effects and UK status

Ipamorelin is a synthetic five-amino-acid peptide that releases growth hormone through the ghrelin receptor, and its reputation for selectivity comes from animal work published in 1998. This guide sets out what that work showed, what the healthy-volunteer a...

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Scientific Guide Trusted Evidence Reviewed
Published September 27, 2026

YK-11: a steroidal compound sold as a SARM, what is actually known

YK-11 is marketed as a SARM and as a "myostatin inhibitor", but it is a synthetic steroid derivative whose evidence base is a handful of cell-culture papers, a few rodent studies (two of which reported harmful changes in the rat brain) and anti-doping paper...

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