RAD-150 (TLB-150)

RAD-150, also called TLB-150 and sometimes written RAD150 or TLB150, is sold as the benzoate ester of the selective androgen receptor modulator RAD-140 (testolone), and UK Anti-Doping lists it by name among SARMs prohibited in sport. Sellers say the ester slows release of the parent molecule; no peer-reviewed study has examined this. This page lists every brand of RAD-150 stocked at Free Muscle, compared on strength per capsule, capsules per pack and batch testing, and sets out honestly how thin the published evidence for this compound is.

What is RAD-150?

RAD-150 is described by its manufacturers as a benzoate ester of RAD-140, a non-steroidal SARM first reported by Radius Health in 2011. In pharmacology, esterification is a familiar technique: attaching an ester group to a molecule that carries a free hydroxyl often makes it more fat-soluble, so that it is released more slowly and acts for longer once the ester is cleaved by esterase enzymes. Whether RAD-150 actually behaves this way in any biological system has not been tested in the published literature. The structure is not a market invention, however: a Radius Health patent with a 2008 priority date, granted in the US in 2012 (US 8,268,872), describes it as Example 87, one of several RAD-140 esters whose synthesis the patent sets out. No published study of the ester followed.

Everything that can be said with any confidence about its mechanism is inherited from the parent molecule. RAD-140 binds the androgen receptor with high affinity and was designed for tissue selectivity, favouring muscle and bone over prostate. If RAD-150 is hydrolysed to RAD-140 in vivo, its receptor pharmacology would be expected to follow, but the rate and extent of that conversion, and the fate of the benzoate fragment, are unknown.

RAD-150 has no human trial data, no published animal data, and has never been submitted for approval anywhere. It holds no marketing authorisation from the MHRA, EMA or FDA and is not a medicine in any jurisdiction.

Identity, as recorded in PubChem under the title TLB 150 Benzoate:

• PubChem CID: 68547459
• Molecular formula: C27H20ClN5O3
• Molecular weight: 497.9
• CAS number: suppliers quote 1208070-53-4, which PubChem lists only among depositor synonyms; it shows no validated CAS entry
• Systematic name: [(1R,2S)-1-(3-chloro-4-cyano-2-methylanilino)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]propan-2-yl] benzoate

What the published research reports

PubMed searches run on 2 October 2026 found no records for RAD150, TLB150, TLB-150 or RAD140 benzoate, and the three records matching "RAD-150" concern unrelated subjects. There are no controlled studies, no pharmacokinetic work and no case reports. Because of this, the only relevant evidence is the literature on RAD-140, and even that must be read with the caveat that an ester is a different chemical entity.

RAD-140 discovery paper (2011). Miller and colleagues described the design, synthesis and preclinical characterisation of RAD140 as a potent, orally bioavailable, non-steroidal SARM, tested in several animal models of anabolic androgen action. No human data are included.

RAD-140 first-in-human study (2022). LoRusso and colleagues reported a phase 1 dose-escalation study of RAD140 in 22 postmenopausal women with ER-positive, HER2-negative metastatic breast cancer. Elevated AST (59.1 per cent), elevated ALT (45.5 per cent) and raised bilirubin (27.3 per cent) were the most common treatment-emergent adverse events, and grade 3 or 4 events occurred in 72.7 per cent of patients. Clinical benefit rate at 24 weeks was 18.2 per cent. It is the only published clinical trial of the parent compound.

UK market analysis of SARM products (2021). Leaney and colleagues, working in a UK laboratory, purchased supplement products marketed as SARMs to UK consumers and analysed them by high-resolution mass spectrometry. They found discrepancies ranging from products with no active ingredient at all to products containing undeclared prohibited substances, and where a SARM was present its measured concentration often differed from the label. The authors noted that no SARM has yet gained clinical approval from the EMA or FDA and that toxicity data, especially for combinations, are incomplete.

These findings describe study participants, laboratory animals and purchased products from other suppliers. None of them is a claim about the RAD-150 listed on this page, and none of the RAD-140 findings can be assumed to transfer to the ester.

Brands of RAD-150 we stock

• Free Muscle RAD-150 (TLB-150), Bioreactive Series, 25mg, 60 capsules. Our own brand, capsule form, 1,500mg of compound per pack. Every batch is assayed by Janoshik Analytical and the certificate for your batch is available by email on request. View the Free Muscle RAD-150 listing.

RAD-150 is currently a single-brand line at Free Muscle. Third-party brands in the Muscle Market range (iMuscle, Yakka Strength, Thoroughbred Labs and BioLab) do not supply it at present.

How to compare them

With one brand on the page the comparison is against the RAD-140 collection rather than between RAD-150 products. Compute total milligrams per pack (strength per capsule multiplied by capsules per pack), divide the price by that figure for cost per milligram, and remember that a milligram of the ester contains less of the parent molecule because the benzoate group adds mass: by formula weight, 393.8 of the ester's 497.9 comes from RAD-140, roughly 79 per cent. That figure is worked out from the formulas; it is not a measurement of how much RAD-140 is released. Above all, check the batch certificate: with a compound this poorly characterised, an independent identity and purity assay is the only objective information available. Our guide to price per milligram covers the arithmetic.

Batch testing and certificates of analysis

RAD-150 has no published analytical literature, so the batch certificate is the main evidence of what a capsule holds, and for an ester it has to answer a sharper question than usual: is the material the ester, or RAD-140 sold under another name? In liquid chromatography with mass spectrometry, the ester's protonated molecule is expected near m/z 498, calculated from its formula, while RAD-140 gives about m/z 394. A distinct RAD-140 peak alongside the ester suggests leftover starting material or partial hydrolysis. Nuclear magnetic resonance (NMR), which some certificates include, is a separate identity technique that shows how the atoms are connected and can tell an ester from its parent without relying on mass.

Janoshik Analytical, an independent laboratory, tests every Free Muscle batch of RAD-150, and we email the certificate for any batch on request when given the batch number printed on the bottle. A certificate with no batch number or test date, or one whose identity result names RAD-140, does not describe these capsules. The lab tests page sets out how a certificate is matched to its batch.

Legal status in the UK

No SARM appears in the Misuse of Drugs Act 1971, RAD-150 included. The ester has never been granted an MHRA marketing authorisation, which rules out its sale or presentation as a medicine, and, as UK Anti-Doping points out, the Food Standards Agency considers SARMs unauthorised novel foods, making their sale or advertising as food, or inside dietary supplements, unlawful in the UK. Free Muscle supplies RAD-150 for laboratory research only, to buyers aged 18 or over.

The 2026 WADA Prohibited List does not name the ester, but the S1.2 heading reads "including, but not limited to", and its SARM entry gives examples rather than a closed list. For athletes tested in the UK, UK Anti-Doping lists RAD-150 (TLB-150) by name among commonly available SARMs, prohibited at all times under S1. The wider SARM class is covered in our research guide to SARMs.

Storage and handling

Moisture is the particular risk for an ester, because water can split RAD-150 back into RAD-140 and benzoic acid, so keep the capsules sealed in their original, batch-numbered bottle in a cool, dry, dark place, away from children and pets, and handle them with ordinary laboratory good practice. Condensation, record keeping and disposal are covered in more detail on the Free Muscle RAD-150 page.

Delivery and returns

Every RAD-150 order is sent from our UK operations in Scunthorpe with free tracked delivery to any UK address, in plain packaging. Orders placed before 2pm Monday to Friday are processed the same working day, and EU orders normally arrive within 3 to 7 working days. Unopened items may be returned within 30 days. Customers must be 18 or over. See the shipping page and guarantee page for the full terms.

Related reading

• RAD-140 vs RAD-150 (TLB-150): ester chemistry and the evidence gap
• RAD-140 (testolone): what the research says
• How to read a certificate of analysis
• What is Janoshik Analytical?
• How to choose a SARMs supplier in the UK: a checklist

Related collections: RAD-140 (Testolone), Bioreactive Series, YK-11, all SARMs.

References

• Miller CP, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-129. PMID: 24900290.
• LoRusso P, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. PMID: 34565686.
• Leaney AE, et al. Analysis of supplements available to UK consumers purporting to contain selective androgen receptor modulators. Drug Test Anal. 2021;13(1):122-127. PMID: 32748554.
• Miller CP (inventor), Radius Health Inc (original assignee). Selective androgen receptor modulators. US Patent 8,268,872 B2, granted 18 September 2012; priority date 22 February 2008.
• UK Anti-Doping. SARMs (supplement ingredient warning). Last updated 29 April 2026.
• World Anti-Doping Agency. Prohibited List 2026, section S1.2, other anabolic agents.

Research compounds sold by Free Muscle are supplied for laboratory research use only and are not for human consumption. They are not authorised as medicines by the MHRA, EMA or FDA, are not food supplements, and are sold only to adults aged 18 or over. Nothing on this page is medical or dosing advice. Summaries of published research describe study findings and are not claims about any product.

Research guides

• RAD-140 vs RAD-150 (TLB-150): ester chemistry and the evidence gap
• All research guides